Arachidonic acid metabolites, hydrogen peroxide, and EDHF in cerebral arteries

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 289, Issue 3 58-3, 2005, Pages

  You, Junping ^a   Golding, Elke M ^a   Bryan Jr , Robert M ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Adenosine triphosphate; Endothelium; Endothelium derived hyperpolarizing factor; Epoxyeicosatrienoic acids; Epoxygenase; Hydroxyl radical; Lipoxygenase; Reactive oxygen species; Superoxide anion; Uridine triphosphate

Indexed keywords

1 AMINOBENZOTRIAZOLE; 14,15 EPOXYEICOSA 5 ENOIC ACID; ADENOSINE TRIPHOSPHATE; ARACHIDONIC ACID; BAICALEIN; CATALASE; DEFEROXAMINE; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; EPOXYGENASE; EPOXYGENASE INHIBITOR; EPOXYICOSATRIENOIC ACID; HYDROGEN PEROXIDE; HYDROXYL RADICAL; INDOMETACIN; LIPOXYGENASE; MICONAZOLE; N METHYLSULFONYL 6 (2 PROPARGYLOXYPHENYL)HEXANOIC ACID; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NORDIHYDROGUAIARETIC ACID; OXYGENASE; OXYGENASE INHIBITOR; PROSTAGLANDIN SYNTHASE; PURINE P2Y2 RECEPTOR; REACTIVE OXYGEN METABOLITE; SCAVENGER; SUPEROXIDE DISMUTASE; TIRON; UNCLASSIFIED DRUG; URIDINE TRIPHOSPHATE;

ANIMAL TISSUE; ARACHIDONIC ACID METABOLISM; ARTERY DILATATION; ARTICLE; CATALYST; CHEMICAL REACTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME SUBSTRATE; ISOLATED ARTERY; MALE; METABOLITE; MIDDLE CEREBRAL ARTERY; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; RAT;

AMIDES; ANIMALS; ARACHIDONIC ACID; BIOLOGICAL FACTORS; CEREBRAL ARTERIES; CYCLOOXYGENASE INHIBITORS; ENZYME INHIBITORS; HYDROGEN PEROXIDE; INDOMETHACIN; LIPOXYGENASE; MALE; MICONAZOLE; NG-NITROARGININE METHYL ESTER; OXIDOREDUCTASES; RATS; RATS, LONG-EVANS;

EID: 23944512767     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.01046.2004     Document Type: Article

References (65)

