Genetic Switches During Bacteriophage λ Development

Progress in Nucleic Acid Research and Molecular Biology

Volumn 79, Issue , 2005, Pages 1-48

  Wegrzyn, Grzegorz ^a   Wegrzyn, Alicja ^b  

^a UNIVERSITY OF GDA SK   (Poland)

^b INSTITUTE OF BIOCHEMISTRY AND BIOPHYSICS   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIOPHAGE LAMBDA; DNA REPLICATION; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; LYSOGENIZATION; PHYSIOLOGY; REVIEW; VIRUS ACTIVATION;

BACTERIOPHAGE LAMBDA; DNA REPLICATION; GENE EXPRESSION REGULATION, VIRAL; LYSOGENY; VIRUS ACTIVATION;

EID: 23944469082     PISSN: 00796603     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0079-6603(04)79001-7     Document Type: Review

References (222)

1. Friedman D.I.D.I., and Court D.L. Bacteriophage lambda: Alive and well and still doing its thing. Curr. Opin. Microbiol. 4 (2001) 201-207
2. In: Hendrix R.W., Roberts J.W., Stahl J.W., and Weisberg R.A. (Eds). Lambda II (1983), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
3. Ptashne M. "A Genetic Switch,". 2nd Ed (1992), Cell Press and Blackwell Scientific Publications, Cambridge, MA
4. Taylor K., and Wegrzyn G. Replication of coliphage lambda DNA. FEMS Microbiol. Rev. 17 (1995) 109-119
5. Taylor K., and Wegrzyn G. Regulation of bacteriophage λ replication. In: Busby S.J.W., Thomas C.M., and Brown N.L. (Eds). "Molecular Microbiology" (1998), Springer Verlag, Berlin 81-97
6. Stillman B. Initiation of chromosomal DNA replication in eukaryotes. Lessons from lambda. J. Biol. Chem. 269 (1994) 7047-7050
7. Wegrzyn A., and Wegrzyn G. Inheritance of the replication complex: A unique or common phenomenon in the control of DNA replication?. Arch. Microbiol. 175 (2001) 86-93
8. Wegrzyn G., Wegrzyn A., and Tylki-Szymańska A. A general model for genetic regulation of turnover of glycosaminoglycans suggests a possible procedure for prediction of severity and clinical progress of mucopolysaccharidoses. Med. Hypoth. 62 (2004) 986-992
9. Fattah K.R., Mizutani S., Fattah F.G., Matsushiro A., and Sugino Y. A comparative study of the immunity region of lambdoid phages including Shiga-toxin-converting phages: Molecular basis for cross immunity. Genes Genet. Syst. 75 (2000) 223-232
10. Figueroa-Bossi N., Uzzau S., Maloriol D., and Bossi L. Variable assortment of prophages provides a transferable repertoire of pathogenic determinants in Salmonella. Mol. Microbiol. 39 (2001) 260-271
11. Johansen B.K., Wasteson Y., Granum P.E., and Brynestad S. Mosaic structure of Shiga-toxin-2-encoding phages isolated from Escherichia coli O157:H7 indicates frequent gene exchange between lambdoid phage genomes. Microbiology 147 (2001) 1929-1936
12. Shi T., and Friedman D.I. The operator-early promoter regions of Shiga-toxin bearing phage H-19B. Mol. Microbiol. 41 (2001) 585-599
13. Wagner P.L., Livny J., Neely M.N., Acheson D.W., Friedman D.I., and Waldor M.K. Bacteriophage control of Shiga toxin 1 production and release by Escherichia coli. Mol. Microbiol. 44 (2002) 957-970
14. Mathur M.D., Vidhani S., and Mehndiratta P.L. Bacteriophage therapy: An alternative to conventional antibiotics. J. Assoc. Physicians India 51 (2003) 593-596
15. Levin B.R., and Bull J.J. Population and evolutionary dynamics of phage therapy. Nature. Rev. Microbiol. 2 (2004) 166-173
16. Thiel K. Old dogma, new tricks: 21st century phage therapy. Nature Biotechnol. 22 (2004) 31-36
17. Hadas H., Einav M., Fishov I., and Zaritsky A. Bacteriophage T4 development depends on the physiology of its host Escherichia coli. Microbiology 143 (1997) 178-185
18. Palva E.T., Liljestrom P., and Harayama S. Cosmid cloning vector and transposon mutagenesis in Salmonella typhimurium using phage λ vehicles. Mol. Gen. Genet. 181 (1981) 153-157
19. De Vries G.E., Raymond C.K., and Ludwig R.A. Extension of bacteriophage λ host range: Selection, cloning and characterization of a constitutive receptor gene. Proc. Natl. Acad. Sci. USA 81 (1984) 6080-6084
20. Harkki A., and Palva E.T. Application of phage lambda technology to Salmonella typhimurium: Construction of a lambda-sensitive Salmonella strain. Mol. Gen. Genet. 195 (1984) 256-259
21. Harkki A., and Palva E.T. A lamB expression plasmid for extending the host range of phage λ to other enterobacteria. FEMS Microbiol. Lett. 27 (1985) 183-187
22. Harkki A., Hirst T.R., Homgren J., and Palva E.T. Expression of Escherichia coli lamB gene in Vibrio cholerae. Microb. Pathog. 1 (1986) 283-288
23. Salmond G.P.C., Hinton J.C.D., Gill D.R., and Perombelon M.C.M. Transposon mutagenesis of Erwinia using phage λ vectors. Mol. Gen. Genet. 203 (1986) 524-528
24. Jasiecki J., Czyz A., Gabig M., and Wegrzyn G. Construction and use of a broad-host-range plasmid expressing the lamB gene for utilization of bacteriophage λ vectors in the marine bacterium Vibrio harveyi. Mar. Biotechnol. 3 (2001) 336-345
25. Casjens S., and Hendrix R. Control mechanisms in dsDNA bacteriophage assembly. In: Calendar R. (Ed). "The Bacteriophages" (1988), Plenum Press, New York 15-91
