The Effects of Serotonin Antagonists in an Animal Model of Sleep-Disordered Breathing

American Journal of Respiratory and Critical Care Medicine

Volumn 153, Issue 2, 1996, Pages 776-786

  Veasey, Sigrid C ^a   Panckeri, Karen A ^b   Hoffman, Eric A ^b   Pack, Allan I ^b   Hendricks, Joan C ^b  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

METHYSERGIDE MALEATE; OXYGEN; OXYHEMOGLOBIN; RITANSERIN; SEROTONIN ANTAGONIST;

ANIMAL MODEL; ARTICLE; BREATHING MUSCLE; COMPUTER ASSISTED TOMOGRAPHY; DIAPHRAGM MUSCLE; DOG; MOTONEURON; MUSCLE CONTRACTION; NONHUMAN; OXYGEN SATURATION; PRIORITY JOURNAL; RAPHE NUCLEUS; SEROTONINERGIC SYSTEM; SLEEP APNEA SYNDROME; THORAX WALL;

ANIMALS; DIAPHRAGM; DOGS; ELECTROMYOGRAPHY; LARYNGEAL MUSCLES; METHYSERGIDE; MUSCLE CONTRACTION; MUSCLES; NASOPHARYNX; OXYHEMOGLOBINS; PALATE; RESPIRATION; RESPIRATORY SYSTEM; RITANSERIN; SEROTONIN; SEROTONIN ANTAGONISTS; SLEEP APNEA SYNDROMES;

EID: 0030050213     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.153.2.8564132     Document Type: Article

References (36)

