Effects of anticonvulsants on soman-induced epileptiform activity in the guinea-pig in vitro hippocampus

European Journal of Pharmacology

Volumn 518, Issue 2-3, 2005, Pages 123-132

  Harrison, Patrick K ^a   Sheridan, Robert D ^a   Green, A Chris ^a   Tattersall, John E H ^a  

^a Dstl ^*  (United Kingdom)

Author keywords

Acetylcholinesterase; Anticonvulsant; Epileptiform activity; Hippocampal slice; Organophosphate; Soman

Indexed keywords

CARBAMAZEPINE; CLOMETHIAZOLE; ETIRACETAM; FELBAMATE; GABAPENTIN; ORGANOPHOSPHATE; PHENYTOIN; RETIGABINE; SOMAN; TOPIRAMATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; BRAIN SLICE; DRUG EFFECT; DRUG MECHANISM; EPILEPTIC DISCHARGE; GUINEA PIG; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL;

AMINES; ANIMALS; ANTICONVULSANTS; CARBAMATES; CARBAMAZEPINE; CHLORMETHIAZOLE; CLOZAPINE; CYCLOHEXANECARBOXYLIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; EPILEPSY; FRUCTOSE; GAMMA-AMINOBUTYRIC ACID; GUINEA PIGS; HIPPOCAMPUS; MALE; PHENYLENEDIAMINES; PIRACETAM; PROPYLENE GLYCOLS; SOMAN;

EID: 23644433186     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2005.06.032     Document Type: Article

References (56)

