Antioxidants; not the only reason to eat fruit and vegetables

Phytochemistry Reviews

Volumn 1, Issue 2, 2002, Pages 167-174

  Collins, Andrew R ^a   Harrington, Vikki ^b  

^a UNIVERSITY OF OSLO   (Norway)

^b ROBERT GORDON UNIVERSITY   (United Kingdom)

Author keywords

Antioxidants; Cancer; Comet assay; DNA oxidation; DNA repair

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; BETA CAROTENE; CAROTENOID; EQUOL; FLAVONOID; GENISTEIN; LYCOPENE; MYRICETIN; PHYTOESTROGEN; PLANT MEDICINAL PRODUCT; QUERCETIN; TRACE ELEMENT;

ANTIOXIDANT ACTIVITY; CANCER PREVENTION; CANCER RISK; CARROT; CELL DAMAGE; CONFERENCE PAPER; DIET SUPPLEMENTATION; DNA DAMAGE; DNA REPAIR; DRUG BLOOD LEVEL; ENZYME INHIBITION; EX VIVO STUDY; FOOD COMPOSITION; FRUIT; HUMAN; IN VITRO STUDY; KIWIFRUIT; LYMPHOCYTE; NONHUMAN; ONION; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; SOYBEAN MILK; VEGETABLE; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION;

ACTINIDIA DELICIOSA; ALLIUM CEPA; DAUCUS CAROTA; GLYCINE MAX;

EID: 23844451812     PISSN: 15687767     EISSN: 1572980X     Source Type: Journal    
DOI: 10.1023/A:1022514432233     Document Type: Article

References (32)