26. Hancock R.E.W. The bacterial outer membrane as a drug barrier. Trends Microbiol. 5 (1997) 37-42
27. Gabig M., Herman-Antosiewicz A., Kwiatkowska M., Łoś M., Thomas M.S., and Wegrzyn G. The cell surface protein Ag43 facilitates phage infection of Escherichia coli in the presence of bile salts and carbohydrates. Microbiololgy 148 (2002) 1533-1542
28. Owen P. The Gram-negative outer membrane: Structure, biochemistry and vaccine potential. Biochem. Soc. Trans. 20 (1992) 1-6
29. Caffrey P., and Owen P. Purification and N-terminal sequence of the α subunit of antigen 43, a unique protein complex associated with the outer membrane of Escherichia coli. J. Bacteriol. 171 (1989) 3634-3640
30. Henderson I.R., Meehan M., and Owen P. A novel regulatory mechanism for a novel phase-variable outer membrane protein of Escherichia coli. In: Paul P.S., Francis D.H., and Benfield D.A. (Eds). "Mechanisms in the Pathogenesis of Enteric Diseases, Advances in Experimental Medicine and Biology" Vol. 412 (1997), Plenum Press, New York 349-355
31. Owen P., Caffrey P., and Josefsson L.G. Identification and partial characterization of a novel bipartite protein antigen associated with the outer membrane of Escherichia coli. J. Bacteriol. 169 (1987) 3770-3777
32. Diderichsen B. flu, a metastable gene controlling surface properties of Escherichia coli. J. Bacteriol. 141 (1980) 858-867
33. Warne S.R., Varley J.M., Boulnois G.J., and Norton M.G. Identification and characterization of a gene that controls colony morphology and auto-aggregation in Escherichia coli K12. J. Gen. Microbiol. 136 (1990) 455-462
34. Hasman H., Chakraborty T., and Klemm P. Antigen-43-mediated autoaggregation of Escherichia coli is blocked by fimbriation. J. Bacteriol. 181 (1999) 4834-4841
35. Hasman H., Schembri M.A., and Klemm P. Antigen 43 and type 1 fimbriae determine colony morphology of Escherichia coli K-12. J. Bacteriol. 182 (2000) 1089-1095
36. Kjaergaard K., Schembri M.A., Ramos C., Molin S., and Klemm P. Antigen 43 facilitates formation of multispecies biofilms. Environ. Microbiol. 2 (2000) 695-702
37. Kjaergaard K., Schembri M.A., Hasman H., and Klemm P. Antigen 43 from Escherichia coli induces inter- and intraspecies cell aggregation and changes in colony morphology of Pseudomonas fluorescens. J. Bacteriol. 182 (2000) 4789-4796
38. Danese P.L., Pratt L.A., Dove S.L., and Kolter R. The outer membrane protein, antigen 43, mediates cell-to-cell interactions within Escherichia coli biofilms. Mol. Microbiol. 37 (2000) 424-432
39. Wegrzyn G., and Thomas M.S. Modulation of the susceptibility of intestinal bacteria to bacteriophages in response to Ag43 phase variation: A hypothesis. Med. Sci. Monit. 8 (2002) HY15-HY18
40. Little J.W., Shepley D.P., and Wert D.W. Robustness of a gene regulatory circuit. EMBO J. 18 (1999) 4299-4307
41. McAdams H.H., and Shapiro L. Circuit simulation of genetic networks. Science 269 (1995) 650-656
42. Arkin A., Ross J., and McAdams H.H. Stochastic kinetic analysis of developmental pathway bifurcation in phage λ-infected Escherichia coli cells. Genetics 149 (1998) 1633-1648
43. Herman C., Ogura T., Tomoyasu T., Hiraga S., Akiyama Y., Ito K., Thomas R., D'Ari, and Bouloc P. Cell growth and lambda phage development controlled by the same essential Escherichia coli gene, ftsH/hflB. Proc. Natl. Acad. Sci. USA 90 (1993) 10861-10865
44. Shotland Y., Koby S., Teff D., Mansur N., Oren D.A., Tatematsu K., Tomoyasu T., Kessel M., Bukau B., Ogura T., and Oppenheim A.B. Proteolysis of the phage λ CII regulatory protein by FtsH (HflB) of Escherichia coli. Mol. Microbiol. 24 (1997) 1303-1310
45. Shotland Y., Shifrin A., Ziv T., Teff D., Koby S., Kobiler O., and Oppenheim A.B. Proteolysis of bacteriophage λ CII by Escherichia coli FtsH (HflB). J. Bacteriol. 182 (2000) 3111-3116
46. Belfort M., and Wulff D. The roles of the lambda c3 gene and the Escherichia coli catabolite gene activation system in the establishment of lysogeny by bacteriophage lambda. Proc. Natl. Acad. Sci. USA 71 (1974) 779-782
47. Herskowitz I. Master regulatory loci in yeast and lambda. Cold Spring Harbor Symp. Quant. Biol. 50 (1985) 565-574
48. Słomińska M., Neubauer P., and Wegrzyn G. Regulation of bacteriophage λ development by guanosine 5′-diphosphate-3′-diphosphate. Virology 262 (1999) 431-441
49. Cashel M., Gentry D.R., Hernandez V.J., and Vinella D. The stringent response. In: Neidhardt F.C., Curtiss III R., Ingraham J.L., Lin E.C.C., Low K.B., Magasanik B., Reznikoff W.S., Riley M., Schaechter M., and Umbarger H.E. (Eds). "Escherichia coli and Salmonella: Cellular and Molecular Biology" (1996), American Society for Microbiology, Washington, DC 1458-1496
50. Szalewska-Pałasz A., Wegrzyn A., Herman A., and Wegrzyn G. The mechanism of the stringent control of λ plasmid DNA replication. EMBO J. 13 (1994) 5779-5785
51. Szalewska-Pałasz A., and Wegrzyn G. Inhibition of transcription starting from bacteriophage λ pR promoter during the stringent response in Escherichia coli: Implications for λ DNA replication. Acta Biochim. Pol. 42 (1995) 233-240
