Disposition of inorganic mercury following biliary obstruction and chemically induced glutathione depletion: Dispositional changes one hour after the intravenous administration of mercuric chloride

Toxicology and Applied Pharmacology

Volumn 154, Issue 2, 1999, Pages 135-144

  Zalups, Rudolfs K ^a   Barfuss, Delon W ^b   Lash, Lawrence H ^c  

^a MERCER UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GEORGIA STATE UNIVERSITY   (United States)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE; MERCURIC CHLORIDE;

ANIMAL EXPERIMENT; ARTICLE; BILE DUCT OBSTRUCTION; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG DISPOSITION; DRUG DISTRIBUTION; KIDNEY; MALE; NONHUMAN; RAT; TISSUE DISTRIBUTION;

ANIMALIA;

EID: 0033556448     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1998.8562     Document Type: Article

References (21)

1. Abbott W. A., Meister A. Intrahepatic transport and utilization of biliary glutathione and its metabolites. Proc. Natl. Acad. Sci. USA. 83:1986;1246-1250.
2. Baggett J. M., Berndt W. O. The effect of depletion of nonprotein sulfhydryls by diethyl maleate plus buthionine sulfoximine on renal uptake of mercury in the rat. Toxicol. Appl. Pharmacol. 83:1986;556-562.
3. Ballatori N., Clarkson T. W. Dependence of biliary secretion of inorganic mercury on the biliary transport of glutathione. Biochem. Pharmacol. 33:1984;1093-1098.
4. Berndt W. O., Baggett J. M., Blacker A., Houser M. Renal glutathione and mercury uptake by kidney. Fundam. Appl. Toxicol. 5:1985;832-839.
5. Cornell J. S., Meister A. Glutathione and gamma-glutamyl cycle enzymes in crypt and villus tip cells of rats jejunal mucosa. Proc. Natl. Acad. Sci. USA. 73:1976;420-422.
6. deCeaurriz J., Payan J. P., Morel G., Brondeau M. T. Role of extracellular glutathione and γ-glutamyltranspeptidase in the disposition and kidney toxicity of inorganic mercury in rats. J. Appl. Toxicol. 14:1994;201-206.
7. Griffith O. W., Meister A. Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-N. J. Biol. Chem. 254:1979;7558-7560.
8. Lash L. H., Jones D. P., Anders M. W. Glutathione homeostasis and glutathioneS. Rev. Biochem. Toxicol. 9:1988;29-67.
9. Martensson J., Jain A., Meister A. Glutathione is required for intestinal function. Proc. Natl. Acad. Sci. USA. 87:1990;1715-1719.
10. Scott R. D., Curthoys N. P. Renal clearance of glutathione measured in rats pretreated with inhibitors of glutathione metabolism. Am. J. Physiol. 252:1987;F877-F882.
11. Tanaka T., Naganuma A., Imura N. Role of γ-glutamyltranspeptidase in renal uptake and toxicity of inorganic mercury in mice. Toxicology. 60:1990;187-198.
12. Zalups R. K. Organic anion transport and action of γ-glutamyltranspeptidase in kidney linked mechanistically to renal tubular uptake of inorganic mercury. Toxicol. Appl. Pharmacol. 132:1995;289-298.
13. Zalups R. K. Basolateral uptake of mercuric conjugates ofN. J. Toxicol. Environ. Health. 55:1998a;13-29.
14. Zalups R. K. Intestinal handling of mercury in the rat: Implication of intestinal secretion of inorganic mercury following biliary ligation or cannulation. J. Toxicol. Environ. Health. 53:1998b;615-636.
15. Zalups R. K., Barfuss D. W. Accumulation and handling of inorganic mercury in the kidney after co-administration with glutathione. J. Toxicol. Environ. Health. 44:1995a;385-399.
16. Zalups R. K., Barfuss D. W. Renal disposition of mercury in rats after intravenous injection of inorganic mercury and cysteine. J. Toxicol. Environ. Health. 44:1995b;401-413.
17. Zalups R. K., Barfuss D. W. Diversion or prevention of biliary outflow from the liver diminishes the renal uptake of injected inorganic mercury. Drug Metab. Dispos. 24:1996;480-486.
18. Zalups R. K., Barfuss D. W. Participation of mercuric conjugates of cysteine, homocysteine andN. J. Am. Soc. Nephrol. 9:1998;551-561.
19. Zalups R. K., Lash L. H. Recent advances in the study of transport and toxicity of mercury in the kidney. J. Toxicol. Environ. Health. 42:1994;1-44.
20. Zalups R. K., Lash L. H. Depletion of glutathione in the kidney and the renal disposition of administered inorganic mercury. Drug Metab. Dispos. 25:1997a;516-523.
21. Zalups R. K., Lash L. H. Binding of mercury in renal brush-border and basolateral membrane-vesicles: Implication of a cysteine-conjugate of mercury involved in the luminal uptake of inorganic mercury in the kidney. Biochem. Pharmacol. 53:1997b;1889-1900.