Does episodic hypoxia affect upper airway dilator muscle function? Implications for the pathophysiology of obstructive sleep apnoea

Respiratory Physiology and Neurobiology

Volumn 147, Issue 2-3 SPEC. ISS., 2005, Pages 223-234

  Bradford, Aidan ^a   McGuire, Michelle ^b   O'Halloran, Ken D ^c  

^a ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Asphyxia; Contractile properties; Control of breathing; Electromyogram; Episodic hypoxia; Hypoxia; Muscle; Patency; Upper airway; Ventilation

Indexed keywords

AIRWAY OBSTRUCTION; ASPHYXIA; BREATHING MUSCLE; CENTRAL NERVOUS SYSTEM; DISEASE COURSE; DISEASE EXACERBATION; ELECTROMYOGRAM; ENDURANCE; HUMAN; HYPOXIA; MUSCLE EXCITATION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; SKELETAL MUSCLE; SLEEP APNEA SYNDROME; SLEEP DISORDERED BREATHING;

EID: 23444440622     PISSN: 15699048     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.resp.2005.04.001     Document Type: Article

References (66)

1. 2+ release channel J. Biol. Chem. 272 1997 3739 3748
2. L. Bernardi Interval hypoxic training Adv. Exp. Med. Biol. 502 2001 377 399
3. A.X. Bigard, A. Brunet, C.Y. Guezennec, and H. Monod Skeletal muscle changes after endurance training at high altitude J. Appl. Physiol. 71 1991 2114 2121
4. J.J. Cottrell Altitude exposures during aircraft flight: flying higher Chest 92 1986 82 84
5. J.A. Dempsey, P.G. Hanson, and K.S. Henderson Exercise-induced arterial hypoxemia in healthy human subjects at sea level J. Physiol. Lond. 355 1984 161 175
6. T.J. Eddinger, and R.L. Moss Mechanical properties of skinned single fibres of identified types from rat diaphragm Am. J. Physiol. 253 1987 C210 C218
7. R. Elsner Perspectives in diving and asphyxia Undersea Biomed. Res. 16 1989 339 344
8. R. El-Khoury, K.D. O'Halloran, and A. Bradford Effects of chronic hypobaric hypoxia on contractile properties of rat sternohyoid and diaphragm muscles Clin. Exp. Pharmacol. Physiol. 30 2003 551 554
9. V. Fenik, L. Kubin, S. Okabe, A.I. Pack, and R.O. Davies Differential sensitivity of laryngeal and pharyngeal motoneurons to iontophoretic application of serotonin Neuroscience 81 1997 873 885
10. D.C. Flenley Sleep in chronic obstructive lung disease Clin. Chest Med. 6 1985 51 61
11. W.D. Flitter Free radicals and myocardial reperfusion injury Br. Med. Bull. 49 1993 545 555
12. R.B. Fogel, A. Malhotra, and D.P. White Sleep 2: pathophysiology of obstructive sleep apnoea/hypopnoea syndrome Thorax 59 2004 159 163
13. D. Gozal, J.M. Daniel, and G.P. Dohanich Behavioral and anatomical correlates of chronic episodic hypoxia during sleep in the rat J. Neurosci. 21 2001 2442 2450
14. X.Q. Gu, and G.G. Haddad Decreased neuronal excitability in hippocampal neurons of mice exposed to cyclic hypoxia J. Appl. Physiol. 91 2001 1245 1250
15. J.C. Hendricks, B.J. Petrof, K. Panckeri, and A.I. Pack Upper airway dilating muscle hyperactivity during non-rapid eye movement sleep in English bulldogs Am. Rev. Respir. Dis. 148 1993 185 194
16. L.M.A. Heunks, and P.N.R. Dekhuijzen Respiratory muscle function and free radicals: from cell to COPD Thorax 55 2000 704 716
17. J.R. Holtman Jr., T.E. Dick, and A.J. Berger Serotonin mediated excitation of recurrent laryngeal and phrenic motoneurons evoked by stimulation of the raphe obscurus Brain Res. 417 1987 12 20
18. R.L. Horner Motor control of the pharyngeal musculature and implications for the pathogenesis of obstructive sleep apnea Sleep 19 1996 827 853
19. R.L. Horner The neuropharmacology of upper airway motor control in the awake and asleep states: implications for obstructive sleep apnoea Respir. Res. 2 2001 286 294
20. A. Hurtado Some clinical aspects of life at high altitude Ann. Intern. Med. 53 1960 247 258
21. A. Ishihara, K. Itoh, Y. Oishi, M. Itoh, C. Hirofuji, and H. Hayashi Effects of hypobaric hypoxia on histochemical fiber-type composition and myosin heavy chain isoform component in the rat soleus muscle Pflügers Arch. 429 1995 601 606