52. R promoter in Escherichia coli. Mol. Gen. Genet. 257 (1998) 490-495
53. Barker M.M., Gaal T., Josaitis C.A., and Gourse R.L. Mechanism of regulation of transcription initiation by ppGpp. I. Effects of ppGpp on transcription initiation in vivo and in vitro. J. Mol. Biol. 305 (2001) 673-688
54. R promoter. J. Biol. Chem. 277 (2002) 43785-43791
55. Potrykus K., Wegrzyn G., and Hernandez V.J. Direct stimulation of the λ paQ promoter by the transcription effector guanosine-3′,5′-(bis)pyrophosphate in a defined in vitro system. J. Biol. Chem. 279 (2004) 19860-19866
56. Krinke L., and Wulff D.L. OOP RNA, produced from multicopy plasmids, inhibits λ cII gene expression through an RNase III-dependent mechanism. Genes Dev. 1 (1987) 1005-1013
57. Krinke L., and Wulff D.L. RNase III-dependent hydrolysis of λcII-O gene mRNA mediated by λ OOP antisense RNA. Genes Dev. 4 (1990) 2223-2233
58. Krinke L., Mahoney M., and Wulff D.L. The role of the OOP antisense RNA in coliphage λ development. Mol. Microbiol. 5 (1991) 1265-1272
59. Wróbel B., Herman-Antosiewicz A., Szalewska-Pałasz A., and Wegrzyn G. Polyadenylation of oop RNA in the regulation of bacteriophage λ development. Gene 212 (1998) 57-65
60. O'Hara E.B., Chekanova J.A., Ingle C.A., Kushner Z.R., Peters E., and Kushner S.R. Polyadenylylation helps regulate mRNA decay in Escherichia coli. Proc. Natl. Acad. Sci. USA 92 (1995) 1807-1811
61. Xu F., and Cohen S.N. RNA degradation in Escherichia coli regulated by 3′ adenylation and 5′ phosphorylation. Nature 374 (1995) 180-183
62. Blum E., Carpousis A.J., and Higgins C.F. Polyadenylation promotes degradation of 3′-structured RNA by the Escherichia coli mRNA degradosome in vitro. J. Biol. Chem. 274 (1999) 4009-4016
63. Carpousis A.J., Vanzo N.F., and Raynal L.C. mRNA degradation: A tale of poly(A) and multiprotein machines. Trends Genet. 15 (1999) 24-28
64. Rauhut R., and Klug G. mRNA degradation in bacteria. FEMS Microbiol. Rev. 23 (1999) 353-370
65. Regnier P., and Arraiano C.M. Degradation of mRNA in bacteria: Emergence of ubiquitous features. BioEssays 22 (2000) 235-244
66. Steege D.A. Emerging features of mRNA decay in bacteria. RNA 6 (2000) 1079-1090
67. Szalewska-Pałasz A., Wróbel B., and Wegrzyn G. Rapid degradation of polyadenylated oop RNA. FEBS Lett. 432 (1998) 70-72
68. Jasiecki J., and Wegrzyn G. Growth-rate-dependent RNA polyadenylation in Escherichia coli. EMBO Rep. 4 (2003) 172-177
69. Friedman D.I., and Court D.L. Transcription antitermination: The lambda paradigm updated. Mol. Microbiol. 18 (1995) 191-200
70. Greenblatt J., Mah T.F., Legault P., Mogridge J., Li J., and Kay L.E. Structure and mechanism in transcriptional antitermination by the bacteriophage lambda N protein. Cold Spring Harbor Symp. Quant. Biol. 63 (1998) 327-336
71. Weisberg R.A., and Gottesman M.E. Processive antitermination. J. Bacteriol. 181 (1999) 359-367
72. Van Gilst M.R., and von Hippel P.H. Quantitative dissection of transcriptional control system: N-dependent antitermination complex of phage lambda as regulatory paradigm. Methods Enzymol. 323 (2000) 1-31
73. Gusarov I., and Nudler E. Control of intrinsic transcription termination by N and NusA: The basic mechanisms. Cell 107 (2001) 437-449
74. Zhou Y., Mah T.F., Yu Y.T., Mogridge J., Olson E.R., Greenblatt J., and Friedman D.I. Interactions of an Arg-rich region of transcription elongation protein NusA with NUT RNA: Implications for the order of assembly of the λ N antitermination complex in vivo. J. Mol. Biol. 310 (2001) 33-49
75. Wilson H.R., Kameyama L., Zhou J.-G., Guarneros G., and Court D.L. Translation repression by a transcription elongation factor. Genes Dev. 11 (1997) 2204-2213
76. Wilson H.R., Yu D., Peters H., Zhou III J., and Court D.L. The global regulator RNase III modulates translational repression by the transcriptional elongation factor N. EMBO J. 21 (2002) 4154-4161
77. Wilson H.R., Zhou J.-G., Yu D., and Court D.L. Translation repression by an RNA polymerase elongation complex. Mol. Microbiol. 53 (2004) 821-828
78. Gottesman S., Gottesman M., Shaw J.E., and Pearson M.L. Protein degradation in E. coli: The lon mutation and bacteriophage lambda N and cll protein stability. Cell 24 (1981) 225-233
79. Czyz A., Zielke R., and Wegrzyn G. Rapid degradation of bacteriophage λ O protein by ClpP/ClpX protease influences the lysis-versus-lysogenization decision of the phage under certain growth conditions of the host cells. Arch. Virol. 146 (2001) 1487-1498
80. Bejarano I., Klemes Y., Schoulaker-Schwarz R., and Engelberg-Kulka H. Energy-dependent degradation of λO protein in Escherichia coli. J. Bacteriol. 175 (1993) 7720-7723
81. Gottesman S., Clark W.P., de Crecy-Lagard V., and Maurizi M.R. ClpX, an alternative subunit for the ATP-dependent Clp protease of Escherichia coli. J. Biol. Chem. 268 (1993) 22618-22626
