In vivo and in vitro hepatotoxicity and glutathione interactions of N-methyldithiocarbamate and N,N-dimethyldithiocarbamate in the rat

Toxicological Sciences

Volumn 70, Issue 2, 2002, Pages 269-280

  Thompson, Rodney W ^a   Valentine, Holly L ^a   Valentine, William M ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Glutathione; Hepatotoxicity; Metam sodium; Methyl isothiocynate; N,N methyldithiocarbamate; N methyldithiocarbamate

Indexed keywords

CELL PROTEIN; DITHIOCARBAMIC ACID; DITHIOCARBAMIC ACID DERIVATIVE; GLUTATHIONE; GLUTATHIONE DERIVATIVE; GLUTATHIONE DISULFIDE; ISOTHIOCYANIC ACID DERIVATIVE; METHAM; N,N METHYLDITHIOCARBAMATE; THIOL DERIVATIVE; THIOL GROUP; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL TISSUE; BILE; CELL LEVEL; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXICITY; DETOXIFICATION; DOSE RESPONSE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; ISOLATION PROCEDURE; LIVER MITOCHONDRION; LIVER NECROSIS; LIVER PERFUSION; LIVER TOXICITY; MALE; MITOCHONDRIAL RESPIRATION; MOLECULAR INTERACTION; NONHUMAN; PROTEIN DEPLETION; RAT; REVIEW; TANDEM MASS SPECTROMETRY;

ADMINISTRATION, ORAL; ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIMETHYLDITHIOCARBAMATE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; GLUTATHIONE; HEPATOCYTES; L-LACTATE DEHYDROGENASE; LIVER; MALE; MASS SPECTROMETRY; MITOCHONDRIA, LIVER; OXYGEN; PERFUSION; RATS; RATS, SPRAGUE-DAWLEY; THIOCARBAMATES; TIME FACTORS;

ANIMALIA;

EID: 0036902772     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/70.2.269     Document Type: Review

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