Effect of methylmercury on some neurotransmitters and oxidative damage of rats

Journal of Environmental Sciences

Volumn 17, Issue 3, 2005, Pages 469-473

  Cheng, Jin Ping ^a   Yang, Yi Chen ^a   Hu, Wei Xuan ^a   Yang, Liu ^a   Wang, Wen Hua ^a   Jia, Jin Ping ^a   Lin, Xue Yu ^b  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b JILIN UNIVERSITY   (China)

Author keywords

Methylmercury; Neurotransmitter; Oxidative damage

Indexed keywords

ANTIOXIDANTS; BIOLOGICAL ORGANS; BIOMEDICAL ENGINEERING; BLOOD; ENZYME INHIBITION; FREE RADICALS; MOLECULAR BIOLOGY; NITROGEN OXIDES; STATISTICAL METHODS; TOXICITY;

ACETYLCHOLINE; METHYLMERCURY; NEUROTRANSMITTER; OXIDATIVE DAMAGE;

MERCURY COMPOUNDS;

ACETYLCHOLINE; ACETYLCHOLINESTERASE; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; GLUTATHIONE; METHYLMERCURY DERIVATIVE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; SUPEROXIDE DISMUTASE;

METHYLMERCURY; NEUROLOGY; POLLUTION EFFECT;

ANIMAL; ARTICLE; BLOOD; BRAIN; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECT; KIDNEY; LIVER; METABOLISM; OXIDATIVE STRESS; RAT; SPECTROPHOTOMETRY;

ACETYLCHOLINE; ACETYLCHOLINESTERASE; ANIMALS; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE; KIDNEY; LIVER; METHYLMERCURY COMPOUNDS; NEUROTRANSMITTER AGENTS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXIDATIVE STRESS; RATS; SPECTROPHOTOMETRY; SUPEROXIDE DISMUTASE;

