Cognitive dysfunctions in multiple sclerosis patients;Kognitive defizite bei multipler sklerose

Nervenarzt

Volumn 76, Issue 8, 2005, Pages 943-953

  Engel, C ^a   Greim, B ^a   Zettl, U K ^a  

^a UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

Cognitive dysfunctions; Diagnosis; Multiple sclerosis; Prevalence; Therapy options

Indexed keywords

IMMUNOMODULATING AGENT;

ATTENTION; COGNITIVE DEFECT; COMORBIDITY; DEPRESSION; DIAGNOSTIC PROCEDURE; DIFFERENTIAL DIAGNOSIS; DISEASE COURSE; FATIGUE; MEMORY; MULTIPLE SCLEROSIS; PERFORMANCE; PHYSICAL DISABILITY; QUALITY OF LIFE; REVIEW; SOCIAL ASPECT; TRAINING; VISION;

COGNITION DISORDERS; COMORBIDITY; HUMANS; INCIDENCE; MULTIPLE SCLEROSIS; PROGNOSIS; RISK ASSESSMENT; RISK FACTORS;

EID: 23944500563     PISSN: 00282804     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00115-005-1901-1     Document Type: Review

References (122)

1. Achiron A, Barak Y (2003) Cognitive impairment in probable multiple sclerosis. J Neurol Neurosurg Psychiatry 74:443-446
2. Amato MR, Bartolozzi ML, Zipoli V et al. (2004) Neocortical volume decrease in relapsing-remitting MS patients with mild cognitive impairment. Neurology 63:89-93
3. Amato MP, Ponziani G, Pracucci G et al. (1995) Cognitive impairment in early-onset multiple sclerosis. Arch Neurol 52:168-172
4. Amato MP, Ponziani G, Siracusa G et al. (2001) Cognitive dysfunction in early-onset multiple sclerosis. Arch Neurol 58:1602-1606
5. Arnett PA, Higginson CI, Voss WD et al. (2002) Relationship between coping, cognitive dysfunction and depression in multiple sclerosis. Clin Neuropsychol 16:341-355
6. Arnett PA, Higginson CI, Voss WD et al. (1999) Depressed mood in multiple sclerosis: relationship to capacity-demanding memory and attentional functioning. Neuropsychology 13:434-446
7. Arnett PA, Rao SM, Bernardin L et al. (1994) Relationship between frontal lobe lesions and Wisconsin Card Sorting Test performance in patients with multiple sclerosis. Neurology 44:420-425
8. Arnett PA, Rao SM, Grafman J et al. (1997) Executive functions in multiple sclerosis: an analysis of temporal ordering, semantic encoding and planning abilities. Neuropsychology 11:535-544
9. Aschenbrenner S, Tucha O, Lange KW (2000) Regensburger Wortflüssigkeits-Test (RWT). Hogrefe, Göttingen
10. Audoin B, Van Au Duong M, Ranjeva JP et al. (2004) Magnetic resonance study of the influence of tissue damage and cortical reorganization on PASAT performance at the earliest stage of multiple sclerosis. Hum Brain Mapp 24:216-228
11. Bagert B, Camplair P, Bourdette D (2002) Cognitive dysfunction in multiple sclerosis. Natural history, pathophysiology and management. CNS Drugs 16:445-455
12. Bakshi R, Shaikh ZA, Miletich RS et al. (2000) Fatigue in multiple sclerosis and its relationship to depression and neurologic disability. Mult Scler 6:181-185
13. Barak Y, Achiron A (2002) Effect of Interferon-beta-1b on cognitive functions in multiple sclerosis. Eur Neurol 47:11-14
14. Barak Y, Gabbay U, Gilad R et al. (1999) Neuropsychiatric assessment as a secondary outcome measure in a multiple sclerosis intravenous immunoglobulin (IVIg) trial. Int J Psychiatr Clin Pract 3:31-34
15. Basso MR, Beason-Hazen S, Lynn J et al. (1996) Screening for cognitive dysfunction in multiple sclerosis. Arch Neurol 53:980-984
