-
1
-
-
2342575293
-
Scientific strategy in neuroscience: Discovery science versus hypothesis -driven research
-
Akil H. Scientific strategy in neuroscience: discovery science versus hypothesis -driven research. Neurosci. Q., Summer. 2003;4-5
-
(2003)
Neurosci. Q., Summer
, pp. 4-5
-
-
Akil, H.1
-
2
-
-
0030841343
-
Conformational disease
-
Carrell R.W., Lomas D.A. Conformational disease. Lancet. 350:1997;134-138
-
(1997)
Lancet
, vol.350
, pp. 134-138
-
-
Carrell, R.W.1
Lomas, D.A.2
-
4
-
-
0035203294
-
Mutant ubiquitin expressed in Alzheimer's disease causes neuronal death
-
de Vrij F.M.S., Sluijs J.A., Gregori L., Fischer D.F., Hermens W.T.J.M.C., Goldgaber D., Verhaagen J., Van Leeuwen F.W., Hol E.M. Mutant ubiquitin expressed in Alzheimer's disease causes neuronal death. FASEB J. 15:2001;2680-2688
-
(2001)
FASEB J.
, vol.15
, pp. 2680-2688
-
-
De Vrij, F.M.S.1
Sluijs, J.A.2
Gregori, L.3
Fischer, D.F.4
Hermens, W.T.J.M.C.5
Goldgaber, D.6
Verhaagen, J.7
Van Leeuwen, F.W.8
Hol, E.M.9
-
5
-
-
2342466439
-
+1) in muscle fibers implicates a novel mechanism of molecular misreading in the pathogenesis of inclusion-body myositis
-
in press
-
+1) in muscle fibers implicates a novel mechanism of molecular misreading in the pathogenesis of inclusion-body myositis. Neurology. 2004;. in press
-
(2004)
Neurology
-
-
Engel, W.K.1
Van Leeuwen, F.W.2
Hol, E.M.3
Vattemi, G.4
Askanas, V.5
-
6
-
-
0028307315
-
Frameshift mutations at two hot spots in vasopressin transcripts in post-mitotic neurons
-
Evans D.A.P., Van der Kley A.A.M., Sonnemans M.A.F., Burbach J.P.H., van Leeuwen F.W. Frameshift mutations at two hot spots in vasopressin transcripts in post-mitotic neurons. Proc. Natl. Acad. Sci. USA. 91:1994;6059-6063
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 6059-6063
-
-
Evans, D.A.P.1
Van Der Kley, A.A.M.2
Sonnemans, M.A.F.3
Burbach, J.P.H.4
Van Leeuwen, F.W.5
-
7
-
-
0030005829
-
Mutant vasopressin precursors in the human hypothalamus: Evidence for neuronal somatic mutations in man
-
Evans D.A.P., Burbach J.P., Swaab D.F., van Leeuwen F.W. Mutant vasopressin precursors in the human hypothalamus: evidence for neuronal somatic mutations in man. Neuroscience. 71:1996;1025-1030
-
(1996)
Neuroscience
, vol.71
, pp. 1025-1030
-
-
Evans, D.A.P.1
Burbach, J.P.2
Swaab, D.F.3
Van Leeuwen, F.W.4
-
8
-
-
0033959110
-
Neurofibrillary tangles in progressive supranuclear palsy brains exhibit immunoreactivity to frameshift mutant ubiquitin-B protein
-
Fergusson J., Landon M., Lowe J., Ward L., van Leeuwen F.W., Mayer R.J. Neurofibrillary tangles in progressive supranuclear palsy brains exhibit immunoreactivity to frameshift mutant ubiquitin-B protein. Neurosci. Lett. 279:2000;69-72
-
(2000)
Neurosci. Lett.
, vol.279
, pp. 69-72
-
-
Fergusson, J.1
Landon, M.2
Lowe, J.3
Ward, L.4
Van Leeuwen, F.W.5
Mayer, R.J.6
-
9
-
-
0242611535
-
Disease-specific accumulation of mutant ubiquitin as a marker for proteasomal dysfunction in the brain
-
Fischer D.F., de Vos R.A.I., Proper E.A., van Dijk R., de Vrij F.M.S., Sonnemans M.A.F., Verhage M.C., Sluijs J.A., Hobo B., Zouambia M., Jansen Steur E.N.H., Kamphorst W., Hol E., van Leeuwen F.W. Disease-specific accumulation of mutant ubiquitin as a marker for proteasomal dysfunction in the brain. FASEB J. 17:2003;2014-2024
-
(2003)
FASEB J.