82. Wojtkowiak D., Georgopoulos C., and Zylicz M. Isolation and characterization of ClpX, a new ATP-dependent specificity component of the Clp protease of Escherichia coli. J. Biol. Chem. 268 (1993) 22609-22617
83. Wegrzyn G., Pawłowicz A., and Taylor K. Stability of coliphage λ DNA replication initiator, the λO protein. J. Mol. Biol. 226 (1992) 675-680
84. Wegrzyn A., Wegrzyn G., and Taylor K. Protection of coliphage λO initiator protein from proteolysis in the assembly of the replication complex in vivo. Virology 207 (1995) 179-184
85. Zylicz M., Liberek K., Wawrzynów A., and Georgopoulos C. Formation of the preprimosome protects λ O from RNA transcription-dependent proteolysis by ClpP/ClpX. Proc. Natl. Acad. Sci. USA 95 (1998) 15259-15263
86. Pakula A.A., Young V.B., and Sauer R.T. Bacteriophage λ cro mutations: Effects on activity and intracellular degradation. Proc. Natl. Acad. Sci. USA 83 (1986) 8829-8833
87. Gabig M., Obuchowski M., Wegrzyn A., Szalewska-Pałasz A., Thomas M.S., and Wegrzyn G. Excess production of phage λ delayed early proteins under conditions supporting high Escherichia coli growth rates. Microbiology 144 (1998) 2217-2224
88. Wegrzyn A., Czyz A., Gabig M., and Wegrzyn G. ClpP/ClpX-mediated degradation of the bacteriophage λ O protein and regulation of λ phage and λ plasmid replication. Arch. Microbiol. 174 (2000) 89-96
89. Gabig M., Obuchowski M., Ciesielska A., Latała B., Wegrzyn A., Thomas M.S., and Wegrzyn G. The Escherichia coli RNA polymerase α subunit and transcriptional activation by bacteriophage λ CII protein. Acta Biochim. Pol. 45 (1998) 271-280
90. RE are identical in the presence and absence of CII protein. Nucleic Acids Res. 32 (2004) 1083-1090
91. Wegrzyn G., Glass R.E., and Thomas M.S. Involvement of the Escherichia coli RNA polymerase α subunit in transcriptional activation by the bacteriophage lambda CI and CII proteins. Gene 122 (1992) 1-7
92. E promoter: Identification of important residues and positioning of the α C-terminal domains. Nucleic Acids Res. 32 (2004) 834-841
93. Datta A.B., Roy S., and Parrack P. Disorder-order transition of lambda CII promoted by low concentrations of guanidine hydrochloride suggests a stable core and a flexible C-terminus. Eur. J. Biochem. 270 (2003) 4439-4446
94. Obuchowski M., Shotland Y., Koby S., Giladi H., Gabig M., Wegrzyn G., and Oppenheim A.B. Stability of CII is a key element in the cold stress response of bacteriophage λ infection. J. Bacteriol. 179 (1997) 5987-5991
95. Gabig M., Obuchowski M., Śrutkowska S., and Wegrzyn G. Regulation of replication of λ phage and plasmid at low temperature. Mol. Gen. Genet. 258 (1998) 494-502
96. Shimatake H., and Rosenberg M. Purified λ regulatory protein cII positively activates promoters for lysogenic development. Nature 292 (1981) 128-132
97. Rattray A., Altuvia S., Mahajna G., Oppenheim A.B., and Gottesman M. Control of bacteriophage lambda cII activity by bacteriophage and host functions. J. Bacteriol. 159 (1984) 238-242
98. Hammer K., Jensen K.F., Poulsen P., Oppenheim A.B., and Gottesman M. Isolation of Escherichia coli rpoB mutants resistant to killing by λ cII protein and altered in pyrE gene attenuation. J. Bacteriol. 169 (1987) 5289-5297
99. Kedzierska B., Glinkowska M., Iwanicki A., Obuchowski M., Sojka P., Thomas M.S., and Wegrzyn G. Toxicity of the bacteriophage λ cII gene product to Escherichia coli arises from inhibition of host cell DNA replication. Virology 313 (2003) 622-628
100. Szalewska-Pałasz A., Wegrzyn A., Obuchowski M., Pawłowski R., Bielawski K., Thomas M.S., and Wegrzyn G. Drastically decreased transcription from CII-activated promoters is responsible for impaired lysogenization of the Escherichia coli rpoA341 mutant by bacteriophage λ. FEMS Microbiol. Lett. 144 (1996) 21-27
101. Obuchowski M., Giladi H., Koby S., Szalewska-Pałasz A.W., A., Oppenheim A.B., Thomas M.S., and Wegrzyn G. Impaired lysogenisation of the Escherichia coli rpoA341 mutant by bacteriophage λ is due to the inability of CII to act as a transcriptional activator. Mol. Gen. Genet. 254 (1997) 304-311
102. Herman C., Thevenet D., D'Ari R., and Bouloc P. The HflB protease of Escherichia coli degrades its inhibitor λ cIII. J. Bacteriol. 179 (1997) 358-363
103. Latała B., Obuchowski M., and Wegrzyn G. Bacteriophage λ cIII gene product has an additional function apart from inhibition of cII degradation. Virus Genes 22 (2001) 127-132
104. Giladi H., Goldenberg D., Koby S., and Oppenheim A.B. Enhanced activity of the bacteriophage λ pL promoter at low temperature. Proc. Natl. Acad. Sci. USA 92 (1995) 2184-2188
105. Giladi H., Goldenberg D., Koby S., and Oppenheim A.B. Enhanced activity of the bacteriophage lambda pL promoter at low temperature. FEMS Microbiol. Rev. 17 (1995) 135-140
106. Altuvia S., Kornitzer D., Teff D., and Oppenheim A.B. Alternative mRNA structures of the cIII gene of bacteriophage lambda determine the rate of its translation initiation. J. Mol. Biol. 210 (1989) 265-280
107. Altuvia S., Kornitzer D., Kobi S., and Oppenheim A.B. Functional and structural elements of the mRNA of the cIII gene of bacteriophage lambda. J. Mol. Biol. 218 (1991) 723-733
