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Volumn 48, Issue 8, 2005, Pages 1496-1502

The Pro12Ala and C-681G variants of the PPARG locus are associated with opposing growth phenotypes in young schoolchildren

Author keywords

Body mass; Children; Growth; Height; Human genetics; Obesity

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

EID: 23844527870     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-005-1817-0     Document Type: Article
Times cited : (31)

References (36)
  • 1
    • 0345257102 scopus 로고    scopus 로고
    • Prevalence of overweight among children in Europe
    • Lobstein T, Frelut ML (2003) Prevalence of overweight among children in Europe. Obes Rev 4:195-200
    • (2003) Obes Rev , vol.4 , pp. 195-200
    • Lobstein, T.1    Frelut, M.L.2
  • 3
    • 0035814614 scopus 로고    scopus 로고
    • Prevalence and trends in overweight and obesity in three cross sectional studies of British Children, 1974-94
    • Chinn S, Rona RJ (2001) Prevalence and trends in overweight and obesity in three cross sectional studies of British Children, 1974-94. BMJ 322:24-26
    • (2001) BMJ , vol.322 , pp. 24-26
    • Chinn, S.1    Rona, R.J.2
  • 4
    • 70349566593 scopus 로고
    • Diabetes mellitus: A 'thrifty' genotype rendered detrimental by 'progress'?
    • Neel JV (1962) Diabetes mellitus: a 'thrifty' genotype rendered detrimental by 'progress'? Am J Hum Genet 14:353-362
    • (1962) Am J Hum Genet , vol.14 , pp. 353-362
    • Neel, J.V.1
  • 5
    • 0032588487 scopus 로고    scopus 로고
    • PPARgamma, the ultimate thrifty gene
    • Auwerx J (1999) PPARgamma, the ultimate thrifty gene. Diabetologia 42:1033-1049
    • (1999) Diabetologia , vol.42 , pp. 1033-1049
    • Auwerx, J.1
  • 6
    • 0036007024 scopus 로고    scopus 로고
    • C/EBPalpha induces adipogenesis through PPARgamma: A unified pathway
    • Rosen ED, Hsu CH, Wang X et al (2002) C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway. Genes Dev 16:22-26
    • (2002) Genes Dev , vol.16 , pp. 22-26
    • Rosen, E.D.1    Hsu, C.H.2    Wang, X.3
  • 7
    • 0036146384 scopus 로고    scopus 로고
    • A novel heterozygous mutation in peroxisome proliferator-activated receptor-gamma gene in a patient with familial partial lipodystrophy
    • Agarwal AK, Garg A (2002) A novel heterozygous mutation in peroxisome proliferator-activated receptor-gamma gene in a patient with familial partial lipodystrophy. J Clin Endocrinol Metab 87:408-411
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 408-411
    • Agarwal, A.K.1    Garg, A.2
  • 8
    • 0036894397 scopus 로고    scopus 로고
    • PPARG F388L, a transactivation-deficient mutant, in familial partial lipodystrophy
    • Hegele RA, Cao H, Frankowski C, Mathews ST, Leff T (2002) PPARG F388L, a transactivation-deficient mutant, in familial partial lipodystrophy. Diabetes 51:3586-3590
    • (2002) Diabetes , vol.51 , pp. 3586-3590
    • Hegele, R.A.1    Cao, H.2    Frankowski, C.3    Mathews, S.T.4    Leff, T.5
  • 9
    • 0344375097 scopus 로고    scopus 로고
    • Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-gamma
    • Savage DB, Tan GD, Acerini CL et al (2003) Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-gamma. Diabetes 52:910-917
    • (2003) Diabetes , vol.52 , pp. 910-917
    • Savage, D.B.1    Tan, G.D.2    Acerini, C.L.3
  • 10
    • 0345164399 scopus 로고    scopus 로고
    • Molecular scanning of the human peroxisome proliferator activated receptor gamma (hPPAR gamma) gene in diabetic Caucasians: Identification of a Pro12Ala PPAR gamma 2 missense mutation
    • Yen CJ, Beamer BA, Negri C et al (1997) Molecular scanning of the human peroxisome proliferator activated receptor gamma (hPPAR gamma) gene in diabetic Caucasians: identification of a Pro12Ala PPAR gamma 2 missense mutation. Biochem Biophys Res Commun 241:270-274
