Multiple interleukin-2 signaling pathways differentially regulated by microgravity

Immunopharmacology

Volumn 44, Issue 3, 1999, Pages 273-279

  Licato, Laura L ^a   Grimm, Elizabeth A ^a  

^a Molecular and Cellular Biology   (United States)

Author keywords

Cellular activation; Cytokines; Human; NK cells; Signal transduction

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL CULTURE; CELL STRUCTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; IMMUNE STATUS; IN VITRO STUDY; MICROGRAVITY; NATURAL KILLER CELL; NORMAL HUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SIMULATION; TECHNIQUE;

FLIGHT EXPERIMENT; MANNED; SHORT DURATION; STS-56 SHUTTLE PROJECT;

CELLS, CULTURED; CYTOKINES; HUMANS; INTERLEUKIN-2; KILLER CELLS, LYMPHOKINE-ACTIVATED; KILLER CELLS, NATURAL; LEUKOCYTES, MONONUCLEAR; SIGNAL TRANSDUCTION; WEIGHTLESSNESS;

EID: 0032777047     PISSN: 01623109     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0162-3109(99)00123-X     Document Type: Article

References (16)

1. Cogoli A., Cogoli-Greuter M. Activation and proliferation of lymphocytes and other mammalian cells in microgravity. Adv. Space Biol. Med. 6:1997;33-79.
2. Gmunder F.K., Konstantinova I., Cogoli A., Lesnyak A., Bogomolov W., Grachov A.W. Cellular immunity in cosmonauts during long duration spaceflight on board the orbital MIR station. Aviat. Space Environ. Med. 65:1994;419-423.
3. Gmunder, F.K., Cogoli, A., Fregly, M.J., Blatteis, C.M. (Eds.), 1996. Effect of spaceflight on lymphocyte function and immunity. Handbook of Physiology. Oxford Univ. Press, New York, 35, pp. 799-813.
4. Grimm, E.A., Loudon, W.L., 1995. The generation and quantitation of cell-mediated cytotoxicity. Anonymous Cytokines - A Practical Approach, 2nd edn., Vol. 12. Oxford Press, pp. 197-213.
5. Heaton K.M., Ju G., Grimm E.A. Induction of lymphokine-activated killing with reduced secretion of interleukin-1β, tumor necrosis factor-α, and interferon-gamma by interleukin-2 analogs. Ann. Surg. Oncol. 1(3):1994;198-203.
6. Karnitz L.M., Abraham R.T. Interleukin-2 receptor signaling mechanisms. Adv. Immunol. 61:1996;147-199.
7. Konstantinova I., Sonnenfeld G., Lesnyak A.T., Schaffar L., Mandel A., Rykova M.P., Antropova E.N., Ferrua B. Cellular immunity and lymphokine production during spaceflights. Physiologist. 34:1991;S52-S56.
8. Meehan R.T., Neale L.S., Kraus E.T., Stuart C.A., Smith M.L., Cintron N.M., Sams C.F. Alteration in human mononuclear leukocytes following space flight. Immunology. 76:1992;491-497.
9. Naume B., Johnson A.-C., Espevik T., Sundan A. Gene expression and secretion of cytokines and cytokine receptors from highly purified CD56+ natural killer cells stimulated with interleukin-2, interleukin-7 and interleukin-12. Eur. J. Immunol. 23:1993;1831-1838.
10. Pellis N.R., Goodwin T.J., Risin D., McIntyre B.W., Pizzini R.P., Cooper D., Baker T.L., Spaulding G.F. Changes in gravity inhibit lymphocyte locomotion through type I collagen. In Vitro Cell Dev. Biol.: Anim. 33(5):1997;398-405.
11. Takeshita T., Asao H., Ohtani K., Ishii N., Kumaki S., Tanaka N., Munakata H., Nakamura M., Sugamura K. Cloning of the gamma chain of the human IL-2 receptor. Science. 257:1992;379-382.
12. Taylor G.R., Dardano J.R. Human cellular immune responsiveness following space flight. Aviat. Space Environ. Med. 54:1983;S55-S59.
13. Taylor G.R., Janney R.P. In vivo testing confirms a blunting of the human cell-mediated immune mechanisms during space flight. J. Leukocyte Biol. 51:1992;129-132.
14. Taylor G.R., Neale L.S., Dardano J.R. Immunological analyses of U.S. space shuttle crewmembers. Aviat. Space Environ. Med. 57:1986;213-217.
15. Taylor G.R., Konstantinova I., Sonnenfeld G., Jennings R. Changes in the immune system during and after spaceflight. Adv. Space Biol. Med. 6:1997;1-32.
16. Theze J., Alzari P.M., Bertoglio J. Interleukin 2 and its receptors: recent advances and new immunological functions. Immunol. Today. 17:1996;481-486.