Purkinje cells express neuronal nitric oxide synthase after methylmercury administration

Brain Research

Volumn 718, Issue 1-2, 1996, Pages 189-192

  Himi, Toshiyuki ^a   Ikeda, Masayuki ^a   Sato, Ikuko ^a   Yuasa, Tatsuhiko ^b   Murota, Sei Itsu ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Cerebellum; Mercury poisoning; Nitric oxide; Purkinje cell

Indexed keywords

METHYLMERCURY; NITRIC OXIDE SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CEREBELLUM; CONTROLLED STUDY; HISTOCHEMISTRY; IMMUNOCYTOCHEMISTRY; MALE; MOUSE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL;

EID: 0030014308     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(96)00017-0     Document Type: Article

References (16)

1. Aschner, M., Du, Y.-L., Gannon, M. and Kimelberg, H.K., Methylmercury-induced alterations in excitatory amino acid transport in rat primary astrocyte cultures, Brain Res., 602 (1993) 181-186.
2. Atchison, W.D. and Hare, M.F., Mechanisms of methylmercury-induced neurotoxicity, FASEB J., 8 (1994) 622-629.
3. Bredt, D.S., Glatt, C.E., Hwang, P.M., Fotuhi, M., Dawson, T.M. and Snyder, S.H., Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase, Neuron, 7 (1991) 615-624.
4. Chen, S. and Aston-Jones, G., Cerebellar injury induces NADPH diaphorase in Purkinje and inferior olivary neurons in the rat, Exp. Neurol., 126 (1994) 270-276.
5. Dawson, T.M., Dawson, V.L. and Snyder, S.H., A novel neuronal messenger molecule in brain: The free radical, nitric oxide, Ann. Neurol., 32 (1992) 297-311.
6. Garthwaite, J., Glutamate, nitric oxide and cell-cell signalling in the nervous system, Trends Neurosci., 14 (1991) 60-67.
7. Ikeda, M., Ishihara, Y., Matsui, K., Morita, I., Murota, S., Yuasa, T. and Miyatake, T., Cerebellar nitric oxide synthase, cGMP and motor function in two lines of cerebellar mutant mice, Staggerer and Wriggle Mouse Sagami, Neurosci. Lett., 168 (1994) 65-68.
8. Ikeda, M., Morita, I., Murota, S., Sekiguchi, F., Yuasa, T. and Miyatake, T., Cerebellar nitric oxide synthase is reduced in nervous and Purkinje cell degeneration mutants but not in climbing fiber-lesioned mice, Neurosci. Lett., 155 (1993) 148-150.
9. Klein, R., Herman, S.P., Brubaker, P.E., Lucier, G.W. and Krigman, M.R., A model of acute methylmercury intoxication in rats, Arch. Pathol., 93 (1972) 408-418.
10. Leyshon-Sorland, K., Jasani, B. and Morgan, A.J., The localization of mercury and metallothionein in the cerebellum of rats experimentally exposed to methylmercury, Histochem. J., 26 (1994) 161-169.
11. 32P phospholabeling in cerebellar granule cell culture, J. Neurochem., 55 (1990) 913-921.
12. Sato, I., Kim, Y., Himi, T. and Murota, S., Induction of calcium-independent nitric oxide synthase activity in cultured cerebellar granule neurons, Neurosci. Lett., 184 (1995) 145-148.
13. Saxon, D.W. and Beitz, A.J., Cerebellar injury induces NOS in Purkinje cells and cerebellar afferent neurons, Neuroreport, 5 (1994) 809-812.
14. Shibuki, K. and Okada, D., Endogenous nitric oxide release required for long-term synaptic depression in the cerebellum, Nature, 349 (1991) 326-328.
15. Verge, V.M., Xu, Z., Xu, X.J., Wiesenfeld, H.Z. and Hokfelt, T., Marked increase in nitric oxide synthase mRNA in rat dorsal root ganglia after peripheral axotomy: in situ hybridization and functional studies, Proc. Natl. Acad. Sci. USA, 89 (1992) 11617-11621.
16. Wu, W., Expression of nitric oxide synthase (NOS) in injured CNS neurons as shown by NADPH diaphorase histochemistry, Exp. Neurol., 120 (1993) 153-159.