Loss of mismatch repair protein immunostaining in colorectal adenomas from patients with hereditary nonpolyposis colorectal cancer

Modern Pathology

Volumn 18, Issue 8, 2005, Pages 1095-1101

  Halvarsson, Britta ^a,c   Lindblom, Annika ^b   Johansson, Leif ^a   Lagerstedt, Kristina ^b   Nilbert, Mef ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c HELSINGBORG HOSPITAL   (Sweden)

Author keywords

Adenoma; Hereditary nonpolyposis colorectal cancer (HNPCC); Immunohistochemistry; Mismatch repair

Indexed keywords

MISMATCH REPAIR PROTEIN PMS2; PROTEIN MLH1; PROTEIN MSH2; PROTEIN MSH6;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COLORECTAL ADENOMA; COLORECTAL CANCER; FEMALE; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MALIGNANT TRANSFORMATION; MICROSATELLITE INSTABILITY; MISMATCH REPAIR; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR LOCALIZATION; TUMOR VOLUME;

ADENOMA; ADENOSINE TRIPHOSPHATASES; ADULT; AGED; BASE PAIR MISMATCH; CARRIER PROTEINS; COLORECTAL NEOPLASMS; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DNA REPAIR; DNA REPAIR ENZYMES; DNA-BINDING PROTEINS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MUTS HOMOLOG 2 PROTEIN; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS;

EID: 24044540727     PISSN: 08933952     EISSN: None     Source Type: Journal    
DOI: 10.1038/modpathol.3800392     Document Type: Article

References (28)

1. Jass JR, Stewart SM, Stewart J, et al. Hereditary non-polyposis colorectal cancer-morphologies, genes and mutations. Mutat Res 1994;310:125-133.
2. Lindgren G, Liljegren A, Jaramillo E, et al. Adenoma prevalence and cancer risk in familial non-polyposis colorectal cancer. Gut 2002;50:228-234.
3. Rijcken FEM, Hollema H, Kleibeuker JH. Proximal adenomas in hereditary non-polyposis colorectal cancer are prone to rapid malignant transformation. Gut 2002;50:382-386.
4. Lindor NM, Burgart LJ, Leontovich O, et al. Immunohistochemistry versus microsatellite instability testing in phenotyping colorectal tumors. J Clin Oncol 2002;20:1043-1048.
5. Halvarsson B, Lindblom A, Rambech E, et al. Microsatellite instability and/or immunostaining for the diagnosis of hereditary nonpolyposis colorectal cancer? Virchows Arch 2004;444:135-141.
6. Thibodeau SN, Bren G, Schaid D. Microsatellite instability in cancer of the proximal colon. Science 1993;260:816-819.
7. Mitchell RJ, Farrington SM, Dunlop MG, et al. Mismatch repair genes hMLH1 and hMSH2 and colorectal cancer: a HuGE review. Am J Epidemiol 2002;156:885-902.
8. Young J, Leggett B, Gustafson C, et al. Genomic instability occurs in colorectal carcinomas but not in adenomas. Hum Mutat 1993;2:351-354.
9. Samowitz WS, Slattery ML. Transforming growth factor-B receptor type 2 mutations and microstatellite instability in sporadic colorectal adenomas and carcinomas. Am J Pathol 1997;151:33-35.
10. Loukola A, Salovaara R, Kristo P, et al. Microsatellite instability in adenomas as a marker for hereditary nonpolyposis colorectal cancer. Am J Pathol 1999;155:1849-1853.
11. Konishi K, Yamochi T, Makino R, et al. Molecular differences between sporadic serrated and conventional colorectal adenomas. Clin Cancer Res 2004;10:3082-3090.
12. Cunningham JM, Christensen ER, Tester DJ, et al. Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability. Cancer Res 1998;58:3455-3460.
13. Aaltonen LA, Peltomäki P, Mecklin JP, et al. Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients. Cancer Res 1994;54:1645-1648.
14. Jacoby RF, Marshall DJ, Kailas S, et al. Genetic instability associated with adenomas to carcinoma progression in hereditary nonpolyposis colon cancer. Gastroenterology 1995;109:73-82.
15. Konishi M, Kikuchi-Yanoshita R, Tanaka K, et al. Molecular nature of colon tumor in hereditary nonpolyposis colorectal cancer, familial polyposis and sporadic colon cancer. Gastroenterology 1996;111:307-317.
16. Akiyama Y, Iwanaga R, Saitoh K, et al. Transforming growth factor B type II receptor gene mutations in adenomas from hereditary nonpolyposis colorectal cancer. Gastroenterology 1997;112:33-39.
17. Sasaki S, Masaki T, Umetani N, et al. Microsatellite instability is associated with the macroscopic configuration of neoplasms in patients with multiple colorectal adenomas. Jpn J Clin Oncol 1998;28:427-430.
18. Iino H, Jass JR, Simms LA, et al. DNA microsatellite instability in hyperplastic polyps, serrated adenoma, and mixed polyps: a mild mutator pathway for colorectal cancer? J Clin Pathol 1999;52:455-460.
19. Iino H, Simms L, Young J, et al. DNA microsatellite instability and mismatch repair protein loss in adenomas presenting in hereditary non-polyposis colorectal cancer. Gut 2000;47:37-42.
20. Liu T, Wahlberg S, Burek E, et al. Microsatellite instability as a predictor of a mutation in a DNA mismatch repair gene in familial colorectal cancer. Genes Chromosomes Cancer 2000;27:17-25.
21. Voskuil DW, Kampman E, van Geloof W, et al. No major difference in K-ras and p53 abnormalities in sporadic and hereditary nonpolyposis colorectal adenomas. Drug Dis Sci 2000;45:2187-2194.
22. Rashid A, Houlihan PS, Booker S, et al. Phenotypic and molecular characteristics of hyperplastic polyposis. Gastroenterology 2000;119:323-332.
23. Chan TL, Zhao W, Leung SY, et al. Cancer Genome Project. BRAF and KRAS mutations in colorectal hyperplastic polyps and serrated adenomas. Cancer Res 2003;63:4878-4881.
24. Kambara T, Simms LA, Whitehall VLJ, et al. BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum. Gut 2004;53:1137-1144.
25. Liljegren A, Lindblom A, Rotstein S, et al. Prevalence and incidence of hyperplastic polyps and adenomas in familial colorectal cancer: correlation between the two types of colon polyps. Gut 2003;52:1140-1147.
26. Goldstein NS, Bhanot P, Odish E, et al. Hyperplastic-like colon polyps that preceded microsatellite-unstable adenocarcinomas. Am J Clin Pathol 2003;119:778-796.
27. Rijcken REM, van der Sluis T, Hollema H, et al. Hyperplastic polyps in hereditary nonpolyposis cancer. Am J Gastroenterol 2003;98:2306-2311.
28. Sawyer EJ, Cerar A, Hanby AM, et al. Molecular characteristics of serrated adenomas of the colorectum. Gut 2003;51:200-206.