Mechanisms of depression: Role of the HPA axis

Drug Discovery Today: Disease Mechanisms

Volumn 1, Issue 4, 2004, Pages 413-418

  Van Den Eede, Filip ^a   Claes, Stephan J ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

1 [5 CHLORO 1 (2,4 DIMETHOXYLPHENYLSULFONYL) 2,3 DIHYDRO 3 (2 METHOXYPHENYL) 2 OXO 1H INDOL 3 YL] 4 HYDROXY N,N DIMETHYL 2 PYRROLIDINECARBOXAMIDE; 11BETA (1,3 BENZODIOXOL 5 YL) 17BETA HYDROXY 17ALPHA (1 PROPYNYL)ESTRA 4,9 DIEN 3 ONE; 3 (6 DIMETHYLAMINO 4 METHYL 3 PYRIDINYL) 7 DIPROPYLAMINO 2,5 DIMETHYLPYRAZOLO[1,5 A]PYRIMIDINE; AMINOGLUTHETIMIDE; ANTIDEPRESSANT AGENT; CORTICOTROPIN RELEASING FACTOR; GLUCOCORTICOID ANTAGONIST; GLUCOCORTICOID RECEPTOR; KETOCONAZOLE; METYRAPONE; MIFEPRISTONE; ORG 34850; UNCLASSIFIED DRUG;

CLINICAL TRIAL; DISEASE COURSE; DRUG EFFICACY; DRUG MECHANISM; DRUG TARGETING; DRUG TOLERABILITY; HOMEOSTASIS; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MAJOR DEPRESSION; PATHOPHYSIOLOGY; RECURRENT DISEASE; REVIEW; STRESS; THALAMUS MIDLINE NUCLEUS;

EID: 23444437509     PISSN: 17406765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ddmec.2004.11.021     Document Type: Review

References (35)

