Protective effects of valproic acid against hypoxic-ischemic brain injury in neonatal rats

Journal of Child Neurology

Volumn 20, Issue 7, 2005, Pages 582-587

  Kabakus, Nimet ^a,c   Ay, Ilknur ^a   Aysun, Sabiha ^a   Söylemezoglu, Figen ^a   Özcan, Ayhan ^b   Celasun, Bulent ^b  

^a HACETTEPE UNIVERSITY   (Turkey)

^b GULHANE SCHOOL OF MEDICINE   (Turkey)

^c FIRAT UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

OXYGEN; VALPROIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTERY LIGATION; ARTICLE; BASAL GANGLION; BRAIN CORTEX; BRAIN HYPOXIA; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN NERVE CELL; COMMON CAROTID ARTERY; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG MEGADOSE; EXPOSURE; HIPPOCAMPUS; LEFT HEMISPHERE; LOW DRUG DOSE; NEUROPATHOLOGY; NEUROPROTECTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; RIGHT HEMISPHERE;

EID: 24344433954     PISSN: 08830738     EISSN: None     Source Type: Journal    
DOI: 10.1177/08830738050200070801     Document Type: Article

References (31)

1. Perlman JM: Intrapartum hypoxic-ischemic cerebral injury and subsequent cerebral palsy: Medicolegal issues. Pediatrics 1997;99:851-859.
2. Vannucci RC: Hypoxic-ischemic encephalopathy. Am J Perinatol 2000;17:113-120.
3. Johnston MV, Trescher WH, Ishida A, Nakajima W: Neurobiology of hypoxic-ischemic injury in the developing brain. Pediatr Res 2001;49:735-741.
4. Vannucci RC, Perlman JM: Interventions for perinatal hypoxic-ischemic encephalopathy. Pediatrics 1997;100:1004-1014.
5. Fisher DE, Paton JB, Behrman RE: The effect of phenobarbital on asphyxia in the newborn monkey. Pediatr Res 1975;9:181-184.
6. Michenfelder JD, Milde JH, Sundt TM Jr: Cerebral protection by barbiturate anesthesia. Use after middle cerebral artery occlusion in Java monkeys. Arch Neurol 1976;33:345-350.
7. Artru AA, Michenfelder JD: Cerebral protective, metabolic, and vascular effects of phenytoin. Stroke 1980;11:377-382.
8. Minato H, Kikuta C, Fujitani B, Masuda Y: Protective effect of zonisamide, an antiepileptic drug, against transient focal cerebral ischemia with middle cerebral artery occlusion-reperfusion in rats. Epilepsia 1997;38:975-980.
9. Murakami A, Furui T: Effects of the conventional anticonvulsants, phenytoin, carbamazepine, and valproic acid, on sodium-potassium-adenosine triphosphatase in acute ischemic brain. Neurosurgery 1994;34:1047-1051.
10. Shuaib A, Murabit MA, Kanthan R, et al: The neuroprotective effects of gamma-vinyl GABA in transient global ischemia: A morphological study with early and delayed evaluations. Neurosci Lett 1996;204:1-4.
11. Griswold KS, Pessar LF: Management of bipolar disorder. Am Fam Physician 2000;62:1343-1353, 1357-1358.
12. Shelton CE, Connelly JF: Valproic acid: A migraine prophylaxis alternative. Ann Pharmacother 1996;30:865-866.
13. Mora A, Gonzalez-Polo RA, Fuentes JM, et al: Different mechanisms of protection against apoptosis by valproate and Li+. Eur J Biochem 1999;266:886-891.
14. Kulinskii VI, Mikhel'son GV: The neuroprotective effect of GABA-ergic substances in cerebral ischemia, abstract. Eksp Klin Farmakol 1997;60:56-58.
15. Perucca E: Pharmacological and therapeutic properties of valproate: A summary after 35 years of clinical experience. CNS Drugs 2002;16:695-714.
16. Thurston JH, Hauhart RE: Valproate doubles the anoxic survival time of normal developing mice: Possible relevance to valproate-induced decreases in cerebral levels of glutamate and aspartate, and increases in taurine. Life Sci 1989;45:59-62.
17. Driever PH, Knupfer MM, Cinatl J, Wolff JE: Valproic acid for the treatment of pediatric malignant glioma. Klin Padiatr 1999; 211: 323-328.
18. Samid D, Yeh A, Prasanna P: Induction of erythroid differentiation and fetal hemoglobin production in human leukemic cells treated with phenylacetate. Blood 1992;80:1576-1581.
19. Bittigau P, Sifringer M, Genz K, et al: Antiepileptic drugs and apoptotic neurodegeneration in the developing brain. Proc Natl Acad Sci U S A 2002;99:15089-15094.
20. Nagata N, Saji M, Ito T, et al: Repetitive intermittent hypoxia-ischemia and brain damage in neonatal rats. Brain Dev 2000;22:315-320.
21. Roohey T, Raju TN, Moustogiannis AN: Animal models for the study of perinatal hypoxic-ischemic encephalopathy: A critical analysis. Early Hum Dev 1997;47:115-146.
22. Schwartz PH, Massarweh WF, Vinters HV, Wasterlain CG: A rat model of severe neonatal hypoxic-ischemic brain injury. Stroke 1992;23:539-546.
23. Rowley HL, Marsden CA, Martin KF: Differential effects of phenytoin and sodium valproate on seizure-induced changes in gamma-aminobutyric acid and glutamate release in vivo. Eur J Pharmacol 1995;294:541-546.
24. Paxinos G, Watson C: The Rat Brain in Stereotaxic Coordinates, 3rd ed. London, Academic Press, 1997.
25. Spandou E, Karkavelas G, Soubasi V, et al: Effect of ketamine on hypoxic-ischemic brain damage in newborn rats. Brain Res 1999;819:1-7.
26. Towfighi J, Yager JY, Housman C, Vannucci RC: Neuropathology of remote hypoxic-ischemic damage in the immature rat. Acta Neuropathol (Berl) 1991;81:578-587.
27. Palmer C, Roberts RL, Bero C: Deferoxamine posttreatment reduces ischemic brain injury in neonatal rats. Stroke 1994;25:1039-1045.
28. Cheng Y, Gidday JM, Yan Q, et al: Marked age-dependent neuro-protection by brain-derived neurotrophic factor against neonatal hypoxic-ischemic brain injury. Ann Neurol 1997;41:521-529.
29. Volpe JJ: Neurology of the Newborn, 3rd ed. Philadelphia, WB Saunders, 1995.
30. Li R, El-Mallahk RS: A novel evidence of different mechanisms of lithium and valproate neuroprotective action on human SY5Y neuroblastoma cells: Caspase-3 dependency. Neurosci Lett 2000;294:147-150.
31. Kawagoe R, Kawagoe H, Sano K: Valproic acid induces apoptosis in human leukemia cells by stimulating both caspase-dependent and -independent apoptotic signaling pathways. Leuk Res 2002;26:495-502.