1. Alkayed NJ, Birks EK, Narayanan J, Petrie KA, Kohler-Cabot AE, and Harder DR. Role of P-450 arachidonic acid epoxygenase in the response of cerebral blood flow to glutamate in rats. Stroke 28: 1066-1072, 1997.
2. Alkayed NJ, Narayanan J, Gebremedhin D, Medhora M, Roman RJ, and Harder DR. Molecular characterization of an arachidonic acid epoxygenase in rat brain astrocytes. Stroke 27: 971-979, 1996.
3. Alonso-Galicia M, Maier KG, Greene AS, Cowley AW Jr, and Roman RJ. Role of 20-hydroxyeicosatetraenoic acid in the renal and vasoconstrictor actions of angiotensin 11. Am J Physiol Regul Integr Comp Physiol 283: R60-R68, 2002.
4. Baba A, Kimoto M, Tatsuno T, Inoue T, and Iwata H. Membrane-bound lipoxygenase of rat cerebral microvessels. Biochem Biophys Res Commun 127: 283-288, 1985.
5. Bauersachs J, Popp R, Hecker M, Sauer E, Fleming I, and Busse R. Nitric oxide attenuates the release of endothelium-derived hyperpolarizing factor. Circulation 94: 3341-3347, 1996.
6. Bhardwaj A, Northington FJ, Carhuapoma JR, Falck JR, Harder DR, Traystman RJ, and Koehler RC. P-450 epoxygenase and NO synthase inhibitors reduce cerebral blood flow response to N-methyl-D-aspartate. Am J Physiol Heart Circ Physiol 279: H1616-H1624, 2000.
7. 2+ changes and dilation in isolated resistance arteries. FASEB J 14: 255-260, 2000.
8. Brash AR. Arachidonic acid as a bioactive molecule. J Clin Invest 107: 1339-1345, 2001.
9. Bryan RM Jr, You J, Golding EM, and Marrelli SP. Endothelium-derived hyperpolarizing factor: a cousin to nitric oxide and prostacyclin esiology. In press.
10. 2 adrenoceptors dilates the rat middle cerebral artery. Anesthesiology 85: 82-90, 1996.
11. Busse R, Edwards G, Feletou M, Fleming I, Vanhoutte PM, and Weston AH. EDHF: bringing the concepts together. Trends Pharmacol Sci 23: 374-380, 2002.
12. Campbell WB, Gebremedhin D, Pratt PF, and Harder DR. Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors. Circ Res 78: 415-423, 1996.
13. Campbell WB, Spitzbarth N, Gauthier KM, and Pfister SL. 11,12,15-Trihydroxyeicosatrienoic acid mediates ACh-induced relaxations in rabbit aorta. Am J Physiol Heart Circ Physiol 285: H2648-H2656, 2003.
14. Capello S, Henderson L, DeGrazia F, Liberato D, Garland W, and Town C. The effect of the cytochrome P-450 suicide inactivator, 1-aminobenzotriazole, on the in vivo metabolism and pharmacologic activity of flurazepam. Drug Metab Dispos 18: 190-196, 1990.
15. Chaytor AT, Evans WH, and Griffith TM. Central role of heterocellular gap junctional communication in endothelium-dependent relaxations of rabbit arteries. J Physiol 508: 561-573, 1998.
16. 2A receptors. Br J Pharmacol 141: 441-448, 2004.
17. Dong H, Jiang Y, Cole WC, and Triggle CR. Comparison of the pharmacological properties of EDHF-mediated vasorelaxation in guinea-pig cerebral and mesenteric resistance vessels. Br J Pharmacol 130: 1983-1991, 2000.
18. Dos Santos EA, Dahly-Vernon AJ, Hoagland KM, and Roman RJ. Inhibition of the formation of EETs and 20-HETE with 1-aminobenzotriazole attenuates pressure natriuresis. Am J Physiol Regul Integr Comp Physiol 287: R58-R68, 2004.
19. Ellis EF, Police RJ, Yancey L, McKinney JS, and Amruthesh SC. Dilation of cerebral arterioles by cytochrome P-450 metabolites of arachidonic acid. Am J Physiol Heart Circ Physiol 259: H1171-H1177, 1990.
20. + channels. Am J Physiol Regul Integr Comp Physiol 281: R246-R253, 2001.
21. Fisslthaler B, Popp R, Kiss L, Potente M, Harder DR, Fleming I, and Busse R. Cytochrome P450 2C is an EDHF synthase in coronary arteries. Nature 401: 493-497, 1999.
22. Gauthier KM, Deeter C, Krishna UM, Reddy YK, Bondlela M, Falck JR, and Campbell WB. 14,15-Epoxyeicosa-5(Z)-enoic acid: a selective epoxyeicosatrienoic acid antagonist that inhibits endothelium-eependent hyperpolarization and relaxation in coronary arteries. Circ Res 90: 1028-1036, 2002.
23. Gebremedhin D, Ma YH, Falck JR, Roman RJ, VanRollins M, and Harder DR. Mechanism of action of cerebral epoxyeicosatrienoic acids on cerebral arterial smooth muscle. Am J Physiol Heart Circ Physiol 263: H519-H525, 1992.
