Up-regulation of NKX3.1 expression and inhibition of LNCaP cell proliferation induced by an inhibitory element decoy

Acta Biochimica et Biophysica Sinica

Volumn 37, Issue 5, 2005, Pages 335-340

  Jiang, An Li ^a   Hu, Xiao Yan ^a   Zhang, Peng Ju ^a   He, Mei Lan ^a   Kong, Feng ^a   Liu, Zhi Fang ^a   Yuan, Hui Qing ^a   Zhang, Jian Ye ^a  

^a SHANDONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Cell proliferation; cis acting element; Decoy oligodeoxynucleotide; Human NKX3.1 gene; Negative regulation

Indexed keywords

HOMEODOMAIN PROTEIN; NKX3 1 PROTEIN, HUMAN; NKX3-1 PROTEIN, HUMAN; OLIGODEOXYRIBONUCLEOTIDE; TRANSCRIPTION FACTOR;

ARTICLE; BINDING SITE; CELL PROLIFERATION; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; HUMAN; MALE; METABOLISM; METHODOLOGY; PROSTATE TUMOR; SILENCER ELEMENT; TUMOR CELL LINE; UPREGULATION;

BINDING SITES; CELL LINE, TUMOR; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HOMEODOMAIN PROTEINS; HUMANS; MALE; OLIGODEOXYRIBONUCLEOTIDES; PROSTATIC NEOPLASMS; SILENCER ELEMENTS, TRANSCRIPTIONAL; TRANSCRIPTION FACTORS; TRANSFECTION; UP-REGULATION;

EID: 23844545647     PISSN: 16729145     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1745-7270.2005.00047.x     Document Type: Article

References (22)

1. Vocke CD, Pozzatti RO, Bostwick DG, Florence CD, Jennings SB, Strup SE, Duray PH et al. Analysis of 99 microdissected prostate carcinomas reveals a high frequency of allelic loss on chromosome 8p12-21. Cancer Res 1996, 56:2411-2416
2. Trapman J, Sleddens HF, van der Weiden MM, Dinjens WN, Konig JJ, Schroder FH, Faber PW et al. Loss of heterozygosity of chromosome 8 microsatellite loci implicates a candidate tumor suppressor gene between the loci D8S87 and D8S133 in human prostate cancer. Cancer Res 1994, 54: 6061-6064
3. He WW, Sciavolino PJ, Wing J, Augustus M, Hudson P, Meissner PS, Curtis RT et al. A novel human prostate-specific, androgen-regulated homeobox gene (NKX3.1) that maps to 8p21, a region frequently deletion in prostate cancer. Genomics 1997, 43: 69-77
4. Bhatia-Gaur R, Donjacour AA, Sciavolino PJ, Kim M, Desai N, Young P, Norton CR et al. Roles for Nkx3.1 in prostate development and cancer. Genes Dev 1999, 13: 966-977
5. Abdulkadir SA, Magee JA, Peters TJ, Kaleem Z, Naughton CK, Humphrey PA, Milbrandt J. Conditional loss of Nkx3.1 in adult mice induces prostatic intraepithelial neoplasia. Mol Cell Biol 2002, 22: 1495-1503
6. Kim MJ, Bhatia-Gaur R, Banach-Petrosky WA, Desai N, Wang Y, Hayward SW, Cunha GR et al. Nkx3.1 mutant mice recapitulate early stages of prostate carcinogenesis. Cancer Res 2002, 62: 2999-3004
7. Voeller HJ, Augustus M, Madike V, Bova GS, Carter KC, Gelmann EP. Coding region of NKX3.1, a prostate-specific homeobox gene on 8p21, is not mutated in human prostate cancers. Cancer Res 1997, 57: 4455-4459
8. Morishita R, Higaki J, Tomita N, Ogihara T. Application of transcription factor "decoy" strategy as means of gene therapy and study of gene expression in cardiovascular disease. Circ Res 1998, 82: 1023-1028
9. Cho-Chung YS, Park YG, Lee YN. Oligonucleotides as transcription factor decoys. Curr Opin Mol Ther 1999, 1: 386-392
10. Mann MJ, Dzau VJ. Therapeutic applications of transcription factor decoy oligonucleotides. J Clin Invest 2000, 106: 1071-1075
11. Morishita R, Gibbons GH, Horiuchi M, Ellison KE, Nakama M, Zhang L, Kaneda Y et al. A gene therapy strategy using a transcription factor decoy of the E2F binding site inhibits smooth muscle proliferation in vivo. Proc Natl Acad Sci USA 1995, 92: 5855-5859
12. Gaubatz S, Wood JG, Livingston DM. Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6. Proc Natl Acad Sci USA 1998, 95: 9190-9195
13. Tomita S, Tomita N, Yamada T, Zhang L, Kaneda Y, Morishita R, Ogihara T et al. Transcription factor decoy to study the molecular mechanism of negative regulation of renin gene expression in the liver in vivo. Circ Res 1999, 84: 1059-1066
14. Bielinska A, Shivdasani RA, Zhang L, Nabel GJ. Regulation of gene expression with double-stranded phosphorothioate oligonucleotides. Science 1990, 250: 997-1000
15. Morishita R, Sugimoto T, Aoki M, Kida I, Tomita N, Moriguchi A, Maeda K et al. In vivo transfection of cis element "decoy" against nuclear factor-κB binding site prevents myocardial infarction. Nature Med 1997, 3: 894-899
16. Jiang AL, Zhang JY, Young C, Hu XY, Wang YM, Liu ZF, He ML. Molecular cloning and characterization of human homeobox gene NKX3.1 promoter. Acta Biochim Biophys Sin 2004, 36: 64-67
17. Chu BC, Orgel LE. The stability of different forms of double-stranded decoy DNA in serum and nuclear extracts. Nucleic Acids Res 1992, 20: 5857-5858
18. Iwase R, Namba M, Yamaoka T, Murakami A. Gene regulation by decoy approach (I): Synthesis and properties of photo-crosslinked oligonucleotides. Nucleic Acids Symp Ser 1997, 37: 203-204
19. Amoah-Apraku B, Fang MZ, Guzman NJ. A non-nucleotide-bridged DNA decoy inhibits renal epithelial nitric oxide synthase expression. Kidney Int 2000, 57: 83-91
20. White RR, Sullenger BA, Rusconi CP. Developing aptamers into therapeutics. J Clin Invest 2000, 106: 929-934
21. Hosoya T, Takeuchi H, Kanesaka Y, Yamakawa H, Miyano-Kurosaki N, Takai K, Yamamoto N et al. Sequence-specific inhibition of a transcription factor by circular dumbbell DNA oligonucleotides. FEBS Lett 1999, 461: 136-140
22. Rita C, Marzia B, Lucia G, Mauro M. Design and characterization of decoy oligonucleotide containing locked nucleic acids. Nucleic Acids Res 2002, 30: 2435-2443