1. Gold, P.W. et al. (2002) Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states. Mol. Psychiatry 7, 254-275
2. Tsigos, C. et al. (2002) Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress. J. Psychosom. Res. 53, 865-871
3. de Kloet, E.R. et al. (1998) Brain corticosteroid receptor balance in health and disease. Endocr. Rev. 19, 269-301
4. Schmider, J. et al. (1995) Combined dexamethasone/corticotrophin- releasing hormone test in acute and remitted manic patients, in acute depression, and in normal controls: I. Biol. Psychiatry 38, 797-802
5. Watson, S. et al. (2004) Hypothalamic-pituitary-adrenal axis function in patients with bipolar disorder. Br. J. Psychiatry 184, 496-502
6. Plotsky, P.M. et al. (1998) Psychoneuroendocrinology of depression. Psychoneuroendocrinology 21, 293-307
7. Holsboer, F. (1999) The rationale for corticotropin-releasing hormone receptor (CRH-R), antagonists to treat depression and anxiety. J. Psychiatr. Res. 33, 181-214
8. Juruena, M.F. et al. (2003) Molecular mechanisms of glucocorticoid receptor sensitivity and relevance to affective disorders. Acta Neuropsychiatr. 15, 354-367
9. Pariante, C.M. et al. (2001) Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment. Biol. Psychiatry 49, 391-404
10. Makino, S. et al. (2002) Multiple feedback mechanisms activating corticotropin-releasing hormone system in the brain during stress. Pharmacol. Biochem. Behav. 73, 147-158
11. Mazure, C.M. et al. (2000) Adverse life events and cognitive-personality characteristics in the prediction of major depression and antidepressant response. Am. J. Psychiatry 157, 896-903
12. Kendler, K.S. et al. (2003) Life event dimensions of loss, humiliation entrapment, and danger in the prediction of onsets of major depression. Arch. Gen. Psychiatry 60, 789-796
13. Heim, C. et al. (2004) Importance of studying the contributions of early adverse experience to neurobiological findings in depression. Neuropsychopharmacology 29, 641-648
14. Holsboer, F. et al. (1995) Altered hypothalamic-pituitary-adrenocortical regulation in healthy subjects at high familial risk for affective disorders. Neuroendocrinology 62, 340-347
15. Modell, S. et al. (1998) Hormonal response pattern in the combined DEX-CRH test is stable over time in subjects at high familial risk for affective disorders. Neuropsychopharmacology 18, 253-262
16. Wolkowitz, O.M. et al. (1999) Treatment of depression with antiglucocorticoid drugs. Psychosom. Med. 61, 698-711
17. Zobel, A.W. et al. (2001) Cortisol response in the combined dexamethasone/CRH test as predictor of relapse in patients with remitted depression: a prospective study. J. Psychiatr. Res. 35, 83-94
18. Schatzberg, A.F. et al. (2000) Neuropsychological deficits in psychotic versus non-psychotic major depression and no mental illness. Am. J. Psychiatry 157, 1095-1100
19. Claes, S.J. (2004) CRH, stress, and major depression: a psychobiological interplay. Vitam. Horm. 69, 117-150
20. Wüst, S. et al. (2004) Common polymorphisms in the glucocorticoid receptor gene are associated with adrenocortical responses to psychological stress. J. Clin. Endocrinol. Metab. 89, 565-573
21. Bale, T.L. et al. (2000) Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress. Nat. Genet. 24, 410-414
22. Villafuerte, S. et al. (2002) Gene-based SNP genetic association study of the corticotropin-releasing hormone receptor-2 (CRHR2) in major depression. Am. J. Med. Genet. 8, 222-226
23. Claes, S.J. et al. (2003) The corticotropin-releasing hormone binding protein is associated with major depression in a population from Northern Sweden. Biol. Psychiatry 54, 867-872
24. Van West, D. et al. (2003) A major SNP haplotype of the arginine-vasopressin 1B receptor protects against recurrent major depression. Mol. Psychiatry 9, 287-292
25. Holsboer, F. et al. (1996) Antidepressants and hypothalamic-pituitary- adrenocortical regulation. Endocr. Rev. 17, 187-205
26. Pariante, C.M. (2004) Depression, stress and the adrenal axis. J. Neuroendocrinol 15, 811-812
27. Pariante, C.M. et al. (2004) Do antidepressants regulate how cortisol affects the brain? Psychoneuroendocrinology 29, 423-447
28. Alonso, R. et al. (2004) Blockade of CRF(1) or V(1b) receptors reverses stress-induced suppression of neurogenesis in a mouse model of depression. Mol. Psychiatry 9, 278-286
29. Grammatopoulos, D.K. et al. (2002) Functional characteristics of CRH receptors and potential clinical applications of CRH-receptor antagonists. Trends Endocrinol. Metab. 13, 436-444
30. Zobel, A. W. et al. (2000) Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated. J. Psychiatr. Res. 34, 171-181
31. Held, K. et al. (2004) Treatment with the CRH1-receptor-antagonist R121919 improves sleep-EEG in patients with depression. J. Psychiatr. Res. 38, 129-136
32. Belanoff, J.K. et al. (2002) An open label trial of C-1073 (mifepristone) for psychotic major depression. Biol. Psychiatry 52, 386-392
33. Young, A.H. et al. (2004) Improvements in neurocognitive function and mood following adjunctive treatment with mifepristone (RU-486) in bipolar disorder. Neuropsychopharmacology 29, 1538-1545
34. Ruigt, G.S.F. et al. (2004) Clinical data from phase I and limited phase II studies with the glucocorticoid antagonists Org 34517 and Org 34850. Proceedings of the 35th Annual International Society of Psychoneuroendocrinology, 18-21 July 2004, Glasgow, Scotland, UK.
35. Tezval, H. et al. (2004) Cortagine, a specific agonist of corticotropin-releasing factor receptor subtype 1, is anxiogenic and antidepressive in the mouse model. Proc. Natl. Acad. Sci. USA 101, 9468-9473