Synthesis, characterization, activities, cell uptake and DNA binding of trinuclear complex: [{trans-PtCl(NH3)}2μ-{trans- Pt(NH3)(2-hydroxypyridine)-(H2N(CH2) 6NH2)2]Cl4

European Journal of Medicinal Chemistry

Volumn 40, Issue 8, 2005, Pages 772-781

  Cheng, Howard ^a   Huq, Fazlul ^a   Beale, Philip ^b   Fisher, Keith ^c  

^a UNIVERSITY OF SYDNEY   (Australia)

^b ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Anticancer activity; Cell culture; Cell uptake; DNA binding; Gel electrophoresis; Platinum

Indexed keywords

ANTINEOPLASTIC AGENT; CH 9; CISPLATIN; DNA; DOUBLE STRANDED DNA; PLASMID DNA; PLATINUM COMPLEX; PYRIDINE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DNA CONFORMATION; DNA DRUG COMPLEX; DNA STRAND; DRUG DNA BINDING; DRUG DNA INTERACTION; DRUG MECHANISM; DRUG SYNTHESIS; DRUG UPTAKE; HUMAN; HUMAN CELL; OVARY CELL CULTURE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CISPLATIN; DNA; ELECTROPHORESIS; FEMALE; HUMANS; MASS SPECTROMETRY; ORGANOPLATINUM COMPOUNDS; SPECTROPHOTOMETRY, INFRARED;

EID: 23944507127     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2005.03.009     Document Type: Article

References (48)

