New substituted triaza-benzo[cd]azulen-9-ones as promising phosphodiesterase-4 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 12, 2004, Pages 3303-3306

  Devillers, Ingrid ^a   Pevet, Isabelle ^a   Jacobelli, Henry ^a   Durand, Corinne ^a   Fasquelle, Véronique ^a   Puaud, Jocelyne ^a   Gaudillière, Bernard ^a   Idrissi, Moulay ^a   Moreau, François ^a   Wrigglesworth, Roger ^a  

^a PFIZER INC   (United States)

Author keywords

Azabenzodiazepine; CI 1044; ortho Directed metallation; PDE4 inhibitor; Pyridine

Indexed keywords

ANTIINFLAMMATORY AGENT; AZULENE DERIVATIVE; DIAZEPINE DERIVATIVE; IMMUNOMODULATING AGENT; PHOSPHODIESTERASE IV INHIBITOR;

ARTICLE; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; AZULENES; CYCLOHEPTANES; PHOSPHODIESTERASE INHIBITORS;

EID: 2442534749     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.03.067     Document Type: Article

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