    • (1997) Biochem Biophys Res Commun , vol.241 , pp. 270-274
    • Yen, C.J.1    Beamer, B.A.2    Negri, C.3
  • 11
    • 0031595923 scopus 로고    scopus 로고
    • A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity
    • Deeb SS, Fajas L, Nemoto M et al (1998) A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat Genet 20:284-287
    • (1998) Nat Genet , vol.20 , pp. 284-287
    • Deeb, S.S.1    Fajas, L.2    Nemoto, M.3
  • 12
    • 0033624575 scopus 로고    scopus 로고
    • The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
    • Altshuler D, Hirschhorn JN, Klannemark M et al (2000) The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 26:76-80
    • (2000) Nat Genet , vol.26 , pp. 76-80
    • Altshuler, D.1    Hirschhorn, J.N.2    Klannemark, M.3
  • 13
    • 1842866370 scopus 로고    scopus 로고
    • Association of the Pro12Ala and C1431T variants of PPARG and their haplotypes with susceptibility to type 2 diabetes
    • Doney AS, Fischer B, Cecil JE et al (2004) Association of the Pro12Ala and C1431T variants of PPARG and their haplotypes with susceptibility to type 2 diabetes. Diabetologia 47:555-558
    • (2004) Diabetologia , vol.47 , pp. 555-558
    • Doney, A.S.1    Fischer, B.2    Cecil, J.E.3
  • 14
    • 0037073439 scopus 로고    scopus 로고
    • Haplotype analysis of the PPARgamma Pro12Ala and C1431T variants reveals opposing associations with body weight
    • Doney A, Fischer B, Frew D et al (2002) Haplotype analysis of the PPARgamma Pro12Ala and C1431T variants reveals opposing associations with body weight. BMC Genet 3:21
    • (2002) BMC Genet , vol.3 , pp. 21
    • Doney, A.1    Fischer, B.2    Frew, D.3
  • 15
    • 0041630975 scopus 로고    scopus 로고
    • The PPAR-gamma P12A polymorphism modulates the relationship between dietary fat intake and components of the metabolic syndrome: Results from the Quebec Family Study
    • Robitaille J, Despres JP, Perusse L, Vohl MC (2003) The PPAR-gamma P12A polymorphism modulates the relationship between dietary fat intake and components of the metabolic syndrome: results from the Quebec Family Study. Clin Genet 63:109-116
    • (2003) Clin Genet , vol.63 , pp. 109-116
    • Robitaille, J.1    Despres, J.P.2    Perusse, L.3    Vohl, M.C.4
  • 16
    • 0345306138 scopus 로고    scopus 로고
    • Interaction between a peroxisome proliferator-activated receptor gamma gene polymorphism and dietary fat intake in relation to body mass
    • Memisoglu A, Hu FB, Hankinson SE et al (2003) Interaction between a peroxisome proliferator-activated receptor gamma gene polymorphism and dietary fat intake in relation to body mass. Hum Mol Genet 12:2923-2929
    • (2003) Hum Mol Genet , vol.12 , pp. 2923-2929
    • Memisoglu, A.1    Hu, F.B.2    Hankinson, S.E.3
  • 17
    • 0035123646 scopus 로고    scopus 로고
    • Evidence for gene-nutrient interaction at the PPARgamma locus
    • Luan J, Browne PO, Harding AH et al (2001) Evidence for gene-nutrient interaction at the PPARgamma locus. Diabetes 50:686-689
    • (2001) Diabetes , vol.50 , pp. 686-689
    • Luan, J.1    Browne, P.O.2    Harding, A.H.3
  • 19
    • 0347316400 scopus 로고    scopus 로고
    • Does peroxisome proliferator-activated receptor gamma genotype (Pro12ala) modify the association of physical activity and dietary fat with fasting insulin level?
    • Franks PW, Luan J, Browne PO et al (2004) Does peroxisome proliferator-activated receptor gamma genotype (Pro12ala) modify the association of physical activity and dietary fat with fasting insulin level? Metabolism 53:11-16
    • (2004) Metabolism , vol.53 , pp. 11-16
    • Franks, P.W.1    Luan, J.2    Browne, P.O.3
  • 20
    • 0033304551 scopus 로고    scopus 로고
    • Two polymorphisms in the peroxisome proliferator-activated receptor-gamma gene are associated with severe overweight among obese women