108. Wegrzyn G., Szalewska-Pałasz A., Wegrzyn A., Obuchowski M., and Taylor K. Transcriptional activation of coliphage λ DNA replication is regulated by the host DnaA initiator function. Gene 154 (1995) 47-50
109. Wegrzyn G., Wegrzyn A., Pankiewicz A., and Taylor K. Allele specificity of the Escherichia coli dnaA gene function in the replication of plasmids derived from phage λ. Mol. Gen. Genet. 252 (1996) 580-586
110. Szalewska-Pałasz A., Wegrzyn A., Błaszczak A., Taylor K., and Wegrzyn G. DnaA-stimulated transcriptional activation of oriλ: Escherichia coli RNA polymerase β subunit as a transcriptional activator contact site. Proc. Natl. Acad. Sci. USA 95 (1998) 4241-4246
111. Szalewska-Pałasz A., Weigel C., Speck C., Śrutkowska S., Konopa G., Lurz R., Marszałek J., Taylor K., Messer W., and Wegrzyn G. Interaction of the Escherichia coli DnaA protein with bacteriophage λ DNA. Mol. Gen. Genet. 259 (1998) 679-688
112. Szalewska-Pałasz A., Lemieszek E., Pankiewicz A., Wegrzyn A., Helinski D.R., and Wegrzyn G. Escherichia coli dnaA gene function and bacteriophage λ replication. FEMS Microbiol. Lett. 167 (1998) 27-32
113. Konopa G., Szalewska-Pałasz A., Schmidt A., Śrutkowska S., Messer W., and Wegrzyn G. The presence of two DnaA-binding sequences is required for efficient interaction of the Escherichia coli DnaA protein with each particular weak DnaA box region. FEMS Microbiol. Lett. 174 (1999) 25-31
114. Glinkowska M., Konopa G., Wegrzyn A., Herman-Antosiewicz A., Weigel C., Seitz H., Messer W., and Wegrzyn G. The double mechanism of incompatibility between λ plasmids and Escherichia coli dnaA(ts) host cells. Microbiology 147 (2001) 1923-1928
115. R promoter activity by Escherichia coli DnaA protein. J. Biol. Chem. 278 (2003) 22250-22256
116. Kur J., Górska I., and Taylor K. Escherichia coli dnaA initiation function is required for replication of plasmids derived from coliphage lambda. J. Mol. Biol. 198 (1987) 203-210
117. Wegrzyn A., Wegrzyn G., and Taylor K. Plasmid and host functions required for λ plasmid replication carried out by the inherited replication complex. Mol. Gen. Genet. 245 (1995) 501-508
118. Wegrzyn G., Wegrzyn A., Konieczny I., Bielawski K., Konopa G., Obuchowski M., Helinski D.R., and Taylor K. Involvement of the host initiator function dnaA in the replication of coliphage λ. Genetics 139 (1995) 1469-1481
119. Glinkowska M., Wegrzyn A., and Wegrzyn G. Replication of bacteriophage λ in the Escherichia coli dnaA Δrac hosts. Genetics 151 (1999) 1633-1635
120. Słomińska M., Wegrzyn A., Konopa G., Skarstad K., and Wegrzyn G. SeqA, the Escherichia coli origin sequestration protein, is also a specific transcription factor. Mol. Microbiol. 40 (2001) 1371-1380
121. Słomińska M., Konopa G., Ostrowska J., Kedzierska B., Wegrzyn G., and Wegrzyn A. SeqA-mediated stimulation of a promoter activity by facilitating functions of a transcription activator. Mol. Microbiol. 47 (2003) 1669-1679
122. Strzelczyk B., Słomińska-Wojewódzka M., Wegrzyn G., and Wegrzyn A. Non-random distribution of GATC sequences in regions of promoters stimulated by the SeqA protein of Escherichia coli. Acta Biochim. Pol. 50 (2003) 941-945
123. R promoter activity. J. Mol. Biol. 329 (2003) 59-68
124. Boye E., Stokke T., Kleckner N., and Skarstad K. Coordinating DNA replication initiation with cell growth: Differential roles for DnaA and SeqA proteins. Proc. Natl. Acad. Sci. USA 93 (1996) 12206-12211
125. Norris V., Fralick J., and Danchin A. A SeqA hyperstructure and ts interactions direct the replication and sequestration of DNA. Mol. Microbiol. 37 (2000) 696-702
126. Wegrzyn A., Wróbel B., and Wegrzyn G. Altered biological properties of cell membranes in Escherichia coli dnaA and seqA mutants. Mol. Gen. Genet. 261 (1999) 762-769
127. Kihara A., Akiyama Y., and Ito K. Revisiting the lysoganization control of bacteriophage λ: Identification and characterization of a new host component, HflD. J. Biol. Chem. 276 (2001) 13695-13700
128. Obuchowski M., and Wegrzyn G. Synthesis of the bacteriophage λ P protein in amino acid-starved Escherichia coli cells. Biochem. Biophys. Res. Commun. 222 (1996) 612-618
129. Wróbel B., Słomiński B., and Wegrzyn G. The optimal eukaryotic signal for translation initiation from non-AUG codons, present upstream of bacteriophage λ P cistron, in inactive in Escherichia coli. Cell. Mol. Biol. Lett. 8 (2003) 305-310
130. Aurell E., Brown S., Johanson J., and Sneppen K. Stability puzzles in phage lambda. Phys. Rev. E. Stat. Nonlin. Soft. Matter. Phys. 65 (2002) 051914
131. Hochschild A. The λ switch: cI closes the gap in autoregulation. Curr. Biol. 12 (2002) R87-R89
132. Johnson A.D., Poteete A.R., Lauer G., Sauer R.T., Ackers G.K., and Ptashne M. λ repressor and Cro - components of an efficient molecular switch. Nature 294 (1981) 217-223
133. Meyer B.J., and Ptashne M. Gene regulation at the right operator (OR) of bacteriophage λ. III. λ repressor directly activated gene transcription. J. Mol. Biol. 139 (1981) 195-205
