Respiratory syncytial virus and T cells: Interplay between the virus and the host adaptive immune system

Proceedings of the American Thoracic Society

Volumn 2, Issue 2, 2005, Pages 141-146

  Braciale, Thomas J ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Injury; Respiratory syncytial virus; T cells; Vaccine

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; RESPIRATORY SYNCYTIAL VIRUS VACCINE; VACCINIA VACCINE;

ASTHMA; BRONCHUS HYPERREACTIVITY; CONFERENCE PAPER; DISEASE EXACERBATION; HOST RESISTANCE; HUMAN; IMMUNOCOMPETENT CELL; LUNG INJURY; MEMORY CELL; NONHUMAN; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; T LYMPHOCYTE; VACCINATION; VIRUS CELL INTERACTION; VIRUS INFECTION; WHEEZING;

CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; HUMANS; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUSES; RESPIRATORY SYSTEM; T-LYMPHOCYTES;

EID: 24144485801     PISSN: 15463222     EISSN: None     Source Type: Journal    
DOI: 10.1513/pats.200503-022AW     Document Type: Conference Paper

References (46)

1. Hall CB. Respiratory syncytial virus and parainfluenza virus. N Engl J Med 2001;344:1917-1928.
2. Paramore LC, Ciuryla V, Ciesla G, Liu L. Economic impact of respiratory syncytial virus-related illness in the US: an analysis of national databases. Pharmacoeconomics 2004;22:275-284.
3. Hall CB, Long CE, Schnabel KC. Respiratory syncytial virus infections in previously healthy working adults. Clin Infect Dis 2001;33:792-796.
4. Falsey AR. Respiratory syncytial virus infection in older persons. Vaccine 1998;16:1775-1778.
5. Sigurs N, Bjarnason R, Sigurbergsson F, Kjellman B. Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7. Am J Respir Crit Care Med 2000;161:1501-1507.
6. Larouch V, Rivard G, Deschesnes F, Goulet R, Turcotte H, Boulet LP. Asthma and airway hyper-responsiveness in adults who required hospital admission for bronchiolitis in early childhood. Respir Med 2000;94:288-294.
7. Martinez FD. Respiratory syncytial virus bronchiolitis and the pathogenesis of childhood asthma. Pediatr Infect Dis J 2003;22:S76-S82.
8. Glezen WP, Taber LH, Frank AL, Kasel JA. Risk of primary infection and reinfection with respiratory syncytial virus. Am J Dis Child 1986;140:543-546.
9. Henderson FW, Collier AM, Clyde WA Jr, Denny FW. Respiratory-syncytial- virus infections, reinfections and immunity: a prospective, longitudinal study in young children. N Engl J Med 1979;300:530-534.
10. Chin J, Magoffin RL, Shearer LA, Schieble JH, Lennette EH. Field evaluation of a respiratory syncytial virus vaccine and a trivalent para-influenza virus vaccine in a pediatric population. Am J Epidemiol 1969;89:449-463.
11. Fulginiti VA, Eller JJ, Sieber OF, Joyner JW, Minamitani M, Meiklejohn G. Respiratory virus immunization: I. A field trial of two inactivated respiratory virus vaccines; an aqueous trivalent parainfluenza virus vaccine and an alum-precipitated respiratory syncytial virus vaccine. Am J Epidemiol 1969;89:435-448.
12. Durbin JE, Durbin RK. Respiratory syncytial virus-induced immunoprotection and immunopathology. Viral Immunol 2004;17:370-380.
13. Krishnan S, Halonen M, Welliver RC. Innate immune responses in respiratory syncytial virus infections. Viral Immunol 2004;17:220-233.
14. Roberts NJ Jr, Prill AH, Mann TN. Interleukin 1 and interleukin 1 inhibitor production by human macrophages exposed to influenza virus or respiratory syncytial virus: respiratory syncytial virus is a potent inducer of inhibitor activity. J Exp Med 1986;163:511-519.