    • Valve R, Sivenius K, Miettinen R et al (1999) Two polymorphisms in the peroxisome proliferator-activated receptor-gamma gene are associated with severe overweight among obese women. J Clin Endocrinol Metab 84:3708-3712
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 3708-3712
    • Valve, R.1    Sivenius, K.2    Miettinen, R.3
  • 21
    • 0031912333 scopus 로고    scopus 로고
    • A genetic polymorphism of the peroxisome proliferator-activated receptor gamma gene influences plasma leptin levels in obese humans
    • Meirhaeghe A, Fajas L, Helbecque N et al (1998) A genetic polymorphism of the peroxisome proliferator-activated receptor gamma gene influences plasma leptin levels in obese humans. Hum Mol Genet 7:435-440
    • (1998) Hum Mol Genet , vol.7 , pp. 435-440
    • Meirhaeghe, A.1    Fajas, L.2    Helbecque, N.3
  • 22
    • 8644275374 scopus 로고    scopus 로고
    • The 161TT genotype in the exon 6 of peroxisome proliferator-activated receptor gamma gene is associated with premature acute myocardial infarction and increased lipid peroxidation in habitual heavy smokers
    • Lond
    • Chao TH, Li YH, Chen JH et al (2004) The 161TT genotype in the exon 6 of peroxisome proliferator-activated receptor gamma gene is associated with premature acute myocardial infarction and increased lipid peroxidation in habitual heavy smokers. Clin Sci (Lond) 107:461-466
    • (2004) Clin Sci , vol.107 , pp. 461-466
    • Chao, T.H.1    Li, Y.H.2    Chen, J.H.3
  • 23
    • 0033434025 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma C161→T polymorphism and coronary artery disease
    • Wang XL, Oosterhof J, Duarte N (1999) Peroxisome proliferator-activated receptor gamma C161→T polymorphism and coronary artery disease. Cardiovasc Res 44:588-594
    • (1999) Cardiovasc Res , vol.44 , pp. 588-594
    • Wang, X.L.1    Oosterhof, J.2    Duarte, N.3
  • 24
    • 0037329337 scopus 로고    scopus 로고
    • A functional polymorphism in a STAT5B site of the human PPAR gamma 3 gene promoter affects height and lipid metabolism in a French population
    • Meirhaeghe A, Fajas L, Gouilleux F et al (2003) A functional polymorphism in a STAT5B site of the human PPAR gamma 3 gene promoter affects height and lipid metabolism in a French population. Arterioscler Thromb Vasc Biol 23:289-294
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 289-294
    • Meirhaeghe, A.1    Fajas, L.2    Gouilleux, F.3
  • 25
    • 5044234664 scopus 로고    scopus 로고
    • Altered growth in male peroxisome proliferator-activated receptor gamma (PPARgamma) heterozygous mice: Involvement of PPARgamma in a negative feed-back regulation of growth hormone action
    • Rieusset J, Seydoux J, Anghel SI et al (2004) Altered growth in male peroxisome proliferator-activated receptor gamma (PPARgamma) heterozygous mice: involvement of PPARgamma in a negative feed-back regulation of growth hormone action. Mol Endocrinol 18:2363-2377
    • (2004) Mol Endocrinol , vol.18 , pp. 2363-2377
    • Rieusset, J.1    Seydoux, J.2    Anghel, S.I.3
  • 26
    • 4644292542 scopus 로고    scopus 로고
    • The Pro12Ala polymorphism of the PPAR gamma 2 gene regulates weight from birth to adulthood
    • Pihlajamaki J, Vanhala M, Vanhala P, Laakso M (2004) The Pro12Ala polymorphism of the PPAR gamma 2 gene regulates weight from birth to adulthood. Obes Res 12:187-190
    • (2004) Obes Res , vol.12 , pp. 187-190
    • Pihlajamaki, J.1    Vanhala, M.2    Vanhala, P.3    Laakso, M.4
  • 27
    • 2442720272 scopus 로고    scopus 로고
    • Male preponderance in early diagnosed type 2 diabetes is associated with the ARE insertion/deletion polymorphism in the PPP1R3A locus
    • Doney AS, Fischer B, Cecil JE et al (2003) Male preponderance in early diagnosed type 2 diabetes is associated with the ARE insertion/deletion polymorphism in the PPP1R3A locus. BMC Genet 4:11
    • (2003) BMC Genet , vol.4 , pp. 11