134. Meyer B.J., Maurer R., and Ptashne M. Gene regulation at the right operator (OR) of bacteriophage λ. II. OR1, OR2, and OR3: Their roles in mediating the effect of repressor and cro. J. Mol. Biol. 139 (1980) 163-194
135. Bell C.E., Frescura P., Hochschild A., and Lewis M. Crystal structure of the λ repressor C-terminal domain provides a model for cooperative operator binding. Cell 101 (2000) 801-811
136. Bell C.E., and Lewis M. Crystal structure of the λ repressor C-terminal domain octamer. J. Mol. Biol. 314 (2001) 1127-1136
137. Li M., Moyle H., and Susskind M.M. Target of the transcriptional activation function of phage λ cI protein. Science 263 (1994) 75-77
138. 70 that result in defects in phage λ repressor-stimulated transcription. J. Bacteriol. 176 (1994) 2991-2998
139. 70 region 4 involved in transcription activation by λcI. J. Mol. Biol. 324 (2002) 17-34
140. Browning D.F., and Busby S.J.W. The regulation of bacterial transcription initiation. Nature Rev. Microbiol. 2 (2004) 1-9
141. Barnard A., Wolfe A., and Busby S. Regulation at complex bacterial promoters: How bacteria use different promoter organization to produce different regulatory outcomes. Curr. Opin. Microbiol. 7 (2004) 102-108
142. Dove S.L., Huang F.W., and Hochschild A. Mechanism for a transcriptional activator that works at the isomerization step. Proc. Natl. Acad. Sci. USA 97 (2000) 13215-13220
143. Maurer R., Meyer B.J., and Ptashne M. Gene regulation at the right operator (OR) of bacteriophage λ. OR3 and autogenous negative control by repressor. J. Mol. Biol. 139 (1980) 147-161
144. RM and efficient switching from lysogeny. Genes Dev. 15 (2001) 3013-3022
145. Jain D., Nickels B.E., Sun L., Hochschild A., and Darst S.A. Structure of a ternary transcription activation complex. Mol. Cell 13 (2004) 45-53
146. Dodd I.B., Shearvin K.E., Perkins A.J., Burr T., Hochschild A., and Egan J.B. Cooperativity in long-range gene regulation by the λ CI repressor. Genes Dev. 18 (2004) 344-354
147. Janion C. Some aspects of the SOS response system: A critical survey. Acta Biochim. Pol. 48 (2001) 599-610
148. Little J.W. Autodigestion of LexA and phage λ repressors. Proc. Natl. Acad. Sci USA 81 (1984) 1375-1379
149. Wegrzyn G., and Wegrzyn A. Stress responses and replication of plasmids in bacterial cells. Microb. Cell Factor 1 (2002) 2
150. Potrykus K., Barańska S., Wegrzyn A., and Wegrzyn G. Composition of the λ plasmid heritable replication complex. Biochem. J. 364 (2002) 857-862
151. Wegrzyn A., Wegrzyn G., Herman A., and Taylor K. Protein inheritance: λ plasmid replication perpetuated by the heritable replication complex. Genes Cells 1 (1996) 953-963
152. Wegrzyn G., Kwaśnik E., and Taylor K. Replication of λ plasmid in amino acid-starved strains of Escherichia coli. Acta Biochim. Pol. 38 (1991) 181-186
153. Wegrzyn G., Neubauer P., Krueger S., Hecker M., and Taylor K. Stringent control of replication of plasmids derived from coliphage λ. Mol. Gen. Genet. 225 (1991) 94-98
154. Wegrzyn G., and Taylor K. Inheritance of the replication complex by one of two daughter copies during λ plasmid replication in Escherichia coli. J. Mol. Biol. 226 (1992) 681-688
155. Pawłowicz A., Wegrzyn G., and Taylor K. Effect of coliphage λP gene mutations on the stability of the λO protein, the initiator of λDNA replication. Acta Biochim. Pol. 40 (1993) 29-31
156. Herman A., Wegrzyn A., and Wegrzyn G. Differential replication of plasmids during stringent and relaxed response of Escherichia coli. Plasmid 32 (1994) 89-94
157. Szalewska A., Wegrzyn G., and Taylor K. Neither absence nor excess of λ O initiator-digesting ClpXP protease affects λ plasmid or phage replication in Escherichia coli. Mol. Microbiol. 13 (1994) 469-474
158. Herman A., and Wegrzyn G. Effect of increased ppGpp concentration on DNA replication of different replicons in Escherichia coli. J. Basic Microbiol. 35 (1995) 33-39
159. Wegrzyn G. Amplification of λ plasmids in Escherichia coli relA mutants. J. Biotechnol. 43 (1995) 139-143
160. Wegrzyn A., Taylor K., and Wegrzyn G. The cbpA chaperone gene function compensates for dnaJ in λ plasmid replication during amino acid starvation of Escherichia coli. J. Bacteriol. 178 (1996) 5847-5849
161. Wróbel B., and Wegrzyn G. Replication and amplification of λ plasmids in Escherichia coli during amino acid starvation and limitation. FEMS Microbiol. Lett. 153 (1997) 151-157
162. Wegrzyn A., and Wegrzyn G. Random inheritance of the replication complex by one of two daughter λ plasmid copies after a replication round in Escherichia coli. Biochem. Biophys. Res. Commun. 246 (1998) 634-639
163. Potrykus K., Santos S., Lemonnier M., Diaz-Orejas R., and Wegrzyn G. Differential effects of Kid toxin on two modes of replication of lambdoid plasmids suggest that this toxin acts before, but not after, the assembly of the replication complex. Microbiology 148 (2002) 2489-2495
