The D-domain of Sp3 modulates its protein levels and activation of the p21CIP1/WAF1 promoter

Biochemical and Biophysical Research Communications

Volumn 335, Issue 2, 2005, Pages 377-384

  Hammill, Deborah ^a   Jain, Nidhi ^a   Armstrong, Susan ^a   Mueller, Christopher R ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

Cyclin dependent kinase inhibitor; Differentiation; Growth arrest; p21CIP1 WAF1; Protein; Regulation; Sp1; Sp3; Transcription; Zinc finger

Indexed keywords

BUTYRIC ACID; CYCLIN DEPENDENT KINASE INHIBITOR 1; TRANSCRIPTION FACTOR SP1; TRANSCRIPTION FACTOR SP3;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CYCLE; CELL STRAIN HEPG2; CONTROLLED STUDY; GROWTH DISORDER; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INDUCTION;

AMINO ACID SEQUENCE; BASE SEQUENCE; BINDING SITES; BLOTTING, WESTERN; CELL CYCLE PROTEINS; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; CLONING, MOLECULAR; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA-BINDING PROTEINS; GENE DELETION; GENE EXPRESSION REGULATION; HUMANS; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; MUTATION; PLASMIDS; PROMOTER REGIONS (GENETICS); PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SP1 TRANSCRIPTION FACTOR; SP3 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; ZINC FINGERS;

EID: 23744497181     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.07.084     Document Type: Article

References (45)

