Porphyrin-DNA cross-linking agent hybrids: Chemical synthesis and biological studies

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 12, 2004, Pages 3013-3016

  He, Hanping ^a   Tian, Tian ^a   Wang, Ping ^a   Wu, Lin ^a   Xu, Jingjing ^a   Zhou, Xiang ^a,b   Zhang, Xiaolian ^a   Cao, Xiaoping ^c   Wu, Xiaojun ^a  

^a WUHAN UNIVERSITY   (China)

^b PEKING UNIVERSITY   (China)

^c LANZHOU UNIVERSITY   (China)

Author keywords

Anti tumor agent; DNA cross linking; Photocleavage

Indexed keywords

DNA; PORPHYRIN; PORPHYRIN DERIVATIVE;

ARTICLE; BIOLOGY; CELL STRAIN; CROSS LINKING; DNA CLEAVAGE; DRUG ACTIVITY; DRUG SCREENING; DRUG SYNTHESIS; HYBRID; IC 50; IRRADIATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; CROSS-LINKING REAGENTS; DNA; DNA DAMAGE; HUMANS; PORPHYRINS;

EID: 2442536828     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.04.044     Document Type: Article

References (25)

1. Rajski S.R., Williams R.M. Chem. Rev. 98:1998;2723
2. Hartley J.A., Hazrati A., Hokdgkinson T.J., Kelland L.R., Khanim R., Shipman M., Suzenet F. Chem. Commun. 2000;2325
3. Wolkenberg S.E., Boger D.L. Chem. Rev. 102:2002;2477
4. Sherman S.E., Lippard S.J. Chem. Rev. 87:1987;1153
5. Li V.-S., Choi D., Tang M.-S., Kohn H. J. Am. Chem. Soc. 118:1996;3765
6. Sternberg E.D., Dolphin D. Tetrahedron. 54:1998;4151
7. Dougherty T.J. J. Natl. Cancer Inst. 90:1998;889
8. Sessler J.L., Weghorn S.J. Expanded, Contracted and Isomeric Porphyrins. 1997;Elsevier, Oxford
9. Bonnett R., Martinez G. Tetrahedron. 57:2001;9513
10. Kim Y.-S., Song R., Kim D.H., Jun M.J., Sohn Y.S. Bioorg. Med. Chem. 11:2003;1753
11. Wang P., Liu R.-P., Wu X.-J., Ma H.-J., Cao X.-P., Zhou P., Zhang J.-Y., Weng X.-C., Zhang X.-L., Qi J., Zhou X., Weng L.-H. J. Am. Chem. Soc. 125:2003;1116
12. Modica E., Zanaletti R., Freccero M., Mella M. J. Org. Chem. 66:2001;41
13. Pande P., Shearer J., Yang J., Greenberg W.A., Rokita S.E. J. Am. Chem. Soc. 121:1999;6773
14. O'Brien P.M., Slikovic D.R., Blankley C.J., Roth B.D., Willson M.W., Hamelehle K.L., Krause B.R., Stanfield R.L. J. Med. Chem. 37:1994;1810
15. Wang Q.M., Bruce D.W. Synlett. 1995;1267
16. Lee C.H., Lindsey J.S. Tetrahedron. 50:1994;11436
17. Lindsey J.S., Wagner R.W. J. Org. Chem. 54:1989;828
18. Little B.J., Ciringh Y., Lindsey J.S. J. Org. Chem. 64:1999;2864
19. + - 2I)/2]) calcd 395.1992, found 395.1998
20. Zhang J.-Y., Wu X.-J., Cao X.-P., Yang F., Wang J.-F., Zhou X., Zhang X.-L. Bioorg. Med. Chem. Lett. 13:2003;1097
21. Michelsen D., Kliesch H., Wohrle D. Photochem. Photobiol. 64:1996;694
22. Oda K., Ogura S., Osekura I. J. Photochem. Photobiol. B. 59:2000;20
23. Alley M.C., Scudiero D., Monks A., Hursey M.L., Czerwinski M.J., Fine D.L., Abbott B., Mayo J.G., Shoemaker R.H., Boyd M.R. Cancer Res. 48:1998;589
24. Chen B., Qin W., Wang P., Tian T., Ma H.-J., Cao X.-P., Wu X.-J., Zhou X., Zhang X.-L., Liu F., Zheng F., Li X. Bioorg. Med. Chem. Lett. 13:2003;3731
25. Wu S., Wang P., Tian T., Wu L., He H.-P., Zhou X., Zhang X.-L., Cao X.-P. Bioorg. Med. Chem. Lett. 14:2004;2575