Mitochondrial calcium signaling and energy metabolism

Annals of the New York Academy of Sciences

Volumn 1047, Issue , 2005, Pages 127-137

  Nguyen, My Hanh T ^a   Jafri, M Saleet ^a,b  

^a GEORGE MASON UNIVERSITY   (United States)

^b UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE   (United States)

Author keywords

Calcium; Computational model; Energy metabolism; Mitochondria

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM ION; CARRIER PROTEIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; SODIUM CALCIUM EXCHANGE PROTEIN;

ANIMAL CELL; CALCIUM SIGNALING; CALCIUM TRANSPORT; CITRIC ACID CYCLE; CONFERENCE PAPER; ENERGY METABOLISM; GUINEA PIG; HEART MITOCHONDRION; HEART PACING; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; MUSCLE FIBRIL; NONHUMAN; STEADY STATE;

CAVIA PORCELLUS; MAMMALIA;

EID: 23744438352     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1341.012     Document Type: Conference Paper

References (26)

1. JAFRI, M.S., S.J. DUDYCHA & B. O'ROURKE. 2001. Cardiac energy metabolism: models of cellular respiration. Annu. Rev. Biomed. Eng. 3: 57-81.
2. CORTASSA, S., M.A. AON, E. MARBAN, et al. 2003. An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics. Biophys. J. 84: 2734-2755.
3. 2+ handling. Am. J. Physiol. 273: C717-C733.
4. MAGNUS, G. & J. KEIZER. 1998. Model of beta-cell mitochondrial calcium handling and electrical activity. II. Mitochondrial variables. Am. J. Physiol. 274: C1174-C1184.
5. MAGNUS, G. & J. KEIZER. 1998. Model of beta-cell mitochondrial calcium handling and electrical activity. J. Cytoplasmic variables. Am. J. Physiol. 274: C1158-C1173.
6. WINGROVE, D.E., J.M. AMATRUDA & T.E. GUNTER. 1984. Glucagon effects on the membrane potential and calcium uptake rate of rat liver mitochondria. J. Biol. Chem. 259: 9390-9394.
7. WAN, B., K.F. LANOUE, J.Y. CHEUNG & R.C. SCADUTO, JR. 1989. Regulation of citric acid cycle by calcium. J. Biol. Chem. 264: 13430-13439.
8. CHALMERS, S. & D.G. NICHOLLS. 2003. The relationship between free and total calcium concentrations in the matrix of liver and brain mitochondria. J. Biol. Chem. 278: 19062-19070.
9. BUNTINAS, L., K.K. GUNTER, G.C. SPARAGNA & T.E. GUNTER. 2001. The rapid mode of calcium uptake into heart mitochondria (RaM): comparison to RaM in liver mitochondria. Biochim. Biophys. Acta. 1504: 248-261.
10. 2+-indicating fluorophores. Biophys. J. 79: 39-50.
11. DUCHEN, M.R., A. LEYSSENS & M. CROPMPTON. 1998. Transient mitochondrial depolarizations reflect focal sarcoplasmic reticular calcium release in single rat cardiomyocytes. J. Cell Biol. 142: 975-988.
12. 2+ marks: miniature calcium signals in single mitochondria driven by ryanodine receptors. Proc. Natl. Acad. Sci. U.S.A. 99: 2380-2385.
13. KIRICHOK, Y., G. KRAPIVINSKY & D.E. CLAPMAN. 2004. The mitochondrial calcium uniporter is a highly selective ion channel. Nature 427: 360-364.
14. WINGROVE, D.E. & T.E. GUNTER. 1986. Kinetics of mitochondrial calcium transport. II. A kinetic description of the sodium-dependent calcium efflux mechanism of liver mitochondria and inhibition by ruthenium red and by tetraphenylphosphonium. J. Biol. Chem. 261: 15166-15171.
15. + exchanger. Am. J. Physiol. 266:C800-C808.
16. JUNG, D.W., K. BAYSAL & G.P. BRIERLEY. 1995. The sodium-calcium antiport of heart mitochondria is not electroneutral. J. Biol. Chem. 270: 672-678.
17. DUDYCHA, S. 2000. A detailed model of the tricarboxylic acid cycle in heart cells. Master's thesis, Johns Hopkins University.
18. 2+ can result in increases in NADH production. Biophys. J. 80: 589.
19. 2+ dynamics: the roles of ryanodine receptor adaptation and sarcoplasmic reticulum load. Biophys. J. 74: 1149-1168.
20. KAIM, G. & P. DIMROTH. 1999. ATP synthesis by F-type ATP synthase is obligatorily dependent on the transmembrane voltage. EMBO J. 18: 4118-4127.
21. 0-ATPase. J. Biol. Chem. 259: 4757-4763.
22. BALABAN, R.S., S. BOSE, S.A. FRENCH & P.R. TERRITO, et al. 2003. Role of calcium in metabolic signaling between cardiac sarcoplasmic reticulum. Am. J. Physiol. Cell Physiol. 278: C285-C293.
23. MURPHY, M. & M. BRAND. 1988. The stoichiometry of charge translocation by cytochrome oxidase and the cytochrome bcl complex of mitochondria at high membrane potential. Eur. J. Biochem. 173: 645-651.
24. 13C isotope isomers. Am. J. Physiol. 259: H987-H995.
25. SHERRY, A.D., P. ZHAO, A.J. WIETHOFF, et al. 1998. Effects of aminooxyacetate on glutamate compartmentation and TCA cycle kinetics in rat hearts. Am. J. Physiol. 274:H591-H599.
26. 13C NMR resonance of glutamate for measuring oxygen consumption in tissue. Am. J. Physiol. 277:E1111-E1121.