22. K. Itoh, T. Moritani, K. Ishida, C. Hirofuji, S. Taguchi, and M. Itoh Hypoxia-induced fiber type transformation in rat hindlimb muscles Eur. J. Appl. Physiol. 60 1990 331 336
23. L. Kubin, H. Tojima, R.O. Davies, and A.I. Pack Serotonergic excitatory drive to hypoglossal motoneurons in the decerebrate cat Neurosci. Lett. 139 1992 243 248
24. L. Kubin, C. Reignier, H. Tojima, O. Taguchi, A.I. Pack, and R.O. Davies Changes in serotonin level in the hypoglossal nucleus region during carbachol-induced atonia Brain Res. 645 1994 291 302
25. L. Kubin, H. Tojima, C. Reignier, A.I. Pack, and R.O. Davies Interaction of serotonergic excitatory drive to hypoglossal motoneurons with carbachol-induced, REM sleep-like atonia Sleep 19 1996 187 195
26. L. Lavie Obstructive sleep apnoea syndrome - an oxidative stress disorder Sleep Med. Rev. 7 2003 35 51
27. R.C. Li, B.W. Row, E. Gozal, L. Kheirandish, Q. Fan, K.R. Brittian, S.Z. Guo, L.R. Sachleben Jr., and D. Gozal Cyclooxygenase 2 and intermittent hypoxia-induced spatial deficits in the rat Am. J. Respir. Crit. Care Med. 168 2003 469 475
28. A. Malhotra, and D.P. White Obstructive sleep apnoea Lancet 360 2002 237 245
29. B.E. Marshall, and M.Q. Wyche Hypoxemia during and after anaesthesia Anesthesiology 37 1972 178 209
30. J.M. McCord Oxygen derived free radicals in post ischaemic injury N. Engl. J. Med. 312 1985 159 163
31. D.R. McCrimmon, M.S. Dekin, and G.S. Mitchell Glutamate, GABA, and serotonin in ventilatory control J.A. Dempsey A.I. Pack Lung Biology in Health and Disease: Regulation of Breathing: Central Nervous System vol. 79 1995 Marcel-Dekker New York, NY 151 218
32. M. McGuire, and A. Bradford Chronic intermittent hypoxia increases haematocrit and causes right ventricular hypertrophy in the rat Respir. Physiol. 117 1999 53 58
33. M. McGuire, and A. Bradford Chronic intermittent hypercapnic hypoxia increases pulmonary arterial pressure and haematocrit in rats Eur. Respir. J. 18 2001 279 285
34. M. McGuire, M. MacDermott, and A. Bradford The effects of chronic episodic hypoxia on rat upper airway muscle contractile properties and fiber-type distribution Chest 122 2002 1012 1017
35. M. McGuire, M. MacDermott, and A. Bradford The effects of chronic episodic hypercapnic hypoxia on rat upper airway muscle contractile properties and fiber-type distribution Chest 122 2002 1400 1406
36. M. McGuire, M. MacDermott, and A. Bradford Effects of chronic intermittent asphyxia on rat diaphragm and limb muscle contractility Chest 123 2003 875 881
37. W.T. McNicholas, G. Bowes, N. Zamel, and E.A. Phillipson Impaired detection of added inspiratory resistance in patients with obstructive sleep apnea Am. Rev. Respir. Dis. 129 1984 45 48
38. W.S. Mezzanotte, D.J. Tangel, and D.P. White Waking genioglossal electromyogram in sleep apnea patients versus normal controls (a neuromuscular compensatory mechanism) J. Clin. Invest. 89 1992 1571 1579
39. G.S. Mitchell, T.L. Baker, S.A. Nanda, D.D. Fuller, A.G. Zabka, B.A. Hodgeman, R.W. Bavis, K.J. Mack, and E.B. Olson Jr. Intermittent hypoxia and respiratory plasticity J. Appl. Physiol. 90 2001 2466 2475
40. K. Nakanishi, F. Tajima, A. Nakamura, S. Yagura, T. Ookawara, H. Yamashita, K. Suzuki, N. Taniguchi, and H. Ohno Effects of hypobaric hypoxia on antioxidant enzymes in rats J. Physiol. Lond. 489 1995 869 876
41. K.D. O'Halloran, M. McGuire, T. O'Hare, and A. Bradford Chronic intermittent asphyxia impairs rat upper airway muscle responses to acute hypoxia and asphyxia Chest 122 2002 269 275
42. 1 receptors in the control of hypoglossal motoneurons in vivo Sleep 19 1996 S150 S153
43. B.J. Petrof, A.I. Pack, A.M. Kelly, J. Eby, and J.C. Hendricks Pharyngeal myopathy of loaded upper airway in dogs with sleep apnoea J. Appl. Physiol. 76 1994 1746 1752
44. F.L. Powell, W.K. Milsom, and G.S. Mitchell Time domains of the hypoxic ventilatory response Respir. Physiol. 112 1998 123 134
45. M.B. Reid, K.E. Haack, K.M. Franchek, P.A. Valberg, L. Kobzik, and M.S. West Reactive oxygen in skeletal muscle. I. Intracellular oxidant kinetics and fatigue in vitro J. Appl. Physiol. 73 1992 1797 1804
