Differential sensitivity of laryngeal and pharyngeal motoneurons to iontophoretic application of serotonin

Neuroscience

Volumn 81, Issue 3, 1997, Pages 873-885

  Fenik, V ^a   Kubin, L ^a   Okabe, S ^a   Pack, A I ^a   Davies, R O ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Hypoglossal motoneurons; Iontophoresis; Serotonin; Sleep apnea syndrome; Upper airway; Vagal motoneurons

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; FEMALE; HYPOGLOSSAL NERVE; IONTOPHORESIS; MALE; MOTONEURON; NERVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; SEROTONIN BLOOD LEVEL; SEROTONINERGIC TRANSMISSION; SLEEP APNEA SYNDROME;

ACTION POTENTIALS; ANIMALS; CATS; DECEREBRATE STATE; FEMALE; HYPOGLOSSAL NERVE; IONTOPHORESIS; LARYNGEAL NERVES; MALE; MOTOR NEURONS; PHARYNX; SEROTONIN; VAGOTOMY;

EID: 0031587268     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(97)00215-7     Document Type: Article

References (49)

1. Agnati L. F., Zoli M., Strömberg I., Fuxe K. Intercellular communication in the brain: wiring versus volume transmission. Neuroscience. 69:1995;711-726.
2. Aldes L. D., Marco L. A., Chronister R. B. Serotonin-containing axon terminals in the hypoglossal nucleus of the rat. An immuno-electron microscopic study. Brain Res. Bull. 23:1989;249-256.
3. Altschuler S. M., Bao X., Miselis R. R. Dendritic architecture of hypoglossal motoneurons projecting to extrinsic tongue musculature in the rat. J. comp. Neurol. 342:1994;538-550.
4. Arita H., Ochiishi M. Opposing effects of 5-hydroxytryptamine on two types of medullary inspiratory neurons with distinct firing patterns. J. Neurophysiol. 66:1991;285-292.
5. Arita H., Sakamoto M., Hirokawa Y., Okado N. Serotonin innervation patterns differ among the various medullary motoneuronal groups involved in upper airway control. Expl Brain Res. 95:1993;100-110.
6. Bartlett D., Jr. (1986) Upper airway motor systems. In Handbook of Physiology, Section 3: The Respiratory System, Vol. II: Control of Breathing, Part 1 (eds Cherniack N. S. and Widdicombe J. D.), pp. 223-245. Am. Physiol. Soc., Bethesda, MD.
7. Berger A. J., Bayliss D. A., Viana F. Modulation of neonatal rat hypoglossal motoneuron excitability by serotonin. Neurosci. Lett. 143:1992;164-168.
8. Cohen M. I., Feldman J. L. Discharge properties of dorsal medullary inspiratory neurons: relation to pulmonary afferents and phrenic efferent discharge. J. Neurophysiol. 51:1984;753-776.
9. Dobbins E. G., Feldman J. L. Differential innervation of protruder and retractor muscles of the tongue in rat. J. comp. Neurol. 357:1995;376-394.
10. Douse M. A., White D. P. Serotonergic effects on hypoglossal neural activity and reflex responses. Brain Res. 726:1996;213-222.
11. Fenik V., Kubin L., Okabe S., Pack A. I., Davies R. O. Excitation of upper airway motoneurons by iontophoretic application of serotonin. Soc. Neurosci. Abstr. 21:1995;925.
12. Guilleminault C., Hill M. W., Simmons F. B., Dement W. C. Obstructive sleep apnea: electromyographic and fiberoptic studies. Expl Neurol. 62:1978;48-67.
13. Harding R., England S. J., Stradling J. R., Kozar L. F., Phillipson E. A. Respiratory activity of laryngeal muscles in awake and sleeping dogs. Resp. Physiol. 66:1986;315-326.
14. Heym J., Steinfels G. F., Jacobs B. L. Activity of serotonin-containing neurons in the nucleus raphe pallidus of freely moving cats. Brain Res. 251:1982;259-276.
15. Holtman J. R. Jr., Dick T. E., Berger A. J. Serotonin-mediated excitation of recurrent laryngeal and phrenic motoneurons evoked by stimulation of the raphe obscurus. Brain Res. 417:1987;12-20.
16. Holtman J. R. Jr., Marion L. J., Speck D. F. Origin of serotonin-containing projections to the ventral respiratory group in the rat. Neuroscience. 37:1990;541-552.
17. Iscoe S. D. (1988) Central control of the upper airway. In Respiratory Function of the Upper Airway (eds Mathew O. P. and Sant'Ambrogio G.), pp. 125-192. Marcel Dekker, New York.
18. Jacobs B. L., Azmitia E. C. Structure and function of the brain serotonin system. Physiol. Rev. 72:1992;165-229.
19. Jiang C., Mitchell G. S., Lipski J. Prolonged augmentation of respiratory discharge in hypoglossal motoneurons following superior laryngeal nerve stimulation. Brain Res. 538:1991;215-225.
20. Katakura N., Chandler S. H. An iontophoretic analysis of the pharmacologic mechanisms responsible for trigeminal motoneuronal discharge during masticatory-like activity in the guinea pig. J. Neurophysiol. 63:1990;356-369.
21. Kimura H., Kubin L., Davies R. O., Pack A. I. Cholinergic stimulation of the pons depresses respiration in decerebrate cats. J. appl. Physiol. 69:1990;2280-2289.
22. Kirsten E. B., St John W. M. A feline decerebration technique with low mortality and long-term homeostasis. J. pharmac. Meth. 1:1978;263-268.
