Insight into the pathophysiology of restless legs syndrome

Journal of Neuroscience Research

Volumn 62, Issue 5, 2000, Pages 623-628

  Earley, Christopher J ^a,d   Allen, Richard P ^a   Beard, John L ^c   Connor, James R ^b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

^c PENNSYLVANIA STATE UNIVERSITY   (United States)

^d JOHNS HOPKINS BAYVIEW MEDICAL CENTER   (United States)

Author keywords

Animal; Central nervous system; Dopamine; Human; Iron; MRI

Indexed keywords

DOPAMINE RECEPTOR; DOPAMINE RECEPTOR STIMULATING AGENT; DOPAMINE TRANSPORTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; BASAL GANGLION; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID ANALYSIS; CONTROLLED STUDY; DOPAMINERGIC TRANSMISSION; IRON DEFICIENCY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PREVALENCE; PRIORITY JOURNAL; RESTLESS LEGS SYNDROME; SHORT SURVEY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ANIMALS; BIOLOGICAL TRANSPORT; BRAIN; DISEASE MODELS, ANIMAL; DOPAMINE; HUMANS; IRON; RESTLESS LEGS SYNDROME;

EID: 0033665422     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-4547(20001201)62:5<623::AID-JNR1>3.0.CO;2-H     Document Type: Short Survey

References (79)

1. Distribution of transferrin synthesis in brain and other tissues in the rat
2. Magnetic resonance image measurement of regional brain iron content in patients with restless legs syndrome
3. Normal deposition of brain iron in childhood and adolescence; MR imaging at 1.5 T
4. Nutritional, iron and dopamine binding sites in the rat brain
5. Expression of transferrin mRNA in the CNS of normal and jimpy mice
6. Iron in the brain
7. 2 receptors
8. Ferritin, transferrin and iron in selected regions of the adult and aged rat brain
9. Comparison between akathisia developing on treatment with phenothiazine derivatives and the restless legs syndrome
10. Transport of iron in the blood-brain-cerebrospinal fluid system
11. Clonazepam: Effective treatment for restless legs syndrome in uremia
12. Low serum iron status and akathisia
13. Belgrade rats have an altered cellular distribution of brain iron
14. Abnormal rat brain monoamine metabolism in iron deficiency anemia
15. Brain iron, transferrin and ferritin concentrations are altered in developing iron-deficient rats
16. Practice parameters for the treatment of restless legs syndrome and periodic limb movement disorder
17. Periodic movements in sleep (nocturnal myoclonus) and restless legs syndrome
18. Periodic movements in sleep (nocturnal myoclonus): Relations to sleep disorders
19. Iron regulation in the brain at the cell and molecular level
20. A histochemical study of iron-positive cells in the developing rat brain
21. Regional variation in the levels of transferrin in the CNS of normal and myelin-deficient rats
22. Iron and transferrin uptake by brain and cerebrospinal fluid in the rat
23. Brain iron: Persistent deficiency following short term iron deprivation in the young rat
24. Brain iron in the rat: Extremely slow turnover in normal rats may explain long-lasting effects of early iron deficiency
25. 54Mn in hypotransferrinemic mice
26. Prochlorperazine induces akathisia in emergency patients
27. Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndrome
28. CSF dopamine, serotonin and biopterin metabolites in patients with restless legs syndrome
29. Restless legs syndrome
30. The role of iron in neurodegenerative disease
31. Regional brain iron, ferritin and transferrin concentrations during iron deficiency and iron repletion in developing rats
32. Diminished iron acquisition by cells and tissues of Belgrade laboratory rats
33. Dystonia with marked diurnal variation associated with biopterin deficiency
34. Antiemetic-induced akathisia in cancer patients receiving chemotherapy
35. The clinic phenomenon of akathisia
36. Akathisia
37. The treatment of restless legs syndrome and periodic limb movement disorder
38. Circadian rhythm of motor restlessness and sensory symptoms in the idiopathic restless legs syndrome
39. Characterization and distribution of ferritin binding sites in the adult mouse brain
40. Distribution of transferrin and ferritin binding in normal and multiple sclerotic human brains
41. Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase gene
42. Restless legs syndrome and sleep bruxism: Prevalence and association among Canadians
43. Iron deficiency and infant development
44. Transferrin response to normal and iron-deficient mice heterozygotic for hypotransferrinemia: Effects on iron and manganese accumulation
45. Existing and emerging mechanisms for transport of iron and manganese to the brain
46. The influence of d-amphetamine on rat brain striatal reduced biopterin concentration
47. Iron deficiency and restless legs
48. Iron regulation in the developing rat brain: Effect of in utero ethanol exposure
49. Immobilization tests and periodic leg movements in sleep for the diagnosis of restless leg syndrome
50. Familial restless legs with periodic movements in sleep: Electrophysiologic, biochemical, and pharmacologic study
51. Restless legs syndrome and periodic leg movements in sleep: The primary role of dopaminergic mechanisms
52. Immunohistochemical localization of intraneuronal transferrin receptor immunoreactivity in the adult mouse central nervous system
53. 125I] transferrin injected into the ventricular system of the rat
54. A genetic developmental model of iron deficiency: Biological aspects
55. In vivo dopamine metabolism is altered in iron-deficient anemic rats
56. The influence of sex, age and sleep/wake state on characteristics of periodic leg movements in restless legs syndrome patients
57. Therapy in restless legs
58. Dopa-responsive dystonia: Delineation of the clinical syndrome and clues to pathogenesis
59. Iron status and restless legs syndrome in the elderly
60. The circadian variation in dopamine metabolism in the subhuman primate
61. Variations in dietary iron alter brain iron metabolism in developing rats
62. Periodic leg movements (PLM): Their relationship to sleep stages
63. Recognizing and managing akathisia
64. Human circadian rhythms in temperature, trace metals, and blood variables
65. Hereditary progressive dystonia with marked diurnal fluctuation
66. Circadian rhythms of dopamine and cholecystokinin in nucleus accumbens and striatum of rats - Influence on dopaminergic stimulation
67. Circadian variation in dopamine levels in man
68. 2-receptor alteration
69. The symptom of restless legs
70. Iron and the restless legs syndrome
71. Iron metabolism: Clinical chronobiological aspects
72. Transferrin and iron uptake by the brain: Effects of altered iron status
73. Circadian rhythm of periodic limb movements and sensory symptoms of restless legs syndrome
74. 5-HT induced transferrin production by choroid plexus epithelial cells in culture: Role of 5-HT(1C) receptor
75. Striatal dopaminergic function in restless legs syndrome
76. Toward a better definition of the restless legs syndrome
77. Brain iron in the ferrocene-loaded rat: Its chelation and influence on dopamine metabolism
78. Effects of age on dopamine and serotonin receptors measured by positron tomography in the living human brain