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Saigo M, Waters DD, Abe S, et al. Soluble fibrin, C-reactive protein, fibrinogen, factor VII, antithrombin, proteins C and S, tissue factor, D-dimer, and prothrombin fragment 1 + 2 in men with acute myocardial infarction =45 years of age. Am J Cardiol 2004; 94:1410-1413. Prothrombotic factors and CRP were elevated in patients with acute myocardial infarction. Soluble fibrin was the strongest predictor of acute myocardial infarction.
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Speidl WS, Zeiner A, Nikfardjam M, et al. An increase of C-reactive protein is associated with enhanced activation of endogenous fibrinolysis at baseline but an impaired endothelial fibrinolytic response after venous occlusion. J Am Coll Cardiol 2005; 45:30-34. This study of 50 patients 6 months after acute myocardial infarction showed correlation of CRP levels with impaired fibrinolytic response to venous occlusion.
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Clinical usefulness of very high and very low levels of C-reactive protein across the full range of Framingham Risk Scores
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Ridker PM, Cook N. Clinical usefulness of very high and very low levels of C-reactive protein across the full range of Framingham Risk Scores. Circulation 2004; 109:1955-1959. This article reports a study of 27,939 apparently healthy women and shows linear correlation between levels of CRP and risk of major adverse cardiovascular events, even after adjustment for conventional risk factors. All the data are presented as relative risks.
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Circulation
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Ridker, P.M.1
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Limitations of the odds ratio in gauging the performance of a diagnostic, prognostic, or screening marker
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Pepe MS, Janes H, Longton G, et al. Limitations of the odds ratio in gauging the performance of a diagnostic, prognostic, or screening marker. Am J Epidemiol 2004; 159:882-890. This article shows that epidemiologic risk studies using odds ratios or relative risks are important for public health measures or to generate hypothesis; however, a test intended for screening, for diagnosis, or to guide therapy requires good sensitivity, specificity, and predictive values. The article shows tables and examples relating odds ratios to sensitivity and specificity.
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Am J Epidemiol
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Pepe, M.S.1
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Poor predictive value of high-sensitivity C-reactive protein indicates need for reassessment
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Levinson SS, Miller JJ, Elin RJ. Poor predictive value of high-sensitivity C-reactive protein indicates need for reassessment. Clin Chem 2004; 50:1 733-1 735. This article reports a re-examination of cohort studies of CRP as a predictor of CAD in apparently healthy individuals, showing very low positive predictive values.
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Clin Chem
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Levinson, S.S.1
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C-reactive protein levels and outcomes after statin therapy
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Ridker PM, Cannon CP, Morrow D, et al. C-reactive protein levels and outcomes after statin therapy. N Engl J Med 2005; 352:20-28. This randomized controlled trial of two regimens of statin treatment in 3745 patients with acute coronary syndrome shows an association between reduction of CRP levels after statin treatment and outcome.
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N Engl J Med
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Ridker, P.M.1
Cannon, C.P.2
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Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease
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Nissen SE, Tuzcu EM, Schoenhagen P, et al. Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease. N Engl J Med 2005; 352: 29-38. This randomized controlled trial of two regimens of statin treatment in 502 patients with CAD shows that the higher-intensity statin treatment results in lower CRP levels and reduces progression of CAD.
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N Engl J Med
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Nissen, S.E.1
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