Failure in peripheral immuno-surveillance due to thymic atrophy: Importance of thymocyte maturation and apoptosis in adult tumor-bearer

Life Sciences

Volumn 77, Issue 21, 2005, Pages 2703-2716

  Mandal, Debaprasad ^a   Bhattacharyya, Arindam ^a   Lahiry, Lakshmishri ^a   Choudhuri, Tathagata ^a   Sa, Gaurisankar ^a   Das, Tanya ^a  

^a BOSE INSTITUTE   (India)

Author keywords

Apoptosis; Bcl 2 Bax; Ehrlich's ascites carcinoma; Maturation; Thymic atrophy

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; PROTEIN BAX; PROTEIN BCL 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BLOOD; CARCINOGENESIS; CELL MIGRATION; CONTROLLED STUDY; DOWN REGULATION; EHRLICH ASCITES TUMOR; HOST; IMMUNOSUPPRESSIVE TREATMENT; IMMUNOSURVEILLANCE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; SPLEEN; T LYMPHOCYTE SUBPOPULATION; THYMOCYTE; THYMUS ATROPHY; TUMOR; TUMOR GROWTH; UPREGULATION;

ANIMALS; ANNEXIN A5; APOPTOSIS; ATROPHY; BCL-2-ASSOCIATED X PROTEIN; CARCINOMA, EHRLICH TUMOR; CD4-CD8 RATIO; CELL CYCLE; DNA; FLOW CYTOMETRY; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENT DYES; GENES, BCL-2; IMMUNOLOGIC SURVEILLANCE; LONGITUDINAL STUDIES; MICE; NEOPLASM TRANSPLANTATION; PROTO-ONCOGENE PROTEINS C-BCL-2; SPLEEN; T-LYMPHOCYTES; THYMUS GLAND;

MURINAE;

EID: 24344455122     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2005.05.038     Document Type: Article

References (46)