, vol.17
, pp. 2014-2024
-
-
Fischer, D.F.1
De Vos, R.A.I.2
Proper, E.A.3
Van Dijk, R.4
De Vrij, F.M.S.5
Sonnemans, M.A.F.6
Verhage, M.C.7
Sluijs, J.A.8
Hobo, B.9
Zouambia, M.10
Jansen Steur, E.N.H.11
Kamphorst, W.12
Hol, E.13
Van Leeuwen, F.W.14
-
10
-
-
85059925410
-
Ubiquitin, proteasomes, and the aging brain
-
Gray D.A., Tsirigotis M., Woulfe J. Ubiquitin, proteasomes, and the aging brain. Sci. Aging Knowl. Environ. J. 27:2003;1-6
-
(2003)
Sci. Aging Knowl. Environ. J.
, vol.27
, pp. 1-6
-
-
Gray, D.A.1
Tsirigotis, M.2
Woulfe, J.3
-
11
-
-
0141925714
-
Frameshifted APP (APP+1) is a secretory protein and the level of APP+1 in cerebrospinal fluid is linked to Alzheimer pathology
-
Hol E.M., van Dijk R., Sluijs J.A., Gerez L., Hobo B., Tonk M.T., de Haan A., Kamphorst W., Fischer D.F., van Leeuwen F.W. Frameshifted APP (APP+1) is a secretory protein and the level of APP+1 in cerebrospinal fluid is linked to Alzheimer pathology. J. Biol. Chem. 2003;39637-39643
-
(2003)
J. Biol. Chem.
, pp. 39637-39643
-
-
Hol, E.M.1
Van Dijk, R.2
Sluijs, J.A.3
Gerez, L.4
Hobo, B.5
Tonk, M.T.6
De Haan, A.7
Kamphorst, W.8
Fischer, D.F.9
Van Leeuwen, F.W.10
-
12
-
-
0042385056
-
The temporal localization of frame-shift ubiquitin-B and amyloid precursor protein, and complement proteins in the brain of non-demented control patients with increasing Alzheimer's disease pathology
-
Konishi Y., Beach T., Sue L.I., Hampel H., Lindholm K., Shen Y. The temporal localization of frame-shift ubiquitin-B and amyloid precursor protein, and complement proteins in the brain of non-demented control patients with increasing Alzheimer's disease pathology. Neurosci. Lett. 348:2003;46-50
-
(2003)
Neurosci. Lett.
, vol.348
, pp. 46-50
-
-
Konishi, Y.1
Beach, T.2
Sue, L.I.3
Hampel, H.4
Lindholm, K.5
Shen, Y.6
-
13
-
-
0034730172
-
Inhibition of the ubiquitin-proteasome system in Alzheimer's disease
-
Lam A., Pickart C.M., Alban A., Landon M., Jamieson C., Ramage R., Mayer R.J., Layfield R. Inhibition of the ubiquitin-proteasome system in Alzheimer's disease. Proc. Natl. Acad. Sci. USA. 97:2000;9902-9906
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 9902-9906
-
-
Lam, A.1
Pickart, C.M.2
Alban, A.3
Landon, M.4
Jamieson, C.5
Ramage, R.6
Mayer, R.J.7
Layfield, R.8
-
14
-
-
0037193469
-
Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion-degradation substrate that blocks proteasomal degradation
-
Lindsten K., de Vrij F.M.S., Verhoef L.G.G.C., Fischer D.F., van Leeuwen F.W., Hol E.M., Masucci M.G., Dantuma N.P. Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion-degradation substrate that blocks proteasomal degradation. J. Cell Biol. 157:2002;417-429
-
(2002)
J. Cell Biol.
, vol.157
, pp. 417-429
-
-
Lindsten, K.1
De Vrij, F.M.S.2
Verhoef, L.G.G.C.3
Fischer, D.F.4
Van Leeuwen, F.W.5
Hol, E.M.6
Masucci, M.G.7
Dantuma, N.P.8
-
15
-
-
0036083089
-
Molecular misreading of the ubiquitin B gene and hepatic Mallory body formation
-
McPhaul L.W., Wang J., Hol E.M., Sonnemans M.A.F., Riley N., Nguyen V., Yuan Q.X., van Leeuwen F.W., French S.W. Molecular misreading of the ubiquitin B gene and hepatic Mallory body formation. Gastroenterology. 122:2002;1878-1885
-
(2002)
Gastroenterology
, vol.122
, pp. 1878-1885
-
-
McPhaul, L.W.1
Wang, J.2
Hol, E.M.3
Sonnemans, M.A.F.4
Riley, N.5
Nguyen, V.6
Yuan, Q.X.7
Van Leeuwen, F.W.8
French, S.W.9
-
17
-
-
0038689039
-
Protein aggregation and the ubiquitin proteasome pathway: Gaining the UPPer hand on neurodegeneration
-
Shoesmith Berke S.J., Paulson H.L. Protein aggregation and the ubiquitin proteasome pathway: gaining the UPPer hand on neurodegeneration. Curr. Opin. Genet. Dev. 13:2003;253-261
-
(2003)
Curr. Opin. Genet. Dev.