15. Schlender J, Walliser G, Fricke J, Conzelmann KK. Respiratory syncytial virus fusion protein mediates inhibition of mitogen-induced T-cell proliferation by contact. J Virol 2002;76:1163-1170.
16. Mellman I, Steinman RM. Dendritic cells: specialized and regulated antigen processing machines. Cell 2001;106:255-258.
17. Kondo Y, Matsuse H, Machida I, Kawano T, Saeki S, Tomari S, Obase Y, Fukushima C, Kohno S. Regulation of mite allergen-pulsed murine dendritic cells by respiratory syncytial virus. Am J Respir Crit Care Med 2004;169:494-498.
18. Bartz H, Turkel O, Hoffjan S, Rothoeft T, Gonschorek A, Schauer U. Respiratory syncytial virus decreases the capacity of myeloid dendritic cells to induce interferon-gamma in naive T cells. Immunology 2003;109:49-57.
19. Schauer U, Hoffjan S, Rothoeft T, Bartz H, Konig S, Fuchs E, Bittscheidt J, Kochling A, Stephan V. Severe respiratory syncytial virus infections and reduced interferon-gamma generation in vitro. Clin Exp Immunol 2004;138:102-109.
20. Chang J, Braciale TJ. Respiratory syncytial virus infection suppresses lung CD8+ T-cell effector activity and peripheral CD8+ T-cell memory in the respiratory tract. Nat Med 2002;8:54-60.
21. Chang J, Srikiatkhachorn A, Braciale TJ. Visualization and characterization of respiratory syncytial virus F-specific CD8(+) T cells during experimental virus infection. J Immunol 2001;167:4254-4260.
22. Altman JD, Moss PA, Goulder PJ, Barouch DH, McHeyzer-Williams MG, Bell JI, McMichael AJ, Davis MM. Phenotypic analysis of antigen-specific T lymphocytes. Science 1996;274:94-96.
23. Kapikian AZ, Mitchell RH, Chanock RM, Shvedoff RA, Stewart CE. An epidemiologic study of altered clinical reactivity to respiratory syncytial (RS) virus infection in children previously vaccinated with an inactivated RS virus vaccine. Am J Epidemiol 1969;89:405-421.
24. Kim HW, Canchola JG, Brandt CD, Pyles G, Chanock RM, Jensen K, Parrott RH. Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine. Am J Epidemiol 1969;89:422-434.
25. Openshaw PJ. Immunity and immunopathology to respiratory syncytial virus: the mouse model. Am J Respir Crit Care Med 1995;152:S59-S62.
26. Polack FP, Teng MN, Collins PL, Prince GA, Exner M, Regele H, Lirman DD, Rabold R, Hoffman SJ, Karp CL, et al. A role for immune complexes in enhanced respiratory syncytial virus disease. J Exp Med 2002;196:859-865.
27. Legg JP, Hussain IR, Warner JA, Johnston SL, Warner JO. Type 1 and type 2 cytokine imbalance in acute respiratory syncytial virus bronchiolitis. Am J Respir Crit Care Med 2003;168:633-639.
28. Roman M, Calhoun WJ, Hinton KL, Avendano LF, Simon V, Escobar AM, Gaggero A, Diaz PV. Respiratory syncytial virus infection in infants is associated with predominant Th-2-like response. Am J Respir Crit Care Med 1997;156:190-195.
29. Brandenburg AH, Kleinjan A, van Het Land B, Moll HA, Timmerman HH, de Swart RL, Neijens HJ, Fokkens W, Osterhaus AD. Type 1-like immune response is found in children with respiratory syncytial virus infection regardless of clinical severity. J Med Virol 2000;62:267-277.
30. Connors M, Kulkarni AB, Firestone CY, Holmes KL, Morse HC III, Sotnikov AV, Murphy BR. Pulmonary histopathology induced by respiratory syncytial virus (RSV) challenge of formalin-inactivated RSV-immunized BALB/c mice is abrogated by depletion of CD4+ T cells. J Virol 1992;66:7444-7451.
