-
1
-
-
78651010566
-
Temporary remissions in acute leukemia in children produced by folic acid antagonist. 4-aminopteroyl-glutamic acid (aminopterin)
-
Farber S, Diamond LK, Mercer RD et al. Temporary remissions in acute leukemia in children produced by folic acid antagonist. 4-aminopteroyl-glutamic acid (aminopterin). N Engl J Med 1948;238:787-793.
-
(1948)
N Engl J Med
, vol.238
, pp. 787-793
-
-
Farber, S.1
Diamond, L.K.2
Mercer, R.D.3
-
2
-
-
77049268597
-
Effect of methotrexate therapy upon choriocarcinoma and chorioadenoma
-
Li MC, Hertz R, Spencer DB. Effect of methotrexate therapy upon choriocarcinoma and chorioadenoma. Proc Soc Exp Biol Med 1956;93:361-366.
-
(1956)
Proc Soc Exp Biol Med
, vol.93
, pp. 361-366
-
-
Li, M.C.1
Hertz, R.2
Spencer, D.B.3
-
3
-
-
0002231530
-
Antifolates
-
Chabner BA, Collins JM, eds. Philadelphia: JB Lippincott
-
Allegra CJ, Antifolates. In: Chabner BA, Collins JM, eds. Cancer Chemotherapy: Principles and Practice. Philadelphia: JB Lippincott, 1990:110-153.
-
(1990)
Cancer Chemotherapy: Principles and Practice
, pp. 110-153
-
-
Allegra, C.J.1
-
4
-
-
0027222801
-
Acquisition of resistance to antifolates caused by enhanced γ-glutamyl hydrolase activity
-
Rhee MS, Wang Y, Nair MG et al. Acquisition of resistance to antifolates caused by enhanced γ-glutamyl hydrolase activity. Cancer Res 1993;53:2227-2230.
-
(1993)
Cancer Res
, vol.53
, pp. 2227-2230
-
-
Rhee, M.S.1
Wang, Y.2
Nair, M.G.3
-
5
-
-
0025361947
-
Dihydrofolate reductase as a therapeutic target
-
Schweitzer BI, Dicker AP, Bertino JR. Dihydrofolate reductase as a therapeutic target. FASEB J 1990;4:2441-2452.
-
(1990)
FASEB J
, vol.4
, pp. 2441-2452
-
-
Schweitzer, B.I.1
Dicker, A.P.2
Bertino, J.R.3
-
7
-
-
0023471363
-
Determinants of resistance to antifolates: Biochemical phenotypes, their frequency of occurrence and circumvention
-
Sirotnak FM. Determinants of resistance to antifolates: biochemical phenotypes, their frequency of occurrence and circumvention. NCI Monographs 1986;5:27-35.
-
(1986)
NCI Monographs
, vol.5
, pp. 27-35
-
-
Sirotnak, F.M.1
-
8
-
-
0027982786
-
A novel cDNA restores reduced folate carrier activity and methotrexate sensitivity to transport deficient cells
-
Dixon KH, Lanpher BC, Chiu J et al. A novel cDNA restores reduced folate carrier activity and methotrexate sensitivity to transport deficient cells. J Biol Chem 1994;269:17-20.
-
(1994)
J Biol Chem
, vol.269
, pp. 17-20
-
-
Dixon, K.H.1
Lanpher, B.C.2
Chiu, J.3
-
9
-
-
0027963626
-
Isolation of a hamster cDNA clone coding for a function involved in methotrexate uptake
-
Williams FMR, Murray RC, Underhill TM et al. Isolation of a hamster cDNA clone coding for a function involved in methotrexate uptake. J Biol Chem 1994;269:5810-5816.
-
(1994)
J Biol Chem
, vol.269
, pp. 5810-5816
-
-
Williams, F.M.R.1
Murray, R.C.2
Underhill, T.M.3
-
10
-
-
0026675617
-
Defective transport as a mechanism of acquired resistance to methotrexate in patients with acute leukemia
-
Trippett T, Schlemmer S, Elisseyeff Y et al. Defective transport as a mechanism of acquired resistance to methotrexate in patients with acute leukemia. Blood 1992;80:1158-1162.
