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Volumn 108, Issue 15, 2004, Pages 4885-4898

Anhydrous Polyproline Helices and Globules

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CONFORMATIONS; ELECTRON MOBILITY; HYDROGEN BONDS; MASS SPECTROMETRY; MOLECULAR STRUCTURE; SOLUTIONS;

EID: 2342622637     PISSN: 15206106     EISSN: None     Source Type: Journal    
DOI: 10.1021/jp036454a     Document Type: Article
Times cited : (46)

References (52)
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    • For recent reviews, see: (a) Clemmer, D. E.; Jarrold, M. F. J. Mass Spectrom. 1997, 32, 577. (b) Hoaglund Hyzer, C. S.; Counterman, A. E.; Clemmer, D. E. Chem. Rev. 1999, 99, 3037.
    • (1997) J. Mass Spectrom. , vol.32 , pp. 577
    • Clemmer, D.E.1    Jarrold, M.F.2
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    • (a) von Helden, G.; Wyttenbach, T.; Bowers, M. T. Science, 1995, 267, 1483. (b) Wyttenbach, T.; von Helden, G.; Bowers, M. T. J. Am. Chem. Soc. 1996, 118, 8355.
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    • Von Helden, G.1    Wyttenbach, T.2    Bowers, M.T.3
  • 38
    • 0030905633 scopus 로고    scopus 로고
    • For recent reviews of ion mobility studies of biomolecules see: (a) Clemmer, D. E.; Jarrold, M. F. J. Mass Spectrom. 1997, 32, 577. (b) Hoaglund Hyzer, C. S.; Counterman, A. E.; Clemmer, D. E. Chem. Rev. 1999, 99, 3037.
    • (1997) J. Mass Spectrom. , vol.32 , pp. 577
    • Clemmer, D.E.1    Jarrold, M.F.2
  • 39
    • 0001625867 scopus 로고    scopus 로고
    • For recent reviews of ion mobility studies of biomolecules see: (a) Clemmer, D. E.; Jarrold, M. F. J. Mass Spectrom. 1997, 32, 577. (b) Hoaglund Hyzer, C. S.; Counterman, A. E.; Clemmer, D. E. Chem. Rev. 1999, 99, 3037.
    • (1999) Chem. Rev. , vol.99 , pp. 3037
    • Hoaglund Hyzer, C.S.1    Counterman, A.E.2    Clemmer, D.E.3
  • 40
    • 85088337976 scopus 로고    scopus 로고
    • note
    • linear = 25.95n + 27.75. as determined from a fit to calculated cross sections (as described in ref 19) for linear structures.
  • 42
    • 0028555378 scopus 로고
    • Because of limitations in our modeling software, we chose to place protons on imide nitrogens of the proline residues rather than at the more basic carbonyl oxygens [for measurements of proton affinities, see, for instance, the following: (a) Zhang, K.; Cassady, C. J.; Chung-Phillips, A. J. Am. Chem. Soc. 1994, 116, 11512. (b) Addario, V.; Guo, Y.; Chu, I. K.; Ling, Y.; Ruggerio, G.; Rodriguez, C. F.; Hopkinson, A. C.; Siu, K. W. M. Int. J. Mass Spectrom. 2002, 219, 1011. Our justification for placing the protons is that for these large systems. Coulombic repulsion between charges is the dominant driving force (as observed in our work on large, multiply protonated polyalanine systems; see, for instance, refs 20 and 23). Our measurement allows us to discriminate between different conformer types (such as different types of helices or globules) but does not provide the ability to resolve structures at atomic resolution. In modeling the large polymer systems examined here, the exact placement of protonation sites should not significantly affect the results.
    • (1994) J. Am. Chem. Soc. , vol.116 , pp. 11512
    • Zhang, K.1    Cassady, C.J.2    Chung-Phillips, A.3
  • 43
    • 0036685575 scopus 로고    scopus 로고
    • Because of limitations in our modeling software, we chose to place protons on imide nitrogens of the proline residues rather than at the more basic carbonyl oxygens [for measurements of proton affinities, see, for instance, the following: (a) Zhang, K.; Cassady, C. J.; Chung-Phillips, A. J. Am. Chem. Soc. 1994, 116, 11512. (b) Addario, V.; Guo, Y.; Chu, I. K.; Ling, Y.; Ruggerio, G.; Rodriguez, C. F.; Hopkinson, A. C.; Siu, K. W. M. Int. J. Mass Spectrom. 2002, 219, 1011. Our justification for placing the protons is that for these large systems. Coulombic repulsion between charges is the dominant driving force (as observed in our work on large, multiply protonated polyalanine systems; see, for instance, refs 20 and 23). Our measurement allows us to discriminate between different conformer types (such as different types of helices or globules) but does not provide the ability to resolve structures at atomic resolution. In modeling the large polymer systems examined here, the exact placement of protonation sites should not significantly affect the results.
    • (2002) Int. J. Mass Spectrom. , vol.219 , pp. 1011
    • Addario, V.1    Guo, Y.2    Chu, I.K.3    Ling, Y.4    Ruggerio, G.5    Rodriguez, C.F.6    Hopkinson, A.C.7    Siu, K.W.M.8
  • 50
    • 85088340370 scopus 로고    scopus 로고
    • calc = (97.1n + z)/z
    • calc = (97.1n + z)/z.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.