    • Doney, A.S.1    Fischer, B.2    Cecil, J.E.3
  • 28
    • 0035071957 scopus 로고    scopus 로고
    • A new statistical method for haplotype reconstruction from population data
    • Stephens M, Smith NJ, Donnelly P (2001) A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 68:978-989
    • (2001) Am J Hum Genet , vol.68 , pp. 978-989
    • Stephens, M.1    Smith, N.J.2    Donnelly, P.3
  • 29
    • 3042641333 scopus 로고    scopus 로고
    • 2LD, GENECOUNTING and HAP: Computer programs for linkage disequilibrium analysis
    • Zhao JH (2004) 2LD, GENECOUNTING and HAP: Computer programs for linkage disequilibrium analysis. Bioinformatics 20:1325-1326
    • (2004) Bioinformatics , vol.20 , pp. 1325-1326
    • Zhao, J.H.1
  • 31
    • 0029033734 scopus 로고
    • Body mass index reference curves for the UK, 1990
    • Cole TJ, Freeman JV, Preece MA (1995) Body mass index reference curves for the UK, 1990. Arch Dis Child 73:25-29
    • (1995) Arch Dis Child , vol.73 , pp. 25-29
    • Cole, T.J.1    Freeman, J.V.2    Preece, M.A.3
  • 32
    • 0034611996 scopus 로고    scopus 로고
    • Establishing a standard definition for child overweight and obesity worldwide: International survey
    • Cole TJ, Bellizzi MC, Flegal KM, Dietz WH (2000) Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 320:1240-1243
    • (2000) BMJ , vol.320 , pp. 1240-1243
    • Cole, T.J.1    Bellizzi, M.C.2    Flegal, K.M.3    Dietz, W.H.4
  • 33
    • 0042733636 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma2-Pro12Ala and endothelial nitric oxide synthase-4a/b gene polymorphisms are associated with essential hypertension
    • Rodriguez-Esparragon FJ, Rodriguez-Perez JC, Macias-Reyes A, Alamo-Santana F (2003) Peroxisome proliferator-activated receptor-gamma2- Pro12Ala and endothelial nitric oxide synthase-4a/b gene polymorphisms are associated with essential hypertension. J Hypertens 21:1649-1655
    • (2003) J Hypertens , vol.21 , pp. 1649-1655
    • Rodriguez-Esparragon, F.J.1    Rodriguez-Perez, J.C.2    Macias-Reyes, A.3    Alamo-Santana, F.4
  • 34
    • 0042733635 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gammaPro12Ala polymorphism and the association with blood pressure in type 2 diabetes: Skaraborg Hypertension and Diabetes Project
    • Ostgren CJ, Lindblad U, Melander O, Melander A, Groop L, Rastam L (2003) Peroxisome proliferator-activated receptor-gammaPro12Ala polymorphism and the association with blood pressure in type 2 diabetes: Skaraborg Hypertension and Diabetes Project. J Hypertens 21:1657-1662
    • (2003) J Hypertens , vol.21 , pp. 1657-1662
    • Ostgren, C.J.1    Lindblad, U.2    Melander, O.3    Melander, A.4    Groop, L.5    Rastam, L.6
  • 35
    • 0037625000 scopus 로고    scopus 로고
    • Alanine for proline substitution in the peroxisome proliferator-activated receptor gamma-2 (PPARG2) gene and the risk of incident myocardial infarction
    • Ridker PM, Cook NR, Cheng S et al (2003) Alanine for proline substitution in the peroxisome proliferator-activated receptor gamma-2 (PPARG2) gene and the risk of incident myocardial infarction. Arterioscler Thromb Vasc Biol 23:859-863
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 859-863
    • Ridker, P.M.1    Cook, N.R.2    Cheng, S.3
  • 36
    • 10644262362 scopus 로고    scopus 로고
    • Cardiovascular risk in type 2 diabetes is associated with variation at the PPARG locus. A Go-DARTS study
    • Doney AS, Fischer B, Leese G, Morris AD, Palmer CN (2004) Cardiovascular risk in type 2 diabetes is associated with variation at the PPARG locus. A Go-DARTS study. Arterioscler Thromb Vasc Biol 24:2403-2407
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 2403-2407
    • Doney, A.S.1    Fischer, B.2    Leese, G.3    Morris, A.D.4    Palmer, C.N.5


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