31. Waris ME, Tsou C, Erdman DD, Zaki SR, Anderson LJ. Respiratory synctial virus infection in BALB/c mice previously immunized with formalin-inactivated virus induces enhanced pulmonary inflammatory response with a predominant Th2-like cytokine pattern. J Virol 1996;70:2852-2860.
32. Prince GA, Curtis SJ, Yim KC, Porter DD. Vaccine-enhanced respiratory syncytial virus disease in cotton rats following immunization with Lot 100 or a newly prepared reference vaccine. J Gen Virol 2001;82:2881-2888.
33. De Swart RL, Kuiken T, Timmerman HH, Amerongen Gv G, Van Den Hoogen BG, Vos HW, Neijens HJ, Andeweg AC, Osterhaus AD. Immunization of macaques with formalin-inactivated respiratory syncytial virus (RSV) induces interleukin-13-associated hypersensitivity to subsequent RSV infection. J Virol 2002;76:11561-11569.
34. Antonis AF, Schrijver RS, Daus F, Steverink PJ, Stockhofe N, Hensen EJ, Langedijk JP, van der Most RG. Vaccine-induced immunopathology during bovine respiratory syncytial virus infection: exploring the parameters of pathogenesis. J Virol 2003;77:12067-12073.
35. Openshaw PJ, Clarke SL, Record FM. Pulmonary eosinophilic response to respiratory syncytial virus infection in mice sensitized to the major surface glycoprotein G. Int Immunol 1992;4:493-500.
36. Openshaw PJ, Pemberton RM, Ball LA, Wertz GW, Askonas BA. Helper T cell recognition of respiratory syncytial virus in mice. J Gen Virol 1988;69:305-312.
37. Openshaw PJ, Anderson K, Wertz GW, Askonas BA. The 22,000-kilodalton protein of respiratory syncytial virus is a major target for Kd-restricted cytotoxic T lymphocytes from mice primed by infection. J Virol 1990;64:1683-1689.
38. Tebbey PW, Hagen M, Hancock GE. Atypical pulmonary eosinophilia is mediated by a specific amino acid sequence of the attachment (G) protein of respiratory syncytial virus. J Exp Med 1998;188:1967-1972.
39. Srikiatkhachorn A, Braciale TJ. Virus-specific CD8+ T lymphocytes downregulate T helper cell type 2 cytokine secretion and pulmonary eosinophilia during experimental murine respiratory syncytial virus infection. J Exp Med 1997:186:421-432.
40. Abbas AK, Murphy KM, Sher A. Functional diversity of helper T lymphocytes. Nature 1996;383:787-793.
41. Asnagli H, Murphy KM. Stability and commitment in T helper cell development. Curr Opirt Immunol 2001;13:242-247.
42. Hussell T, Baldwin CJ, O'Garra A, Openshaw PJ. CD8+ T cells control Th2-driven pathology during pulmonary respiratory syncytial virus infection. Eur J Immunol 1997;27:3341-3349.
43. Srikiatkhachorn A, Chang W, Braciale TJ. Induction of Th-1 and Th-2 responses by respiratory syncytial virus attachment glycoprotein is epitope and major histocompatibility complex independent. J Virol 1999;73:6590-6597.
44. Sallusto F, Geginat J, Lanzavecchia A. Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu Rev Immunol 2004;22:745-763.
45. Varga SM, Wissinger EL, Braciale TJ. The attachment (G) glycoprotein of respiratory syncytial virus contains a single immunodominant epitope that elicits both Th1 and Th2 CD4+ T cell responses. J Immunol 2000;165:6487-6495.
46. Varga SM, Wang X, Welsh RM, Braciale TJ. Immunopathology in RSV infection is mediated by a discrete oligoclonal subset of antigen-specific CD4(+) T cells. Immunity 2001;15:637-646.