1. P. Pil, and S.J. Lippard Cisplatin and related drug J.R. Bertini Encyclopaedia of Cancer 1997 Academic Press San Diego 392 410
2. U. Bierbach, Y. Qu, T.W. Hambley, J. Peroutka, H.L. Nguyen, M. Doedee, and N. Farrell Inorg. Chem. 38 1999 3535 3542
3. R.W. Hay, and S. Miller Polyhedron 17 1998 2337 2343
4. P. Perego, C. Caserini, L. Gatti, N. Carenini, S. Romanelli, R. Supino, D. Colangelo, L. Vino, R. Leone, S. Spinelli, G. Pezzoni, C. Monzotti, N. Farrell, and F. Zunino Mol. Pharm. 55 1999 528 534
5. P.J. Loehrer, and L.H. Einhorn Ann. Intern. Med. 100 1984 704 713
6. P. Di Blasi, A. Bernareggi, G. Beggiolin, L. Piazzoni, E. Menta, and M.I.L. Formento Cytotoxicity, Anticancer Res. 18 1998 3113 3117
7. M.A. Fuertes, J. Castilla, P.A. Nguewa, C. Alonso, and J.M. Perez Novel concepts in the development of platinum antitumour drugs: an update Med. Chem. Rev. - online 1 2004 187 198
8. R.B. Weiss, and M.C. Cristian Drugs 46 1993 360
9. M.J. Bloemink, and J. Reedijk J A. Sigel H. Sigel Metal Ions Biological Systems, vol. 32 1996 Marcel Dekker New York 641 685 (Chapter 19)
10. M. Adams, R.P. A'Hern, A.H. Calvert, J. Carmichael, P.I. Clark, R.E. Coleman, H.M. Earl, C.J. Gallagher, M.E. Gore, J.D. Graham, P.G. Harper, G.C. Jayson, S.B. Kaye, J.A. Ledermann, R.J. Osborne, T.J. Perren, C.J. Poole, J.A. Radford, G.J. Rustin, M.L. Slevin, J.F. Smyth, H. Thomas, and P.M. Wilkinson Br. J. Cancer 78 1998 1404 1406
11. P.R. Perez, P.J. O'Dwyer, L.M. Handel, R.F. Ozols, and T.C. Hamilton Int. J. Cancer 48 1991 265 269
12. S.W. Johnson, K.V. Ferry, and T.C. Hamilton Drug Resistance Update 1 1998 243 254
13. M.S. Ali, K.H. Whitmire, T. Toyomasu, Z.H. Siddik, and A.R. Khokhar J. Inorg. Biochem. 77 1999 231 238
14. N. Farrell, Y. Qu, and M.P. Hacker J. Med. Chem. 33 1990 2179 2184
15. L.R. Kelland, B.A. Murrer, G. Abel, C.M. Giandomenico, P. Mistry, and K.R. Harrap Cancer Res. 52 1992 822 828
16. P. Perego, L. Gatti, C. Caserini, R. Supino, D. Colangelo, and R. Leone J. Inorg. Biochem. 77 1999 59 64
17. H. Daghriri, F. Huq, and P. Beale J. Inorg. Biochem. 98 2004 1722 1733
18. 4 J. Inorg. Biochem. 2005 (under review)
19. 2 where L = 2-hydroxypyridine, 3-hydroxypyridine, imidazole, and imidazo(1,2-α)pyridine Eur. J. Med. Chem. 39 8 2004 691 697
20. G.B. Kauffman, and D.O. Cowan cis- and trans-dichlorodiammineplatinum (II) Inorg. Synth. 7 1963 239 245
21. H. Rauter, and R. Didomenico Inorg. Chem. 36 18 1997 3919 3927
22. G. Zhao, and H. Lin Anticancer Drug Des. 13 7 1998 769 777
23. M. Meroueh, and J. Kjellstrom Inorg. Chim. Acta 297 1-2 2000 145 155
24. P.W. Atkins Physical Chemistry 1998 Oxford University Press Oxford, Melbourne, Tokyo
25. N. Stellawagen Nucleic Acid Electrophoresis 1998 Springer Berlin, New York 1-53
26. G. Collela, M. Nennati, R. Leone, D. Colangelo, C. Manzotti, and M.G. Daidone Br. J. Cancer 84 2001 1387 1390
27. M.S. Davies, D.S. Thomas, A. Hegmans, S.J. Berners-Price, and N. Farrell Inorg. Chem. 41 2002 1101 1109
28. I.R. Freshney Culture of Animal Cells: A Manual of Basic Technique, forth ed 2000 Wily-Liss New York
29. T. Mosmann J. Immun. Methods 65 1983 55 63
30. N. Farrell, and L.R. Kelland Cancer Res. 52 1992 5065 5072
31. D.D. Bowtell Anal. Biochem. 162 2 1987 463 465
32. J. Heptinstall, and R. Rapley R. Rapley The Nucleic Acid Protocols Handbook 2002 Humana Press Totowa, NJ 57 60
33. R.M. Silverstein, G.C. Bassler, and T.C. Morrill Spectrometric Identification of Organic Compounds, fifth ed 1991 Wiley & Sons
34. N. Farrell, Y. Qu, L. Feg, and B. Van Houten Biochemistry 29 1990 9522 9531
35. K. Nakamoto Infrared and Raman Spectra of Inorganic and Coordination Compounds Part B: Applications in Coordination Organometallic and Bioinorganic Chemistry 1997 Wiley New York
36. S.J. Berners-Price, and P.J. Sadler Coord Chem. Rev. 151 1996 1 40
37. H.E. Gottlieb, V. Kotlyar, and A. Nudelman J. Org. Chem. 62 21 1997 7512 7515
38. R.S. Macomber A Complete Introduction to Modern NMR Spectroscopy 1998 Wiley New York
39. Y. Qu, N.J. Scarsdale, M.C. Tran, and N. Farrell J. Biol. Inorg. Chem. 8 2003 19 28
40. N. Farrell, and S. Spinell N. Farrell Uses of Inorganic Chemistry in Medicine 1999 Royal Society of Chemistry Cambridge 124 134
41. F. Huq, H. Daghriri, J.Q. Yu, P. Beale, and M. Zhang Eur. J. Med. Chem. 39 2004 947 958
42. E. Jamieson, and S.J. Lippard Chem. Rev. 99 1999 2467 2498
43. J. Zehunlova, and J. Kasparkova J. Biol. Chem. 276 25 2001 22191 22199
44. R.J. Roberts, G.A. Wilson, and F.E. Young Nature 265 1977 82 84
45. J.D. Roberts, J. Peroutka, G. Beggiolon, C. Manzotti, L. Piazzoni, and N. Farrell J. Inorg. Biochem. 77 1999 47 50
46. T.D. McGregor, and Z. Balcarova J. Inorg. Biochem. 77 1-2 1999 43 46
47. N.J. Wheate, and J.G. Collin Coord. Chem. Rev. 241 1-2 2003 133 145
48. Y. Wang, N. Farrell, and N.J.D. Burgess J. Am. Chem. Soc. 123 23 2001 5576 5577