Microbubble-enhanced ultrasound exposure promotes uptake of methotrexate into synovial cells and enhanced antiinflammatory effects in the knees of rabbits with antigen-induced arthritis

Arthritis and Rheumatism

Volumn 52, Issue 8, 2005, Pages 2559-2566

  Nakaya, Hiroyuki ^a   Shimizu, Tominaga ^b   Isobe, Ken Ichi ^b   Tensho, Keiji ^b   Okabe, Takahiro ^b   Nakamura, Yukio ^b   Nawata, Masashi ^b   Yoshikawa, Hideki ^a   Takaoka, Kunio ^c   Wakitani, Shigeyuki ^b  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ECHO CONTRAST MEDIUM; FREUND ADJUVANT; FS 069; INTERLEUKIN 1BETA; MESSENGER RNA; METHOTREXATE; OVALBUMIN; RNA 18S;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG UPTAKE; FLUORESCENCE MICROSCOPY; HISTOPATHOLOGY; IMMUNOSUPPRESSIVE TREATMENT; KNEE ARTHRITIS; NONHUMAN; PRIORITY JOURNAL; RABBIT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYNOVIOCYTE; ULTRASOUND;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARTHRITIS, EXPERIMENTAL; INJECTIONS, INTRA-ARTICULAR; KNEE JOINT; METHOTREXATE; MICROBUBBLES; OSMOLAR CONCENTRATION; OVALBUMIN; RABBITS; SYNOVIAL MEMBRANE; ULTRASONICS;

EID: 23644462711     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.21154     Document Type: Article

References (27)

1. Hall GH, Jones BJ, Head AC, Jones VE. Intra-articular methotrexate: clinical and laboratory study in rheumatoid and psoriatic arthritis. Ann Rheum Dis 1978;37:351-6.
2. Marks JS, Stewart IM, Hunter JA. Intra-articular methotrexate in rheumatoid arthritis [letter]. Lancet 1976;2:857-8.
3. Franchi F, Seminara P, Codacci-Pisanelli G, Aronne T, Avella A, Bonomo L. Intra-articular methotrexate in the therapy of rheumatoid arthritis. Recenti Prog Med 1989;80:261-2.
4. Bertino JR, Goker E, Gorlick R, Li WW, Banerjee D. Resistance mechanisms to methotrexate in tumors [review]. Stem Cells 1996; 14:5-9.
5. Nakashima-Matsushita N, Homma T, Yu S, Matsuda T, Sunahara N, Nakamura T, et al. Selective expression of folate receptor β and its possible role in methotrexate transport in synovial macrophages from patients with rheumatoid arthritis. Arthritis Rheum 1999;42: 1609-16.
6. Ifergan I, Meller I, Issakov J, Assaraf YG. Reduced folate carrier protein expression in osteosarcoma: implications for the prediction of tumor chemosensitivity. Cancer 2003;98:1958-66.
7. Tachibana K, Uchida T, Ogawa K, Yamashita N, Tamura K. Induction of cell-membrane porosity by ultrasound [letter]. Lancet 1999;353:1409.
8. Kim HJ, Greenleaf JF, Kinnick RR, Bronk JT, Bolander ME. Ultrasound-mediated transfection of mammalian cells. Hum Gene Ther 1996;7:1339-46.
9. Ohta S, Suzuki K, Tachibana K, Yamada G. Microbubble-enhanced sonoporation: efficient gene transduction technique for chick embryos. Genesis 2003;37:91-101.
10. Hashiya N, Aoki M, Tachibana K, Taniyama Y, Yamasaki K, Hiraoka K, et al. Local delivery of E2F decoy oligodeoxynucleotides using ultrasound with microbubble agent (Optison) inhibits intimai hyperplasia after balloon injury in rat carotid artery model. Biochem Biophys Res Commun 2004;317:508-14.
11. Yamasaki K, Asai T, Shimizu M, Aoki M, Hashiya N, Sakonjo H, et al. Inhibition of NFκB activation using cis-element 'decoy' of NFκB binding site reduces neointimal formation in porcine balloon-injured coronary artery model. Gene Ther 2003;10:356-64.
12. Tachibana K, Tachibana S. The use of ultrasound for drug delivery [review]. Echocardiography 2001;18:323-8.
13. Kojima T, Mwale F, Yasuda T, Girard C, Poole AR, Laverty S. Early degradation of type IX and type II collagen with the onset of experimental inflammatory arthritis. Arthritis Rheum 2001;44: 120-7.
14. Sanchez-Pernaute O, Lopez-Armada MJ, Hernandez P, Palacios I, Navarro F, Martinez J, et al. Antifibroproliferative effect of tenidap in chronic antigen-induced arthritis. Arthritis Rheum 1997;40:2147-56.
15. Gibson UE, Heid CA, Williams PM. A novel method for real time quantitative RT-PCR. Genome Res 1996;6:995-1001.
16. Ward M, Wu J, Chiu JF. Experimental study of the effects of Optison concentration on sonoporation in vitro. Ultrasound Med Biol 2000;26:1169-75.
17. Hui SW. The application of electroporation to transfect hematopoietic cells and to deliver drugs and vaccines transcutaneously for cancer treatment [review]. Technol Cancer Res Treat 2002;1: 373-84.
18. Lin YC, Li M, Wu CC. Simulation and experimental demonstration of the electric field assisted electroporation microchip for in vitro gene delivery enhancement. Lab Chip 2004;4:104-8.
19. Weiss JM, Shivakumar R, Feller S, Li LH, Hanson A, Fogler WE, et al. Rapid, in vivo, evaluation of antiangiogenic and antineoplastic gene products by nonviral transfection of tumor cells. Cancer Gene Ther 2004;11:346-53.
20. Shimizu T, Nikaido T, Gomyo H, Yoshimura Y, Horiuchi A, Isobe K, et al. Electrochemotherapy for digital chondrosarcoma. J Orthop Sci 2003;8:248-51.
21. Abbing A, Blaschke UK, Grein S, Kretschmar M, Stark CM, Thies MJ, et al. Efficient intracellular delivery of a protein and a low molecular weight substance via recombinant polyomavirus-like particles. J Biol Chem 2004;279:27410-21.
22. Ochi T, Iwase R, Kimura T, Hirooka A, Masada K, Owaki H, et al. Effect of early synovectomy on the course of rheumatoid arthritis. J Rheumatol 1991;18:1794-8.
23. Hayem G, Domarle O, Thuong-Guyot M, Pocidalo JJ, Meyer O. Effects of methotrexate on the oxidative metabolism of cultured rabbit articular chondrocytes. J Rheumatol 2000;27:1117-20.
24. Neidel J, Sova L, Schroers B, Sintermann F, Manzke O, Bohlen H. It is effects of methotrexate on normal articular cartilage in vitro and in vivo. Ann Rheum Dis 1998;57:414-21.
25. Zhang ZJ, Huckle J, Francomano CA, Spencer RG. The effects of pulsed low-intensity ultrasound on chondrocyte viability, proliferation, gene expression and matrix production. Ultrasound Med Biol 2003;29:1645-51.
26. Zhang ZJ, Huckle J, Francomano CA, Spencer RG. The influence of pulsed low-intensity ultrasound on matrix production of chondrocytes at different stages of differentiation: an explant study [published erratum appears in Ultrasound Med Biol 2003;29: 1223]. Ultrasound Med Biol 2002;28:1547-53.
27. Li T, Tachibana K, Kuroki M, Kuroki M. Gene transfer with echo-enhanced contrast agents: comparison between Albunex, Optison, and Levovist in mice: initial results. Radiology 2003;229:423-8.