1. D.R. Anderson, L.W. Harris, F.C.T. Chang, W.B. Baze, B.R. Capacio, S.L. Byers, and W.J. Lennox Antagonism of soman-induced convulsions by midazolam, diazepam and scopolamine Drug Chem. Toxicol. 20 1997 115 131
2. 2+ transients and epileptiform potentials in hippocampal neurons NeuroReport 14 2003 471 475
3. C.R. Ashby, and R.Y. Wang Pharmacological actions of the atypical antipsychotic drug clozapine: a review Synapse 24 1996 349 394
4. D. Ashton, R. Willems, E. de Prins, and A. Wauquier Field potential assay of antiepileptic drugs in the hippocampal slice Epilepsia 29 1988 321 329
5. D. Ashton, R. Willems, E. de Prins, and A. Wauquier Selective inhibition of synaptic versus non-synaptic epileptogenesis by NMDA antagonists in the in vitro hippocampus Epilepsy Res. 2 1988 219 222
6. B. Ault, M. Gruenthal, D.R. Armstrong, J.V. Nadler, and C.M. Wang Baclofen suppresses bursting activity induced in hippocampal slices by differing convulsant treatments Eur. J. Pharmacol. 126 1986 289 292
7. M. Bialer, S.I. Johannessen, H.J. Kupferberg, R.H. Levy, P. Loiseau, and E. Perucca Progress report on new antiepileptic drugs: a summary of the fourth Eilat conference (EILAT IV) Epilepsy Res. 34 1999 1 41
8. S. Birnstiel, E. Wulfert, and S.G. Beck Levetiracetam (ucb LO59) affects in vitro models of epilepsy in CA3 pyramidal neurons without altering normal synaptic transmission Naunyn Schmiedebergs's Arch. Pharmacol. 356 1997 611 618
9. C. Bolden, B. Cusack, and E. Richelson Antagonism by antimuscarinic and neuroleptic compounds at the five cloned human muscarinic cholinergic receptors expressed in Chinese hamster ovary cells J. Pharmacol. Exp. Ther. 260 1992 576 580
10. J.A. Bourne, P. Fosbraey, and J. Halliday SCH 23390 affords protection against soman-evoked seizures in the freely moving guinea-pig: a concomitant neurochemical, electrophysiological and behavioural study Neuropharmacology 40 2001 279 288
11. A.G. Chapman, K. Nanan, M. Williams, and B.S. Meldrum Anticonvulsant activity of two metabotropic glutamate group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893) Neuropharmacology 39 2000 1567 1574
12. A.E. Cole, and R.A. Nicoll Characterization of a slow cholinergic post-synaptic potential recorded in vitro from rat hippocampal pyramidal cells J. Physiol. (London) 352 1984 173 188
13. ++ model in the hippocampal slice preparation Epilepsy Res. 38 2000 53 66
14. A receptor function Brain Res. 884 2000 31 34
15. W. Endres, A. Spuler, and G. ten Bruggencate Acetylcholinesterase reactivators antagonize epileptiform bursting induced by paraoxon in guinea pig hippocampal slices J. Pharmacol. Exp. Ther. 251 1989 1181 1186
16. A. Forster, J.P. Gardaz, P.M. Suter, and M. Gemperle Respiratory depression by midazolam and diazepam Anesthesiology 53 1980 494 497
17. R.R. Gainetdinov, and M.G. Caron Delineating muscarinic receptor functions Proc. Natl. Acad. Sci. 96 1999 12222 12223
18. G. Gatti, A.R. Ferrari, R. Guerrini, P. Bonanni, I. Bonomi, and E. Perucca Plasma gabapentin concentrations in children with epilepsy: influence of age, relationship with dosage, and preliminary observations on correlation with clinical response Ther. Drug Monit. 25 2003 54 60
19. R.B. Goossen, D.J. Freeman, A.M. Satchell, and B.L. Urquhart Monitoring clozapine: are fingerprick blood and plasma clozapine levels equivalent to arm venipuncture blood and plasma levels? Ther. Drug Monit. 25 2003 469 472
20. A.R. Green Clomethiazole (Zendra) in acute ischemic stroke: Basic pharmacology and biochemistry and clinical efficacy Pharmacol. Ther. 80 1998 123 147
21. C.L. Harden, R. Trifiletti, and H. Kutt Felbamate levels in patients with epilepsy Epilepsia 37 1996 280 283
22. P.K. Harrison, R.D. Sheridan, A.C. Green, I.R. Scott, and J.E.H. Tattersall Spectrum of anticonvulsant activity against soman-induced bursting in the guinea-pig in vitro hippocampus Br. J. Pharmacol. Nov. Suppl. 134 2001 (125 pp.)
23. P.K. Harrison, R.D. Sheridan, A.C. Green, I.R. Scott, and J.E.H. Tattersall Profile of clinically employed antiepileptics against soman-induced epileptiform activity in the guinea-pig hippocampal slice Br. J. Pharmacol. Mar. Suppl. 135 2002 (365 pp.)
24. P.K. Harrison, R.D. Sheridan, A.C. Green, I.R. Scott, and J.E.H. Tattersall A guinea pig hippocampal slice model of organophosphate-induced seizure activity J. Pharmacol. Exp. Ther. 310 2004 678 686
25. U. Heinemann, J. Dreier, A. Leschinger, J. Stabel, A. Draguhn, and C. Zhang Effects of anticonvulsant drugs on hippocampal neurons Hippocampus 4 1994 291 296
26. S.S. Jahromi, M.R. Pelletier, P.J. McDonald, H. Khosravani, and P.L. Carlen Antiepileptic efficacy of topiramate: assessment in two in vitro seizure models Brain Res. 872 2000 20 28
27. L. Karalliedde, and N. Senanayake Organophosphorus insecticide poisoning Br. J. Anaesth. 63 1989 736 750
28. N.W. Kleckner, J.C. Glazewski, C.C. Chen, and T.D. Moscrip Subtype-selective antagonism of N-methyl-d-aspartate receptors by felbamate: insights into the mechanism of action J. Pharmacol. Exp. Ther. 289 1999 886 894
29. H. Klitgaard, A. Matagne, R. Grimee, J. Vanneste-Goemaere, and D.G. Margineanu Electrophysiological, neurochemical and regional effects of levetiracetam in the rat pilocarpine model of temporal lobe epilepsy Seizure 12 2003 92 100
