Up-regulation in endothelin-1 by Helicobacter pylori lipopolysaccharide interferes with gastric mucin synthesis via epidermal growth factor receptor transactivation

Scandinavian Journal of Gastroenterology

Volumn 40, Issue 8, 2005, Pages 921-928

  Slomiany, Bronislaw L ^a,b   Slomiany, Amalia ^a  

^a UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

^b RUTGERS SCHOOL OF DENTAL MEDICINE   (United States)

Author keywords

ECE 1; EGFR transactivation; ET 1; Gastric mucin synthesis; H. pylori LPS

Indexed keywords

4 (3 BROMOANILINO) 6,7 DIMETHOXYQUINAZOLINE; 4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; BACTERIUM LIPOPOLYSACCHARIDE; BQ 610; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR ANTAGONIST; ENDOTHELIN CONVERTING ENZYME; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; PHOSPHORAMIDON; PROTEIN TYROSINE KINASE INHIBITOR; STOMACH MUCIN; VIRULENCE FACTOR;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; HELICOBACTER PYLORI; MICROBIAL ACTIVITY; MUCOSA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; STOMACH MUCOSA; TRANSACTIVATION; UPREGULATION;

ANIMALS; ASPARTIC ENDOPEPTIDASES; CELLS, CULTURED; ENDOTHELIN-1; ENZYME INHIBITORS; GASTRIC MUCIN; GASTRIC MUCOSA; HELICOBACTER PYLORI; LIPOPOLYSACCHARIDES; METALLOENDOPEPTIDASES; QUINAZOLINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, EPIDERMAL GROWTH FACTOR; TRANS-ACTIVATION (GENETICS); UP-REGULATION;

EID: 23644447181     PISSN: 00365521     EISSN: None     Source Type: Journal    
DOI: 10.1080/00365520510015890     Document Type: Article

References (35)

