Impairment of antigen-specific cellular immune responses under simulated microgravity conditions

In Vitro Cellular and Developmental Biology - Animal

Volumn 37, Issue 4, 2001, Pages 203-208

  Sastry, K Jagannadha ^b   Nehete, Pramod N ^b   Savary, Cherylyn A ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Cell mediated immunity; Cytotoxic T lymphocytes; Rotating wall vessel; Synthetic peptides

Indexed keywords

ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; VIRUS PROTEIN;

ACCESSORY CELL; ANIMAL CELL; ANIMAL EXPERIMENT; CELL CULTURE; CELLULAR IMMUNITY; CONFERENCE PAPER; CONTROLLED STUDY; CULTURE MEDIUM; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; EFFECTOR CELL; IMMUNOCOMPETENT CELL; IMMUNOPATHOLOGY; INFECTION; MICROGRAVITY; MOUSE; MOUSE STRAIN; NONHUMAN; PATHOPHYSIOLOGY; SIMULATION; SPACE FLIGHT; T LYMPHOCYTE SUBPOPULATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; T-LYMPHOCYTES, CYTOTOXIC; WEIGHTLESSNESS;

EID: 0034974578     PISSN: 10712690     EISSN: None     Source Type: Journal    
DOI: 10.1290/1071-2690(2001)037<0203:IOASCI>2.0.CO;2     Document Type: Conference Paper

References (27)

1. Stimulating killer cells
2. Cytotoxic T-lymphocyte response induced by a V3 loop synthetic peptide from an African HIV-1 isolate is cross-reactive against HIV-1 strains from North America/Europe regions
3. Cross-reactive cytotoxic T lymphocytes induced by V3 loop synthetic peptides from different strains of human immunodeficiency virus type 1
4. Signal transduction in T lymphocytes in microgravity
5. Activation and proliferation of lymphocytes and other mammalian cells in microgravity
6. Suppressed PHA activation of T lymphocytes in simulated microgravity is restored by direct activation of protein kinase C
7. Cellular immunity in cosmonauts during spaceflight on board the orbital MIR station
8. General method for the rapid solid-phase synthesis of large numbers of peptides: Specificity of antigen-antibody interaction at the level of individual amino acids
9. Prospects for use of microgravity-based bioreactors to study three-dimensional host-tumor interactions in human neoplasia
10. Immune changes during long-duration missions
11. Multiple interleukin-2 signaling pathways differentially regulated by microgravity
12. In vivo effector function of influenza virus-specific cytotoxic T lymphocyte clones is highly specific
13. Solid phase peptide synthesis
14. Use of helper T cell-inducing peptides from conserved regions in HIV-1 env in a non-covalent mixture with a CTL-inducing V3-loop peptide for in vivo induction of long-lasting systemic CTL response
15. Studies on in vivo induction of HIV-1 envelope-specific cytotoxic T lymphocytes by synthetic peptides from the V3 loop region of HIV-1 IIIB gp120
16. Studies on in vivo induction of cytotoxic T lymphocyte responses by synthetic peptides from E6 and E7 oncoproteins of human papillomavirus type 16
17. Effects of influenza virus-specific cytotoxic T-lymphocyte responses induced by a synthetic nucleoprotein peptide on the survival of mice challenged with a lethal dose of virus
18. + cytotoxic T lymphocytes by a 15-amino acid unmodified free peptide from the immunodominant V3-loop of gp120
19. Effects of space flight on levels and activity of immune cells
20. The role of cytokines in immune changes induced by spaceflight
21. Cell culture for three-dimensional modeling in rotating-wall vessels: An application in microgravity
22. Overview of spaceflight immunology studies
23. Immune changes during short-duration missions
24. In vivo testing confirms a blunting of the human cell-mediated immune mechanisms during space flight
25. Changes in the immune system during and after spaceflight
26. Immunological analyses of U.S. space shuttle crewmembers
27. Responses of gravity level variations in the NASA/JSC bioreactor system