24. Golding EM, Burns RA, Goodman JC, Coleman HA, Parkington HC, and Tare M. Gap junctions mediate endothelium-derived hyperpolarizing factor-mediated dilations in the rat middle cerebral artery (Abstract). Abstracts Soc Neurosci 33: 236.10, 2003.
25. Golding EM, Marrelli SP, You J, and Bryan RM Jr. Endothelium-derived hyperpolarizing factor in the brain: a new regulator of cerebral blood flow? Stroke 33: 661-663, 2002.
26. Hambrecht GS, Adesuyi SA, Holt S, and Ellis EF. Brain 12-HETE formation in different species, brain regions, and in brain microvessels. Neurochem Res 12: 1029-1033, 1987.
27. Hatoum OA, Binion DG, Miura H, Telford G, Otterson MF, and Gutterman DD. Role of hydrogen peroxide in ACh-induced dilation of human submucosal intestinal microvessels. Am J Physiol Heart Circ Physiol 288: H48-H54, 2005.
28. Hecker M, Bara AT, Bauersachs J, and Busse R. Characterization of endothelium-derived hyperpolarizing factor as a cytochrome P450-derived arachidonic acid metabolite in mammals. J Physiol 481: 407-414, 1994.
29. Huang A, Sun D, Smith CJ, Connetta JA, Shesely EG, Koller A, and Kaley G. In eNOS knockout mice skeletal muscle arteriolar dilation to acetylcholine is mediated by EDHF. Am J Physiol Heart Circ Physiol 278: H762-H768, 2000.
30. Imig JD, Falck JR, Wei SZ, and Capdevila JH. Epoxygenase metabolites contribute to nitric oxide-independent afferent arteriolar vasodilation in response to bradykinin. J Vasc Res 38: 247-255, 2001.
31. Johnson TD, Marrelli SP, Steenberg ML, Childres WF, and Bryan RM Jr. Inward rectifier potassium channels in the rat middle cerebral artery. Am J Physiol Regul Integr Comp Physiol 274: R541-R547, 1998.
32. Knickle LC and Bend JR. Dose-dependent, mechanism-based inactivation of cytochrome P450 monooxygenases in vivo by 1-aminobenzotriazole in liver, lung, and kidney of untreated, phenobarbital-treated, and beta-naphthoflavone-treated guinea pigs. Can J Physiol Pharmacol 70: 1610-1617, 1992.
33. Lacza Z, Puskar M, Kis B, Perciaccante JV, Miller AW, and Busija DW. Hydrogen peroxide acts as an EDHF in the piglet pial vasculature in response to bradykinin. Am J Physiol Heart Circ Physiol 283: H406-H411, 2002.
34. Ca channels in cerebral EDHF-mediated dilations. Am J Physiol Heart Circ Physiol 285: H1590-H1599, 2003.
35. Matoba T, Shimokawa H, Kubota H, Morikawa K, Fujiki T, Kunihiro I, Mukai Y, Hirakawa Y, and Takeshita A. Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in human mesenteric arteries. Biochem Biophys Res Commun 290: 909-913, 2002.
36. Matoba T, Shimokawa H, Nakashima M, Hirakawa Y, Mukai Y, Hirano K, Kanaide H, and Takeshita A. Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in mice. J Clin Invest 106: 1521-1530, 2000.
37. McLean PG, Aston D, Sarkar D, and Ahluwalia A. Protease-activated receptor-2 activation causes EDHF-like coronary vasodilation: selective preservation in ischemia/reperfusion injury: involvement of lipoxygenase products, VR1 receptors, and C-fibers. Circ Res 90: 465-472, 2002.
38. Meschter CL, Mico BA, Mortillo M, Feldman D, Garland WA, Riley JA, and Kaufman LS. A 13-week toxicologic and pathologic evaluation of prolonged cytochromes P450 inhibition by 1-aminobenzotriazole in male rats. Fundam Appl Toxicol 22: 369-381, 1994.
39. Miller AW, Dimitropoulou C, Han G, White RE, Busija DW, and Carrier GO. Epoxyeicosatrienoic acid-induced relaxation is impaired in insulin resistance. Am J Physiol Heart Circ Physiol 281: H1524-H1531, 2001.
40. + channels. Circ Res 83: 501-507, 1998.
41. + channels. Circulation 99: 3132-3138, 1999.
42. Miura H, Bosnjak JJ, Ning G, Saito T, Miura M, and Gutterman DD. Role for hydrogen peroxide in flow-induced dilation of human coronary arterioles. Circ Res 92: 31e-e40, 2003.
43. Mombouli JV, Ntsikoussalabongui B, Ballard K, Orskiszewski R, Taylor AA, and Vanhoutte PM. Phospholipid-derived epoxyeicosatrienoic acids mediate the relaxations attributed to endothelium-derived hyperpolarizing factor. In: Endothelium-Dependent Hyperpolarizations, edited by Vanhoutte PM. Amsterdam: Harwood, 1996, p. 29-39.
