The effect of γ-tocopherol administration on α-tocopherol levels and metabolism in humans

European Journal of Clinical Nutrition

Volumn 59, Issue 8, 2005, Pages 900-905

  Yoshikawa, Sosuke ^a   Morinobu, T ^b   Hamamura, K ^c   Hirahara, F ^d   Iwamoto, T ^d   Tamai, H ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

^b Seikeikai Hospital   (Japan)

^c EISAI CO LTD   (Japan)

^d NATIONAL INSTITUTE OF HEALTH AND NUTRITION   (Japan)

Author keywords

CEHC; tocopherol; CEHC; tocopherol; tocopherol supplementation

Indexed keywords

ALPHA TOCOPHEROL; ALPHA TOCOPHEROL DERIVATIVE; GAMMA TOCOPHEROL; SODIUM;

ADULT; ARTICLE; BIOAVAILABILITY; BLOOD ANALYSIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG WITHDRAWAL; ELECTROCHEMICAL DETECTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; SODIUM EXCRETION; TREATMENT OUTCOME; URINALYSIS; URINARY EXCRETION; VITAMIN METABOLISM; VOLUNTEER;

ADULT; ALPHA-TOCOPHEROL; ANTIOXIDANTS; BIOLOGICAL AVAILABILITY; CHROMANS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GAMMA-TOCOPHEROL; HUMANS; MALE; PROPIONATES; PROPIONIC ACIDS; SODIUM; VITAMIN E;

EID: 23944446616     PISSN: 09543007     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ejcn.1602154     Document Type: Article

References (28)

