Protection from spontaneous hepatocellular damage by N-benzyl-D-glucamine dithiocarbamate in Long-Evans Cinnamon rats, an animal model of Wilson's disease

Toxicology and Applied Pharmacology

Volumn 202, Issue 1, 2005, Pages 59-67

  Shimada, Hideaki ^a   Takahashi, Makiko ^b   Shimada, Akinori ^b   Okawara, Tadashi ^a   Yasutake, Akira ^c   Imamura, Yorishige ^a   Kiyozumi, Morio ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b TOTTORI UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE FOR MINAMATA DISEASE   (Japan)

Author keywords

Long Evans Cinnamon rats; N benzyl D glucamine dithiocarbamate; Wilson's disease

Indexed keywords

CARBAMIC ACID DERIVATIVE; COPPER; N BENZYL DEXTRO GLUCAMINE DITHIOCARBAMATE; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILIARY EXCRETION; BILIRUBIN BLOOD LEVEL; BIOACCUMULATION; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; LIVER CELL DAMAGE; LIVER INJURY; NONHUMAN; PROTECTION; RAT; URINARY EXCRETION; WILSON DISEASE;

ANIMALS; BODY WEIGHT; CHELATING AGENTS; COPPER; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HEPATOLENTICULAR DEGENERATION; HUMANS; LIVER; RATS; RATS, LONG-EVANS; SORBITOL; THIOCARBAMATES;

ANIMALIA; CINNAMOMUM VERUM;

EID: 10044230190     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.taap.2004.06.005     Document Type: Article

References (39)

