-
1
-
-
0029129057
-
Drug safety discontinuations in the United Kingdom, the United States, and Spain from 1974 through 1993: A regulatory perspective
-
Bakke OM, Manocchia M, de Abajo F, Kaitin KI and Lasagna L (1995) Drug safety discontinuations in the United Kingdom, the United States, and Spain from 1974 through 1993: A regulatory perspective. Clin Pharmacol Ther 58:108-117.
-
(1995)
Clin Pharmacol Ther
, vol.58
, pp. 108-117
-
-
Bakke, O.M.1
Manocchia, M.2
De Abajo, F.3
Kaitin, K.I.4
Lasagna, L.5
-
2
-
-
0021180058
-
Drug discontinuations in the United Kingdom and the United States, 1964 to 1983: Issues of safety
-
Bakke OM, Wardell WM and Lasagna L (1984) Drug discontinuations in the United Kingdom and the United States, 1964 to 1983: Issues of safety. Clin Pharmacol Ther 35:559-567.
-
(1984)
Clin Pharmacol Ther
, vol.35
, pp. 559-567
-
-
Bakke, O.M.1
Wardell, W.M.2
Lasagna, L.3
-
3
-
-
0017184389
-
A rapid sensitive method for the quanlitation of microgram quantities of protein utilizing the principle of protein-dye binding
-
Bradford MM (1976) A rapid sensitive method for the quanlitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
-
(1976)
Anal Biochem
, vol.72
, pp. 248-254
-
-
Bradford, M.M.1
-
4
-
-
0017800711
-
Disposition and metabolism of benoxaprofen in laboratory animals and man
-
Chatfield DH and Green JN (1978) Disposition and metabolism of benoxaprofen in laboratory animals and man. Xenobiotica 8:133-144.
-
(1978)
Xenobiotica
, vol.8
, pp. 133-144
-
-
Chatfield, D.H.1
Green, J.N.2
-
5
-
-
0020368013
-
Pharmacology, clinical efficacy, and adverse effects of the nonsteroidal anti-inflammatory agent benoxaprofen
-
Dahl SL and Ward JR (1982) Pharmacology, clinical efficacy, and adverse effects of the nonsteroidal anti-inflammatory agent benoxaprofen. Pharmacotherapy 2:354-366.
-
(1982)
Pharmacotherapy
, vol.2
, pp. 354-366
-
-
Dahl, S.L.1
Ward, J.R.2
-
6
-
-
0003677191
-
The biological function of glucuronidation
-
(Dutton GJ ed), CRC Press, Boca Raton
-
Dutton GJ (1980) The biological function of glucuronidation, in Glucuronidation of Drugs and Other Compounds (Dutton GJ ed) pp 3-12, CRC Press, Boca Raton.
-
(1980)
Glucuronidation of Drugs and Other Compounds
, pp. 3-12
-
-
Dutton, G.J.1
-
7
-
-
0021707968
-
Properties of acyl glucuronides: Implications for studies of the pharmacokinetics and metabolism of acidic drugs
-
Faed EM (1984) Properties of acyl glucuronides: Implications for studies of the pharmacokinetics and metabolism of acidic drugs. Drug Metab Rev 15:1213-1249.
-
(1984)
Drug Metab Rev
, vol.15
, pp. 1213-1249
-
-
Faed, E.M.1
-
8
-
-
0026051767
-
Drug metabolizing enzyme induction by simple diaryl pyridines; 2-substituted isomers selectively increase only conjugation enzyme activities, 4-substituted isomers also induce cytochrome P450
-
Franklin MR (1991) Drug metabolizing enzyme induction by simple diaryl pyridines; 2-substituted isomers selectively increase only conjugation enzyme activities, 4-substituted isomers also induce cytochrome P450. Toxicol Appl Pharmacol 111:24-32.
-
(1991)
Toxicol Appl Pharmacol
, vol.111
, pp. 24-32
-
-
Franklin, M.R.1
-
9
-
-
0027414970
-
Selective induction of rat liver phase II enzymes by N-heterocycle analogues of phenanthrene: A response exhibiting high correlation between UDP-glucuronosyltransferases and microsomal epoxide hydrolase activities
-
Franklin MR, Slawson MH and Moody DE (1993) Selective induction of rat liver phase II enzymes by N-heterocycle analogues of phenanthrene: A response exhibiting high correlation between UDP-glucuronosyltransferases and microsomal epoxide hydrolase activities. Xenobiotica 23:267-277.