1. W.S. el-Deiry, T. Tokino, V.E. Velculescu, D.B. Levy, R. Parsons, J.M. Trent, D. Lin, W.E. Mercer, K.W. Kinzler, and B. Vogelstein WAF1, a potential mediator of p53 tumor suppression Cell 75 1993 817 825
2. M.B. Datto, Y. Yu, and X.F. Wang Functional analysis of the transforming growth factor beta responsive elements in the WAF1/Cip1/p21 promoter J. Biol. Chem. 270 1995 28623 28628
3. G.Z. Yan, and E.B. Ziff Nerve growth factor induces transcription of the p21 WAF1/CIP1 and cyclin D1 genes in PC12 cells by activating the Sp1 transcription factor J. Neurosci. 17 1997 6122 6132
4. S.K. Moon, S.Y. Jung, Y.H. Choi, Y.C. Lee, and C.H. Kim Platelet-derived growth factor induces p21/WAF1 promoter in vascular smooth muscle cells via activation of an Sp1 site FEBS Lett. 552 2003 130 134
5. Y.X. Zeng, and W.S. el-Deiry Regulation of p21WAF1/CIP1 expression by p53-independent pathways Oncogene 12 1996 1557 1564
6. H. Xiao, T. Hasegawa, and K. Isobe Both Sp1 and Sp3 are responsible for p21waf1 promoter activity induced by histone deacetylase inhibitor in NIH3T3 cells J. Cell. Biochem. 73 1999 291 302
7. K. Nakano, T. Mizuno, Y. Sowa, T. Orita, T. Yoshino, Y. Okuyama, T. Fujita, N. Ohtani-Fujita, Y. Matsukawa, T. Tokino, H. Yamagishi, T. Oka, H. Nomura, and T. Sakai Butyrate activates the WAF1/Cip1 gene promoter through Sp1 sites in a p53-negative human colon cancer cell line J. Biol. Chem. 272 1997 22199 22206
8. J.R. Biggs, J.E. Kudlow, and A.S. Kraft The role of the transcription factor Sp1 in regulating the expression of the WAF1/CIP1 gene in U937 leukemic cells J. Biol. Chem. 271 1996 901 906
9. G.I. Owen, J.K. Richer, L. Tung, G. Takimoto, and K.B. Horwitz Progesterone regulates transcription of the p21(WAF1) cyclin-dependent kinase inhibitor gene through Sp1 and CBP/p300 J. Biol. Chem. 273 1998 10696 10701
10. H. Xiao, T. Hasegawa, and K. Isobe p300 collaborates with Sp1 and Sp3 in p21(waf1/cip1) promoter activation induced by histone deacetylase inhibitor J. Biol. Chem. 275 2000 1371 1376
11. N. Billon, D. Carlisi, M.B. Datto, L.A. van Grunsven, A. Watt, X.F. Wang, and B.B. Rudkin Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation Oncogene 18 1999 2872 2882
12. K. Pardali, A. Kurisaki, A. Moren, P. Dijke, D. Kardassis, and A. Moustakas Role of Smad proteins and transcription factor Sp1 in p21WAF-1/Cip-1 regulation by transforming growth factor-beta J. Biol. Chem. 275 2000 29244 29256
13. D.M. Prowse, L. Bolgan, A. Molnar, and G.P. Dotto Involvement of the Sp3 transcription factor in induction of p21Cip1/WAF1 in keratinocyte differentiation J. Biol. Chem. 272 1997 1308 1314
14. Y. Sowa, T. Orita, S. Minamikawa-Hiranabe, T. Mizuno, H. Nomura, and T. Sakai Sp3, but not Sp1, mediates the transcriptional activation of the p21/WAF1/Cip1 gene promoter by histone deacetylase inhibitor Cancer Res. 59 1999 4266 4270
15. A.L. Gartel, E. Goufman, F. Najmabadi, and A.L. Tyner Sp1 and Sp3 activate p21 (WAF1/CIP1) gene transcription in the Caco-2 colon adenocarcinoma cell line Oncogene 19 2000 5182 5188
16. M. Marin, A. Karis, P. Visser, F. Grosveld, and S. Philipsen Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation Cell 89 1997 619 628
17. P. Bouwman, H. Gollner, H.P. Elsasser, G. Eckhoff, A. Karis, F. Grosveld, S. Philipsen, and G. Suske Transcription factor Sp3 is essential for post-natal survival and late tooth development EMBO J. 19 2000 655 661
18. P.F. Van Loo, P. Bouwman, K.W. Ling, S. Middendorp, G. Suske, F. Grosveld, E. Dzierzak, S. Philipsen, and R.W. Hendriks Impaired hematopoiesis in mice lacking the transcription factor Sp3 Blood 102 2003 858 866
19. G. Hagen, S. Muller, M. Beato, and G. Suske Sp1-mediated transcriptional activation is repressed by Sp3 EMBO J. 13 1994 3843 3851
20. L. Li, S. He, J.M. Sun, and J.R. Davie Gene regulation by Sp1 and Sp3 Biochem. Cell Biol. 82 2004 460 471
21. A.J. Courey, and R. Tjian Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motif Cell 44 1988 887 898
22. G. Gill, E. Pascal, Z.H. Tseng, and R. Tjian A glutamine-rich hydrophobic patch in transcription factor Sp1 contacts the dTAFII110 component of the Drosophila TFIID complex and mediates transcriptional activation Proc. Natl. Acad. Sci. USA 91 1994 192 196
23. J.T. Kadonaga, A.J. Courey, J. Ladika, and R. Tjian Distinct regions of Sp1 modulate DNA binding and transcriptional activation Science 242 1988 1566 1570
24. K. Matsushita, M. Hagihara, and Y. Sugiura Participation of oligomerization through C-terminal D domain region of Sp1 in DNA binding Biol. Pharm. Bull. 21 1998 1094 1097
