Antiviral 6-amino-quinolones: Molecular basis for potency and selectivity

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 19, 2005, Pages 4247-4251

  Richter, Sara N ^a   Gatto, Barbara ^a   Tabarrini, Oriana ^b   Fravolini, Arnaldo ^b   Palumbo, Manlio ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF PERUGIA   (Italy)

Author keywords

Cytotoxicity; Magnesium binding; Quinolones; Selectivity index

Indexed keywords

ANTIVIRUS AGENT; MAGNESIUM ION; NUCLEIC ACID; QUINOLINE DERIVED ANTIINFECTIVE AGENT; QUINOLONE; VIRUS DNA; VIRUS RNA;

ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; CHELATION; CHEMICAL MODIFICATION; DNA BINDING; DNA TEMPLATE; DRUG BINDING; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; HOST CELL; RNA BINDING; STRUCTURE ACTIVITY RELATION;

AMINOQUINOLINES; ANTIVIRAL AGENTS; BINDING SITES; BINDING, COMPETITIVE; CELL DEATH; GENE PRODUCTS, TAT; HIV LONG TERMINAL REPEAT; MAGNESIUM; NUCLEIC ACIDS; STRUCTURE-ACTIVITY RELATIONSHIP;

DNA VIRUSES;

EID: 23944500355     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.06.074     Document Type: Article

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