1. B. Adkins, C. Muller, C.Y. Okada, R.A. Reichert, I.L. Weissman, and G.J. Spangrude Early events in T-cell maturation Annual Review of Immunology 5 1987 325 365
2. B. Adkins, V. Charyulu, Q.L. Sun, D. Lobo, and D.M. Lopez Early block in maturation is associated with thymic involution in mammary tumor-bearing mice Journal of Immunology 164 11 2000 5635 5640
3. J.M. Bertho, C. Demarquay, N. Moulian, A. Van Der Meeren, S. Berrih-Aknin, and P. Gourmelon Phenotypic and immunohistological analyses of the human adult thymus: evidence for an active thymus during adult life Cellular Immunology 179 1 1997 30 40
4. A. Bhattacharyya, T. Choudhuri, S. Pal, S. Chattopadhyay, G.K. Datta, G. Sa, and T. Das Apoptogenic effects of black tea on Ehrlich's ascites carcinoma cell Carcinogenesis 24 1 2003 75 80
5. H.J. Brady, G. Gil-Gomez, J. Kirberg, and A.J. Berns Bax alpha perturbs T cell development and affects cell cycle entry of T cells EMBO Journal 15 24 1996 6991 7001
6. T. Das, G. Sa, S. Chattopadhyay, and P.K. Ray Protein A-induced apoptosis of cancer cells is affected by soluble immune mediators Cancer Immunology and Immunotherapy 51 7 2002 376 380
7. L. Dominguez-Gerpe, and M. Rey-Mendez Evolution of the thymus size in response to physiological and random events throughout life Microscopy Research and Technique 62 6 2003 464 476
8. M.J. Ehrke, S. Verstovsek, C.M. Krawczyk, P. Ujhazy, G. Zaleskis, and D.L. Mac-cubbin Cyclophosphamide plus tumor necrosis factor a chemoimmunotherapy cured mice: life-long immunity and rejection of re-implanted primary lymphoma International Journal of Cancer 63 3 1995 463 471
9. Y. Fu, N. Altman, and D.M. Lopez Thymic atrophy induced by murine mammary adenocarcinoma in vivo In Vivo 3 1 1989 1 5
10. Y. Fu, D.P. Ronald, Y. Wang, and D.M. Lopez Thymic involution and phenotypic alterations induced by murine mammary adenocarcinomas Journal of Immunology 143 12 1989 4300 4307
11. R.A. Goldsby, T.J. Kindt, and B.A. Osborne J. Kuby: immunology fourth ed. 2000 W.H. Freeman and Company New York Chapter 22
12. J.W. Hadden Immunodeficiency and cancer: prospects for correction International Immunopharmacology 3 8 2003 1061 1071
13. H. He, P.A. Hershberger, and S.A. McCarthy Characterization of a novel Bax-associated protein expressed in hemopoietic tissues and regulated during thymocyte apoptosis Journal of Immunology 161 3 1998 1169 1175
14. T. Hernandez-Caselles, and O. Stutman Immune function of tumor necrosis factor: I. Tumor necrosis factor induces apoptosis of mouse thymocytes and can also stimulate or inhibit IL-6 induced proliferation depending on the concentration of mitogenic co-stimulation Journal of Immunology 151 8 1993 3999 4012
15. K. Hirokawa, M. Utsuyama, M. Kasai, and C. Kurashima Aging and immunity Acta Pathologica Japonica 42 8 1992 537 548
16. D.M. Hockenbery, M. Zutter, W. Hickey, M. Nahm, and S.J. Korsmeyer BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death Proceedings of the National Academy of Sciences of the United States of America 88 16 1991 6961 6965
17. P. Hokland, J. Bonde, H. Vestergaard, K. Meyer, and M. Hokland Hemopoietic cells: isolation of mononuclear cells from human blood and bone marrow and identification of leukocyte subsets by multiparameter flowcytometry J.E. Celis Second edition Cell Biology: A Laboratory Hand Book vol. 1 1998 Academic Press London 164 171
18. M.D. Kendall Functional anatomy of the thymic microenvironment Journal of Anatomy 177 1991 1 29
19. S.J. Korsmeyer, J.R. Shutter, D.J. Veis, D.E. Merry, and Z.N. Oltvai Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death Seminars in Cancer Biology 4 6 1993 327 332
20. C.M. Krawczyk, S. Verstovsek, P. Ujhazy, D. Maccubbin, and M.J. Ehrke Protective specific immunity induced by cyclophosphamide plus tumor necrosis factor a combination treatment of EL4-lymphoma-bearing C57BL/6 mice Cancer Immunology, Immunotherapy 40 6 1995 347 357
21. G. Kroemer The proto-oncogene Bcl-2 and its role in regulating apoptosis Nature Medicine 3 6 1997 614 620
22. I. Kuss, B. Hathaway, R.L. Ferris, W. Gooding, and T.L. Whiteside Decreased absolute counts of T lymphocyte subsets and their relation to disease in squamous cell carcinoma of the head and neck Clinical Cancer Research 10 11 2004 3755 3762