23. Kubin L., Fenik V., Pack A. I., Davies R. O. Stereotyped pattern of suppression of upper airway motor tone during the carbachol-induced, REM sleep-like atonia. Soc. Neurosci. Abstr. 22:1996;690.
24. Kubin L., Kimura H., Tojima H., Pack A. I., Davies R. O. Behavior of VRG neurons during the atonia of REM sleep induced by pontine carbachol in decerebrate cats. Brain Res. 592:1992;91-100.
25. Kubin L., Tojima H., Davies R. O., Pack A. I. Serotonergic excitatory drive to hypoglossal motoneurons in the decerebrate cat. Neurosci. Lett. 139:1992;243-248.
26. Kubin L., Reignier C., Tojima H., Taguchi O., Pack A. I., Davies R. O. Changes in serotonin level in the hypoglossal nucleus region during carbachol-induced atonia. Brain Res. 645:1994;291-302.
27. Kubin L., Tojima H., Reignier C., Pack A. I., Davies R. O. Interaction of serotonergic excitatory drive to hypoglossal motoneurons with carbachol-induced, REM sleep-like atonia. Sleep. 19:1996;187-195.
28. Kuna S. T., Sant'Ambrogio G. Pathophysiology of upper airway closure during sleep. J. Am. med. Ass. 266:1991;1384-1389.
29. Kurasawa I., Toda K., Nakamura Y. Non-reciprocal facilitation of trigeminal motoneurons innervating jaw-closing and jaw-opening muscles induced by iontophoretic application of serotonin in the guinea pig. Brain Res. 515:1990;126-134.
30. Larkman P. M., Kelly J. S. Ionic mechanisms mediating 5-hydroxytryptamine- and noradrenaline-evoked depolarization of adult rat facial motoneurones. J. Physiol., Lond. 456:1992;473-490.
31. Li Y.-Q., Takada M., Mizuno N. The sites of origin of serotoninergic afferent fibers in the trigeminal motor, facial, and hypoglossal nuclei in the rat. Neurosci. Res. 17:1993;307-313.
32. Lindsay A. D., Feldman J. L. Modulation of respiratory activity of neonatal rat phrenic motoneurones by serotonin. J. Physiol., Lond. 461:1993;213-233.
33. Manaker S., Tischler L. J. Origin of serotonergic afferents to the hypoglossal nucleus in the rat. J. comp. Neurol. 334:1993;466-476.
34. McCall R. B., Aghajanian G. K. Serotonergic facilitation of facial motoneuron excitation. Brain Res. 169:1979;11-27.
35. Neuman R. S. Action of serotonin and norepinephrine on spinal motoneurones following blockade of synaptic transmission. Can. J. Physiol. Pharmac. 63:1985;735-738.
36. Núñez-Abades P. A., Spielmann J. M., Barionuevo G., Cameron W. E. In vitro electrophysiology of developing genioglossal motoneurons in the rat. J. Neurophysiol. 70:1993;1401-1411.
37. Remmers J. E. (1981) Control of breathing during sleep. In Regulation of Breathing (ed. Hornbein T. F.), pp. 1197-1249. Dekker, New York.
38. Sauerland E. K., Orr W. C., Hairston L. E. EMG patterns of oropharyngeal muscles during respiration in wakefulness and sleep. Electroenceph. clin. Neurophysiol. 21:1981;307-316.
39. Takahashi T., Berger A. J. Direct excitation of rat spinal motoneurones by serotonin. J. Physiol., Lond. 423:1990;63-76.
40. Tojima H., Kubin L., Kimura H., Davies R. O. Spontaneous ventilation and respiratory motor output during carbachol-induced atonia of REM sleep in the decerebrate cat. Sleep. 15:1992;404-414.
41. Trulson M. E., Trulson V. M. Activity of nucleus raphe pallidus neurons across the sleep-waking cycle in freely moving cats. Brain Res. 237:1982;232-237.
42. VanderMaelen C. P., Aghajanian G. K. Serotonin-induced depolarization of rat facial motoneurons in vivo: comparison with amino acid transmitters. Brain Res. 239:1982;139-152.
43. Veasey S. C., Fornal C. A., Metzler C. W., Jacobs B. L. Response of serotonergic caudal raphe neurons in relation to specific motor activities in freely moving cats. J. Neurosci. 15:1995;5346-5359.
44. White S. R., Neuman R. S. Facilitation of spinal motoneurone excitability by 5-hydroxytryptamine and noradrenaline. Brain Res. 188:1980;119-127.
45. White S. R., Neuman R. S. Pharmacological antagonism of facilitatory but not inhibitory effects of serotonin and norepinephrine on excitability of spinal motoneurons. Neuropharmacology. 22:1983;489-494.
46. White S. R., Crane G. K., Jackson D. A. Thyrotropin-releasing hormone (TRH) effects on spinal cord neuronal excitability. Ann. N. Y. Acad. Sci. 553:1989;337-350.
47. Woch G., Davies R. O., Pack A. I., Kubin L. Behavior of raphe cells projecting to the dorsomedial medulla during carbachol-induced atonia in the cat. J. Physiol., Lond. 490:1996;745-758.
48. Yoshida Y., Miyazaki T., Hirano M., Shin T., Kanaseki T. Arrangement of motoneurons innervating the intrinsic laryngeal muscles of cats as demonstrated by horseradish peroxidase. Acta otolar. 94:1982;329-334.
49. Zifa E., Fillion G. 5-Hydroxytryptamine receptors. Pharmac. Rev. 44:1992;401-432.