1. Clement M & Bourre JM (1997): Graded dietary levels of RRR-γ-tocopherol induce a marked increase in the concentrations of α-and γ-tocopherol in nervous tissues, heart, liver and muscle of vitamin-E-deficient rats. Biochim. Biophys. Acta 1334, 173-181.
2. Galli F, Floridi AG, Floridi A & Buoncristiani U (2004): Accumulation of vitamin E metabolites in the blood of renal failure patients. Clin. Nutr. 23, 205-212.
3. Galli F, Lee R, Atkinson J, Floridi A & Kelly FJ (2003): γ-Tocopherol biokinetics and transformation in humans. Free Radic. Res. 37 (11), 1225-1233.
4. Galli F, Lee R, Dunster C & Kelly FJ (2002): Gas chromatography mass spectrometry anarysis of carboxyethyl-hydroxychroman metabolites of α- and γ-tocopherol in human plasma. Free Radic. Biol. Med. 32 (4), 333-340.
5. Grammas P, Hamdheydari L, Benaksas EJ, Mou S, Pye QN, Wechter WJ, Floyd RA, Stewart C & Hensley K (2004): Anti-inflammatory effects of tocopherol metabolites. Biochem. Biophys. Res. Commun. 319, 1047-1052.
6. Hattori A, Fukushima T & Imai K (2000a): Occurrence and determination of a natriuretic hormone, 2,7,8-trimethyl-2-(β-carboxyethyl)-6-hydroxy chroman, in rat plasma, urine, and bile. Anal. Biochem. 281, 209-215.
7. Hattori A, Fukushima T, Yoshimura H, Abe K & Imai K (2000b): Production of LLU-a following an oral administration of γ-tocotrienol or γ-tocopherol to rats. Biol. Pharm. Bull. 23 (11), 1395-1397.
8. Hensley K, Benaksas EJ, Bolli R, Comp P, Grammas P, Hamdheydari L, Mou S, Pye QN, Stoddard MF, Wallis G, Williamson KS, West M, Wechter WJ & Floyd RA (2004): New perspectives on vitamin E: γ-tocopherol and carboxyethylhydroxychroman metabolites in biology and medicine. Free Radic. Biol. Med. 36 (1), 1-15.
9. Himmelfarb J, Kane J, McMonagle E, Zaltas E, Bobzin S, Boddupalli S, Phinney S & Miller G (2003): Alpha and gamma tocopherol metabolism in healthy subjects and patients with end-stage renal disease. Kidney Int. 64, 978-991.
10. Hosomi A, Arita M, Sato Y, Kiyose C, Ueda T, Igarashi O, Arai H & Inoue K (1997): Affinity for α-tocopherol transfer protein as a deteminant of the biological activities of vitamin E analogs. FEBS Lett. 409, 105-108.
11. Huang HY, Alberg AJ, Norkus EP, Hoffman SC, Comstock GW & Helzlsouer XJ (2003): Prospective study of antioxidant micronutrients in the blood and the risk of developing prostate cancer. Am. J. Epidemiol. 157, 335-344.
12. Ikeda S, Tohyama T & Yamashita K (2002): Dietary sesame seed and its lignans inhibit 2,7,8-trimethyl-2(2′-carboxyethyl)-6-hydroxychroman excretion into urine of rats fed γ-tocopherol. J. Nutr. 132, 961-966.
13. Jiang Q & Ames BN (2003): γ-Tocopherol, but not α-tocopherol, decreases proinflammatory eicosanoids and inflammation damage in rats. FASEB J. 17, 816-822.
14. Jiang Q, Christen S, Shigenaga MK & Ames BN (2001): γ-Tocopherol, the major form of vitamin E in the US diet, deserves more attention. Am. J. Clin. Nutr. 74, 714-722.
15. Jiang Q, Elson-Schwab I, Courtemanche C & Ames BN (2000): γ-Tocopherol and its major metabolite, in contrast to α-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells. Proc. Natl. Acad. Sci. USA 97, 11494-11499.
16. Kiyose C, Saito H, Kaneko K, Hamamura K, Tomioka M, Ueda T & Igarashi O (2001): α-Tocopherol affects the urinary and biliary excretion of 2,7,8,-trimethyl-2(2′-carboxyethyl)-6-hydroxychroman, γ-tocopherol metabolite, in rats. Lipids 36, 467-472.
17. Liu M, Wallmon A, Mortlock CO, Wallin R & Saldeen T (2003): Mixed tocopherols inhibit platelet aggregation in humans: potential mechanisms. Am. J. Clin. Nutr. 77, 700-706.
18. Lodge JK, Ridlington J, Leonard S, Vaule H & Traber MG (2001): α-and γ-Tocotrienols are metabolized to carboxyethyl-hydroxychroman derivatives and excreted in human urine. Lipids 36, 43-48.
19. Morinobu T, Yoshikawa S, Hamamura K & Tamai H (2003): Measurement of vitamin E metabolites by high-performance liquid chromatography during high-dose administration of α-tocopherol. Eur. J. Clin. Nutr. 57, 410-414.
20. Murray Jr ED, Wechter WJ, Kantoci D, Wang WH, Pham T, Quiggle DD, Gibson KM, Leipold D & Anner BM (1997): Endogenous natriuretic factors 7: biospecificity of a natriuretic γ-tocopherol metabolite LLU-α. J. Pharmacol. Exp. Ther. 282, 657-662.
21. Radosavac D, Graf P, Polidori MC, Sies H & Stahl W (2002): Tocopherol metabolites 2,5,7,8-tetramethyl-2-(2′-carboxyethyl)6-hydroxychroman (α-CEHC) and 2,7,8,-trimethyl-2-(2′-carboxyethyl)-6-hydroxychroman (γ-CEHC) in human serum after a single dose of natural vitamin E. Eur. J. Nutr. 41, 119-124.
22. Resources Council, Science and Technology Agency (2000): Standard Tables of Food Composition in Japan, 5th Edition, Tokyo: National Printing Bureau (in Japanese).
23. Saito H, Kiyose C, Yoshimura H, Ueda T, Kondo K & Igarashi O (2003): γ-Tocotrienol, a vitamin E homolog, is a natriuretic hormone precursor. J. Lipid Res. 44 (8), 1530-1535.
24. Smith KS, Lee CL, Ridlington JW, Leonard SW, Devaraj S & Traber MG (2003): Vitamin E supplementation increases circulating vitamin E metabolites tenfold in end-stage renal disease patients. Lipids 38, 813-819.
25. Tamai H, Manago M, Yokota K, Kitagawa M & Mino M (1988): Determination of alpha-tocopherol in buccal mucosal cells using an electrochemical detector. Int. J. Vitam. Nutr. Res. 58, 202-207.
26. Traber MG, Sokol RJ, Burton GW, Ingold KU, Papas AM, Huffaker JE & Kayden HJ (1990): Impaired ability of patients with familial isolated vitamin E deficiency to incorporate α-tocopherol into lipoproteins secreted by the liver. J. Clin. Invest. 85, 397-407.
27. Wechter WJ, Kantoci D, Murray Jr ED, D'Amico DC, Jung ME & Wang WH (1996): A new endogenous natriuretic factor: LLU-α. Proc. Natl. Acad. Sci. USA 93, 6002-6007.
28. Williamson KS, Gabbita SP, Mou S, West M, Pye QN, Markesbery WR, Cooney RV, Grammas P, Philipp UR, Floyd RA & Hensley K (2002): The nitration product 5-nitro-γ-tocopherol is increased in the Alzheimer brain. Nitric Oxide 6, 221-227.