EID: 23944511947     PISSN: 10010742     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Arivazhagan P, Panneerselvam C, 2002. Neurochemical changes related to ageing in the rat brain and the effect of DL-α-Lipoic acid[J]. Experimental Gerontology, 37(12): 1489-1494.
2. Bakan N, Taysi S, Yilmaz Ö et al., 2003. Glutathione peroxidase, glutathione reductase, Cu-Zn superoxide dismutase activities, glutathione, nitric oxide, and malondialdehyde concentrations in serum of patients with chronic lymphocytic leukemia[J]. Clinica Chimica Acta, 338(1/2): 143-149.
3. Bernlssen M H G, Aatland A, Handy R D, 2003. Chronic dietary mercury exposure causes oxidative stress, brain lesions, and altered behaviour in Atlantic salmon(Salmo salar) parr[J]. Aquatic Toxicology, 65(1): 55-72.
4. Bogdanov M B, Wurtman R J, 1997. Possible involvement of nitric oxide in NMDA-induced glutamate release in the rat striatum: An in vivo microdialysis study[J]. Neurosci Lett, 221: 197-201.
5. Cookson M R, Pentreath V W, 1996. Protective roles of glutathione in the toxicity of mercury and cadmium compounds to C6 glioma cells[J]. Toxicology in Vitro, 10(3): 257-264.
6. Friedmann A S, Watzin M C, Brinck-Johnson J et al., 1996. Low levels of dietary methylmercury inhibit growth and gonadal development in juvenile walleye[J]. Aquatic Toxicology, 35: 265-278.
7. Garcia-Conzalez A, Ochoa J L, 1999. Anti-inflammatory activity of Debaryomyces hansenii Cu, Zn-SOD[J]. Archives of Medical Research, 30: 69-73.
8. Géret F, Jouan A, Turpin V et al., 2002. Influence of metal exposure on metallothionein synthesis and lipid peroxidation in two bivalve mollusks: The oyster(Crassostrea gigas) and the mussel(Mytilus edulis)[J]. Aquatic Living Resources, 15(1): 61-66.
9. Golpon H A, Püchner A, Barth P et al., 2003. Nitric oxide-dependent vasorelaxation and endothelial cell damage caused by mercury chloride[J]. Toxicology, 192(2/3): 179-188.
10. Himi T, Ikeda M, Sato I et al., 1996. Purkinje cells express neuronal nitric oxide synthase after methylmercury administration[J]. Brain Research, 718 (1/2): 189-192.
11. Hontela A, Rasmussen J B, Audet C et al., 1999. Impaired cortisol stress response in fish from environments polluted by PAIIS, PCBs, and mercury [J]. Arch Environ Contam Toxicol, 22(3): 278-283.
12. Hultberg B, Andersson A, Isaksson A, 1999. Thiol and redox reactive agents exert different effects on glutathione metabolism in HeLa cell cultures[J]. Clin Chim Acta, 283: 21-32.
13. Ikeda M, Komachi H, Sato I et al., 1999. Induction of neuronal nitric oxide synthase by methylmercury in the cerebellum[J]. Journal of Neuroscience Research, 55(3): 352-356.
14. Kim S H, Johnson V J, Sharma R P, 2002. Mercury inhibits nitric oxide production but activates proin. ammatory cytokine expression in murine macrophage: Dierential modulation of NF-rB and p38 MAPK signaling pathways[J]. Nitric Oxide, 7: 67-74.
15. Morello M, Reiner A, Sancesario G et al., 1997. Ultrastructural study of nitric oxide synthase-containing striatal neurons and their relationship with parvalbumin-containing neurons in rats[J]. Brain Res, 776: 30-39.
16. Ohkuma S, Katsura M, 2001. Nitric oxide and peroxynitrite as factors to stimulate neurotransmitter release in the CNS[J]. Progress in Neurobiology, 64(1): 97-108.
17. Paris-Palacios S, Biagianti-Risbourg S, Vernet G, 2000. Biochemical and(ultra) structural hepatic perturbations of Brachydanio rerio(Teleostei, Cyprinidae) exposed to two sublethal concentrations of copper sulphate[J]. Aquat Toxicol, 50: 109-124.
18. Rana S V, Singh R, Verma S, 1995. Mercury-induced lipid peroxidation in the liver, kidney, brain and gills of a fresh water fish[J]. Channa Punctatus. Jpn J Ichthyol, 42: 255-259.
19. Rajanna B, Chetty C S, Rajanna S et al., 1997. Interaction of metals with muscarinic cholinoceptor and adrenoceptor binding, and agonist-stimulated inositol phospholipid hydrolysis in rat brain[J]. Toxicology and Endocrinology, 116(2): 111-116.
20. Roméo M, Gnassia B M, 1997. Effect of heavy metals on lipid peroxidation in the mediterranean clam ruditapes decussates[J]. Toxicology and Endocrinology, 118(1): 33-37.
21. Segovia G, Mora F, 1998. Role of nitric oxide in modulating the release of dopamine, glutamate, and GABA in striatum of the freely moving rat[J]. Brain Res Bull, 45: 275-279.
22. Shinyashiki M, Kumagai Y, Homma T S et al., 1996. Selective inhibition of the mouse brain Mn-SOD by methylmercury[J]. Environmental Toxicology and Pharmacology, 2(4): 359-366.
23. Srivatsan M, 1999. Effects of organophosphates on cholinesterase activity and neurite regeneration in Aplysia [J]. Chemico-Biological Interactions, (119/120): 371-378.
24. Stuehr D J, 1999. Mammalian nitric oxide synthases[J]. Biochim Biophys Acta, 1411: 217-230.
25. Thirunavukkarasu V, Balakrishnan S D, Ravichandran M K et al., 2003. Influence of 6-week exercise training on erythrocyte and liver antioxidant defense in hyperinsulinemic rats[J]. Comparative Biochemistry and Physiology, Part C, 135(1): 31-37.
26. Tsuzuki K, Sugiyama M, Haramaki N, 1994. DNA single-strand breaks and cytotoxicity induced by chromate(VI), cadmium(II) and mercury(II) in hydrogen peroxide-resistant cell lines[J]. Environ Health Perspect, 102(3): 341-342.
27. Varadarajan S, Yatin S, Aksenova M et al., 2000. Alzheimer's amyloid β-peptide-associated free radical oxidative stress and neurotoxicity[J]. Journal of Structural Biology, 130(2/3): 184-208.
28. Zalups R K, Barfuss D W, Lash L H, 1999. Disposition of inorganic mercury following biliary obstruction and chemically induced glutathione depletion: Dispositional changes one hour after the intravenous administration of mercuric chloride[J]. Toxicology and Applied Pharmacology, 154(2): 135-144.