1. Brewer G.J., Dick R.D., Yuzbasiyan-Gurkan V., Tanakow R., Young A.B., Kluin K. Initial therapy of patients with Wilson's disease with tetrathiomolybdate. Arch. Neurol. 48:1991;42-47
2. Brewer G.J., Dick R.D., Johnson V., Wang Y., Yuzbasiyan-Gurkan V., Kluin K., Fink J.K., Aisen A. Treatment of Wilson's disease with ammonium tetrathiomolybdate. Arch. Neurol. 51:1994;545-554
3. Bull P.C., Thomas G.R., Rommens J.M., Forbes J.R., Cox D.W. The Wilson disease gene is putative copper transporting P-type ATPase similar to the Menkes gene. Nat. Genet. 5:1993;327-337
4. Cantilena L.R. Jr., Klaassen C.D. Comparison of the effectiveness of several chelators after single administration on the toxicity, excretion and distribution of cadmium. Toxicol. Appl. Pharmacol. 58:1981;452-460
5. Gale G.R., Atkins L.M., Walker E.M. Jr., Smith A.B. Effects of combined treatment with diethyldithiocarbamate and diethylenetriaminepentaacetate on organ distribution and excretion of cadmium. Ann. Clin. Lab. Sci. 13:1983;425-431
6. Gibbs K., Walshe J.M. Liver copper concentration in Wilson's disease: effect of treatment with 'anti-copper' agents. J. Gastroenterol. Hepatol. 5:1990;420-424
7. Kasai K., Osanai T., Miyoshi I., Kamimura E., Yoshida M.C., Dempo K. Clinico-pathological studies of LEC rats with hereditary hepatitis and hepatoma in the acute phase of hepatitis. Lab. Anim. Sci. 40:1990;502-505
8. Kato J., Kobune M., Kohgo Y., Sugawara N., Hisai H., Nakamura T., Sakamaki S., Sawada N., Niitsu Y. Hepatic iron deprivation prevents spontaneous development of fulminant hepatitis and liver cancer in Long-Evans Cinnamon rats. J. Clin. Invest. 98:1996;923-929
9. Kiyozumi M., Shimada H., Honda T., Kojima S. Studies on poisonous metals XIX. Comparative effects of chelating agents on distribution and excretion of inorganic mercury in rats. Chem. Pharm. Bull. 36:1988;2599-2606
10. Kojima S., Kaminaka K., Kiyozumi M., Honda T. Comparative effects of three chelating agents on distribution and excretion of cadmium in rats. Toxicol. Appl. Pharmacol. 83:1986;516-524
11. Kojima S., Kiyozumi M., Honda T., Kaminaka K., Oda Y., Senba Y. Effect of N-benzyl-D-glucamine dithiocarbamate on distribution and excretion of cadmium in rats. Toxicology. 45:1987;93-102
12. Kojima S., Shimada H., Kiyozumi M. Comparative effects of chelating agents on distribution, excretion and renal toxicity of inorganic mercury in rats. Res. Commun. Chem. Pathol. Pharmacol. 64:1989;471-483
13. Li Y., Togashi Y., Sato S., Emoto T., Kang J.-H., Takeichi N., Kobayashi H., Kojima Y., Une Y., Uchino J. Spontaneous hepatic copper accumulation in LEC rats with hereditary hepatitis: a model of Wilson's disease. J. Clin. Invest. 87:1991;1858-1861
14. Lindquist R.R. Studies on the pathogenesis of hepatolenticular degeneration. Arch. Pathol. 187:1969;370-379
15. 35S]-labeled metallothionien in vitro; implications for Wilson's disease therapy. J. Inorg. Biochem. 41:1990;87-92
16. Nagayama S., Kitamura R., Yokoi T., Kawaguchi Y., Kasai N., Takeichi N., Kobayashi H., Kamataki T. Occurrence of autoimmune antibodies to liver microsomal proteins in association with fulminant hepatitis in the LEC strain of rats. Biochem. Biophys. Res. Commun. 179:1991;1134-1140
17. Nazer H., Ede R.J., Mowat A.P., Williams R. Wilson's disease: clinical presentation and use of prognostic index. Gut. 27:1986;1377-1381
18. Okayasu T., Tochimaru H., Hyuga T., Takahashi T., Takekoshi Y., Li Y., Togashi Y., Takeichi N., Kasai N., Arashima S. Inherited copper toxicity in Long-Evans cinnamon rats exhibiting spontaneous hepatitis: a model of Wilson's disease. Pediatr. Res. 31:1992;253-257
19. 2 in mice. Arch. Toxicol. 45:1980;45-52
20. Sakurai H., Fukudome A., Tawa R., Kito M., Takeshima S., Kimura M., Otaki N., Nakajima K., Hagino T., Kawano K., Hirai S., Suzuki S. Unusual accumulation of copper related to induction of metallothionien in the liver of LEC rats. Biochem. Biophys. Res. Commun. 184:1992;1393-1397
21. Sakurai H., Kamada H., Fukudome A., Kito M., Takeshima S., Kimura M., Otaki N., Nakajima K., Kawano K., Hagino T. Copper-metallothionien induction in the liver of LEC rats. Biochem. Biophys. Res. Commun. 185:1992;548-552
22. Sawaki M., Enomoto K., Hattori A., Tsuzuki N., Sugawara N., Mori M. Role of copper accumulation and metallothionien induction in spontaneous liver cancer development in LEC rats. Carcinogenesis. 15:1994;1833-1837
23. Sawaki M., Hattori A., Tsuzuki N., Sugawara N., Enomoto K., Sawada N., Mori M. Chronic liver injury promotes hepatocarcinogenesis of the LEC rat. Carcinogenesis. 19:1998;331-335
24. Schaefer M., Gitlin J.D. Genetic disorders of membrane transport IV: Wilson's disease and Menkes disease. Am. J. Physiol. 276:1999;G311-G314
25. Scheinberg I.H., Sternlieb I. Wilson disease and idiopathic copper toxicosis. Am. J. Clin. Nutr. 63:1996;842S-845S
26. Scheinberg I.H., Sternlieb I., Schilsky M., Stockert R.J. Penicillamine may detoxify copper in Wilson's disease. Lancet. 2:1987;95
27. Sternlieb I., Scheinberg I.H. Wilson's disease. Schiff L., Schiff E.R. Diseases of the Liver. 1993;659-668 JB Lippincott Co, Philadelphia
28. Stohs S.J., Bagchi D. Oxidative mechanisms in the toxicity of metal ions. Free Radical Biol. Med. 18:1995;321-336
29. Sugawara N., Sugawara C., Katakura M., Takahashi H., Mori M. Copper metabolism in the LEC rat: involvement of induction of metallothionien and disposition of zinc and iron. Experientia. 47:1991;1060-1063
30. Sugawara N., Sugawara C., Sato M., Katakura M., Takahashi H., Mori M. Copper metabolism in LEC rats aged 30 and 80 days old: induction of Cu-metallothionien and status of zinc and iron. Res. Commun. Chem. Pathol. Pharmacol. 72:1991;353-362
31. Suzuki K.T. Disordered copper metabolism in LEC rats, an animal model of Wilson's disease: roles of metallothionien. Res. Commun. Mol. Pathol. Pharmacol. 88:1995;221-240
32. Suzuki K.T., Ogura Y. Biological regulation of copper and selective removal of copper: therapy for Wilson disease and its molecular mechanism. Yakugaku Zasshi. 120:2000;899-908
33. Suzuki K.T., Kanno S., Misawa S., Aoki A. Copper metabolism leading to and following acute hepatitis in LEC rats. Toxicology. 97:1995;81-92
34. Takeichi N. LEC rats. CRJ Lett. 4:1991;1-8
35. Waalkes M.P., Goering P.L. Metallothionien and other cadmium-binding proteins: recent developments. Chem. Res. Toxicol. 3:1990;281-288
36. 4) as an 'anti-copper' agent in man. Scheinberg I.H., Walshe J.M. Orphan Disease and Orphan Drug. 1982;76-85 University Press, Manchester
37. Walshe J.M. Treatment of Wilson's disease with trientine (triethylene tetramine) dihydrochloride. Lancet. 1:1982;643-647
38. Williams L.A.D., Howell R., Young R., Kahwa I.A. Neuropharmacological actions of some binuclear lanthanide (III) complexes. Comp. Biochem. Physiol., C. 128:2001;119-125
39. Wu J., Forbes J.R., Chen H.S., Cox D.W. The LEC rat has a deletion in the copper transporting ATPase gene homologous to the Wilson disease gene. Nat. Genet. 7:1994;541-545