44. Moore SA, Figard PH, Spector AA, and Hart MN. Brain microvessels produce 12-hydroxyeicosatetraenoic acid. J Neurochem 53: 376-382, 1989.
45. Moore SA, Giordano MJ, Kim HY, Salem N Jr, and Spector AA. Brain microvessel 12-hydroxyeicosatetraenoic acid is the (S) enantiomer and is lipoxygenase derived. J Neurochem 57: 922-929, 1991.
46. Moore SA, Spector AA, and Hart MN. Eicosanoid metabolism in cerebromicrovascular endothelium. Am J Physiol Cell Physiol 254: C37-C44, 1988.
47. Nishikawa Y, Stepp DW, and Chilian WM. Nitric oxide exerts feedback inhibition on EDHF-induced coronary arteriolar dilation in vivo. Am J Physiol Heart Circ Physiol 279: H459-H465, 2000.
48. Peng X, Zhang C, Alkayed NJ, Harder DR, and Koehler RC. Dependency of cortical functional hyperemia to forepaw stimulation on epoxygenase and nitric oxide synthase activities in rats. J Cereb Blood Flow Metab 24: 509-517, 2004.
49. Pomposiello SI, Carroll MA, Falck JR, and McGiff JC. Epoxyeicosatrienoic acid-mediated renal vasodilation to arachidonic acid is enhanced in SHR. Hypertension 37: 887-893, 2001.
50. Richards CF, Johnson AR, and Campbell WB. Specific incorporation of 5-hydroxy-6,8,11,14-eicosatetraenoic acid into phosphatidylcholine in human endothelial cells. Biochim Biophys Acta 875: 569-581, 1986.
51. Roman RJ. P-450 metabolites of arachidonic acid in the control of cardiovascular function. Physiol Rev 82: 131-185, 2002.
52. Rosenblum WI. Hydroxyl radical mediates the endothelium-dependent relaxation produced by bradykinin in mouse cerebral arterioles. Circ Res 61: 601-603, 1987.
53. Schildmeyer LA and Bryan RM Jr. Effect of NO on EDHF response in rat middle cerebral arteries. Am J Physiol Heart Circ Physiol 282: H734-H738, 2002.
54. + channels. Stroke 28: 2290-2294, 1997.
55. Sobey CG, Heistad DD, and Faraci FM. Potassium channels mediate dilatation of cerebral arterioles in response to arachidonate. Am J Physiol Heart Circ Physiol 275: H1606-H1612, 1998.
56. Ujiie H, Chaytor AT, Bakker LM, and Griffith TM. Essential role of gap junctions in NO- and prostanoid-independent relaxations evoked by acetylcholine in rabbit intracerebral arteries. Stroke 34: 544-550, 2003.
57. VanRollins M, Kaduce TL, Fang X, Knapp HR, and Spector AA. Arachidonic acid diols produced by cytochrome P-450 monooxygenases are incorporated into phospholipids of vascular endothelial cells. J Biol Chem 271: 14001-14009, 1996.
58. VanRollins M, Kaduce TL, Knapp HR, and Spector AA. 14,15- Epoxyeicosatrienoic acid metabolism in endothelial cells. J Lipid Res 34: 1931-1942, 1993.
59. Weintraub NL, Fang X, Kaduce TL, VanRollins M, Chatterjee P, and Spector AA. Potentiation of endothelium-dependent relaxation by epoxyeicosatrienoic acids. Circ Res 81: 258-267, 1997.
60. Weintraub NL, Fang X, Kaduce TL, VanRollins M, Chatterjee P, and Spector AA. Epoxide hydrolases regulate epoxyeicosatrienoic acid incorporation into coronary endothelial phospholipids. Am J Physiol Heart Circ Physiol 277: H2098-H2108, 1999.
61. You J, Johnson TD, Marrelli SP, and Bryan RM Jr. Functional heterogeneity of endothelial P2 purinoceptors in the cerebrovascular tree of the rat. Am J Physiol Heart Circ Physiol 277: H893-H900, 1999.
62. You J, Marrelli SP, and Bryan RM Jr. Role of cytoplasmic phospholipase A2 in endothelium-derived hyperpolarizing factor dilations of rat middle cerebral arteries. J Cereb Blood Flow Metab 22: 1239-1247, 2002.
63. You JP, Johnson TD, Childres WF, and Bryan RM Jr. Endothelial-mediated dilations of rat middle cerebral arteries by ATP and ADP. Am J Physiol Heart Circ Physiol 273: H1472-H1477, 1997.
64. You JP, Johnson TD, Marrelli SP, Mombouli JV, and Bryan RM Jr. P2u-receptor mediated release of endothelium-derived relaxing factor/nitric oxide and endothelium-derived hyperpolarizing factor from cerebrovascular endothelium in rats. Stroke 30: 1125-1133, 1999.
65. Zygmunt PM and Högestätt ED. Role of potassium channels in endothelium-dependent relaxation resistant to nitroarginine in the rat hepatic artery. Br J Pharmacol 117: 1600-1606, 1996.