Purification and Characterization of Insulin-Mimetic Inositol Phosphoglycan-Like Molecules from Grass Pea (Lathyrus sativus) Seeds

Molecular Medicine

Volumn 7, Issue 7, 2001, Pages 454-460

  Pañeda, Covadonga ^a   Villar, Ana Victoria ^b   Alonso, Alicia ^b   Goñi, Félix M ^b   Varela, Federico ^c   Brodbeck, Urs ^d   León, Yolanda ^a   Varela Nieto, Isabel ^a   Jones, David R ^e  

^a INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

^b CSIC UPV Unidad de Biofisica UBF   (Spain)

^c Depto de Genetica y Biotecnologia   (Spain)

^d UNIVERSITY OF BERN   (Switzerland)

^e CSIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; FATTY ACID; GLYCOSYLPHOSPHATIDYLINOSITOL; INOSITOL PHOSPHATE; INOSITOL PHOSPHATE GLYCAN; INSULIN; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); POLYSACCHARIDE;

ANIMAL; ARTICLE; CELL DIVISION; CELL LINE; CHEMISTRY; CHICK EMBRYO; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GANGLION; GENE EXPRESSION; HYDROLYSIS; IN VITRO STUDY; ISOLATION AND PURIFICATION; LATHYRUS; LIVER; PLANT SEED; RAT;

ANIMALS; CELL DIVISION; CELL LINE; CHICK EMBRYO; CYCLIC AMP-DEPENDENT PROTEIN KINASES; FATTY ACIDS; GANGLIA; GENE EXPRESSION; GLYCOSYLPHOSPHATIDYLINOSITOLS; HYDROLYSIS; INOSITOL PHOSPHATES; INSULIN; LATHYRUS; LIVER; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); POLYSACCHARIDES; RATS; SEEDS;

EID: 2442432648     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03401850     Document Type: Article

References (38)