16. Beatty WW, Goodkin DE, Monson N et al. (1989) Cognitive disturbances in patients with relapsing remitting multiple sclerosis. Arch Neurol 46:1113-1119
17. Beatty WW, Goodkin DE, Monson N et al. (1990) Implicit learning in patients with chronic progressive multiple sclerosis. Int J Clin Neuropsychol 12:166-172
18. Beatty WW, Goretti B, Siracusa G et al. (2003) Changes in neuropsychological test performances over the workday in multiple sclerosis. Clin Neuropsychol 17:551-560
19. Beatty WW, Monson N (1991) Metamemory in Multiple Sclerosis. J Clin Exp Neuropsychol 13:309-327
20. Beatty WW, Paul RH, Wilbanks SL et al. (1995) Identifying multiple sclerosis patients with mild or global cognitive impairment using the Screening Examination for Cognitive Impairment (SEFCI). Neurology 45:718-723
21. Behmenburg C (1993) Aufmerksamkeitsstörungen bei Patienten mit Multipler Sklerose. Dissertation, Heine-Universität Düsseldorf
22. Benedict RH, Cox D, Thompson LL et al. (2004) Reliable screening for neuropsychological impairment in multiple sclerosis. Mult Scler 10:675-678
23. Benedict RH, Fischer JS, Archibald CJ et al. (2002) Minimal neuropsychological assessment of MS patients: a consensus approach. Clin Neurophysiol 16:381-397
24. Benedict RH, Munschauer F, Linn R et al. (2003) Screening for multiple sclerosis cognitive impairment using a self-administered 15-item questionnaire. Mult Scler 9:95-101
25. Benedict RH, Shapiro A, Priore R et al. (2000) Neuropsychological counseling improves social behavior in cognitively-impaired multiple scleorsis patients. Mult Scler 6:391-396
26. Bjartmar C, Trapp BD (2001) Axonal and neuronal degeneration in multiple sclerosis: mechanisms and functional consequences. Curr Opin Neurol 14:271-278
27. Bo L, Vedeler CA, Nyland H et al. (2003) Subpial demyelination in the cerebral cortex of multiple sclerosis patients. J Neuropathol Exp Neurol 62:723-732
28. Brand M, Kalbe E, Kessler J (2002) Test zum kognitiven Schätzen (TKS). Beltz, Göttingen
29. Brickenkamp R (2002) Test d2: Aufmerksamkeits-Belastungs-Test. Hogrefe, Göttingen
30. Bruce JM, Arnett PA (2004) Self-reported everyday memory and depression in patients with multiple sclerosis. J Clin Exp Neuropsychol 26:200-214
31. Calabrese P, Haupts M, Babinsky R et al. (1993) Alltagsgedä chtnisleistungen bei Multipler Sklerose. Z Neuropsychol 4:4-16
32. Calabrese P, Haupts M, Gehlen W (2000) Verlaufsabhängige Gedächtnisstörungen und Läsionsmuster bei Multipler Sklerose. Neurol Rehabil 6:184-188
33. Canter AH (1951) Direct and indirect measures of psychological deficits in multiple sclerosis. J Gen Psychol 44:3-50
34. Charcot JM (1873) Lessons sur les maladies du système nerveux faites à la Salpetrière. Delahaye, Paris
35. Christodoulou C, Krupp LB, Liang Z et al. (2003) Cognitive performance and MR markers of cerebral injury in cognitively impaired MS patients. Neurology 60:1793-1798
36. Clark CM, Jacova C, Klonoff H et al. (1997) Pathological association and dissociation of functional systems in multiple sclerosis and huntington's disease. J Clin Exp Neuropsychol 19:63-76
37. Comi G, Filippi M, Martinelli V et al. (1995) Brain MRI correlates of cognitive impairment in primary and secondary progressive multiple sclerosis. J Neurol Sci 132:222-227
38. DeLuca J, Barbieri-Berger S, Johnson SK (1994) The nature of memory impairments in multiple sclerosis: acquisition versus retrieval. J Clin Exp Neuropsychol 16:183-189