-
(1992)
Blood
, vol.80
, pp. 1158-1162
-
-
Trippett, T.1
Schlemmer, S.2
Elisseyeff, Y.3
-
11
-
-
0026573504
-
Mechanisms of natural and acquired resistance to antifolates in human soft tissue sarcomas
-
Li WW, Lin JT, Tong WP et al. Mechanisms of natural and acquired resistance to antifolates in human soft tissue sarcomas. Cancer Res 1992;52:1434-1438.
-
(1992)
Cancer Res
, vol.52
, pp. 1434-1438
-
-
Li, W.W.1
Lin, J.T.2
Tong, W.P.3
-
12
-
-
0026342183
-
Basis for natural resistance to methotrexate in human acute non-lymphoblastic leukemia
-
Lin JT, Tong WP, Trippett TM et al. Basis for natural resistance to methotrexate in human acute non-lymphoblastic leukemia. Leukemia Res 1991;15:1191-1196.
-
(1991)
Leukemia Res
, vol.15
, pp. 1191-1196
-
-
Lin, J.T.1
Tong, W.P.2
Trippett, T.M.3
-
13
-
-
0028925157
-
Acute monocytic leukemia: A myeloid subset that may be sensitive to methotrexate
-
Göker E, Kheradpour A, Waltham M et al. Acute monocytic leukemia: a myeloid subset that may be sensitive to methotrexate. Leukemia 1995;9:274-276.
-
(1995)
Leukemia
, vol.9
, pp. 274-276
-
-
Göker, E.1
Kheradpour, A.2
Waltham, M.3
-
14
-
-
0027317529
-
Decreased polyglutamylation of methotrexate in acute lymphoblastic leukemia in adults as compared to children with this disease
-
Göker E, Lin JT, Trippett TM et al. Decreased polyglutamylation of methotrexate in acute lymphoblastic leukemia in adults as compared to children with this disease. Leukemia 1993;7:1000-1004.
-
(1993)
Leukemia
, vol.7
, pp. 1000-1004
-
-
Göker, E.1
Lin, J.T.2
Trippett, T.M.3
-
15
-
-
9044244944
-
A polymerase chain reaction (PCR) assay for folylpolyglutamate synthetase (FPGS) gene expression: Marked variation in human leukemia blast samples
-
Lenz HJ, Schnieders B, Danenberg K et al. A polymerase chain reaction (PCR) assay for folylpolyglutamate synthetase (FPGS) gene expression: marked variation in human leukemia blast samples. Proc Am Soc Can Res 1993;34:504a.
-
(1993)
Proc Am Soc Can Res
, vol.34
-
-
Lenz, H.J.1
Schnieders, B.2
Danenberg, K.3
-
16
-
-
0023940788
-
Gene amplification in cultured cells
-
Schimke RT. Gene amplification in cultured cells. J Biol Chem 1988;263:5989-5992.
-
(1988)
J Biol Chem
, vol.263
, pp. 5989-5992
-
-
Schimke, R.T.1
-
17
-
-
0029075026
-
Amplification of the dihydrofolate reductase gene is a mechanism of acquired resistance to methotrexate in patients with acute lymphoblastic leukemia and is correlated with p53 gene mutations
-
Göker E. Waltham M, Kheradpour A et al. Amplification of the dihydrofolate reductase gene is a mechanism of acquired resistance to methotrexate in patients with acute lymphoblastic leukemia and is correlated with p53 gene mutations. Blood 1995;86:677-684
-
(1995)
Blood
, vol.86
, pp. 677-684
-
-
Göker, E.1
Waltham, M.2
Kheradpour, A.3
-
18
-
-
0027438846
-
Translational regulation of the synthesis of dihydrofolate reductase
-
Ayling JE, Nair MG, Baugh CM, eds. New York: Plenum Press
-
Ercikan E, Banerjee D, Waltham M et al. Translational regulation of the synthesis of dihydrofolate reductase. In: Ayling JE, Nair MG, Baugh CM, eds. Chemistry and Biology of Pteridines and Folates Vol. 338. New York: Plenum Press. 1993:537-540.
