Optimizing the binding affinity of a carrier protein: A case study on the interaction between soluble ifnar2 and interferon β

Journal of Biological Chemistry

Volumn 279, Issue 17, 2004, Pages 18046-18053

  Peleg Shulman, Tal ^a   Roisman, Laila C ^a   Zupkovitz, Gordin ^a   Schreiber, Gideon ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; BLOOD; DISSOCIATION; DRUG PRODUCTS; MIXTURES; PROTEINS; TISSUE;

BINDING AFFINITY; DISSOCIATION RATE; RECEPTORS;

BIOCHEMISTRY;

BETA INTERFERON; CARRIER PROTEIN; INTERFERON RECEPTOR; PRODRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG PROTEIN BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; RAT; TISSUE CULTURE;

ANIMALS; ANTIVIRAL AGENTS; CARRIER PROTEINS; CELL LINE; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; INTERFERON-BETA; KINETICS; LIGANDS; MALE; MEMBRANE PROTEINS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN BINDING; RATS; RATS, WISTAR; RECEPTOR, INTERFERON ALPHA-BETA; RECEPTORS, INTERFERON; THERMODYNAMICS; TIME FACTORS;

ANIMALIA;

EID: 2342426308     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M400033200     Document Type: Article

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