Occurrence and determination of a natriuretic hormone, 2,7,8-trimethyl- 2-(β-carboxyethyl)-6-hydroxy chroman, in rat plasma, urine, and bile

Analytical Biochemistry

Volumn 281, Issue 2, 2000, Pages 209-215

  Hattori, Akihiro ^a   Fukushima, Takeshi ^a   Imai, Kazuhiro ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Chiral column; Coupled column HPLC; DBD PZ; Fluorometric detection; LLU ; CEHC

Indexed keywords

ACETYLATION; METABOLISM;

BIOLOGICAL FLUIDS; CHIRAL COLUMN; COUPLED COLUMN; DBD-PZ; DERIVATIZATIONS; FLUOROMETRIC DETECTION; O-ACETYLATION; OXIDATIVE METABOLISM;

RATS;

2,7,8 TRIMETHYL 2 (BETA CARBOXYETHYL) 6 HYDROXYCHROMAN; GAMMA TOCOPHEROL; NATRIURETIC FACTOR; UNCLASSIFIED DRUG;

ACETYLATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILE LEVEL; CHIRALITY; CONTROLLED STUDY; FLUOROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HORMONE BLOOD LEVEL; HORMONE DETERMINATION; HORMONE STRUCTURE; HORMONE URINE LEVEL; MALE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RAT; VITAMIN METABOLISM;

ANIMALIA;

EID: 0034214168     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1006/abio.2000.4566     Document Type: Article

References (15)

1. Wechter, W. J., Kantoci, D., Murray, E. D., Jr., D'Amico, D. C., Jung, M. E., and Wang, W-H. (1996) A new endogenous natriuretic factor: LLU-α. Proc. Natl. Acad. Sci. USA 93, 6002-6007.
2. Murray, E. D., Jr., Wechter, W. J., Kantoci, D., Wang, W-H., Pharm, T., Quiggle D. D., Gibson, K. M., Leipold, D., and Anner, B. M. (1997) Endogenous natriuretic factors 7: Biospecificity of a natriuretic γ-tocopherol metabolite LLU- α. J. Pharmacol. Exp. Ther. 282, 657-662.
3. Kantoci, D., Wechter, W. J., Murray, E. D., Jr., Dewind, S. A., Borchardt, D., and Khan, S. I. (1997) Endogenous natriuretic factors 6: The stereochemistry of a natriuretic γ-tocopherol metabolite LLU- α. J. Pharmacol. Exp. Ther. 282, 648-656.
4. Wechter, W. J., and Murray, E. D., Jr. (1998) Has the elusive "natriuretic factor" been discovered, and if so, is it a hormone? Exp. Nephrol. 6, 488-490.
5. Traber, M. G., Elsner, A., and Brigelius-Flohe, R. (1998) Synthetic as compared with natural vitamin E is preferentially excreted as α-CEHC in human urine: Studies using deuterated α-tocopheryl acetates. FEBS Lett. 437, 145-148.
6. Swanson, J. E., Ben, R. N., Burton, G. W., and Parker, R. S. (1999) Urinary excretion of 2,7,8-trimethyl-2-(β-carboxyethyl)-6-hydroxychroman is a major route of elimination of γ-tocopherol in humans. J. Lipid Res. 40, 665-671.
7. Stahl, W., Graf, P., Brigelius-Flohe, R., Wechter, W., and Sies H. (1999) Quantification of the α- and γ-tocopherol metabolites 2,5,7,8-tetramethyl-2-(2′-carboxyethyl)-6-hydroxychroman and 2,7,8-trimethyl-2-(2′-carboxyethyl)-6-hydroxychroman in human serum. Anal. Biochem. 275, 254-259.
8. Toyo'oka, T., Ishibashi, M., Takeda, Y., Nakashima, K., Akiyama, S., Uzu, S., and Imai, K. (1991) Precolumn fluorescence tagging reagent for carboxylic acids in high-performance liquid chromatography: 4-Substituted-7-aminoalkylamino-2,1,3-benzoxadiazoles. J. Chromatogr. 588, 61-71.
9. Arai, Y., Fukushima, T., Shirao, M., Yang, X., and Imai, K. (2000) Biomed. Chromatogr., in press.
10. Fukushima, T., Santa, T., Homma, H., Al-kindy, S., and Imai, K. (1997) Enantiomeric separation and detection of 2-arylpropionic acids derivatized with [(N,N-dimethylamino)sulfonyl]benzofurazan reagents on a modified cellulose stationary phase by high-performance liquid chromatography. Anal. Chem. 69, 1793-1799.
11. Ichihara, H., Fukushima, T., and Imai, K. (1999) Enantiomeric determination of D- and L-lactate in rat serum using high-performance liquid chromatography with a cellulose-type chiral stationary phase and fluorescence detection. Anal. Biochem. 269, 379-385.
12. Yashima, E., and Okamoto, Y. (1995) Chiral discrimination on polysaccharides derivatives. Bull. Chem. Soc. Jpn. 68, 3289-3307.
13. Oi, N., Kitahara, H., Aoki, F., and Kisu, N. (1995) Direct separation of carboxylic acid enantiomers by high-performance liquid chromatography with amide and urea derivatives bonded to silica gel as chiral stationary phases. J. Chromatogr. A 689, 195-201
14. Kayden, H. J., and Traber, M. G. (1993) Absorption, lipoprotein transport, and regulation of plasma concentrations of vitamin E in humans. J. Lipid Res. 34, 343-358.
15. Hosomi, A., Arita, M., Sato, Y., Kiyose, C., Ueda, T., Igarashi, O., Arai, H., and Inoue, K. (1997) Affinity for α-tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs. FEBS Lett. 409, 105-108.