39. Derache N, Marié RM, Daniel F et al. (2003) Cognition in early-remitted multiple sclerosis: a psychometric, MR and PET study. Mult Scler 9(Suppl 1):131
40. Dujardin K, Donze A, Hautecoeur P (1998) Attention impairment in recently diagnosed multiple sclerosis. Eur J Neurol 5:61-66
41. Edan G, Sartori E (2004) Recommendations for assessment of cognitive dysfunction in MS. Should assessment of cognitive disturbances and emotional impairments be included in all future clinical trials. In: European Charcot Foundation, Taormina, 11-13 November 2004
42. Engel C, Greim B, Zettl UK (2004) Fatigue bei Multipler Sklerose. Neurol Rehabil 9:263-271
43. Feinstein A (2004) The neuropsychiatry of multiple sclerosis. Can J Psychiatry 49:157-163
44. Fischer JS, Priore RL, Jacobs LD et al. (2000) Neuropsychological effects of interferon beta-1a in relapsing multiple sclerosis. Ann Neurol 48:885-892
45. Flachenecker P, Kumpfel T, Kallmann B et al. (2002) Fatigue in multiple sclerosis: a comparison of different rating scales and correlation to clinical parameters. Mult Scler 8:523-526
46. Foong J, Rozewicz L, Chong WK et al. (2000) A comparison of neuropsychological deficits in primary and secondary progressive multiple scleorsis. J Neurol 247:97-101
47. Foong J, Rozewicz L, Quaghebeur G et al. (1997) Executive function in multiple sclerosis. The role of frontal lobe pathology. Brain 120:15-26
48. Foong J, Rozewicz L, Quaghebeur G et al. (1998) Neuropsychological deficits in multiple sclerosis after acute relapse. J Neurol Neurosurg Psychiatry 64:529-532
49. Fraser C, Stark S (2003) Cognitive symptoms and correlates of physical disability in individuals with multiple sclerosis. J Neurosci Nurs 35:314-320
50. Gadea M, Martinez-Bisbal MC, Marti-Bonmati L et al. (2004) Spectroscopic axonal damage of the right locus coeruleus relates to selective attention impairment in early stage relapsing-remitting multiple sclerosis. Brain 127:89-98
51. Goel V, Grafman J (1995) Are the frontal lobes implicated in planning functions? Interpreting data from the Tower of Hanoi. Neuropsychologia 33:623-642
52. Grafman J, Rao S, Bernardin L et al. (1991) Automatic memory processes in patients with multiple sclerosis. Arch Neurol 48:1072-1075
53. Grafman J, Rao SM, Litvan I (1990) Disorders of memory. In: Rao SM (ed) Neurobehavioral aspects of multiple sclerosis. Oxford, New York, pp 102-117
54. Grant DA, Berg EA (1981) Wisconsin Card Sorting Test (WCST). Psychological Assessment Resources, Odessa
55. Grant I, McDonald WI, Trimble MR et al. (1984) Deficient learning and memory in early and middle phases of multiple sclerosis. J Neurol Neurosurg Psychiatry 47:250-255
56. Greene YM, Jariot PN, Wishart H et al. (2000) A 12-week, open trial of donepezil hydrochloride in patients with multiple sclerosis and associated cognitive impairments. J Clin Psychopharmacol 20:350-356
57. Greim B, Apel A, Zettl UK (2002) Ist Gehen wichtiger als Denken? Häufig unterschätzt und lange vernachlässigt: neuropsychologische Störungen bei MS. In: Schläfke D, Häßler F, Zettl UK (Hrsg) Folgeerkrankungen und Störungen des Alkohol-und Drogenmissbrauchs. Deutscher Universitäts-Verlag, Wiesbaden, S 95-100
58. Greim B, Benecke R, Zettl UK (2001) Qualitative and quantitative evaluation of fatigue in multiple sclerosis (MS). J Neurol 248(Suppl 2):176