30. R.S. Kong, J. Butterworth, W. Aveling, D.A. Stump, M.J. Harrison, J. Hammon, J. Stygall, K.D. Rorie, and S.P. Newman Clinical trial of the neuroprotectant clomethiazole in coronary artery bypass graft surgery: a randomized controlled trial Anesthesiology 97 2002 585 591
31. V. Libri, A. Constanti, M. Zibetti, and S. Nistico Effects of felbamate on muscarinic and metabotropic-glutamate agonist-mediated responses and magnesium-free or 4-aminopyridine-induced epileptiform activity in guinea pig olfactory cortex neurons in vitro J. Pharmacol. Exp. Ther. 277 1996 1759 1769
32. A. Lucke, U. Muβhoff, R. Kohling, M. Osterfeld, T. Mayer, P. Wolf, W. Schutte, and E.J. Speckmann Gabapentin potentiation of the antiepileptic efficacy of vigabatrin in an in vitro model of epilepsy Br. J. Pharmacol. 124 1998 370 376
33. E.A. Lukyanetz, V.M. Shkryl, and P.G. Kostyuk Selective blockade of N-type calcium channels by levetiracetam Epilepsia 43 2002 9 18
34. R.L. MacDonald, and K.M. Kelly Mechanisms of action of currently prescribed and newly developed antiepileptic drugs Epilepsia 35 1994 S41 S50
35. D.G. Margineanu, and H. Klitgaard Inhibition of neuronal hypersynchrony in vitro differentiates levetiracetam from classical antiepileptic drugs Pharmacol. Res. 42 2000 281 285
36. T.C. Marrs Diazepam in the treatment of organophosphorus ester pesticide poisoning Toxicol. Rev. 22 2003 75 81
37. A.M. Mazarati, H. Liu, U. Soomets, R. Sankar, D. Shin, H. Katsumori, U. Langel, and C.G. Wasterlain Galanin modulation of seizures and seizure modulation of hippocampal galanin in animal models of status epilepticus J. Neurosci. 18 1998 10070 10077
38. J.H. McDonough, L.D. Zoeffel, J. McMonagle, T.L. Copeland, C.D. Smith, and T.M. Shih Anticonvulsant treatment of nerve agent seizures: anticholinergics versus diazepam in soman-intoxicated guinea-pigs Epilepsy Res. 38 2000 1 14
39. J.H. McDonough, A. Benjamin, J.D. McMonagle, T. Rowland, and T.M. Shih Effects of fosphenytoin on nerve agent-induced status epilepticus Drug Chem. Toxicol. 27 2004 27 39
40. J.O. McNamara Drugs effective in the therapy of the epilepsies J.G. Hardman L.E. Limbird Goodman and Gilman's: Pharmacological Basis of Therapeutics Ninth edition 1996 McGraw-Hill Book Company New York 461 486
41. G.Y.K. Ng, S. Bertrand, R. Sullivan, N. Ethier, J. Wang, J. Yergey, M. Belley, L. Trimble, K. Bateman, L. Alder, A. Smith, R. McKrnan, K. Metters, G.P. O'Neill, J.C. Lacaille, and T.E. Hebert γ-Aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action Mol. Pharmacol. 59 2001 144 152
42. Ogren, S.O., 1986. Chlormethiazole-mode of action. Acta Psychiatr. Scand. Suppl 329, 73, 13-27.
43. A.P. Oliver, B.J. Hoffer, and R.J. Wyatt The hippocampal slice: a system for studying the pharmacology of seizures and for screening anticonvulsant drugs Epilepsia 18 1977 543 548
44. C. Palmieri, H. Kawasaki, and M. Avoli Topiramate depresses carbachol-induced plateau potentials in subicular bursting cells NeuroReport 11 2000 75 78
45. E. Perucca, B.E. Gidal, and E. Baltes Effects of antiepileptic comedication on levetiracetam pharmacokinetics: a pooled analysis of data from randomized adjunctive therapy trials Epilepsy Res. 53 2003 47 56
46. J.M. Rigo, G. Hans, L. Nguyen, V. Rocher, S. Belachew, B. Malgrange, P. Leprince, G. Moonen, I. Selak, A. Matagne, and H. Klitgaard The anti-epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA- and glycine-gated currents Br. J. Pharmacol. 136 2002 659 672
47. C. Rundfeldt, and R. Netzer Investigations into the mechanism of action of the new anticonvulsant retigabine Drug Res. 50 2000 1063 1070
48. J.H. Schneiderman, and J.C. Evans Effects of anticonvulsants on penicillin-induced bursting in guinea-pig hippocampal slices Epilepsia 27 1986 347 353
49. R.P. Shank, J.F. Gardocki, A.J. Streeter, and B.E. Maryanoff An overview of the preclinical aspects of topiramate: pharmacology, pharmacokinetics and mechanism of action Epilepsia 41 2000 S3 S9
50. T.M. Shih, T.A. Koviak, and B.R. Capacio Anticonvulsants for poisoning by the organophosphorus compounds soman: pharmacological mechanisms Neurosci. Biobehav. Rev. 15 1991 349 362
51. T.M. Shih, J.H. McDonough, and I. Koplovitz Anticonvulsants for soman-induced seizure activity J. Biomed. Sci. 6 1999 86 96
52. P. Taylor Anticholinesterase agents J.G. Hardman L.E. Limbird Goodman and Gilman's: Pharmacological Basis of Therapeutics Ninth edition 1996 McGraw-Hill Book Company New York 161 176
53. C.P. Taylor, N.S. Gee, T.Z. Su, J.D. Kocsis, D.F. Welty, J.P. Brown, D.J. Dooley, P. Boden, and L. Singh A summary of mechanistic hypotheses of gabapentin pharmacology Epilepsy Res. 29 1998 233 249
54. L. Verhulst, Z. Waggie, M. Hatherill, L. Reynolds, and A. Argent Presentation and outcome of severe anticholinesterase insecticide poisoning Arch. Dis. Child. 86 2002 352 355
55. C.G. Wasterlain, H. Liu, A.M. Mazarati, R.A. Baldwin, Y. Shirasaka, H. Katsumori, K.W. Thompson, R. Sankar, A.P. de Vanconselos, and A. Nehlig Self-sustaining status epilepticus: a condition maintained by potentiation of glutamate receptors and by plastic changes in substance P and other peptide neuromodulators Epilepsia 41 2000 S134 S143
56. E.A. Wilson, and M.J. Brodie New antiepileptic drugs Bailliere's Clin. Neurol. 5 1996 723 747