Sodium methyldithiocarbamate inhibits MAP kinase activation through toll-like receptor 4, alters cytokine production by mouse peritoneal macrophages, and suppresses innate immunity

Toxicological Sciences

Volumn 87, Issue 1, 2005, Pages 75-85

  Pruett, Stephen B ^a   Zheng, Qiang ^a   Schwab, Carlton ^a   Fan, Ruping ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Escherichia coli; Immune system; Methylisothiocyanate; Sodium methyldithiocarbamate; Toll like receptor 4

Indexed keywords

CYTOKINE; DITHIOCARBAMIC ACID DERIVATIVE; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 12P35; INTERLEUKIN 12P40; INTERLEUKIN 18; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; ISOTHIOCYANIC ACID DERIVATIVE; LIPOPOLYSACCHARIDE; MACROPHAGE MIGRATION INHIBITION FACTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; SODIUM METHYLDITHIOCARBAMATE; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

AGRICULTURE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL PERITONITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME INHIBITION; ESCHERICHIA COLI; FEMALE; INFECTION; INNATE IMMUNITY; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; SOIL FUMIGATION; SURVIVAL TIME;

ANIMALS; CYTOKINES; ENZYME ACTIVATION; ESCHERICHIA COLI INFECTIONS; FEMALE; IMMUNITY, NATURAL; IMMUNOSUPPRESSIVE AGENTS; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; PESTICIDES; RECEPTORS, IMMUNOLOGIC; THIOCARBAMATES; TOLL-LIKE RECEPTOR 4;

ESCHERICHIA COLI;

EID: 24044532590     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfi215     Document Type: Article

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