59. Gronwall DM (1977) Paced auditory serial-addition task: a measure of recovery from concussion. Percept Mot Skills 44:367-373
60. Haase C, Tinnefeld M, Lienemann M et al. (2003) Depression and cognitive impairment in disability-free early multiple sclerosis. Behav Neurol 14:39-45
61. Hamilton M (1967) Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol 6:278-296
62. Haupts M, Calabrese P (1994) Multiple Sklerose und Alltagsgedä chtnis. In: Haupts M (Hrsg) Neurologie und Gedächtnis. Huber, Bern, S 68-75
63. Haupts M, Calabrese P, Greim B et al. (2001) Neuropsychologische Befunde und Therapieoptionen bei Multipler Sklerose. In: Zettl UK, Mix E (Hrsg) Multiple Sklerose: Kausalorientierte, symptomatische und rehabilitative Therapie. Springer, Berlin Heidelberg New York, S 251-270
64. Haupts M, Calabrese P, Ließ J et al. (1996) Zerebrale Läsionen bei Encephalomyelitis disseminata: Neuropsychologische Befunde und rehabilitative Ansätze. In: Huffmann G, Braune H-J (Hrsg) Zerebrale und spinale Prozesse: Encephalomyelitis disseminata, Epilepsien, degenerative Erkrankungen, Traumen, Tumoren, Rehabilitation. Einhorn, Reinbek, S 155-160
65. Hautzinger M, Bailer M (1993) Allgemeine Depressions-Skala: ADS. Beltz, Göttingen
66. Hautzinger M, Bailer M, Worall H et al. (1994) Beck-Depressions-Inventar (BDI). Huber, Bern
67. Heaton RK, Nelson LM, Thompson DS et al. (1985) Neuropsychological findings in relapsing-remitting and chronic-progressive multiple sclerosis. J Consult Clin Psychol 53:103-110
68. Helmstaedter C, Lendt M, Lux S (2001) Verbaler Lern- und Merkfähigkeitstest (VLMT). Beltz, Göttingen
69. Hildebrandt H, Brokate B, Lanz M et al. (2003) Exekutivfunktionsleistungen bei Patienten mit Multipler Sklerose. Aktuelle Neurol 30:118-126
70. Iriarte J, Katsamakis G, De Castro P (1999) The fatigue descriptive scale (FDS): a useful tool to evaluate fatigue in multiple sclerosis. Mult Scler 5:10-16
71. Ivnik RJ (1978) Neuropsychological stability in multiple sclerosis. J Consult Clin Psychol 46:913-923
72. Jonsson A, Korfitzen EM, Heltberg A et al. (1993) Effects of neuropsychological treatment in patients with multiple sclerosis. Acta Neurol Scand 88:394-400
73. Krupp LB, Alvarez LA, LaRocca NG et al. (1988) Fatigue in multiple sclerosis. Arch Neurol 45:435-437
74. Krupp LB, Christodoulou C, Melville P et al. (2004) Donepezil improved memory in multiple sclerosis in a randomized clinical trial. Neurology 63:1579-1585
75. Krupp LB, Elkins LE (2000) Fatigue and declines in cognitive functioning in multiple sclerosis. Neurology 55:934-939
76. Krupp LB, LaRocca NG, Muir-Nash J et al. (1989) The Fatigue Severity Scale. Application to patients with multiple sclerosis and systematic lupus erythematosus. Arch Neurol 46:1121-1123
77. Kujala P, Portin R, Revonsuo A et al. (1995) Attention related performance in two cognitively different subgroups of patients with multiple sclerosis. J Neurol Neurosurg Psychiatry 59:77-82
78. Kujala R Portin R, Ruutiainen J (1997) The progress of cognitive decline in multiple sclerosis. A controlled 3-year follow-up. Brain 120:289-297
79. Lincoln NB, Dent A, Harding J et al. (2002) Evaluation of cognitive assessment and cognitive intervention for people with multiple sclerosis. J Neurol Neurosurg Psychiatry 72:93-98
80. Litvan I, Grafman J, Vendrell P et al. (1988) Multiple memory deficits in patients with multiple sclerosis. Arch Neurol 45:607-610