1. Sauerland, E. K., and R. M. Harper. 1976. The human tongue during sleep: electromyographic activity of the genioglossus muscle. Exp. Neurol. 51:160-170.
2. Remmers, J. E., W. J. DeGroot, E. K. Sauerland, and A. M. Anch. 1978. Pathogenesis of upper airway occlusion during sleep. J. Appl. Physiol. 44:931-938.
3. Mezzanote, W. S., D. J. Tangel, and D. P. White. 1989. Waking genioglossal electromyogram in sleep apnea patients versus normal controls (a neuromuscular compensatory mechanism). J. Clin. Invest. 89:1571-1579.
4. Strohl, K. P., and L. G. Olson. 1987. Concerning the importance of pharyngeal muscles in the maintenance of upper airway patency during sleep. Chest 92:918-920.
5. Findley, L. J., S. C. Wilhoit, and P. M. Surratt. 1985. Apnea duration and hypoxemia during REM sleep in patients with obstructive sleep apnea. Chest 87:432-436.
6. Kubin, L., H. Kimura, H. Tojima, R. O. Davies, and A. I. Pack. 1993. Suppression of hypoglossal motoneurons during the carbachol-induced atonia of REM sleep is not caused by fast synaptic inhibition. Brain Res. 611:300-312.
7. Soja, P. J., D. M. Finch, and M. H. Chase. 1987. Effect of inhibitory amino acid antagonists on masseteric reflec suppression during active sleep. Exp. Neurol. 96:178-193.
8. Ribiero-do-Valle, L. E., C. W. Metzler, and B. L. Jacobs. 1991. Facilitation of masseter EMG and masseteric (jaw-closure) reflex by serotonin in behaving cats. Brain Res. 550:197-204.
9. Kugin, L., H. Tojima, R. O. Davies, and A. I. Pack. 1992. Serotonergic excitatory drive to hypoglossal motoneurons in the decerebrate cat. Neurosci. Lett. 139:243-248.
10. Fort, P., P. H. Luppi, K. Sakai, D. Salvert, and M. Jouvet. 1990. Nuclei of origin of monoaminergic, peptidergic, and cholinergic afferents to the cat trigeminal nucleus: a double-labeling study with choleratoxin as a retrograde tracer. J. Comp. Neurol. 301:262-275.
11. Manaker, S., and L. J. Tischler. 1993. Origin of serotonergic afferents to the hypoglossal nucleus in the rat. J. Comp. Neurol. 334:466-476.
12. Heym, J., G. F. Steinfels, and B. L. Jacobs. 1982. Activity of serotonin containing neurons in the nucleus raphe pallidus of freely moving cats. Brain Res. 251:259-276.
13. Hendricks, J. C., L. R. Kline, R. J. Kovalski, J. A. O'Brien, A. R. Morrison, and A. I. Pack. 1987. The English bulldog: a natural model of sleep-disordered breathing. J. Appl. Physiol. 63:1344-1350.
14. Hendricks, J. C., R. J. Kovalski, and L. R. Kline. 1991. Phasic respiratory muscle patterns and sleep-disordered breathing in the English bulldog. Am. Rev. Respir. Dis. 144:1112-1120.
15. Hendricks, J. C., B. J. Petrof, K. Panckeri, and A. I. Pack. 1993. Upper airway dilating muscle hyperactivity during non-rapid eye movement sleep in English bulldogs. Am. Rev. Respir. Dis. 148:185-194.
16. Basmajian, J. V., and G. Stecki. 1962. A new bipolar elect rode for electromyography. J. Appl. Physiol. 17:839.
17. Bredberg, U., and L. Paalzow. 1990. Pharmacokinetics of methysergide and its metabolite methylergometrine in the rat. Drug Metab. Dispos. Biol. Fate Chem. 18:336-343.
18. Devaud, L. L., E. B. Hollingsworth, and B. R. Cooper. 1992. Alterations in extracellular and tissue levels of biogenic amines in rat brain induced by the serotonin 2 receptor antagonists, ritanserin. J. Neurochem. 59:1459-1466.
19. Koss, M. C. 1991. Mechanisms of ketanserin-induced sympatho-inhibition. Eur. J. Pharmacol. 194:161-166.
20. Shepard, J. W., A. W. Stanson, P. F. Sheedy, and P. R. Westbrook. 1990. Fast-CT evaluation of the upper airway during wakefulness in patients with obstructive sleep apnea. In P. M. Surratt and J. E. Remmers, editors. Proceedings of the First International Symposium on Sleep and Respiration. Alan R. Liss, New York. 273-282.
21. Schwab, R. J., W. B. Gefter, E. A. Hoffman, K. B. Gupta, and A. I. Pack. 1993. Dynamic upper airway imaging during awake respiration in normal subjects and patients with sleep-disordered breathing. Am. Rev. Respir. Dis. 148:1385-1400.
22. Galvin, J. R., S. A. Rooholamini, and W. Stanford. 1989. Obstructive sleep apnea: diagnosis with ultrafast CT. Radiology 171:775-778.
23. Schwab, R. J., W. B. Gefter, A. I. Pack, and E. A. Hoffman. 1993. Dynamic imaging of the upper airway during respiration in normal subjects. J. Appl. Physiol. 74:1504-1514.
24. McCall, R. B., and G. K. Aghajanian. 1979. Serotonergic facilitation of facial motoneuron excitation. Brain Res. 169:11-27.
25. Berger, A. J., D. A. Bayliss, and F. Viana. 1992. Modulation of neonatal rat hypoglossal motoneuron excitability by serotonin. Neurosci. Lett. 143:164-168.
26. Brancatisano, A. S., S. M. Kelly, A. Tully, S. N. Loring, and L. A. Engel. 1989. Postural changes in spontaneous and evoked regional diaphragm activity in dogs. J. Appl. Physiol. 66:1158-1163.
27. Arita, H., and M. Ochiishi. 1991. Opposing effects of 5-hydroxytryptamine on two types of medullary inspiratory neurons with distinct firing patterns. J. Neurophysiol. 66:285-292.
28. Millhorn, D. E., F. L. Eldridge, and T. G. Waldrop. 1980. Prolonged stimulation of respiration by endogenous central serotonin. Respir. Physiol. 42:171-188.
29. Holtman, J. R., Jr., T. E. Dick, and A. J. Berger. 1986. Involvement of serotonin in the excitation of phrenic motoneurons evoked by stimulation of the raphe obscurus. J. Neurosci. 6:1185-1193.
30. Veasey, S. C., C. A. Fornal, C. W. Metzler, and B. L. Jacobs. 1995. Response of serotonergic caudal raphe neurons in relation to specific motor activities in freely moving cats. J. Neurosci. 15(7):5346-5359.
31. Sauerland, E. K., W. C. Orr, and L. E. Hairston. 1981. EMG patterns of oropharyngeal muscles during respiration in wakefulness and sleep. Electromyogr. Clin. Neurophysiol. 21:307-316.
32. Millhorn, D. E., F. L. Eldridge, and T. G. Waldrop. 1980. Prolonged stimulation of respiration by a new central mechanism. Respir. Physiol. 41:87-103.
33. Schmid, K., G. Böhmer, and S. Merkelbach. 1990. Serotonergic control of phrenic motoneuronal activity at the level of the spinal cord of the rabbit. Neurosci. Lett. 116:204-209.
34. Strohl, K. P., N. S. Cherniack, and B. Gothe. 1986. Physiologic basis of therapy for sleep apnea. Am. Rev. Respir. Dis. 134:791-802.
35. Schmidt, H. S. 1983. L-tryptophan in the treatment of impaired respiration in sleep. Bull. Eur. Physiopathol. Respir. 19:625-629.
36. Hanzel, D. A., N. G. Proia, and D. W. Hudgel. 1991. Response of obstructive sleep apnea to fluoxetine and protryptylline. Chest 100: 416-421.