-
(1993)
Xenobiotica
, vol.23
, pp. 267-277
-
-
Franklin, M.R.1
Slawson, M.H.2
Moody, D.E.3
-
10
-
-
0016915142
-
Bile and urine as complementary pathways for the excretion of foreign compounds
-
Hirom PC, Millburn P and Smith RL (1976) Bile and urine as complementary pathways for the excretion of foreign compounds. Xenobiotica 6:55-64.
-
(1976)
Xenobiotica
, vol.6
, pp. 55-64
-
-
Hirom, P.C.1
Millburn, P.2
Smith, R.L.3
-
11
-
-
0027433317
-
Complementary deoxyribonucleic acid cloning and expression of a human liver uridine diphosphate-glucuronosyltransferase glucuronidating carboxylic acid-containing drugs
-
Jin C, Miners JO, Lillywhite KJ and Mackenzie PI (1993) Complementary deoxyribonucleic acid cloning and expression of a human liver uridine diphosphate-glucuronosyltransferase glucuronidating carboxylic acid-containing drugs. J Pharmacol Exp Ther 274:475-479.
-
(1993)
J Pharmacol Exp Ther
, vol.274
, pp. 475-479
-
-
Jin, C.1
Miners, J.O.2
Lillywhite, K.J.3
Mackenzie, P.I.4
-
12
-
-
0027502617
-
Studies on the reactivity of acyl glucuronides - IV. Covalent binding of diflunisal to tissues of the rat
-
King AR and Dickinson RG (1993) Studies on the reactivity of acyl glucuronides - IV. Covalent binding of diflunisal to tissues of the rat. Biochem Pharmacol 45:1043-1047.
-
(1993)
Biochem Pharmacol
, vol.45
, pp. 1043-1047
-
-
King, A.R.1
Dickinson, R.G.2
-
13
-
-
0022494453
-
Hydroxylation of p-nitrophenol by rabbit ethanol-inducible cytochrome P-450 isozyme 3a
-
Koop D (1986) Hydroxylation of p-nitrophenol by rabbit ethanol-inducible cytochrome P-450 isozyme 3a. Mol Pharmacol 29:399-404.
-
(1986)
Mol Pharmacol
, vol.29
, pp. 399-404
-
-
Koop, D.1
-
14
-
-
0031567152
-
Selective induction of phase II drug metabolizing enzyme activities by quinolines and isoquinolines
-
Le HT and Franklin MR (1997) Selective induction of phase II drug metabolizing enzyme activities by quinolines and isoquinolines. Chem-Biol Interact 103:167-178.
-
(1997)
Chem-Biol Interact
, vol.103
, pp. 167-178
-
-
Le, H.T.1
Franklin, M.R.2
-
15
-
-
0026008585
-
Role of cytochrome P450 1A2 in acetanilide 4-hydroxylation as determined with cDNA expression and monoclonal antibodies
-
Liu G, Gelboin HV and Myers MJ (1991) Role of cytochrome P450 1A2 in acetanilide 4-hydroxylation as determined with cDNA expression and monoclonal antibodies. Arch Biochem Biophys 284:400-406.
-
(1991)
Arch Biochem Biophys
, vol.284
, pp. 400-406
-
-
Liu, G.1
Gelboin, H.V.2
Myers, M.J.3
-
16
-
-
0031953577
-
Stereoselective metabolism of benoxaprofen in rats. Biliary excretion of benoxaprofen taurine conjugate and glucuronide
-
Mohri K, Okada K and Benet LZ (1997) Stereoselective metabolism of benoxaprofen in rats. Biliary excretion of benoxaprofen taurine conjugate and glucuronide. Drug Metab Dispos 26:332-337.
-
(1997)
Drug Metab Dispos
, vol.26
, pp. 332-337
-
-
Mohri, K.1
Okada, K.2
Benet, L.Z.3
-
17
-
-
77049138167
-
The colorimetric estimation of formaldehyde by means of the hantzsch reaction
-
Nash T (1953) The colorimetric estimation of formaldehyde by means of the hantzsch reaction. Biochem J 55:416-421.
-
(1953)
Biochem J
, vol.55
, pp. 416-421
-
-
Nash, T.1
-
18
-
-
0031760270
-
Diclofenac acyl glucuronide, a major biliary metabolite, is directly involved in small intestinal injury in rats
-
Seitz S and Boelsterli UA (1998) Diclofenac acyl glucuronide, a major biliary metabolite, is directly involved in small intestinal injury in rats. Gastroenterology 115:1476-1482.