1. Varela-Nieto I, León Y, Caro HN. (1996) Cell signaling by inositol phosphoglycans from different species. Comp. Biochem. Physiol. 115B: 223-241.
2. McConville MJ, Menon AK. (2000) Recent developments in cell biology and biochemistry of glycosylphosphatidylinositol lipids. Mol. Membr. Biol. 17: 1-16.
3. Jones DR, Varela-Nieto I. (1998) The role of glycosylphosphatidylinositol in signal transduction. Int. J. Biochem. Cell Biol. 30: 313-326.
4. Jones DR, Varela-Nieto I. (1999) Diabetes and the role of inositol-containing lipids in insulin signaling. Mol. Med. 5: 505-514.
5. Gray AM, Flatt PR. (1997) Pancreatic and extra-pancreatic effects of the traditional anti-diabetic plant. Medicare sativa (lucerne). Br. J. Nutr. 78: 325-334.
6. Fitzl G, Martin R, Dettmer D, Hermsdorf V, Drews H, Welt K. (1999) Protective effects of Gingko biloba extracts EGb 761 on myocardium of experimentally diabetic rats I: ultraestructural and biochemical investigation on cardiomyocytes. Exp. Toxicol. Pathol. 51: 189-198.
7. Welt K, Weiss J, Koch S, Fitzl G. (1999) Protective effects of Gingko biloba extracts EGb 761 on myocardium of experimentally diabetic rats II: ultraestructural and immunochemical investigation on microvessels and insterstitium. Exp. Toxicol. Pathol. 51: 213-222.
8. Vartanian GS, Karagezian KG. (1981) Normalizing effects of Bryonia alba L. On blood phospholipids in alloxan diabetes. Vopr. Med. Kim. 27: 179-181.
9. Karagezian KG, Vartanian GS, Panosian AG. (1981) Effect of an extract from the roots of bryony (Bryonia alba) on lipid peroxidation in the liver of rats with alloxan diabetes. Bull Eksp. Biol. Med. 92: 35-37.
10. Almeida RN, Filho JM, Naik SR. (1985) Glycaemic and pharmacology of an ethanol extract of Bumelia sartorum. J. Ethnopharmacol. 14: 173-185.
11. Swanston-Flatt SK, Day C, Flatt PR, Gould BJ, Bailey CJ. (1989) Glycaemic effects of traditional European plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice. Diabetes Res. 10: 69-72.
12. Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR. (1990) Traditional plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice. Diabetologia 33: 462-464.
13. Records of the C.R.F-I.N.I.A., Madrid, Spain.
14. Hoener MC, Brodbeck U. (1992) Phosphatidylinositol-glycanspeciflc phospholipase D is an arnphiphilic glycoprotein that in serum is associated with high-density lipoproteins. Eur. J. Biochem. 206: 747-757.
15. Varela-Nieto I, Alvarez L, Mato JM. (1993) Intracellular mediators of peptide hormone action: glycosylphosphatidylinositol/inositol phosphoglycan system. In: de Pablo F, Scanes CG, eds. Handbook of Endocrine Research Techniques. New York: Academic Press, pp. 391-405.
16. Dietrich H, Espinosa JE, Chiara JL, et al. (1999) Glycosyl inositol derivatives related to inositolphosphoglycan mediators: synthesis, structure and biological activity. Chem. Eur. J. 5: 320-336.
17. Martin-Lomas M, Khiar N, Garcia S, Koessler JL, Nieto PM, Rademacher TW. (2000) Inositolphosphoglycan mediators structurally related to glycosyl phosphatidylinositol anchors: synthesis, structure and biological activity. Chemistry 6: 3608-3621.
18. Villar AV, Goñi FM, Alonso A, Jones DR, León Y, VarelaNieto I. (1998) Phospholipase cleavage of glycosylphosphatidyl inositol reconstituted in liposomal membranes. FEBS Lett. 432: 150-154.
19. Villar AV, Alonso A, Pañeda C, Varela-Nieto I, Brodbeck U, Goñi FM. (1999) Towards the in vitro reconstitution of caveolae. Asymmetric incorporation of glycosylphosphatidylinositol (GPI) and gangliosides into liposomal membranes. FEBS Lett. 457: 71-74.
20. Jones DR, Avila MA, Sanz C, Varela-Nieto I. (1997) Glycosylphosphatidylinositol-phospholipase type D: a possible candidate for generation of second messengers. Biochem. Biophys. Res. Commun. 233: 432-437.
21. Villalba M, Kelly KL, Mato JM. (1988) Inhibition of cyclic AMP-dependent protein kinase by the polar head of an insulinsensitive glycophospholipid. Biochim. Biophys. Acta 968: 69-76.
22. Bernd P, Represa J. (1989) Characterization and localization of nerve growth factor receptors in the embryonic otic vesicle and cochleovestibular ganglion. Dev. Biol. 134: 11-20.
23. Represa J, Miner C, Giraldez F, et al. (1991) Glycosylphosphatidyl inositol phosphoglycans: a signaling system for the low-affinity nerve growth factor receptor. Proc. Natl. Acad. Sci. U.S.A. 88: 8016-8019.
24. Bravo R, MacDonald-Bravo H. (1987) Existence of two populations of cyclin/proliferating cell nuclear antigen during the cell cycle: association with DNA replication sites. J. Cell Biol. 105: 1549-1554.
25. Dietrich DR. (1993) Toxicological and pathological applications of proliferating cell nuclear antigen (PCNA), a novel endogenous marker for cell proliferation. Crit. Rev. Toxicol. 23: 77-109.
26. Lean Y, Sanz C, Giraldez F, Varela-Nieto I. (1998) Induction of cell growth by insulin and insulin-like growth factor-I is associated with jun expression in the otic vesicle. J. Camp. Neurol. 398: 323-332.
27. Alvarez L, Avila MA, Mato JM, Castaño JG, Varela-Nieto I. (1991) Insulin-like effects of inositol phosphate-glycan on messenger UNA expression in rat hepatocytes. Mol. Endocrinol. 5: 1062-1068.
28. Chomczynski P, Sacchi N. (1987) Single-step method of RNA isolation by acid guanidinium thiocianate-phenol-chloroform extraction. Ann. Biochem. 162: 156-159.
29. León Y, Vazquez E, Sanz C, et al. (1995) Insulin-like growth factor-I regulates the proliferation in the developing inner ear, activating glycosyl-phosphatidylinositol hydrolysis and fos expression. Endocrinology 136: 3494-3503.
30. León Y, Sanz C, Frago LM, et al. (1999) Involvement of insulin-like growth factor-I in inner ear organogenesis and regeneration. Harm. Metab. Res. 31: 126-132.
31. Frick W, Bauer A, Bauer J, Wied S, Müller G. (1998) Structure-activity relationship of synthetic phosphoinositolglycans mimicking metabolic insulin action. Biochemistry 37: 13421-13436.
32. Caro HN, Kunjara S, Rademacher TW, et al. (1997) Isolation and partial characterization of insulin-mimetic inositol phosphoglycans from human liver. Biochem. Mol. Med. 61: 214-228.
33. Fonteles MC, Almeida MQ, Lamer J. (2000) Antihyperglycemic effect of 3-O-methyl-D-chiro-inositol associated with manganese in streptozotocin diabetic rats. Harm. Metab. Res. 32: 129-132.
34. Fonteies MC, Huang LC, Lamer J. (1996) Infusion of pH 2.0 D-chiroinositol glycan insulin putative mediator normalizes plasma glucose in streptozotocin diabetic rats at a dose equivalent to insulin without inducing hypoglycemia. Diabetologia 39: 731-734.
35. Narayanan CR, Joshi JJ, Mujumdar AM, Dhekne W. (1987) Pinitol: a new anti-diabetic compound from the leaves of Bougainvillea spectabilis. Curr. Sci. 56: 139-141.
36. Talbot HW Jr, Seidler RJ. (1979) Gas Chromatographic analysis of in situ cyclitol utilization by Klebsielleae growing in redwood extracts. Appl. Environ Microbiol. 38: 599-605.
37. Ogawa K, Watanabe T, Ikeda Y, Korido S. (1997) A new glycoside 1D-2-O-α-D galactopyranosyl-chiro-inositol from jojoba beans. Carbohyd. Res. 302: 219-221.
38. Rubenstein AH, Levin NW, Elliott GA. (1962) Manganeseinduced hypoglycaemia. Lancet II: 1348-1351.