Structural effects of phenolic acids on the transepithelial transport of fluorescein in Caco-2 cell monolayers

Bioscience, Biotechnology and Biochemistry

Volumn 67, Issue 9, 2003, Pages 2014-2017

  Konishi, Yutaka ^a   Kubo, Kazuo ^a   Shimizu, Makoto ^b  

^a KIRIN BREWERY CO LTD   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Caco 2 cell; Fluorescein; Monocarboxylic acid transporter; Phenolic acid; Structural specificity

Indexed keywords

COUMARIC ACID; FLUORESCEIN; HYDROXYBENZOIC ACID DERIVATIVE; MONOCARBOXYLATE TRANSPORTER; PHENOLIC ACID;

ARTICLE; CELL MEMBRANE PERMEABILITY; CELL STRAIN CACO 2; CHEMISTRY; DRUG EFFECT; EPITHELIUM CELL; HUMAN; HYDROXYLATION; METABOLISM; STRUCTURE ACTIVITY RELATION;

CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; COUMARIC ACIDS; EPITHELIAL CELLS; FLUORESCEIN; HUMANS; HYDROXYBENZOIC ACIDS; HYDROXYLATION; MONOCARBOXYLIC ACID TRANSPORTERS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 2342602459     PISSN: 09168451     EISSN: None     Source Type: Journal    
DOI: 10.1271/bbb.67.2014     Document Type: Article

References (13)

1. Steinmetz, K. A., and Potter, J. D., Vegetables, fruit, and cancer prevention. J. Am. Diet. Assoc., 96, 1027-1039 (1996).
2. Criqui, M. H., and Ringel, B. L., Does diet or alcohol explain the French paradox? Lancet, 344, 1719-1723 (1994).
3. Adlercreutz, H., and Mazur, W., Phyto-oestrogens and Western diseases. Ann. Med., 29, 95-120 (1997).
4. Scalbert, A., and Williamson, G., Dietary intake and bioavailability of polyphenols. J. Nutr., 130, 2073S-2085S (2000).
5. Hidalgo, I. J., Raub, T. J., and Borchardt, R. T., Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology, 96, 736-749 (1989).
6. Hilgers, A. R., Conradi, R. A., and Burton, P. S., Caco-2 cell monolayers as a model for drug transport across the intestinal mucosa. Pharm. Res., 7, 902-910 (1990).
7. Artursson, P., and Karlsson, J., Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. Biochem. Biophys. Res. Commun., 175, 880-885 (1991).
8. Hidalgo, I. J., and Borchardt, R. T., Transport of a large neutral amino acid (phenylalanine) in a human intestinal epithelial cell line, Caco-2. Biochim. Biophys. Acta, 1028, 25-30 (1990).
9. Hidalgo, I. J., and Borchardt, R. T., Transport of bile acids in a human intestinal epithelial cell line, Caco-2. Biochim. Biophys. Acta, 1035, 97-103 (1990).
10. Dantzig, A. H., and Bergin, L., Uptake of the cephalosporin, cephalexin, by a dipeptide transport carrier in the human intestinal cell line, Caco-2. Biochim. Biophys. Acta, 1027, 211-217 (1990).
11. Konishi, Y., Hagiwara, K., and Shimizu, M., Transepithelial transport of fluorescein in Caco-2 cell monolayers and its use in in vitro evaluation of phenolic acids availability. Biosci. Biotechnol. Biochem., 66, 2449-2457 (2002).
12. Rahman, B., Schneider, H. P., Broer, A., Deitmer, J. W., and Broer, S., Helix 8 and Helix 10 are involved in substrate recognition in the rat monocarboxylate transporter MCT1. Biochemistry, 38, 11577-11584 (1999).
13. Ogihara, T., Tamai, I., and Tsuji, A., Structural characterization of substrates for the anion exchange transporter in Caco-2 cells. J. Pharm. Sci., 88, 1217-1221 (1999).