Epithelial antimicrobial peptides: Local innate defense effector molecules;Peptides épithéliaux antimicrobiens: Molécules de défenses constitutionnelles locales

Annales de Dermatologie et de Venereologie

Volumn 131, Issue 4, 2004, Pages 411-416

  Schroder J M ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; BETA DEFENSIN; BETA DEFENSIN 4; BETA DEFENSIN 5; BETA DEFENSIN 6; CYSTEINE; DEFENSIN; DROSOMYCIN; LYSOZYME; POLYPEPTIDE ANTIBIOTIC AGENT; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

ARTICLE; CANDIDA ALBICANS; EFFECTOR CELL; ENTEROCOCCUS FAECIUM; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; PSEUDOMONAS AERUGINOSA; SKIN EPITHELIUM; SKIN INFECTION; STAPHYLOCOCCUS AUREUS;

EID: 2342597178     PISSN: 01519638     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0151-9638(04)93629-0     Document Type: Article

References (19)

1. Zasloff M. Antimicrobial peptides of multicellular organisms. Nature 2002;415:389-95.
2. Meister M, Lemaitre B, Hoffmann JA. Antimicrobial peptide defense in Drosophila. Bioessays 1997;19:1019-26.
3. Takeda K, Akira S. Toll receptors and pathogen resistance. Cell Microbiol 2003:143-53.
4. Lemaitre B, Reichhart JM, Hoffmann JA. Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms. Proc Natl Acad Sci USA 1997;94:14614-49.
5. Ferrandon D, Jung AC, Criqui MC, Lemaitre B, Uttenweiler-Joseph S, Michaut L et al. A drosomycin-GFP reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway. EMBO J 1998;17:1217-27.
6. Zasloff M. Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc Natl Acad Sci USA 1987;84:5449-53.
7. Salzman NH, Ghosh D, Huttner KM, Paterson Y, Bevins CL. Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin. Nature 2003;422:522-6.
8. Bals R, Wilson JM. Cathelicidins - a family of multifunctional antimicrobial peptides. Cell Mol Life Sci 2003;60:711-20.
9. Henseler T, Christophers E. Disease concomitance in psoriasis. J Am Acad Dermatol 1995;32:982-6.
10. Harder J, Bartels J, Christophers E, Schröder JM. A peptide antibiotic from human skin. Nature 1997;387:861.
11. Harder J, Meyer-Hoffert U, Teran LM, Schwichtenberg L, Bartels J, Maune S et al. Mucoid Pseudomonas aeruginosa, TNF-α, and IL-1β, but not IL-6 induce human β-Defensin-2 in respiratory epithelia. Am J Respir Cell Mol Biol 2000;22:714-21.
12. Song PI, Park YM, Abraham T, Harten B, Zivony A, Neparidze N, et al. Human keratinocytes express functional CD14 and toll-like receptor 4. J Invest Dermatol 2002;119:424-32.
13. Schröder JM. Epithelial antimicrobial peptides: innate local host response elements. Cell Mol Life Sci 1999;56:32-46.
14. Harder J, Schröder JM. RNase 7, a novel innate immune defense antimicrobial protein of healthy human skin. J Biol Chem 2002;277:46779-84.
15. Nizet V, Ohtake T, Lauth X, Trowbridge J, Rudisill J, Dorschner RA et al. Innate antimicrobial peptide protects the skin from invasive bacterial infection. Nature 2001;414:454-7.
16. Zaiou M, Nizet V, Gallo RL. Antimicrobial and protease inhibitory functions of the human cathelicidin (hCAP18/LL-37) prosequence. J Invest Dermatol 2003;120:810-6.
17. Frohm M, Agerberth B, Ahangari G, Stahle-Backdahl M, Liden S, Wigzell H et al. The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders. J Biol Chem 1997;272:15258-63.
18. Ong PY, Ohtake T, Brandt C, Strickland I, Boguniewicz M, Ganz T et al. Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med 2002;347:1151-60.
19. Nomura I, Goleva E, Howell MD, Hamid QA, Ong PY, Hall CF et al. Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes. J Immunol 2003;171:3262-9.