Platelet activation and "Crossover Appeal": Rab and Rho families united by common links to serotonin

Molecular Interventions

Volumn 4, Issue 2, 2004, Pages 79-81

  Heger, Christopher D ^a   Collins, Ruth N ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 8A; G PROTEIN COUPLED RECEPTOR; GLUTAMIC ACID; GUANINE NUCLEOTIDE EXCHANGE FACTOR; PLATELET DERIVED GROWTH FACTOR; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; RAB PROTEIN; RHO FACTOR; SEROTONIN; SEROTONIN 2 RECEPTOR; TRYPTOPHAN HYDROXYLASE; VON WILLEBRAND FACTOR;

ARTICLE; BLOOD VESSEL INJURY; DNA MODIFICATION; ENZYME ACTIVITY; EXOCYTOSIS; GENE EXPRESSION; MEGAKARYOCYTE; MOUSE; NONHUMAN; PROTEIN FAMILY; PROTEIN MODIFICATION; SIGNAL TRANSDUCTION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION;

ANIMALS; CYTOPLASMIC GRANULES; EXOCYTOSIS; MICE; MICE, KNOCKOUT; PLATELET ACTIVATION; RAB GTP-BINDING PROTEINS; RHO GTP-BINDING PROTEINS; SEROTONIN; TRYPTOPHAN HYDROXYLASE;

EID: 2342653435     PISSN: 15340384     EISSN: None     Source Type: Journal    
DOI: 10.1124/mi.4.2.3     Document Type: Article

References (24)

1. Brass, L.F. More pieces of the platelet activation puzzle slide into place. J. Clin. Invest. 104, 1663-1665 (1999).
2. Sambrano, G.R., Weiss, E.J., Zheng, Y.W., Huang, W., and Coughlin, S.R. Role of thrombin signalling in platelets in haemostasis and thrombosis. Nature 413, 74-78 (2001).
3. Hollopeter, G., Jantzen, H.M., Vincent, D. et al. Identification of the platelet ADP receptor targeted by antithrombotic drugs. Nature 409, 202-207 (2001).
4. Walther, D.J. and Bader, M. A unique central tryptophan hydroxylase isoform. Biochem. Pharmacol. 66, 1673-1680 (2003).
5. Cote, F., Thevenot, E., Fligny, C. et al. Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function. Proc. Natl. Acad. Sci. U. S. A. 100, 13525-13530 (2003).
6. Cook, E.H., Jr., Fletcher, K.E., Wainwright, M., Marks, N., Yan, S.Y., and Leventhal, B.L. 1994. Primary structure of the human platelet serotonin 5-HT2A receptor: Identify with frontal cortex serotonin 5-HT2A receptor. J. Neurochem. 63, 465-469 (1994).
7. Murphy, D.L., Li, Q., Engel, S., Wichems, C., Andrews, A., Lesch, K.P., and Uhl, G. Genetic perspectives on the serotonin transporter. Brain Res. Bull. 56, 487-494 (2001).
8. 3H]-TBZOH binding to the human platelet vesicular monoamine transporter. Life Sci. 69, 2311-2317 (2001).
9. Holmsen, H. and Weiss, H.J. Secretable storage pools in platelets. Annu. Rev. Med. 30, 119-134 (1979).
10. Rendu, F. and Brohard-Bohn, B. The platelet release reaction: Granules' constituents, secretion and functions. Platelets 12, 261-273 (2001).
11. Harrison, P. and Cramer, E.M. Platelet alpha-granules. Blood Rev. 7, 52-62 (1993).
12. Dale, G.L., Friese, P., Batar, P., Hamilton, S.F., Reed, G.L., Jackson, K.W., Clemetson, K.J., and Alberio, L. Stimulated platelets use serotonin to enhance their retention of procoagulant proteins on the cell surface. Nature 415, 175-179 (2002).
13. Lorand, L. and Graham, R.M. Transglutaminases: Crosslinking enzymes with pleiotropic functions. Nat. Rev. Mol. Cell Biol. 4, 140-156 (2003).
14. Griffin, M., Casadio, R., and Bergamini, C.M. Transglutaminases: Nature's biological glues. Biochem J. 368, 377-396 (2002).
15. Henriksson, P., Becker, S., Lynch, G., and Mcdonagh, J. Identification of intracellular factor XIII in human monocytes and macrophages. J. Clin. Invest. 76, 528-534 (1985).
16. Horiguchi, Y., Inoue, N., Masuda, M., Kashimoto, T., Katahira, J., Sugimoto, N., and Matsuda, M. Bordetella bronchiseptica dermonecrotizing toxin induces reorganization of actin stress fibers through deamidation of Gln-63 of the GTP-binding protein Rho. Proc. Natl. Acad. Sci. U. S. A. 94, 11623-11626 (1997).
17. Flatau, G., Lemichez, E., Gauthier, M., Chardin, P., Paris, S., Fiorentini, C., and Boquet, P. Toxin-induced activation of the G protein p21 Rho by deamidation of glutamine. Nature 387, 729-733 (1997).
18. Schmidt, G., Sehr, P., Wilm, M., Selzer, J., Mann, M., and Aktories, K. Gln 63 of Rho is deamidated by Escherichia coli cytotoxic necrotizing factor-1. Nature 387, 725-729 (1997).
19. Hall, A. GTPases. 1st ed. Frontiers in Molecular Biology. Vol. 24. 2000: Oxford University Press.
20. Walther, D.J., Peter, J.U., Winter, S. et al. Serotonylation of small GTPases is a signal transduction pathway that triggers platelet alpha-granule release. Cell 115, 851-862 (2003).
21. 2+-induced alpha-granule secretion in platelets. J. Biol. Chem. 275, 33844-33849 (2000).
22. Soulet, C., Sauzeau, V., Plantavid, M., Herbert, J.M., Pacaud, P., Payrastre, B., and Savi, P. 2004. Gi-dependent and -independent mechanisms downstream of the P2Y12 ADP-receptor. J. Thromb. Haemost. 2, 135-146 (2004).
23. Kamiguian, A., Zahraoui, A., and Tavitian, A. Identification of small GTP-binding rab proteins in human platelets: Thrombin-induced phosphorylation of rab3B, rab6, and rab8 proteins. Proc. Natl. Acad. Sci. U. S. A. 90, 7647-7651 (1993).
24. Collins, R.N. 2003. "Getting it on": GDI displacement and small GTPase membrane recruitment. Mol. Cell 12, 1064-1066 (2003).