-
(1993)
Chemistry and Biology of Pteridines and Folates
, vol.338
, pp. 537-540
-
-
Ercikan, E.1
Banerjee, D.2
Waltham, M.3
-
19
-
-
0027178264
-
Specific binding of human dihydrofolate reductase protein to dihydrofolate reductase messenger RNA in vitro
-
Chu E, Takimoto CH, Voeller D et al. Specific binding of human dihydrofolate reductase protein to dihydrofolate reductase messenger RNA in vitro. Biochemistry 1993;32:4756-4760.
-
(1993)
Biochemistry
, vol.32
, pp. 4756-4760
-
-
Chu, E.1
Takimoto, C.H.2
Voeller, D.3
-
20
-
-
17144366806
-
Absence of retinoblastoma protein mediates intrinsic resistance to antimetabolites in sarcoma cell lines
-
in press
-
Li WW, Fan JG, Zielenski Z et al. Absence of retinoblastoma protein mediates intrinsic resistance to antimetabolites in sarcoma cell lines. Proc Natl Acad Sci USA. (in press).
-
Proc Natl Acad Sci USA
-
-
Li, W.W.1
Fan, J.G.2
Zielenski, Z.3
-
21
-
-
0026801977
-
Wild type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles
-
Yin Y, Tainsky MA, Bischoff FZ et al. Wild type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell 1992;70:937-948.
-
(1992)
Cell
, vol.70
, pp. 937-948
-
-
Yin, Y.1
Tainsky, M.A.2
Bischoff, F.Z.3
-
22
-
-
0026801062
-
Altered cell cycle arrest and gene amplification potential accompany loss of wild type p53
-
Livingstone LR, White A, Sprouse J et al. Altered cell cycle arrest and gene amplification potential accompany loss of wild type p53. Cell 1992;70:923-936.
-
(1992)
Cell
, vol.70
, pp. 923-936
-
-
Livingstone, L.R.1
White, A.2
Sprouse, J.3
-
23
-
-
0023521422
-
Trimetrexate: A second generation folate antagonist in clinical trial
-
Lin JT, Bertino JR. Trimetrexate: a second generation folate antagonist in clinical trial. J Clin Oncol 1987;5:2032-2040.
-
(1987)
J Clin Oncol
, vol.5
, pp. 2032-2040
-
-
Lin, J.T.1
Bertino, J.R.2
-
24
-
-
0028800680
-
A phase II study of continuous infusion of trimetrexate in patients with refractory acute leukemia
-
Kheradpour A, Barman E, Göker E et al. A phase II study of continuous infusion of trimetrexate in patients with refractory acute leukemia. Cancer Invest 1995;13:36-40.
-
(1995)
Cancer Invest
, vol.13
, pp. 36-40
-
-
Kheradpour, A.1
Barman, E.2
Göker, E.3
-
25
-
-
0025006030
-
Phase II trial of trimetrexate in the treatment of recurrent childhood acute lymphoblastic leukemia: Pediatric Oncology Group Study
-
Pappo A, Dubowy R, Ravindranata Y et al. Phase II trial of trimetrexate in the treatment of recurrent childhood acute lymphoblastic leukemia: Pediatric Oncology Group Study. J Natl Cancer Inst 1990;82:1641-1642.
-
(1990)
J Natl Cancer Inst
, vol.82
, pp. 1641-1642
-
-
Pappo, A.1
Dubowy, R.2
Ravindranata, Y.3
-
26
-
-
0023242424
-
Trimetrexate for the treatment of pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome
-
Allegra CJ, Chabner BA, Tuazon CU et al. Trimetrexate for the treatment of pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome. N Engl J Med 1987;317:978-985.
-
(1987)
N Engl J Med
, vol.317
, pp. 978-985
-
-
Allegra, C.J.1
Chabner, B.A.2
Tuazon, C.U.3
-
27
-
-
0029053314
-
Selective treatment of SCID mice bearing methotrexate-transport resistant human acute leukemia tumors with trimetrexate and leucovorin protection
-
Lacerda JF, Göker E, Kheradpour A et al. Selective treatment of SCID mice bearing methotrexate-transport resistant human acute leukemia tumors with trimetrexate and leucovorin protection. Blood 1995;85:2675-2679.
-
(1995)
Blood
, vol.85
, pp. 2675-2679
-
-
Lacerda, J.F.1
Göker, E.2
Kheradpour, A.3
|