, vol.13
, pp. 253-261
-
-
Shoesmith Berke, S.J.1
Paulson, H.L.2
-
18
-
-
0141638441
-
Essential role of E2-25K/Hip-2 in mediating amyloid-β neurotoxicity
-
Song S., Kim S.-Y., Hong Y.-M., Jo D.-G., Lee J.-Y., Shim S.M., Chung C.-W., Seo S.J., Yoo Y.J., Koh J.-Y., Lee M.-C., Yates A.J., Ichijo H., Jung Y.-K. Essential role of E2-25K/Hip-2 in mediating amyloid-β neurotoxicity. Mol. Cell. 12:2003;553-563
-
(2003)
Mol. Cell
, vol.12
, pp. 553-563
-
-
Song, S.1
Kim, S.-Y.2
Hong, Y.-M.3
Jo, D.-G.4
Lee, J.-Y.5
Shim, S.M.6
Chung, C.-W.7
Seo, S.J.8
Yoo, Y.J.9
Koh, J.-Y.10
Lee, M.-C.11
Yates, A.J.12
Ichijo, H.13
Jung, Y.-K.14
-
19
-
-
6844258835
-
Frameshift mutants of β amyloid precursor protein and ubiquitin-B are prominent in Alzheimer and Down patients
-
van Leeuwen F.W., De Kleijn D.P.V., van den Hurk W.H., Neubauer A., Sonnemans M.A.F., Sluijs J.A., Köycü S., Ramdjielal R.D.J., Salehi A., Martens G.J.M., Grosveld F.G., Burbach J.P.H., Hol E.M. Frameshift mutants of β amyloid precursor protein and ubiquitin-B are prominent in Alzheimer and Down patients. Science. 279:1998;242-247
-
(1998)
Science
, vol.279
, pp. 242-247
-
-
Van Leeuwen, F.W.1
De Kleijn, D.P.V.2
Van Den Hurk, W.H.3
Neubauer, A.4
Sonnemans, M.A.F.5
Sluijs, J.A.6
Köycü, S.7
Ramdjielal, R.D.J.8
Salehi, A.9
Martens, G.J.M.10
Grosveld, F.G.11
Burbach, J.P.H.12
Hol, E.M.13
-
20
-
-
0032146362
-
Mutations in RNA: A first example of molecular misreading in Alzheimer's disease
-
van Leeuwen F.W., Burbach J.P.H., Hol E.M. Mutations in RNA: a first example of molecular misreading in Alzheimer's disease. Trends Neurosci. 21:1998;331-335
-
(1998)
Trends Neurosci.
, vol.21
, pp. 331-335
-
-
Van Leeuwen, F.W.1
Burbach, J.P.H.2
Hol, E.M.3
-
21
-
-
0032467862
-
The magnocellular neurons of the hypothalamo-neurohypophyseal system display remarkable neuropeptidergic phenotypes leading to novel insights in neuronal cell biology
-
van Leeuwen F.W., Verwer R.W.H., Spence H., Evans D.A.P., Burbach J.P.H. The magnocellular neurons of the hypothalamo-neurohypophyseal system display remarkable neuropeptidergic phenotypes leading to novel insights in neuronal cell biology. Prog. Brain Res. 119:1998;115-126
-
(1998)
Prog. Brain Res.
, vol.119
, pp. 115-126
-
-
Van Leeuwen, F.W.1
Verwer, R.W.H.2
Spence, H.3
Evans, D.A.P.4
Burbach, J.P.H.5
-
22
-
-
0033870764
-
Molecular misreading in non-neuronal cells
-
van Leeuwen F.W., Hol E.M., Hermanussen R.W.H., Sonnemans M.A.F., Moraal E., Fischer D.F., Evans D.A.P., Chooi K.-F., Burbach J.P.H., Murphy D. Molecular misreading in non-neuronal cells. FASEB J. 14:2000;1595-1602
-
(2000)
FASEB J.
, vol.14
, pp. 1595-1602
-
-
Van Leeuwen, F.W.1
Hol, E.M.2
Hermanussen, R.W.H.3
Sonnemans, M.A.F.4
Moraal, E.5
Fischer, D.F.6
Evans, D.A.P.7
Chooi, K.-F.8
Burbach, J.P.H.9
Murphy, D.10
|