46. M.B. Reid, F.A. Khwali, and M.R. Moody Reactive oxygen in skeletal muscle. III. Contractility of unfatigued muscle J. Appl. Physiol. 75 1993 1081 1087
47. J.E. Remmers, W.J. deGroot, E.K. Sauerland, and A.M. Anch Pathogenesis of upper airway occlusion during sleep J. Appl. Physiol. 44 1978 931 938
48. C.R. Richmonds, and D.W. Hudgel Hypoglossal and phrenic motoneuron responses to serotonergic active agents in rats Respir. Physiol. 106 1996 153 160
49. B.W. Row, R. Liu, W. Xu, L. Kheirandish, and D. Gozal Intermittent hypoxia is associated with oxidative stress and spatial learning deficits in the rat Am. J. Respir. Crit. Care Med. 167 2003 1548 1553
50. H.M. Schotland, E.K. Insko, K.A. Panckeri, J.S. Leigh, A.I. Pack, and J.C. Hendricks Quantitative magnetic resonance imaging of upper airway musculature in an animal model of sleep apnea J. Appl. Physiol. 81 1996 1339 1346
51. T.V. Serebrovskya Intermittent hypoxia research in the former Soviet Union and the Commonwealth of Independent States: history and review of the concept and selected applications High Alt. Med. Biol. 3 2002 205 221
52. F. Series, C. Cote, J.-A. Simoneau, Y. Jelinas, S. St. Pierre, J. Leclerc, R. Ferland, and I. Marc Physiologic, metabolic, and muscle fiber type characteristics of musculus uvulae in sleep apnea hypopnea syndrome and in snorers J. Clin. Invest. 95 1995 20 25
53. F. Series, J.-A. Simoneau, S. St. Pierre, and I. Marc Characteristics of the genioglossus and musculus uvulae in sleep apnea hypopnea syndrome and in snorers Am. J. Respir. Crit. Care Med. 153 1996 1870 1874
54. S. Shiota, T. Okada, H. Naitoh, R. Ochi, and Y. Fukuchi Hypoxia and hypercapnia affect contracile and histological properties of rat diaphragm and hind limb muscles Pathophysiology 11 2004 223 230
55. A.H. Sillau, and N. Banchero Effects of hypoxia on capillary density and fiber composition in rat skeletal muscle Pflügers Arch. 370 1977 227 232
56. S. Smirne, S. Iannaccone, L. Ferini-Strambi, M. Comola, E. Colombo, and R. Nemni Muscle fibre type and habitual snoring Lancet 337 1991 597 599
57. P.M. Suratt, R.F. McTier, and S.C. Wilhoit Upper airway muscle activation is augmented in patients with obstructive sleep apnea compared with that in normal subjects Am. Rev. Respir. Dis. 137 1988 889 894
58. J.L. Stauffer, M.K. Buick, E.O. Bixler, F.E. Sharkey, A.B. Abt, E.K. Manders, A. Kales, R.J. Cadieux, J.D. Barry, and C.W. Zwillich Morphology of the uvula in obstructive sleep apnea Am. Rev. Respir. Dis. 140 1989 724 728
59. B.T. Thach Sleep apnea in infancy and childhood Med. Clin. North Am. 69 1985 1289 1315
60. S.C. Veasey, K.A. Panckeri, E.A. Hoffman, A.I. Pack, and J.C. Hendricks The effects of serotonin antagonists in an animal model of sleep-disordered breathing Am. J. Respir. Crit. Care Med. 153 1996 776 786
61. S.C. Veasey, C.W. Davis, P. Fenik, G. Zhan, Y.-J. Hsu, D. Pratico, and A. Gow Long-term intermittent hypoxia in mice: protracted hypersomnolence with oxidative injury to sleep/wake brain regions Sleep 27 2004 194 201
62. S.C. Veasey, G. Zhan, P. Fenik, and D. Pratico Long-term intermittent hypoxia: reduced excitatory hypoglossal nerve output Am. J. Respir. Crit. Care Med. 170 2004 665 672
63. A.N. Vgontzas, D.A. Papanicolaou, E.O. Bixler, K. Hopper, A. Lotsikas, H.M. Lin, A. Kales, and G.P. Chrousos Sleep apnea and daytime sleepiness and fatigue: relation to visceral obesity, insulin resistance and hypercytokinemia J. Clin. Endocrinol. Metab. 85 2000 1151 1158
64. D.P. White, and W.S. Mezzanotte Neuromuscular compensation in the human upper airway Sleep 16 1993 S90 S92
65. D.P. White Sleep-related breathing disorder. 2. Pathophysiology of obstructive sleep apnea Thorax 50 1995 797 804
66. W. Xu, L. Chi, B.W. Row, R. Xu, Y. Ke, B. Xu, C. Luo, L. Kheirandish, D. Gozal, and R. Liu Increased oxidative stress is associated with chronic intermittent hypoxia-mediated brain cortical neuronal cell apoptosis in a mouse model of sleep apnea Neuroscience 126 2004 313 323