1. Allan JM, Wild CP, Rollinson S, Willett EV, Moorman AV, Dovey GJ, Roddam PL, Roman E, Cartwright RA & Morgan GJ (2001) Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapy-induced leukemia. Proc. Nat. Acad. Sci. 98: 11592-11597.
2. ATBC (Alpha-tocopherol, beta carotene cancer prevention study group) (1994) The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. New Engl. J. Med. 330: 1029-1035.
3. Ames BN, Shigenaga MK & Hagen TM (1993) Oxidants, antioxidants, and the degenerative diseases of aging. Proc. Nat. Acad. Sci. 90: 7915-7922.
4. Boyle SP, Dobson VL, Duthie SJ, Kyle JAM & Collins AR (2000) Absorption and DNA protective effects of flavonoid glycosides from an onion meal. Europ. J. Nutrit. 39: 213-223.
5. Collins A, Dušinská M, Franklin M, Somorovská M, Petrovská H, Duthie S, Fillion L, Panayiotidis M, Rašlová K & Vaughan N (1997a) Comet assay in human biomonitoring studies: reliability, validation, and applications. Environ. Mol. Mutagen. 30: 139-146.
6. Collins A, Cadet J, Epe B & Gedik C (1997b) Problems in the measurement of 8-oxoguanine in human DNA. Report of a workshop, DNA Oxidation, held in Aberdeen, UK, 19-21 January, 1997. Carcinogenesis 18: 1833-1836.
7. Collins AR, Olmedilla B, Southon S, Granado F & Duthie SJ (1998) Serum carotenoids and oxidative DNA damage in human lymphocytes. Carcinogenesis 19: 2159-2162.
8. Collins AR & Horváthová E (2001) Oxidative DNA damage, antioxidants and DNA repair; applications of the comet assay. Biochem. Soc. Transact. 29: 337-341.
9. Collins BH, Horská A, Hotten PM, Riddoch C & Collins AR (2001a) Kiwifruit protects against oxidative DNA damage in human cells and in vitro. Nutrit. Cancer 39: 148-153.
10. Collins AR, Dušinská M, Horváthová E, Munro E, Savio M & Štětina R (2001b) Inter-individual differences in DNA base excision repair activity measured in vitro with the comet assay. Mutagenesis 16: 297-301.
11. Dušinská M, Ficek A, Horská A, Rašlová K, Petrovská H, Vallová B, Drlicková M, Wood SG, Štupáková A, Gašparovic J, Bobek P, Nagyová A, Kováciková Z, Blazícek P, Liegebel U & Collins AR (2001) Glutathione S-transferase polymorphisms influence the level of oxidative DNA damage and antioxidant protection in humans. Mut. Res. 482: 47-55.
12. Duthie SJ, Ma A, Ross MA & Collins AR (1996) Antioxidant supplementation decreases oxidative DNA damage in human lymphocytes. Cancer Res. 56: 1291-1295.
13. Duthie SJ, Collins AR, Duthie GG & Dobson VL (1997) Quercetin and myricetin protect against hydrogen peroxide-induced DNA damage (strand breaks and oxidised pyrimidines) in human lymphocytes. Mut. Res. 393: 223-231.
14. ESCODD (2000) Comparison of different methods of measuring 8-oxoguanine as a marker of oxidative DNA damage. Free Rad. Res. 32: 333-341.
15. ESCODD (2002) Inter-laboratory validation of procedures for measuring 8-oxo-7,8-dihydroguanine/8-oxo-7,8-dihydro-2′-deoxyguanosine in DNA. Free Rad. Res. 36: 239-245.
16. Gedik CM, Boyle SP, Wood SG, Vaughan NJ & Collins AR (2002) Oxidative stress in humans: validation of biomarkers of DNA damage. Carcinogenesis 23: 1441-1446.
17. Helbock HJ, Beckman KB, Shigenaga MK, Walter PB, Woodall AA, Yeo HC & Ames BN (1998) DNA oxidation matters: The HPLC-electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine. Proc. Nat. Acad. Sci. 95: 288-293.
18. Hennekens CH, Buring JE, Manson J, Stampfer M, Rosner B, Cook NR, Belanger C, LaMotte F, Gaziano JM, Ridker PM, Willett W & Peto R (1996) Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. New Engl. J. Med. 334: 1145-1149.
19. Hofer T & Möller L (1998) Reduction of oxidation during the preparation of DNA and analysis of 8-hydroxy-2′-deoxyguanosine. Chem. Res. Toxicol. 11: 882-887.
20. Lowe GM, Booth LA, Young AJ & Bilton RF (1999) Lycopene and b-carotene protect against oxidative damage in HT29 cells at low concentrations but rapidly lose this capacity at higher doses. Free Rad. Res. 30: 141-151.
21. Mitchell JH & Collins AR (1999) Effects of a soy milk supplement on plasma cholesterol levels and oxidative DNA damage in men - A pilot study. Europ. J. Nutrit. 38: 143-148.
22. Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, Keogh JP, Meyskens FL, Valanis B, Williams JH, Barnhart S & Hammar S (1996) Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. New Engl. J. Med. 334: 1150-1155.
23. Panayiotidis M & Collins AR (1997) Ex vivo assessment of lymphocyte antioxidant status using the comet assay. Free Rad. Res. 27: 533-537.
24. Pool-Zobel BL, Bub A, Muller H, Wollowski I & Rechkemmer G (1997) Consumption of vegetables reduces genetic damage in humans: first results of a human intervention trial with carotenoid-rich foods. Carcinogenesis 18: 1847-1850.
25. Ravanat J-L, Turesky RJ, Gremaud E, Trudel LJ & Stadler RH (1995) Determination of 8-oxoguanine in DNA by gas chromatography-mass spectrometry and HPLC-electrochemical detection: Overestimation of the background level of the oxidized base by the gas chromatography-mass spectrometry assay. Chem. Res. Toxicol. 8: 1039-1045.
26. Riis B & ESCODD (2002). Comparison of results from different laboratories in measuring 8-oxo-2′deoxyguanosine in synthetic ologonucleotides. Free Rad. Res. 36: 649-659.
27. Sierens J, Hartley JA, Campbell MJ, Leathem AJC & Woodside JV (2001) Effect of phytoestrogen and antioxidant supplementation on oxidtive DNA damage assessed using the comet assay. Mut. Res. 485: 169-176.
28. Toma S, Albanese E, Palumbo R, Nicolo G, Morerio C, Mangiante PE, Bonatti S, Cancedda R & Santi L (1991) In vitro effects of b-carotene on human oral keratinocytes from precancerous lesions and squamous carcinoma. Anti-Cancer Drugs 2: 581-589.
29. Tomasetti M, Alleva R, Borghi B & Collins AR (2001) In vivo supplementation with coenzyme Q10 enhances the recovery of human lymphocytes from oxidative DNA damage. FASEB J. 10.1096/fj.00-0694fje.
30. Torbergsen AC & Collins AR (2000) Recovery of human lymphocytes from oxidative DNA damage; the apparent enhancement of DNA repair by carotenoids is probably simply an antioxidant effect. Europ. J. Nutrit. 39: 80-85.
31. WCRF/AICR (1997) Food, Nutrition and the Prevention of Cancer: A Global Perspective. WCRF/AICR, Washington, DC.
32. Zhang Y & Talalay P (1994) Anticarcinogenic activities of organic isothiocyanates: Chemistry and mechanisms. Cancer Res. 54 (suppl): 1976s-1981s.