1. Marshall BJ. Helicobacter pylori. Am J Gastroenterol 1994;89:8116-28.
2. Konturek P, Bielanski W, Konturek SJ, Hahn EG. Helicobacter pylori associated pathology. J Physiol Pharmacol 1999;50:695-710.
3. de Boer WA. Topics in Helicobacter pylori infection: focus on a "search-and-treat" strategy for ulcer disease. Scand J Gastroenterol 2000;35(Suppl 232):4-9.
4. Piotrowski J, Majka J, Slomiany A, Slomiany BL. Helicobacter pylori lipopolysaccharide inhibition of gastric mucosal somatostatin receptor. Biochem Mol Biol Int 1995;36:491-8.
5. Slomiany BL, Piotrowski J, Slomiany A. Anti-Helicobacter pylori activities of ebrotidine. Arzneim Forsch Drug Res 1997;47:475-82.
6. Piotrowski J. Lipopolysaccharide a virulence factor of Helicobacter pylori: effect of antiulcer agents. J Physiol Pharmacol 1998;49:3-24.
7. Fu S, Ramanujam KS, Wong A, Fantry GT, Drachenberg CB, James SP, et al. Increased expression and cellular localization of inducible nitric oxide synthase and cyclooxygenase-2 in Helicobacter pylori gastritis. Gastroenterology 1999;116:1319-29.
8. Slomiany BL, Slomiany A. Blockade of p38 mitogen-activated protein kinase pathway inhibits inducible nitric oxide synthase and gastric mucosal inflammatory reaction to Helicobacter pylori lipopolysaccharide. Inflammopharmacology 2001;8:371-82.
9. Liau YH, Lopez RA, Slomiany A, Slomiany BL. Helicobacter pylori lipopolysaccharide effect on the synthesis and secretion of sulfated gastric mucin. Biochem Biophys Res Commun 1992;184:1411-7.
10. Gupta RN, Polk DB, Krishna U, Israel DA, Yan F, DuBois RN, et al. Activation of peroxisome proliferator-activated receptor γ suppresses nuclear factor κB-mediated apoptosis induced by Helicobacter pylori in gastric epithelial cells. J Biol Chem 2001;276:31059-66.
11. Slomiany BL, Slomiany A. Role of ERK and P38 Mitogen-activated protein kinase cascades in gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide. IUBMB Life 2001;51:315-20.
12. Slomiany BL, Piotrowski J, Slomiany A. Involvement of endothelin-1 in up-regulation of gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide. Biochem Biophys Res Commun 1999;258:17-20.
13. Pollack DM, Keith TL, Highsmith RF. Endothelin receptors and calcium signaling. FASEB J 1995;9:1196-4.
14. Robu VG, Pfeiffer ES, Robia SL, Balijepalli RC, Pi YP, Kamp TJ, et al. Localization of functional endothelin receptor signaling complexes in cardiac transverse tubules. J Biol Chem 2003;278:48154-61.
15. Liu S, Premont RT, Kontos CD, Huang J, Rockey DC. Endothelin-1 activates endothelial cell nitric-oxide synthase via heterotrimeric G-protein βγ subunit signaling to protein kinase B/Akt. J Biol Chem 2003;278:49929-35.
16. Michida T, Kawano S, Masuda E, Kobayashi I, Nishimura Y, Tsujii M, et al. Endothelin-1 in the gastric mucosa in stress ulcers of critically ill patients. Am J Gastroenterol 1997;92:1177-81.
17. Slomiany BL, Piotrowski J, Slomiany A. Role of endothelin-1 and constitutive nitric oxide synthase in gastric mucosal resistance to indomethacin injury: effect of antiulcer agents. Scand J Gastroenterol 1999;34:459-64.
18. Xu D, Emoto N, Slaughter C, Kaw S, deWit D, Yanagisawa M. ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1. Cell 1994;78:473-85.
19. Shao RS, Yan W, Rockey DC. Regulation of endothelin-1 synthesis by endothelin-converting enzyme-1 during wound healing. J Biol Chem 1999;274:3228-34.
20. Ehrenreich H, Loffler BM, Hasselblatt M, Langen H, Oldenburg J, Subkowski T, et al. Endothelin converting enzyme activity in primary rat astrocytes is modulated by endothelin B receptor. Biochem Biophys Res Commun 1999;261:149-55.
21. Slomiany BL, Piotrowski J, Slomiany A. Up-regulation of endothelin-converting enzyme-1 in gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide. Biochem Biophys Res Commun 2000;267:801-5.
22. Guo Y, Cernacek P, Giaid A, Hussain SNA. Production of endothelins by the ventilatory muscles in septic shock. Am J Respir Cell Mol Biol 1998;19:470-6.
23. Shiwen X, Howat SL, Renzoni EA, Holms A, Pearson JD, Dashwood MR, et al. Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK. J Biol Chem 2004;279:23098-103.
24. Pierce KL, Premont RT, Lefkowitz RJ. Seven-transmembrane receptors. Nat Rev Mol Cell Biol 2002;3:639-50.
25. Vacca F, Bagnato A, Catt KJ, Tecce R. Transactivation of the epidermal growth factor receptor in endothelin-1-induced mitogenic signaling in human ovarian carcinoma cells. Cancer Res 2000;60:5310-7.
26. Kawanabe Y, Masaki T, Hashimoto N. Involvement of epidermal growth factor receptor-protein tyrosine kinase transactivation in endothelin-1-induced vascular contraction. J Neurosurg 2004;100:1066-71.
27. Imamura T, Huang J, Dalle S, Ugi S, Usui I, Luttrell LM, et al. β-Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transport. J Biol Chem 2001;276:43663-7.
28. Hur EM, Park YS, Le BD, Ho IH, Kim TD, Suh PG, et al. Sensitization of epidermal growth factor-induced signaling by bradykinin is mediated by c-Src. J Biol Chem 2004;279: 5852-60.
29. Slomiany BL, Slomiany A. Impedance of Helicobacter pylori lipopolysaccharide interference with gastric mucin synthesis by peroxisome proliferator-activated receptor γ activation involves phosphatidylinositol 3-kinase/ERK pathway. IUBMB Life 2003;55:97-102.
30. Slomiany BL, Slomiany A. Role of endothelin-converting enzyme-1 in the suppression of constitutive nitric oxide synthase in rat gastric mucosal injury by indomethacin. Scand J Gastroenterol 2000;35:1131-6.
31. Silen W. Gastric mucosal defense and repair. In: Johnson LR, editor. Physiology of the gastrointestinal tract. 2nd ed. New York: Raven Press; 1987. pp 1055-69.
32. Slomiany BL, Slomiany A. Mucus and gastric mucosal protection. In: Domschke W, Konturek SJ, editors. The stomach. Berlin: Springer Verlag; 1993. pp 116-43.
33. Slomiany BL, Slomiany A. Disruption in gastric mucin synthesis by Helicobacter pylori lipopolysaccharide involves ERK and p38 mitogen-activated protein kinase participation. Biochem Biophys Res Commun 2002;294:220-4.
34. Balwierczak JL, Kukkola PJ, Savage P, Jeng AY. Effects of metalloprotease inhibitors on smooth muscle endothelin-converting enzyme activity. Biochem Pharmacol 1995;49: 291-6.
35. Clarke KJ, Zhong Q, Schwartz DD, Coleman ES, Kemppainen RJ, Judd RL. Regulation of adiponectin secretion by endotheli-1. Biochem Biophys Res Commun 2003;312:945-9.