164. Potrykus K., Wróbel B., Wegrzyn A., and Wegrzyn G. Replication of oriJ-based plasmid DNA during the stringent and relaxed responses of Escherichia coli. Plasmid 44 (2000) 111-126
165. Wegrzyn A., Wegrzyn G., and Taylor K. Disassembly of the coliphage λ replication complex due to heat shock induction of the groE operon. Virology 217 (1996) 594-597
166. Wegrzyn A., Herman-Antosiewicz A., Taylor K., and Wegrzyn G. Molecular mechanism of heat shock-provoked disassembly of the coliphage λ replication complex. J. Bacteriol. 180 (1998) 2475-2483
167. Herman-Antosiewicz A., Śrutkowska S., Taylor K., and Wegrzyn G. Replication and maintenance of λ plasmids devoid of the Cro repressor autoregulatory loop in Escherichia coli. Plasmid 40 (1998) 113-125
168. R and Cro function. Virology 249 (1998) 98-107
169. Wegrzyn A., and Wegrzyn G. Formation and stability of bacteriophage λ replication complexes in UV-irradiated Escherichia coli. Curr. Microbiol. 41 (2000) 157-160
170. Matsubara K. Replication control system in λdv. Plasmid 5 (1981) 32-52
171. Szalewska-Pałasz A., and Wegrzyn G. An additional role of transcriptional activation of oriλ in the regulation of λ plasmid replication in Escherichia coli. Biochem. Biophys. Res. Commun. 205 (1994) 802-806
172. Herman-Antosiewicz A., and Wegrzyn G. Replication of λ plasmid DNA in the Escherichia coli cell cycle. Biochem. Biophys. Res. Commun. 247 (1998) 554-557
173. Wegrzyn G. Replication of plasmids during bacterial response to amino acid starvation. Plasmid 41 (1999) 1-16
174. Herman-Antosiewicz A., and Wegrzyn G. Regulation of copy number and
175. Wegrzyn A., and Wegrzyn G. Transcriptional activation of oriλ regulates λ plasmid replication in amino acid-starved Escherichia coli cells. Biochem. Biophys. Res. Commun. 214 (1995) 978-984
176. Ulanowska K., Sikora A., Wegrzyn G., and Czyz A. Role of the cgtA gene function in DNA replication of extrachromosomal elements in Escherichia coli. Plasmid 50 (2003) 45-52
177. Obuchowski M., Wegrzyn A., Szalewska-Pałasz A., Thomas M.S., and Wegrzyn G. An RNA polymerase α subunit mutant impairs N-dependent transcriptional antitermination in Escherichia coli. Mol. Microbiol. 23 (1997) 211-222
178. Szalewska-Pałasz A., Strzelczyk B., Herman-Antosiewicz A., Wegrzyn G., and Thomas M.S. Genetic analysis of bacteriophage lambda N-dependent antitermination suggests a possible role for the RNA polymerase alpha subunit in facilitating specific functions of NusA and NusE. Arch. Microbiol. 180 (2003) 161-168
179. Dodson M., Echols H., Wickner S., Alfano C., Mensa-Wilmot K., Gomes B., LeBowitz J., Roberts J.D., and McMacken R. Specialized nucleoprotein structures at the origin of replication of bacteriophage lambda: Localized unwinding of duplex DNA by a six-protein reaction. Proc. Natl. Acad. Sci. USA 83 (1986) 7638-7642
180. Taylor K., Wegrzyn G., Wegrzyn A., Szalewska-Pałasz A., Herman A., Obuchowski M., Śrutkowska S., and Konopa G. Escherichia coli initiator protein DnaA, cell cycle, and control of λ plasmid replication. Bull. Pol. Acad. Sci. Biol. Sci. 44 (1996) 225-230
181. Konopa G., Barańska S., Wegrzyn A., and Wegrzyn G. Bacteriophage and host mutants causing the rolling-circle λ DNA replication early after infection. FEBS Lett. 472 (2000) 217-220
182. Learn B., Karzai A.W., and McMacken R. Transcription stimulates the establishment of bidirectional λ DNA replication in vitro. Cold Spring Harbor Symp. Quant. Biol. 58 (1993) 389-402
183. Barańska S., Gabig M., Wegrzyn A., Konopa G., Herman-Antosiewicz A., Hernandez P., Schvartzman J.B., Helinski D.R., and Wegrzyn G. Regulation of the switch from early to late bacteriophage λ DNA replication mode. Microbiology 147 (2001) 535-547
184. Barańska S., Konopa G., and Wegrzyn G. Directionality of λ plasmid DNA replication carried out by the heritable replication complex. Nucleic Acids Res. 30 (2002) 1176-1181
185. Klinkert J., and Klein A. Roles of bacteriophage lambda gene products O and P during early and late phases of infection cycle. J. Virol. 25 (1978) 730-737
186. Hayes S., and Szybalski W. Control of short leftward transcripts from the immunity and ori regions in induced coliphage lambda. Mol. Gen. Genet. 126 (1973) 275-290
187. Hayes S., and Szybalski W. Role of oop RNA primer in initiation of coliphage lambda DNA replication. In: Goulian M., and Hanawalt P. (Eds). "DNA Synthesis and Its Regulation" (1975), Benjamin, Menlo Park, CA 486-512
188. O, a promoter for oop RNA synthesis, has a role in replication of plasmids derived from bacteriophage λ. Plasmid 47 (2002) 210-215
189. Mensa-Wilmot K., Seaby R., Alfano C., Wold M.S., Gomes B., and McMacken R. Reconstitution of a nine-protein system that initiates bacteriophage λ DNA replication. J. Biol. Chem. 264 (1989) 2853-2861
190. Young R., Wang L.-N., and Roof W.D. Phages will out: Strategies of host cell lysis. Trends. Microbiol. 8 (2000) 120-128
191. Campbell A., and Campillo-Campbell A.D. Mutant of bacteriophage lambda producing a thermolabile endolysin. J. Bacteriol. 85 (1963) 1202-1207
