The long QT syndrome: A clinical counterpart of hERG mutations

Novartis Foundation Symposium

Volumn 266, Issue , 2005, Pages 186-198

  Schwartz, Peter J ^a  

^a UNIVERSITY OF PAVIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CATION TRANSPORT PROTEIN; ERG1 POTASSIUM CHANNEL; KCNH2 PROTEIN, HUMAN; KCNH6 PROTEIN, HUMAN; POTASSIUM CHANNEL HERG; VOLTAGE GATED POTASSIUM CHANNEL;

GENETICS; HUMAN; LONG QT SYNDROME; MUTATION; REVIEW;

CATION TRANSPORT PROTEINS; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; LONG QT SYNDROME; MUTATION; POTASSIUM CHANNELS, VOLTAGE-GATED;

EID: 23844535600     PISSN: 15282511     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (32)

1. Crotti L, Spazzolini C, De Ferrari GM et al 2004 Is the implantable defibrillator appropriately used in the long QT syndrome? Data from the European Registry. Heart Rhythm 1(suppl):582
2. Curran ME, Splawski I, Timothy KW, Vincent GM, Green ED, Keating MT 1995 A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell 80:795-803
3. Dausse E, Berthet M, Denjoy I et al 1996 A mutation in HERG associated with notched T waves in long-QT syndrome. J Mol Cell Cardiol 28:1609-1615
4. Donger C, Denjoy I, Berthet M et al 1997 KVLQT1 C-terminal missense mutation causes a forme fruste long-QT syndrome. Circulation 96:2778-2781
5. Huang FD, Chen J, Lin M, Keating MT, Sanguinetti MC 2001 Long-QT syndrome-associated missense mutations in the pore helix of the HERG potassium channel. Circulation 104:1071-1075
6. January CT, Gong Q, Zhou Z 2000 Long QT syndrome: cellular basis and arrhythmia mechanism in LQT2. J Cardiovasc Electrophysiol 11:1413-1418
7. Malfatto G, Beria G, Sala S, Bonazzi O, Schwartz PJ 1994 Quantitative analysis of T wave abnormalities and their prognostic implications in the idiopathic long QT syndrome. J Am Coll Cardiol 23:296-301
8. Marx SO, Kurokawa J, Reiken S et al 2002 Requirement of a macromolecular signaling complex for β adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel. Science 295:496-499
9. Members of the Sicilian Gambit 1998 The search for novel antiarrhythmic strategies. Eur Heart J 19:1178-1196 and Jpn Circ J 62:633-648
10. Moss AJ, Zareba W, Benhorin J et al 1995 ECG T-wave patterns in genetically distinct forms of the hereditary long QT syndrome. Circulation 92:2929-2934
11. Moss AJ, Zareba W, Kaufman ES et al 2002 Increased risk of arrhythmic events in long QT syndrome with mutations in the pore region of the human ether-a-go-go-related gene potassium channel. Circulation 105:794-799
12. Priori SG, Schwartz PJ, Napolitano C et al 2003 Risk stratification in the long-QT syndrome. N Engl J Med 348:1866-1874
13. Priori SG, Napolitano C, Schwartz PJ et al 2004 Association of long QT syndrome loci and cardiac events among patients treated with β-blockers. J Am Med Assoc 292:1341-1344
14. Schwartz PJ 1985 Idiopathic long QT syndrome: progress and questions. Am Heart J 109:399-411
15. Schwartz PJ, Periti M, Malliani A 1975 The long QT syndrome. Am Heart J 89:378-390
16. Schwartz PJ, Zaza A, Locati E, Moss AJ 1991 Stress and sudden death. The case of the long QT syndrome. Circulation 83 (suppl 4):II71-II80
17. Schwartz PJ, Moss AJ, Vincent GM, Crampton RS 1993 Diagnostic criteria for the long QT syndrome: an update. Circulation 88:782-784
18. + channel blockade and to increases in heart rate. Implications for gene-specific therapy. Circulation 92:3381-3386
19. Schwartz PJ, Priori SG, Napolitano C 2000 The long QT syndrome. In: Zipes DP, Jalife J (eds) Cardiac electrophysiology. From cell to bedside. III edn. WB Saunders Co., Philadelphia, p 597-615
20. Schwartz PJ, Priori SG, Spazzolini C et al 2001 Genotype-phenotype correlation in the long QT syndrome. Gene-specific triggers for life-threatening arrhythmias. Circulation 103:89-95
21. Schwartz PJ, Priori SG, Cerrone M et al 2004 Left cardiac sympathetic denervation in the management of high-risk patients affected by the long QT syndrome. Circulation 109:1826-1833
22. Shimizu W, Antzelevitch C 1997 Sodium channel block with mexiletine is effective in reducing dispersion of repolarization and preventing torsade de pointes in LQT2 and LQT3 models of the long-QT syndrome. Circulation 96:2038-2047
23. Shimizu W, Antzelevitch C 1998 Cellular basis for the ECG features of the LQT1 form of the long-QT syndrome: effects of b-adrenergic agonists and antagonists and sodium channel blockers on transmural dispersion of repolarization and torsade de pointes. Circulation 98:2314-2322
24. Splawski I, Shen J, Timothy KW et al 2000 Spectrum of mutations in long-QT syndrome genes. Circulation 102:1178-1185
25. v1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism. Cell 119:19-31
26. Stramba-Badiale M, Priori SG, Napolitano C et al 2000 Gene-specific differences in the circadian variation of ventricular repolarization in the long QT syndrome: a key to sudden death during sleep-? Ital Heart J 1:323-328
27. Takenaka K, Ai T, Shimizu W et al 2003 Exercise stress test amplifies genotype-phenotype correlation in the LQT1 and LQT2 forms of the long-QT syndrome. Circulation 107:838-844
28. Wang Q, Shen J, Splawski I et al 1995 SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome. Cell 80:805-811
29. Wellens HJJ, Vermeulen A, Durrer D 1972 Ventricular fibrillation occurring on arousal from sleep by auditory stimuli. Circulation 46:661-665
30. Wilde AAM, Jongbloed RJE, Doevendans PA et al 1999 Auditory stimuli as a trigger for arrhythmic events difierentiate HERG-related (LQTS2) patients from KvLQT1-related patients (LQTS1). J Am Coll Cardiol 33:327-332
31. Zhang L, Timothy KW, Vincent GM et al 2000 Spectrum of ST-T-wave patterns and repolarization parameters in congenital long QT syndrome. ECG findings identify genotypes. Circulation 102:2849-2855
32. Zipes DP 1991 The long QT interval syndrome. A Rosetta stone for sympathetic related ventricular tachyarrhythmias. Circulation 84:1414-1419