81. Mainero C, Caramia F, Pozzilli C et al. (2004) fMRl evidence of brain reorganization during attention and memory tasks in multiple sclerosis. Neuroimage 21:858-867
82. Maor Y, Olmer L, Mozes B (2001) The relation between objective and subjective impairment in cognitive function among multiple sclerosis patients - the role of depression. Mult Scler 7:131-135
83. Mohr DC, Goodkin DE, Likosky W et al. (1997) Identification of Beck Depression Inventory items related to multiple sclerosis. J Behav Med 20:407-414
84. Möller A, Wiedemann G, Rohde U et al. (1994) Correlates of cognitive impairment and depressive disorder in multiple sclerosis. Acta Psychiatr Scand 89:117-121
85. Montgomery SA, Asberg M (1979) A new depression scale designed to be sensitive to change. Br J Psychiatry 134:382-389
86. Multiple-Sklerose-Therapie-Konsensus-Gruppe (2004) Symptomatische Therapie der Multiplen Sklerose. Nervenarzt 75(Suppl 1):1-39
87. Pan JW, Krupp LB, Elkins LE et al. (2001) Cognitive dysfunction lateralizes with NAA in multiple sclerosis. Appl Neuropsychol 8:155-160
88. Parmenter BA, Denney DR, Lynch SG (2003) The cognitive performance of patients with multiple sclerosis during periods of high and low fatigue. Mult Scler 9:111-118
89. Patti F, Failla G, Ciancio MR et al. (1998) Neuropsychological, neuroradiological and clinical findings in multiple sclerosis. A 3 year follow-up study. Eur J Neurol 5:283-286
90. Patzold T, Schwengelbeck M, Ossege LM et al. (2002) Changes of the MS functional composite and EDSS during and after treatment of relapses with methylprednisolone in patients with multiple sclerosis. Acta Neurol Scand 105:164-168
91. Paul RH, Blanco CR, Hames KA et al. (1997) Autobiographical memory in multiple sclerosis. J Int Neuropsychol Soc 3:246-251
92. Pelosi L, Geesken JM, Holly M et al. (1997) Working memory impairment in early multiple sclerosis. Evidence from an event-related potential study of patients with clinically isolated myelopathy. Brain 120:2039-2058
93. Peterson JW, Bo L, Mork S et al. (2001) Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions. Ann Neurol 50:389-400
94. Piras MR, Magnano I, Canu ED et al. (2003) Longitudinal study of cognitive dysfunction in multiple sclerosis: neuropsychological, neuroradiological, and neurophysiological findings. J Neurol Neurosurg Psychiatry 74:878-885
95. Pliskin NH, Hamer DR Goldstein DS et al. (1996) Improved delayed visual reproduction test performances in multiple sclerosis patients receiving interferon beta-1b. Neurology 47:1463-1468
96. Plohmann AM, Kappos L, Ammann W et al. (1998) Computer assisted retraining of attentional impairments in patients with multiple sclerosis. J Neurol Neurosurg Psychiatry 64:455-462
97. Rao SM (1986) Neuropsychology of multiple sclerosis: a critical review. J Clin Exp Neuropsychol 8:503-542
98. Rao SM, Cognitive-Function-Study-Group-of-the-National-Multiple- Sclerosis-Society (1990) A manual for the Brief Repeatable Battery of Neuropsychological Tests in multiple sclerosis. Medical Collage of Wisconsin, Milwaukee
99. Rao SM, Grafman J, DiGiulio D et al. (1993) Memory dysfunction in multiple sclerosis: its relation to working memory, semantic encoding and implicit learning. Neuropsychology 7:364-374