192. Reader R.W., and Siminovitch I. Lysis defective mutants of bacteriophage lambda: genetics and physiology of S cistron mutants. Virology 43 (1971) 607-622
193. Reader R.W., and Siminovitch I. Lysis defective mutants of bacteriophage lambda: On the role of the S function in lysis. Virology 43 (1971) 623-637
194. Young R., Way S., Yin J., and Syvanen M. Transposition mutagenesis of bacteriophage lambda: A new gene affecting cell lysis. J. Mol. Biol. 132 (1979) 307-322
195. Kedzierska S., Wawrzynów A., and Taylor A. The Rz1 gene product of bacteriophage lambda is a lipoprotein localized in the outer membrane of Escherichia coli. Gene 168 (1996) 1-8
196. Bieńkowska-Szewczyk K., Lipińska B., and Taylor A. The R gene product of bacteriophage λ is the murein transglycosylase. Mol. Gen. Genet. 184 (1981) 111-114
197. Evrard C., Fastrez J., and Declercq J.P. Crystal structure of the lysozyme from bacteriophage lambda and its relationship with V and C-type lysozymes. J. Mol. Biol. 276 (1998) 151-164
198. Garrett J., Fusselman R., Hise J., Chiou L., Smith-Grillo D., Schulz R., and Young R. Cell lysis by induction of cloned lambda lysis genes. Mol. Gen. Genet. 182 (1981) 326-331
199. Zhang N., and Young R. Complementation and characterization of the nested Rz and Rz1 reading frames in the genome of bacteriophage lambda. Mol. Gen. Genet. 262 (1999) 659-667
200. Wang L.N., Smith D.L., and Young R. Holins: The protein clocks of bacteriophage infection. Annu. Rev. Microbiol. 54 (2000) 799-825
201. Young R. Bacteriophage lysis: Mechanism and regulation. Microbiol. Rev. 56 (1992) 430-481
202. Blasi U., Nam K., Hartz D., Gold L., and Young R. Dual translational initiation sites control function of the lamnbda S gene. Embo J. 8 (1989) 3501-3510
203. Blasi U., Chang C.-Y., Zagotta M.T., Nam K., and Young R. The lethal lambda S gene encodes its own inhibitor. Embo J. 9 (1990) 981-989
204. Bonovich M.T., and Young R. Dual start motif in two lambdoid S genes unrelated to λ S. J. Bacteriol. 173 (1991) 2897-2905
205. Chang C.-Y., Nam K., Blasi U., and Young R. Synthesis of two bacteriophage lambda S proteins in an in vivo system. Gene 133 (1993) 9-16
206. Wang I.-N., Deaton J., and Young T. Sizing the holin lesion with an endolysin-β-galactosidase fusion. J. Bacteriol. 185 (2003) 779-787
207. Chang C.-Y., Nam K., and Young R. S gene expression and the timing of lysis by bacteriophage λ. J. Bacteriol. 177 (1995) 3282-3294
208. Grundling A., Blasi U., and Young R. Genetic and biochemical analysis of dimer and oligomer interactions of the λ S holin. J. Bacteriol. 182 (2000) 6082-6090
209. Grundling A., Smith D.L., Blasi U., and Young R. Dimerization between the holin and holin inhibitor of phage λ. J. Bacteriol. 182 (2000) 6075-6081
210. Czyz A., Łoś M., Wróbel B., and Wegrzyn G. Inhibition of spontaneous induction of lambdoid prophages in Escherichia coli cultures: Simple procedures with possible biotechnological applications. BMC Biotechnol. 1 (2001) 1
211. Gabig-Cimińska M., Łoś M., Holmgren A., Albers J., Czyz A., Hintsche R., Wegrzyn G., and Enfors S.-O. Detection of bacteriophage infection and prophage induction in bacterial cultures by means of electric DNA chips. Anal. Biochem. 324 (2004) 84-91
212. Łoś M., Czyz A., Sell E., Wegrzyn A., Neubauer P., and Wegrzyn G. Bacteriophage contamination: Is there a simple method to reduce its deleterious effects in laboratory cultures and biotechnological factories?. J. Appl. Genet. 45 (2004) 111-120
213. Herman-Antosiewicz A., Obuchowski M., and Wegrzyn G. A plasmid cloning vector with precisely regulatable copy number in Escherichia coli. Mol. Biotechnol. 17 (2001) 193-199
214. Christensen A.C. Bacteriophage lambda-based expression vectors. Mol. Biotechnol. 17 (2001) 219-224
215. Maruyama I.N., Maruyama H.I., and Brenner S. λfoo: A λ phage vector for the expression of foreign proteins. Proc. Natl. Acad. Sci. USA 91 (1994) 8273-8277
216. Mikawa Y.G., Murayama I.N., and Brenner S. Surface display of proteins on bacteriophage λ heads. J. Mol. Biol. 262 (1996) 21-30
217. Santi E., Capone S., Mennuni C., Lahm A., Tramontano A., Luzzago A., and Nicosia A. Bacteriophage lambda display of complex cDNA libraries: A new approach to functional genomics. J. Mol. Biol. 296 (2000) 497-508
218. Hoess R.H. Bacteriophage lambda as a vehicle for peptide and protein display. Curr. Pharm. Biotechnol. 3 (2002) 23-28
219. Gupta A., Onda M., Pastan I., Adhya S., and Chaudhary V.K. High-density functional display of proteins on bacteriophage lambda. J. Mol. Biol. 334 (2003) 241-254
220. Clark J.R., and March J.B. Bacteriophage-mediated nucleic acid immunization. FEMS Immunol. Med. Microbiol. 40 (2004) 21-26
221. March J.B., Clark J.R., and Jepson C.D. Genetic immunisation against hepatitis B using whole bacteriophage lambda particles. Vaccine 22 (2004) 1666-1671
222. Jepson C.D., and March J.B. Bacteriophage lambda is a highly stable DNA vaccine delivery vehicle. Vaccine 22 (2004) 2413-2419