-
(1998)
Gastroenterology
, vol.115
, pp. 1476-1482
-
-
Seitz, S.1
Boelsterli, U.A.2
-
19
-
-
0022477143
-
Irreversible binding of zomepirac to plasma protein in vitro and in vivo
-
Smith PC, McDonagh AF and Benet LZ (1986) Irreversible binding of zomepirac to plasma protein in vitro and in vivo. J Clin Invest 77:934-939.
-
(1986)
J Clin Invest
, vol.77
, pp. 934-939
-
-
Smith, P.C.1
McDonagh, A.F.2
Benet, L.Z.3
-
20
-
-
0003482908
-
Implication of the conjugation of drugs and other exogenous compounds
-
(Dutton GJ ed), Academic Press, New York
-
Smith RL and Williams RT (1966) Implication of the conjugation of drugs and other exogenous compounds, in Glucuronic Acid Free and Combined. Chemistry, Biochemistry, Pharmacology, and Medicine (Dutton GJ ed) pp 457-491, Academic Press, New York.
-
(1966)
Glucuronic Acid Free and Combined. Chemistry, Biochemistry, Pharmacology, and Medicine
, pp. 457-491
-
-
Smith, R.L.1
Williams, R.T.2
-
21
-
-
0024554315
-
Procedures to characterize in vivo and in vitro enantioselective glucuronidation properly: Studies with benoxaprofen glucuronides
-
Spann H, Iwakawa S, Lin ET and Benet LZ (1989) Procedures to characterize in vivo and in vitro enantioselective glucuronidation properly: Studies with benoxaprofen glucuronides. Pharm Res 6:125-132.
-
(1989)
Pharm Res
, vol.6
, pp. 125-132
-
-
Spann, H.1
Iwakawa, S.2
Lin, E.T.3
Benet, L.Z.4
-
22
-
-
0026532030
-
Acyl glucuronides revisited: Is the glucuronidation process a toxification as well as a detoxification mechanism?
-
Spahn-Langguth H and Benet LZ (1992) Acyl glucuronides revisited: Is the glucuronidation process a toxification as well as a detoxification mechanism? Drug Metab Rev 24:5-47.
-
(1992)
Drug Metab Rev
, vol.24
, pp. 5-47
-
-
Spahn-Langguth, H.1
Benet, L.Z.2
-
23
-
-
0027456389
-
Microsomal acyl glucuronidation: Enzyme-kinetic studies with labile glucuronides
-
Spahn-Langguth H and Benet LZ (1993) Microsomal acyl glucuronidation: Enzyme-kinetic studies with labile glucuronides. Pharmacology 46:268-273.
-
(1993)
Pharmacology
, vol.46
, pp. 268-273
-
-
Spahn-Langguth, H.1
Benet, L.Z.2
-
24
-
-
0021847237
-
Acylation of albumin by 1-O-acyl glucuronides
-
Van Breemen RB and Fenselau C (1985) Acylation of albumin by 1-O-acyl glucuronides. Drug Metab Dispos 13:318-320.
-
(1985)
Drug Metab Dispos
, vol.13
, pp. 318-320
-
-
Van Breemen, R.B.1
Fenselau, C.2
-
25
-
-
0031890965
-
Phase II-selective induction of hepatic drugmetabolizing enzymes by oltipraz [5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione], 1,7-phenanthroline, and 2,2'-dipyridyl in rats is not accompanied by induction of intestinal enzymes
-
Vargas M, Lamb JG and Franklin MR (1997) Phase II-selective induction of hepatic drugmetabolizing enzymes by oltipraz [5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione], 1,7-phenanthroline, and 2,2'-dipyridyl in rats is not accompanied by induction of intestinal enzymes. Drug Metab Dispos 26:91-97.
-
(1997)
Drug Metab Dispos
, vol.26
, pp. 91-97
-
-
Vargas, M.1
Lamb, J.G.2
Franklin, M.R.3
-
26
-
-
0022494396
-
Developmental alterations in hepatic UDP-glucuronozyltransferase. A comparison of the kinetic properties of enzymes from adult sheep and fetal lambs
-
Wang LH, Zakim D, Rudolph AM and Benet LZ (1986) Developmental alterations in hepatic UDP-glucuronozyltransferase. A comparison of the kinetic properties of enzymes from adult sheep and fetal lambs. Biochem Pharmacol 35:3065-3070.
-
(1986)
Biochem Pharmacol
, vol.35
, pp. 3065-3070
-
-
Wang, L.H.1
Zakim, D.2
Rudolph, A.M.3
Benet, L.Z.4
|