Steroid metabolism in Metabolic Syndrome X

Best Practice and Research: Clinical Endocrinology and Metabolism

Volumn 15, Issue 1, 2001, Pages 111-122

  Walker, Brian R ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

11 hydroxylase; 5 reductase; Diabetes mellitus; Hirsutism; Hydroxysteroid dehydrogenases; Hypertension; Obesity

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; ANDROGEN; GLUCOCORTICOID; HYDROCORTISONE; INSULIN; MINERALOCORTICOID; STEROID; STEROID 11BETA MONOOXYGENASE;

ADIPOSE TISSUE; ANDROGEN METABOLISM; CARDIOVASCULAR RISK; DIABETES MELLITUS; DISEASE ASSOCIATION; ENZYME ACTIVITY; ENZYME SYNTHESIS; ESSENTIAL HYPERTENSION; HIRSUTISM; HORMONE DEFICIENCY; HUMAN; HYPERGLYCEMIA; INSULIN RESISTANCE; METABOLIC DISORDER; OBESITY; QUALITATIVE DIAGNOSIS; QUANTITATIVE DIAGNOSIS; REVIEW; STEROID METABOLISM; STEROIDOGENESIS; SYNDROME X;

EID: 0034964575     PISSN: 1521690X     EISSN: None     Source Type: Journal    
DOI: 10.1053/beem.2000.0123     Document Type: Article

References (54)

1. A role for insulin in the aetiology and course of hypertension
2. How common is primary aldosteronism? Is it the most frequent cause of curable hypertension?
3. Is low-renin hypertension a stage in the development of essential hypertension or a diagnostic entity?
4. Renin profiling for diagnosis and treatment of hypertension
5. Medicinal uses of licorice through the millenia: The good and plenty of it
6. Deficient inactivation of cortisol by 11β-hydroxysteroid dehydrogenase in essential hypertension
7. Increased glucocorticoid activity in men with cardiovascular risk factors
8. Molecular basis for hypertension in the 'type II variant' of apparent mineralocorticoid excess
9. Evidence of coexisting changes in 11β-hydroxysteroid dehydrogenase and 5β-reductase activity in patients with untreated essential hypertension
10. How will we know if 11β-hydroxysteroid dehydrogenases are important in common diseases?
11. Cortisol and hypertension: What was not so apparent about 'apparent mineralocorticoid excess'
12. Molecular basis of human salt sensitivity: The role of the 11β-hydroxysteroid dehydrogenase type 2
13. Abnormal renal sodium handling in essential hypertension: Relation to failure of renal and adrenal modulation of responses to angiotensin II
14. Association of the renin-sodium profile with the risk of myocardial infarction in patients with hypertension
15. CA-repeat polymorphism in intron I of HSD11B2: Effects on gene expression and salt sensitivity
16. Abnormalities of glucocorticoid metabolism and the renin-angiotensin system: A four corners approach to the identification of genetic determinants of blood pressure
17. The relationship of blood pressure with glucose, insulin, heart rate, free fatty acids and plasma cortisol levels according to degree of obesity in middle-aged men
18. Independent effects of obesity and cortisol in predicting cardiovascular risk factors in men and women
19. Stress-related cortisol secretion in men: Relationships with abdominal obesity and endocrine, metabolic and haemodynamic abnormalities
20. Low birthweight and elevated plasma cortisol concentrations in adults from three populations
21. Is blood pressure inversely related to birth weight? The strength of evidence from a systematic review of the literature
22. Examination of genotype and phenotype relationships in 14 patients with apparent mineralocorticoid excess
23. Glucocorticoid exposure in utero: New model for adult hypertension
24. Dysfunction of placental glucocorticoid barrier: Link between fetal environment and adult hypertension?
25. Placental 11β-hydroxysteroid dehydrogenase: A key regulator of fetal glucocorticoid exposure
26. Prenatal glucocorticoid exposure leads to offspring hyperglycaemia in the rat: Studies with the 11β-hydroxysteroid dehydrogenase inhibitor carbenoxolone
27. Inhibition of 11β-hydroxysteroid dehydrogenase in pregnant rats and the programming of blood pressure in the offspring
28. The contribution of parental blood pressures to the relationship between low birthweight and adult high blood pressure in a cross-sectional study
29. Glucocorticoids and insulin resistance: Old hormones, new targets
30. Glucocorticoid receptor messenger ribonucleic acid in different regions of human adipose tissue
31. Does central obesity reflect 'Cushing's disease of the omentum'?
32. Endocrine abnormalities in obesity
33. Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene
34. Effects of aging and obesity on aromatase activity of human adipose cells
35. Cortisol production in obesity
36. Hypothalamic arousal, insulin resistance and type 2 diabetes mellitus
37. Inhibition of cortisol secretion by dexamethasone in relation to body fat distribution: A dose-response study
38. Sex difference in the influence of obesity on the 24 hr mean plasma concentration of cortisol
39. Effect of fat distribution on the pharmacokinetics of cortisol in obesity
40. Obesity and gender influence cortisol secretion and metabolism in man
41. Cortisol effects on body mass, blood pressure, and cholesterol in the general population
42. Understanding the role of glucocorticoids in obesity; Tissue-specific alterations of corticosterone metabolism in obese Zucker rats
43. Cortisol metabolism in human obesity: Impaired cortisone-cortisol conversion in subjects with central adiposity
44. Tissue-specific dysregulation of cortisol metabolism in human obesity
45. 5-alpha-reductase activity in polycystic ovarian syndrome
46. Hyperandrogenism in polycystic ovary syndrome: Evidence of dysregulation of 11β-hydroxysteroid hydrogenase
47. An anti-inflammatory role for glucocorticoids in the ovaries?
48. Association of the 5 alpha-reductase type 1 gene with hirsutism in women with polycystic ovary syndrome
49. Elevated plasma cortisol in glucose intolerant men: Different responses to glucose and habituation to venepuncture
50. Altered control of cortisol secretion in adult men with low birthweight and cardiovascular risk factors
51. Lack of relationship between 11β-hydroxysteroid dehydrogenase setpoint and insulin sensitivity in the basal state and after 24 h of insulin infusion in healthy subjects and type 2 diabetic patients.
52. Regulation of 11β-hydroxysteroid dehydrogenase activity in human skin fibroblasts: Enzymatic modulation of glucocorticoid action
53. Insulin inhibits adrenal 17,20-lyase activity in man
54. Insulin action in the normal and polycystic ovary