Studies on the joint cytotoxicity of Wheat Germ Agglutinin and monensin

Toxicology in Vitro

Volumn 18, Issue 6, 2004, Pages 821-827

  Dalla Pellegrina, Chiara ^a   Matucci, Andrea ^a   Zoccatelli, Gianni ^a   Rizzi, Corrado ^a   Vincenzi, Simone ^a   Veneri, Gianluca ^a   Andrighetto, Giancarlo ^a   Peruffo, Angelo D B ^a   Chignola, Roberto ^a  

^a UNIVERSITY OF VERONA   (Italy)

Author keywords

Cytotoxicity; Human blood cells; Monensin; Synergism; Wheat Germ Agglutinin

Indexed keywords

ANTINEOPLASTIC AGENT; CARBOXYLIC ACID DERIVATIVE; IONOPHORE; MONENSIN; WHEAT GERM AGGLUTININ;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL MEMBRANE TRANSPORT; CELL SURFACE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENTIATION; EMBRYO; ENDOCYTOSIS; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN BINDING;

ANTIFUNGAL AGENTS; APOPTOSIS; DRUG INTERACTIONS; HUMANS; LEUKEMIA, ERYTHROBLASTIC, ACUTE; LEUKEMIA, T-CELL; LEUKOCYTES, MONONUCLEAR; MONENSIN; TUMOR CELLS, CULTURED; WHEAT GERM AGGLUTININS;

ANIMALIA; TRITICUM AESTIVUM;

EID: 4744338156     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2004.04.008     Document Type: Article

References (18)

1. Banks W.A., Ibrahimi F., Farr S.A., Flood J.F., Morley J.E. Effects of Wheat Germ Agglutinin and aging on the regional brain uptake of HIV-1GP120. Life Sciences. 65:1999;81-89
2. Chignola R., Colombatti M., Dell'Arciprete L., Candiani C., Tridente G. Distribution of endocytosed molecules to intracellular acidic environments correlates with immunotoxin activity. International Journal of Cancer. 46:1990;1117-1123
3. Kim M., Rao M.V., Tweardy D.J., Prakash M., Galili U., Gorelik E. Lectin induced apoptosis of tumour cells. Glycobiology. 3:1993;447-453
4. Marnell M.H., Stookey M., Draper R.K. Monensin blocks the transport of diphtheria toxin to the cell cytoplasm. Journal of Cell Biology. 93:1982;57-62
5. Miyoshi N., Koyama Y., Katsuno Y., Hayakawa S., Mita T., Ohta T., Kaji K., Isemura M. Apoptosis induction associated with cell cycle dysregulation by Rice Bran Agglutinin. Journal of Biochemistry. 130:2001;799-805
6. Muraille E., Pajak B., Urbain J., Leo O. Carbohydrate-bearing cell surface receptors involved in innate immunity: interleukin-12 induction by mitogenic and nonmitogenic lectins. Cellular Immunology. 191:1999;1-9
7. Ohba H., Bakalowa R., Muraki M. Cytoagglutination and cytotoxicity of Wheat Germ Agglutinin isolectins against normal lymphocytes and cultured leukemia cell lines-relationship between structure and biological activity. Biochimica and Biophysica Acta. 1619:2003;144-150
8. Salman H., Zbaida D., Rabin Y., Chatenay D., Elbaum M. Kinetics and mechanism of DNA uptake into the cell nucleus. Proceedings of the National Academy of Sciences of the United States of America. 98:2001;7247-7252
9. Schwarz R.E., Wojciechowicz D.C., Picon A.I., Schwarz M.A., Paty P.B. Wheat Germ Agglutinin mediated toxicity in pancreatic cancer cells. British Journal of Cancer. 80:1999;1754-1762
10. Tartakoff A.M. Perturbation of vesicular traffic with the carboxylic monensin. Cell. 32:1983;1026-1028
11. Taswell C. Limiting dilution assay for the determination of immunocompetent cell frequency. Validity test for the single-hit Poisson model. Journal of Immunological Methods. 72:1984;29-40
12. Taylor D.S., Reed J.C., Nowell P.C. Stimulation and inhibition of human T cell subsets by Wheat Germ Agglutinin. Journal of Immunology. 134:1985;3756-3761
13. Van Damme E.J.M., Peumans W.J., Pusztai A., Bardocz S. Handbook of Plant Lectins: Properties and Biomedical Applications. 1998;John Wiley & Sons, West Sussex, England. pp. 390-391
14. Vincenzi S., Zoccatelli G., Perbellini F., Rizzi C., Chignola R., Curioni A., Peruffo A.D. Quantitative determination of dietary lectin activities by enzyme-linked immunosorbent assay using specific glycoproteins immobilized on microtiter plates. Journal of Agricultural and Food Chemistry. 50:2002;6266-6270
15. Wang H., Ng T.B., Ooi V.E., Liu W.K. Effect of lectins with different carbohydrate-binding specificities on hepatoma, choriocarcinoma, melanoma and osteosarcoma cell lines. International Journal of Biochemistry & Cell Biology. 32:2000;365-372
16. Wesche J., Rapak A., Olsnes S. Dependence of ricin toxicity on translocation of the toxin A-chain from the endoplasmic reticulum to the cytosol. Journal of Biological Chemistry. 274:1999;34443-34449
17. Wirth M., Kneuer C. Lectin-mediated drug delivery: discrimination between cytoadhesion and cytoinvasion and evidence of lysosomal accumulation of Wheat Germ Agglutinin in the Caco-2 model. Journal of Drug Targeting. 10:2002;439-448
18. Zoccatelli G., Dalla Pellegrina C., Vincenzi S., Rizzi C., Chignola R., Peruffo A. Egg-matrix for large scale single step affinity purification of plant lectins with different carbohydrate specificities. Protein Expression and Purification. 27:2003;182-185