Impedance of Helicobacter pylori lipopolysaccharide interference with gastric mucin synthesis by peroxisome proliferator-activated receptor γ activation involves phosphatidylinositol 3-kinase/ERK pathway

IUBMB Life

Volumn 55, Issue 2, 2003, Pages 97-102

  Slomiany, Bronislaw L ^a,b   Slomiany, Amalia ^a  

^a UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

^b RUTGERS SCHOOL OF DENTAL MEDICINE   (United States)

Author keywords

ERK and PI3K; Gastric mucin synthesis; H. pylori LPS; NOS 2; PPAR activation

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; BACTERIUM LIPOPOLYSACCHARIDE; CIGLITAZONE; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE; STOMACH MUCIN; WORTMANNIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; ENZYME ACTIVITY; HELICOBACTER PYLORI; IMPEDANCE; MUCOSA CELL; NONHUMAN; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; STOMACH MUCOSA; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; LIPOPOLYSACCHARIDES; MITOGEN-ACTIVATED PROTEIN KINASES; MUCINS; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; STOMACH; TRANSCRIPTION FACTORS;

ANIMALIA; BACTERIA (MICROORGANISMS); HELICOBACTER; HELICOBACTER PYLORI;

EID: 0038336251     PISSN: 15216543     EISSN: None     Source Type: Journal    
DOI: 10.1080/1521654031000090887     Document Type: Article

References (22)

1. Konturek, P. C., Bielanski, W., Konturek, S. J., and Hahn, E. G. (1999) Helicobacter pylori associated pathology. J. Physiol. Pharmacol. 50, 695-710.
2. de Boer, W. A. (2000) Topics in Helicobacter pylori infection: focus on a 'search-and-treat' strategy for ulcer disease. Scand. J. Gastroenterol. 35(suppl. 232), 4-9.
3. Piotrowski, J., Piotrowski, E., Skrodzka, D. A., Slomiany, A., and Slomiany, B. L. (1997) Induction of acute gastritis and epithelial cell apoptosis by Helicobacter pylori lipopolysaccharide. Scand. J. Gastroenterol. 32, 203-211.
4. Slomiany, B. L., and Slomiany, A. (2002) Suppression of gastric mucosal inflammatory responses to H. pylori lipopolysaccharide by peroxisome proliferator-activated receptor γ activation. IUBMB Life 53, 303-308.
5. Liau, Y. H., Lopez, R. A., Slomiany, A., and Slomiany, B. L. (1992) Helicobacter pylori lipopolysaccharide effect on the synthesis and secretion of sulfated gastric mucin. Biochem. Biophys. Res. Commun. 184, 1411-1417.
6. Wilson, K. T., Fu, S., Ramanujam, K. S., and Meltzer, S. J. (1998) Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in Barrett's esophagus and associated adenocarcinomas. Cancer Res. 58, 2929-2934.
7. Fu, S., Ramanujam, K. S., Wong, A., Fantry, G. T., Drachenberg, C. B., James, S. P., Meltzer, S. J., and Wilson, K. T. (1999) Increased expression and cellular localization of inducible nitric oxide synthase and cyclooxygenase-2 in Helicobacter pylori gastritis. Gastroenterology 116, 1319-1329.
8. Slomiany, B. L., and Slomiany, A. (2002) Disruption in gastric mucin synthesis by H. pylori lipopolysaccharide involves ERK and p38 mitogen-activated protein kinase participation. Biochem. Biophys. Res. Commun. 294, 220-224.
9. Park, Y. C., Lee, C. H., Kang, H. S., Chung, H. T., and Kim, H. D. (1997) Wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase, enhances LPS-induced NO production from murine peritoneal macrophages. Biochem. Biophys. Res. Commun. 240, 692-696.
10. Guha, M., and Mackman, N. (2002) The phosphatidylinositol 3-kinase-Act pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells. J. Biol. Chem. 277, 32124-32132.
11. 2 and thiazolidinediones activate the MEK/ERK pathway through phosphatidylinositol 3-kinase in vascular smooth muscle cells. J. Biol. Chem. 276, 48950-48955.
12. Wagner, D. A., Glogowski, J., Skipper, P. L., Wishnok, J. S., and Tannenbaum, S. R. (1982) Analysis of nitrate, nitrite and [15N] nitrate in biological fluids. Anal. Biochem. 126, 131-138.
13. Xin, X., Yang, S., Kowalski, J., and Gerritsen, M. E. (1999) Peroxisome proliferator-activated receptor γ ligands are potent inhibitors of angiogenesis. J. Biol. Chem. 274, 9116-9121.
14. Inoue, H., Tanabe, T., and Umesone, K. (2000) Feedback control of cyclooxygenase expression through PPARγ. J. Biol. Chem. 275, 28028-28032.
15. Nakajima, A., Wada, K., Miki, H., Kubota, N., Nakajima, N., Terauchi, Y., Ohnishi, S., Saubermann, L. J., Kadowak, T., Blumberg, R. S., Nagai, R., and Matasuhashi, N. (2001) Endogenous PPARγ mediates anti-inflammatory activity in murine ischemiareperfusion injury. Gastroenterology 120, 460-469.
16. Gupta, R. A., Polk, D. B., Krishna, U., Israel, D. A., Yan, F., BuBois, R. N., and Peek, R. M. (2001) Activation of peroxisome proliferatoractivated receptor γ suppresses nuclear factor κB-mediated apoptosis induced by Helicobacter pylori in gastric epithelial cells. J. Biol. Chem. 276, 31059-31066.
17. Slomiany, B. L., and Slomiany, A. (2001) Role of ERK and p38 Mitogen-activated protein kinase cascades in gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide. IUBMB Life 51, 315-320.
18. Kim, S. J., Ju, J. W., Oh, C. D., Yoon, Y. M., Song, W. K., Kim, J. H., Yoo, Y. J., Bang, O. S., Kang, S. S., and Chun, J. S. (2002) ERK-1/2 and p38 kinase oppositely regulate NO-induced apoptosis of chondrocytes in association with p53, caspase-3, and differentiation status. J. Biol. Chem. 277, 1332-1339.
19. Slomiany, B. L., and Slomiany, A. (2002) Nitric oxide interferes with salivary mucin synthesis: involvement of ERK and p38 mitogenactivated protein kinase. J. Physiol. Pharmacol. 53, 325-336.
20. Watters, J. T., Sommer, J. A., Pjeiffer, Z. A., Prabhu, U., Guerra, A. N., and Bertics, P. J. (2002) A differential role for mitogen-activated protein kinase in lipopolysaccharide signaling. J. Biol. Chem. 277, 9077-9087.
21. Miura, K., and MacGlashan, D. W. (2000) Phosphatidylinositol-3 kinase regulates p21ras activation during IgE-mediated stimulation of human basophilis. Blood 96, 2199-2205.
22. Tanaka, T., Kohno, H., Yoshitani, S., Okumura, A., Muramaki, A., and Hosokawa, M. (2001) Ligands for peroxisome proliferatoractivated receptors α and γ inhibit chemically induced colitis and formation of aberrant crypt foci in rats. Cancer Res. 61, 2424-2428.