23. D.M. Lopez, M. Lopez-Cepero, G.A. Watson, A. Ganju, E. Sotomayor, and Y. Fu Modulation of the immune system by mammary tumor-derived factors Cancer Investigation 9 6 1991 643 653
24. D.M. Lopez, V. Charyulu, and B. Adkins Influence of breast cancer on thymic function in mice Journal of Mammary Gland Biology and Neoplasia 7 2 2002 191 199
25. + T-lymphocyte regeneration after intensive chemotherapy New England Journal of Medicine 332 3 1995 143 149
26. C.L. Mackall, F.T. Hakim, and R.E. Gress T-cell regeneration: all repertoires are not created equal Immunology Today 18 5 1997 245 251
27. C.L. Mackall, J.A. Punt, P. Morgan, A.G. Farr, and R.E. Gress Thymic function in young/old chimeras: substantial thymic T cell regenerative capacity despite irreversible age-associated thymic involution European Journal of Immunology 28 6 1998 1886 1893
28. V.S. Marsden, and A. Strasser Control of apoptosis in the immune system: Bcl-2, BH3-only proteins and more Annual Review of Immunology 21 2003 71 105
29. 2 In Vivo Developmental Immunology 2 4 1992 263 271
30. J.M. McCune Thymic function in HIV-1 disease Seminars in Immunology 9 6 1997 397 404
31. J. Morales-Montor, M. Rodriguez-Dorantes, C.A. Mendoza-Rodriguez, I. Camacho-Arroyo, and M.A. Cerbon Differential expression of the estrogen-regulated proto-oncogenes c-fos, c-jun, and Bcl-2 and of the tumor-suppressor p53 gene in the male mouse chronically infected with Taenia crassiceps cysticerci Parasitology Research 84 8 1998 616 622
32. S. Pal, T. Choudhuri, S. Chattopadhyay, A. Bhattacharya, G.K. Datta, T. Das, and G. Sa Mechanisms of curcumin-induced apoptosis of Ehrlich's ascites carcinoma cells Biochemical and Biophysical Research Communication 288 3 2001 658 665
33. H. Paxton, M. Pins, G. Denton, A.D. McGonigle, P.S. Meisner, and J.P. Phair Comparison of CD4 cell count by a simple enzyme-linked immunosorbent assay using the TRAx CD4 test kit and by flow cytometry and hematology Clinical and Diagnostic Laboratory Immunology 2 1 1995 104 114
34. J.M. Penninger, and T.W. Mak Signal transduction, mitotic catastrophes, and death in T-cell development Immunology Reviews 142 1994 231 272
35. R.M. Prins, M.R. Graf, R.E. Merchant, K.L. Black, and C.J. Wheeler Thymic function and output of recent thymic emigrant T cells during intracranial glioma progression Journal of Neuro-Oncology 64 1-2 2003 45 54
36. T. Saito, G. Dworacki, W. Gooding, M.T. Lotze, and T.L. Whiteside Spontaneous apoptosis of CD8+ T lymphocytes in peripheral blood of patients with advanced melanoma Clinical Cancer Research 6 4 2000 1351 1364
37. A. Shanker, and S.M. Singh Immunopotentiation in mice bearing a spontaneous transplantable T-cell lymphoma: role of thymic extract Neoplasma 50 4 2003 272 279
38. A. Shanker, S.M. Singh, and A. Sodhi Ascitic growth of a spontaneous transplantable T cell lymphoma induces thymic involution. 2. Induction of apoptosis in thymocytes Tumor Biology 21 6 2000 315 327
39. H. Shiku Importance of CD4+ helper T-cells in antitumor immunity International Journal of Hematology 77 5 2003 435 438
40. J. Sprent, D. Lo, E. Gao, and Y. Ron T cell selection in the thymus Immunology Reviews 101 1988 173 190
41. E. Thomas, M. Lee, and C. Rosse Induction of granulocytic hyperplasia, thymic atrophy and hypercalcemia by a selected subpopulation of a murine mammary adenocarcinoma Cancer Research 45 11 Pt 2 1985 5840 5844
42. T. Tuting, W.J. Storkus, and M.T. Lotze Gene-based strategies for the immunotherapy of cancer Journal of Molecular Medicine 75 7 1997 478 491
43. K. Wang, X.M. Yin, D.T. Chao, C.L Milliman, and S.J. Korsmeyer BID: a novel BH3 domain-only death agonist Genes and Development 10 22 1996 2859 2869
44. J. Xiang, D.T. Chao, and S.J. Korsmeyer BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases Proceedings of the National Academy of Sciences of the United States of America 93 25 1996 14559 14563
45. H. Zha, and J.C. Reed Heterodimerization-independent functions of cell death regulatory proteins Bax and Bcl-2 in yeast and mammalian cells Journal of Biological Chemistry 272 50 1997 31482 31488
46. H. Zha, H.A. Fisk, M.P. Yaffe, N. Mahajan, B. Herman, and J.C. Reed Structure-function comparisons of the proapoptotic protein Bax in yeast and mammalian cells Molecular and Cellular Biology 16 11 1996 6494 6508