25. E. Pascal, and R. Tjian Different activation domains of Sp1 govern formation of multimers and mediate transcriptional synergism Genes Dev. 5 1991 1646 1656
26. J.S. Lee, K.M. Galvin, and Y. Shi Evidence for physical interaction between the zinc-finger transcription factors YY1 and Sp1 Proc. Natl. Acad. Sci. USA 90 1993 6145 6149
27. J. Karlseder, H. Rotheneder, and E. Wintersberger Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F Mol. Cell. Biol. 16 1996 1659 1667
28. M. Merika, and S.H. Orkin Functional synergy and physical interactions of the erythroid transcription factor GATA-1 with the Kruppel family proteins Sp1 and EKLF Mol. Cell. Biol. 15 1995 2437 2447
29. A. Doetzlhofer, H. Rotheneder, G. Lagger, M. Koranda, V. Kurtev, G. Brosch, E. Wintersberger, and C. Seiser Histone deacetylase 1 can repress transcription by binding to Sp1 Mol. Cell. Biol. 19 1999 5504 5511
30. J.A. Lee, D.C. Suh, J.E. Kang, M.H. Kim, H. Park, M.N. Lee, J.M. Kim, H.E. Roh, B.N. Jeon, M.Y. Yu, K.Y. Choi, K.Y. Kim, and M.W. Hur The transcriptional activity of Sp1 is regulated by molecular interactions between the zinc finger DNA binding domain and the inhibitory domain with corepressors, and this interaction is modulated by MEK J. Biol. Chem. 280 2005 28061 28071
31. R.W. Leggett, S.A. Armstrong, D. Barry, and C.R. Mueller Sp1 is phosphorylated and its DNA binding activity down-regulated upon terminal differentiation of the liver J. Biol. Chem. 270 1995 25879 25884
32. S.A. Armstrong, D.A. Barry, R.W. Leggett, and C.R. Mueller Casein kinase II-mediated phosphorylation of the C terminus of Sp1 decreases its DNA binding activity J. Biol. Chem. 272 1997 13489 13495
33. Q. Zhu, and K. Liao Differential expression of the adipocyte amino acid transporter is transactivated by SP1 and SP3 during the 3T3-L1 preadipocyte differentiation process Biochem. Biophys. Res. Commun. 271 2000 100 106
34. M.J. Birnbaum, A.J. van Wijnen, P.R. Odgren, T.J. Last, G. Suske, G.S. Stein, and J.L. Stein Sp1 trans-activation of cell cycle regulated promoters is selectively repressed by Sp3 Biochemistry 34 1995 16503 16508
35. D. Kardassis, P. Papakosta, K. Pardali, and A. Moustakas c-Jun transactivates the promoter of the human p21(WAF1/Cip1) gene by acting as a superactivator of the ubiquitous transcription factor Sp1 J. Biol. Chem. 274 1999 29572 29581
36. C.H. Wang, Y.P. Tsao, H.J. Chen, H.L. Chen, H.W. Wang, and S.L. Chen Transcriptional repression of p21(Waf1/Cip1/Sdi1) gene by c-jun through Sp1 site Biochem. Biophys. Res. Commun. 270 2000 303 310
37. J. Dennig, M. Beato, and G. Suske An inhibitor domain in Sp3 regulates its glutamine-rich activation domains EMBO J. 15 1996 5659 5667
38. H. Braun, R. Koop, A. Ertmer, S. Nacht, and G. Suske Transcription factor Sp3 is regulated by acetylation Nucleic Acids Res. 29 2001 4994 5000
39. C. Missero, E. Calautti, R. Eckner, J. Chin, L.H. Tsai, D.M. Livingston, and G.P. Dotto Involvement of the cell-cycle inhibitor Cip1/WAF1 and the E1A- associated p300 protein in terminal differentiation Proc. Natl. Acad. Sci. USA 92 1995 5451 5455
40. A. Sapetschnig, G. Rischitor, H. Braun, A. Doll, M. Schergaut, F. Melchior, and G. Suske Transcription factor Sp3 is silenced through SUMO modification by PIAS1 EMBO J. 21 2002 5206 5215
41. S. Ross, J.L. Best, L.I. Zon, and G. Gill SUMO-1 modification represses Sp3 transcriptional activation and modulates its subnuclear localization Mol. Cell 10 2002 831 842
42. C. Fandos, M. Sanchez-Feutrie, T. Santalucia, F. Vinals, J. Cadefau, A. Guma, R. Cusso, P. Kaliman, J. Canicio, M. Palacin, and A. Zorzano GLUT1 glucose transporter gene transcription is repressed by Sp3. Evidence for a regulatory role of Sp3 during myogenesis J. Mol. Biol. 294 1999 103 119
43. A. Pagliuca, P. Gallo, and L. Lania Differential role for Sp1/Sp3 transcription factors in the regulation of the promoter activity of multiple cyclin-dependent kinase inhibitor genes J. Cell Biochem. 76 2000 360 367
44. M. Hou, X. Wang, N. Popov, A. Zhang, X. Zhao, R. Zhou, A. Zetterberg, M. Bjorkholm, M. Henriksson, A. Gruber, and D. Xu The histone deacetylase inhibitor trichostatin A derepresses the telomerase reverse transcriptase (hTERT) gene in human cells Exp. Cell Res. 274 2002 25 34
45. K. Su, X. Yang, M.D. Roos, A.J. Paterson, and J.E. Kudlow Human Sug1/p45 is involved in the proteasome-dependent degradation of Sp1 Biochem. J. 348 2000 281 289