C-reactive protein levels determine systemic nitric oxide bioavailability in patients with coronary artery disease

European Heart Journal

Volumn 25, Issue 16, 2004, Pages 1412-1418

  Fichtlscherer, Stephan ^a   Breuer, Susanne ^a   Schächinger, Volker ^a   Dimmeler, Stefanie ^a   Zeiher, Andreas M ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

Coronary artery disease; CRP; Endothelium; Inflammation; Nitric oxide

Indexed keywords

ACETYLCHOLINE; ASCORBIC ACID; C REACTIVE PROTEIN; CYTOKINE; N(G) METHYLARGININE; NITRIC OXIDE; OXYGEN; SCAVENGER;

ADULT; AREA UNDER THE CURVE; ARTICLE; BIOAVAILABILITY; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DISEASE ASSOCIATION; FOREARM BLOOD FLOW; HUMAN; MAJOR CLINICAL STUDY; MALE; PREDICTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; STATISTICAL SIGNIFICANCE; SYSTEMIC CIRCULATION; SYSTEMIC DISEASE; VASCULAR ENDOTHELIUM; VEIN OCCLUSION PLETHYSMOGRAPHY;

BIOLOGICAL AVAILABILITY; C-REACTIVE PROTEIN; CORONARY ARTERIOSCLEROSIS; FOREARM; HUMANS; MALE; MIDDLE AGED; NITRIC OXIDE;

EID: 4143080380     PISSN: 0195668X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ehj.2004.06.026     Document Type: Article

References (23)

1. V. Schächinger, M.B. Britten, and A.M. Zeiher Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease Circulation 101 2000 1899 1906
2. J.A. Suwaidi, S. Hamasaki, and S.T. Higano Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction Circulation 101 2000 948 954
3. P.O. Bonetti, L.O. Lerman, and A. Lerman Endothelial dysfunction: a marker of atherosclerotic risk Arterioscler Thromb. Vasc. Biol. 23 2003 168 175
4. P. Libby, and P.M. Ridker Novel inflammatory markers of coronary risk: theory versus practice Circulation 100 1999 1148 1150
5. S. Fichtlscherer, G. Rosenberger, and D.H. Walter Elevated C-reactive protein levels and impaired endothelial vasoreactivity in patients with coronary artery disease Circulation 102 2000 1000 1006
6. S. Verma, C.H. Wang, and S.H. Li A self-fulfilling prophecy: C-reactive protein attenuates nitric oxide production and inhibits angiogenesis Circulation 106 2002 913 919
7. C.-H. Wang, S.-H. Li, and R.D. Weisel C-Reactive protein upregulates angiotensin type 1 receptors in vascular smooth muscle Circulation 107 2003 1783 1790
8. J. Loscalzo, and G. Welch Nitric oxide and its role in the cardiovascular system Prog. Cardiovasc. Dis. 38 1995 87 104
9. T. Heitzer, T. Schlinzig, and K. Krohn Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease Circulation 104 2001 2673 2678
10. T. Heitzer, C. Brockhoff, and B. Mayer Tetrahydrobiopterin improves endothelium-dependent vasodilation in chronic smokers: evidence for a dysfunctional nitric oxide synthase Circ. Res. 86 2000 E36 E41
11. R. Busse, G. Edwards, and M. Feletou EDHF: bringing the concepts together Trends Pharmacol. Sci. 23 2002 374 380
12. S.J. Cleland, N. Sattar, and J.R. Petrie Endothelial dysfunction as a possible link between C-reactive protein levels and cardiovascular disease Clin. Sci. (Colch) 98 2000 531 535
13. U. Landmesser, S. Dikalov, and S.R. Price Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension J. Clin. Invest. 111 2003 1201 1209
14. U. Landmesser, S. Spiekermann, and S. Dikalov Vascular oxidative stress and endothelial dysfunction in patients with chronic heart failure: role of xanthine-oxidase and extracellular superoxide dismutase Circulation 106 2002 3073 3078
15. M. Yoshizumi, M.A. Perrella, and J.C. Burnett Jr. Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life Circ. Res. 73 1993 205 209
16. S.K. Venugopal, S. Devaraj, and I. Yuhanna Demonstration that C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells Circulation 106 2002 1439 1441
17. B.S. Oemar, M.R. Tschudi, and N. Godoy Reduced endothelial nitric oxide synthase expression and production in human atherosclerosis Circulation 97 1998 2494 2498
18. G. Liuzzo, L.M. Biasucci, and J.R. Gallimore The prognostic value of C-reactive protein and serum amyloid a protein in severe unstable angina N. Engl. J. Med. 331 1994 417 424
19. F. Haverkate, S.G. Thompson, and S.D. Pyke Production of C-reactive protein and risk of coronary events in stable and unstable angina. European concerted action on thrombosis and disabilities angina pectoris study group Lancet 349 1997 462 466
20. V. Fuster, L. Badimon, and J.J. Badimon The pathogenesis of coronary artery disease and the acute coronary syndromes (1) N. Engl. J. Med. 326 1992 242 250
21. J.E. Freedman, B. Ting, and B. Hankin Impaired platelet production of nitric oxide predicts presence of acute coronary syndromes Circulation 98 1998 1481 1486
22. S.K. Yao, J.C. Ober, and A. Krishnaswami Endogenous nitric oxide protects against platelet aggregation and cyclic flow variations in stenosed and endothelium-injured arteries Circulation 86 1992 1302 1309
23. A. Maseri, and V. Fuster Is there a vulnerable plaque? Circulation 107 2003 2068 2071