100. Rao SM, Leo GJ, Bernardin L et al. (1991) Cognitive dysfunction in multiple sclerosis. I. Frequency, patterns, and prediction. Neurology 41:685-691
101. Rao SM, Leo GJ, Ellington L et al. (1991) Cognitive dsyfunction in multiple sclerosis. II. Impact on employment and social functioning. Neurology 41:692-696
102. Raven JC (1990) Standard Progressive Matrices (SPM). Psychologists Press, Oxford
103. Rodriguez M, Siva A, Ward J et al. (1994) Impairment, disability, and handicap in multiple sclerosis. A population-based study in Olmsted County, Minnesota. Neurology 44:28-33
104. Rovaris M, Filippi M, Falautano M et al. (1998) Relation between MR abnormalities and patterns of cognitive impairment in multple sclerosis. Neurology 50:1601-1608
105. Ruggieri RM, Palermo R, Vitello G et al. (2003) Cognitive impairment in patients suffering from rela psing-remitting multiple sclerosis with EDSS<3.5. Acta Neurol Scand 108:323-326
106. Sadovnick AD, Eisen K, Ebers GC et al. (1991) Cause of death in patients attending multiple sclerosis clinics. Neurology 41:1193-1196
107. Schiffer RB, Caine ED (1991) The interaction between depressive affective disorder and neuropsychological test performance in multiple sclerosis patients. J Neuropsychiatry Clin Neurosci 3:28-32
108. Schreurs K, de Ridder D, Bensing J (2002) Fatigue in multiple sclerosis: reciprocal relationships with physical disabilities and depression. J Psychosom Res 53:775-781
109. Selby MJ, Ling N, Williams JM et al. (1998) Interferon beta 1-b in verbal memory functioning of patients wit relapsing-remitting multiple sclerosis. Percept Mot Skills 86:1099-1106
110. Solari A, Motta A, Mendozzi L et al. (2004) Computer-aided retraining of memory and attention in people with multiple sclerosis: a randomized, double-blind controlled trial. J Neurol Sci 222:99-104
111. Sperling RA, Guttmann CR, Hohol MJ et al. (2001) Regional magnetic resonance imaging lesion burden and cognitive function in multiple sclerosis. Arch Neurol 58:115-121
112. Staffen W, Mair A, Zauner H et al. (2002) Cognitive function and fMRI in patients with multiple sclerosis: evidence for compensatory cortical activation during an attention task. Brain 125:1275-1282
113. Sturm W, Willmes K (1999) Verbaler und Nonverbaler Lerntest. Hogrefe, Göttingen
114. Thornton AE, Raz N (1997) Memory impairment in multiple sclerosis: a quantitative review. Neuropsychology 11:357-366
115. Trapp BD, Petersen JP, Ransohoff RM et al. (1998) Axonal transection in the lesions of multiple sclerosis. N Engl J Med 338:278-285
116. Tucha G, Lange KW (2004) Turm von London. Hogrefe, Göttingen
117. Wechsler D (1987) Wechsler Memory Scale Revised. Psychological Corporation, San Antonio
118. Weinstein A, Schwid SI, Schiffer RB et al. (1999) Neuropsychologic status in multiple sclerosis after treatment with glatiramer. Arch Neurol 56:319-324
119. Wishart HA, Flashman L, Saykin AJ (2001) The neuropsychology of multiple sclerosis: contributions of neuroimaging research. Curr Psychiatry Rep 3:373-378
120. Zimmermann C, Hohlfeld R (1999) "Fatigue" bei multipler Sklerose. Nervenarzt 70:566-574
121. Zimmermann P, Fimm B (1995) Testbatterie zur Aufmerksamkeitsprüfung (TAP). Psytest, Würselen
122. Zivadinov R, Sepcic J, Nasuelli D et al. (2001) A longitudinal study of brain atrophy and cognitive disturbances in the early phase of relapsing-remitting multiple sclerosis. J Neurol Neurosurg Psychiatry 70:773-780