Genotoxicity testing of methyl tertiary-butyl ether (MTBE) in the salmonella microsuspension assay and mouse bone marrow micronucleus test

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 412, Issue 2, 1998, Pages 131-138

  Kado, Norman Y ^a   Kuzmicky, Paul A ^a   Loarca Piña, Guadalupe ^a,b   Moiz Mumtaz, M ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSIDAD AUTÓNOMA DE QUERÉTARO   (Mexico)

^c Agy Toxic Substances Dis Registry   (United States)

Author keywords

Bone marrow; Methyl tertiary butyl ether; Micronucleus test; Microsuspension; Mutagenicity; Salmonella typhimurium

Indexed keywords

GASOLINE; TERT BUTYL METHYL ETHER;

AMES TEST; ARTICLE; BONE MARROW; ENVIRONMENTAL EXPOSURE; GENOTOXICITY; MICRONUCLEUS TEST; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; SALMONELLA TYPHIMURIUM;

AIR POLLUTANTS; ANIMALS; BONE MARROW; CARCINOGENS; FEMALE; MALE; METHYL ETHERS; MICE; MICRONUCLEUS TESTS; MUTAGENICITY TESTS; MUTAGENS; SALMONELLA TYPHIMURIUM;

ANIMALIA; SALMONELLA; SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 0032579173     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(97)00179-4     Document Type: Article

References (22)

1. US EPA (1993) MTBE-Oxygenated Gasolines and Public Health Issues, 21 pp.
2. Lioy P.L., Weisel C.P., Jo W.-K., Pellizzari E., Raymer J.H. Micro-environmental and personal measurements of methyl-tertiary butyl ether (MTBE) associated with automobile use activities. J. Expos. Anal. Environ. Epidemiol. 4:1994;427-441.
3. Newman A. MTBE detected in survey of urban groundwater. Environ. Sci. Technol. 29:1995;305A.
4. Sugimura T., Terada M., Yokota J., Hirohashi S., Wakabayashi K. Multiple genetic alterations in human carcinogenesis. Environ. Health Perspect. 98:1992;5-12.
5. Anderson M.W., Reynolds S., You M., Maronpot R. Role of protooncogene activation in carcinogenesis. Environ. Health Perspect. 98:1992;13-24.
6. J.S. Chun, H.D. Burleigh-Flayer, W.J. Kintish, Methyl-tertiary-butyl Ether: Vapor Inhalation Oncogenicity Study in Fisher-344 Rats, BRRC Report 91N0013B, Union Carbide, Bushy Run Research Center, Export, PA, 1992.
7. H.D. Burleigh-Flayer, J.S. Chun, W.J. Kintish, Methyl-tertiary-butyl Ether: Vapor Inhalation Oncogenicity Study in CD-1 Mice, BRRC Report 91N0013A, Union Carbide, Bushy Run Research Center, Export, PA, 1992.
8. Belpoggi F., Soffritti M., Maltoni C. Methyl-tertiary-butyl-ether (MTBE) - a gasoline additive - causes testicular and lymphohaematopoietic cancers in rats. Toxicol. Environ. Health. 11:1995;119-149.
9. Ames B.N., McCann J., Yamasaki E. Methods for detecting carcinogens and mutagens with the Salmonella/mammalian microsome mutagenicity test. Mutation Res. 31:1975;347-364.
10. ARCO Chemical Company (1980) Methyl Tertiary Butyl Ether: Acute Toxicological Studies, 74 pp.
11. Brusick D., Andrews H. Comparison of the genetic activity of dimethyl-nitrosamine, ethylmethane sulfonate, 2-acetylaminofluorene and ICR-170 in Saccharomyces cerevisiae strains D3, D4, and D5 using in vitro assays with and without metabolic activation. Mutation Res. 26:1974;491-500.
12. Clive D., Spector J.F.S. Laboratory procedure for assessing specific locus mutations at the TK locus in cultured L5178Y mouse lymphoma cells. Mutation Res. 31:1975;17-29.
13. Kado N.Y., Langley D., Eisenstadt E. A simple modification of the Salmonella liquid incubation assay. Increased sensitivity for detecting mutagens in human urine. Mutation Res. 121:1983;25-32.
14. Kado N.Y., Wong J.M., Kuzmicky P.A., Woodrow J.E., Ning H., Seiber J.N., Hsieh D.P.H. Quantitative integration of the Salmonella microsuspension assay with supercritical fluid extraction of model airborne vapor-phase mutagens. Mutation Res. 271:1992;253-260.
15. Kado N.Y., Guirguis G.N., Flessel C.P., Chan R.C., Chang K., Wesolowski J.J. Mutagenicity of fine (<2.5 μm) airborne particles: diurnal variation in community air determined by a Salmonella micro preincubation (microsuspension) procedure. Environ. Mutagen. 8:1986;53-66.
16. Lowry O.H., Rosebrough J.N., Farr A., Randall R.J. Protein measurement with folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
17. W. Schmid, The micronucleus test for cytogenetic analysis, in: A. Hollaender (Ed.), Chemical Mutagens: Principles and Methods for Their Detection, Plenum, New York, 1976, pp. 31-43.
18. Marnett L.J., Hurd H.K., Hollstein M.C., Levin D.E., Esterbauer H., Ames B.N. Naturally occurring carbonyl compounds are mutagens in Salmonella tester strain TA104. Mutation Res. 148:1985;25-34.
19. Mackerer C.R., Angelosanto F.A., Blackburn G.R., Schreiner C.A. Identification of formaldehyde as the metabolite responsible for the mutagenicity of methyl tertiary-butyl ether in the activated mouse lymphoma assay. Proc. Soc. Exp. Biol. Med. 212:1996;338-341.
20. Sofuni T., Honma H., Hayashi M., Shimada H., Tanaka N., Wakuri S., Awogi T., Yamamoto K.I., Nishi Y., Nakadate M. Detection of in vitro clastogens and spindle poisons by the mouse lymphoma assay using the microwell method: interim report of an international collaborative study. Mutagenesis. 11:1996;349-355.
21. Moser G.J., Wong B.A., Wolf D.C., Moss O.R., Goldsworthy T.L. Comparative short-term effects of methyl tertiary butyl ether and unleaded gasoline vapor in female B6C3F1 mice. Fundam. Appl. Toxicol. 31:1996;173-183.
22. McKee R.H., Bergnes J.S., Galvin J.B., Douglas J.F., Kneiss J.J., Andrews L.S. Assessment of the in vivo mutagenic potential of methyl tertiary-butyl ether. J. Appl. Toxicol. 17:1997;S31-S36.